SIMILAR PATTERNS OF AMINO ACIDS FOR 2AM9_A_TESA1000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
LEU A 707
GLN A 711
MET A 745
ARG A 752
MET A 895
 BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
None
 0.92A 2am9A-2ax9A:
41.3		 2am9A-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ASN A 705
LEU A 707
MET A 742
MET A 745
MET A 749
ARG A 752
MET A 780
LEU A 873
THR A 877
MET A 895
 BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.0A)
None
 0.54A 2am9A-2ax9A:
41.3		 2am9A-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 705
TRP A 741
MET A 742
MET A 780
LEU A 873
THR A 877
MET A 895
 BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.0A)
None
 1.06A 2am9A-2ax9A:
41.3		 2am9A-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
LEU A  35
TRP A  69
MET A  70
MET A  73
ARG A  80
MET A 108
LEU A 201
 1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
 0.47A 2am9A-2q3yA:
37.5		 2am9A-2q3yA:
59.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
TRP A  69
MET A  73
ARG A  80
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
None
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
 0.78A 2am9A-2q3yA:
37.5		 2am9A-2q3yA:
59.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
ARG A 766
LEU A 887
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
 0.77A 2am9A-3kbaA:
35.5		 2am9A-3kbaA:
52.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 719
LEU A 721
MET A 756
MET A 759
MET A 909
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
None
 1.17A 2am9A-3kbaA:
35.5		 2am9A-3kbaA:
52.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 ASN A  33
LEU A  35
TRP A  69
MET A  70
MET A  73
ARG A  80
MET A 108
LEU A 201
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.69A 2am9A-3ry9A:
37.0		 2am9A-3ry9A:
52.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.86A 2am9A-3ry9A:
37.0		 2am9A-3ry9A:
52.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 ASN A 782
LEU A 771
GLN A 726
MET A 847
LEU A 817
 None
 1.41A 2am9A-4fm9A:
undetectable		 2am9A-4fm9A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 286
TRP A 320
MET A 321
ARG A 331
MET A 358
 None
 0.80A 2am9A-4n1yA:
28.8		 2am9A-4n1yA:
29.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 564
LEU A 566
TRP A 600
MET A 601
MET A 604
ARG A 611
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.80A 2am9A-4p6wA:
33.5		 2am9A-4p6wA:
48.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 564
TRP A 600
MET A 601
MET A 604
ARG A 611
LEU A 732
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
 0.74A 2am9A-4p6wA:
33.5		 2am9A-4p6wA:
48.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 570
TRP A 600
MET A 601
MET A 604
ARG A 611
LEU A 732
 MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
 0.95A 2am9A-4p6wA:
33.5		 2am9A-4p6wA:
48.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLN A 570
TRP A 600
MET A 601
MET A 604
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 1.07A 2am9A-4p6wA:
33.5		 2am9A-4p6wA:
48.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 770
LEU A 772
TRP A 806
MET A 807
ARG A 817
LEU A 938
 CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
 0.68A 2am9A-4udbA:
34.0		 2am9A-4udbA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 772
GLN A 776
TRP A 806
MET A 807
ARG A 817
LEU A 938
 CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
 0.93A 2am9A-4udbA:
34.0		 2am9A-4udbA:
49.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 ASN A 798
LEU A 787
GLN A 742
MET A 863
LEU A 833
 None
 1.39A 2am9A-5gwjA:
undetectable		 2am9A-5gwjA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ASN A 770
LEU A 772
TRP A 806
MET A 807
ARG A 817
MET A 845
LEU A 938
 ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
 0.72A 2am9A-5mwpA:
37.1		 2am9A-5mwpA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 ASN A 560
LEU A 562
MET A 597
MET A 600
ARG A 607
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.75A 2am9A-5uc1A:
23.5		 2am9A-5uc1A:
46.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLN A 566
TRP A 596
MET A 597
MET A 600
ARG A 607
 486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 1.01A 2am9A-5uc1A:
23.5		 2am9A-5uc1A:
46.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 562
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 1.11A 2am9A-5uc1A:
23.5		 2am9A-5uc1A:
46.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
LEU A  35
TRP A  69
MET A  70
MET A  73
ARG A  80
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.83A 2am9A-5ufsA:
35.8		 2am9A-5ufsA:
52.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
TRP A  69
MET A  70
MET A  73
ARG A  80
LEU A 201
 1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
 0.82A 2am9A-5ufsA:
35.8		 2am9A-5ufsA:
52.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
LEU A 201
 1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
 0.98A 2am9A-5ufsA:
35.8		 2am9A-5ufsA:
52.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 1.04A 2am9A-5ufsA:
35.8		 2am9A-5ufsA:
52.81