SIMILAR PATTERNS OF AMINO ACIDS FOR 2ACL_E_REAE504_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1akm | ORNITHINETRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ALA A 65ALA A 66GLN A 69ASN A 46ILE A 103 | None | 1.12A | 2aclE-1akmA:undetectable | 2aclE-1akmA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7k | ZINC ENDOPROTEASE (Streptomycescaespitosus) |
PF02031(Peptidase_M7) | 5 | ILE A 18ALA A 21ALA A 22LEU A 34ALA A 82 | None | 1.08A | 2aclE-1c7kA:undetectable | 2aclE-1c7kA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eom | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F3 (Elizabethkingiameningoseptica) |
PF00704(Glyco_hydro_18) | 5 | ILE A 127ALA A 193LEU A 163ALA A 157ILE A 86 | NoneNoneNoneSO4 A 702 ( 4.3A)None | 1.09A | 2aclE-1eomA:undetectable | 2aclE-1eomA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 5 | ALA A 105ALA A 106ASN A 27LEU A 57ALA A 166 | None | 0.81A | 2aclE-1iduA:undetectable | 2aclE-1iduA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jne | IMAGINAL DISC GROWTHFACTOR-2 (Drosophilamelanogaster) |
PF00704(Glyco_hydro_18) | 5 | ALA A 255GLN A 258ASN A 273LEU A 219ILE A 416 | NoneNAG A3100 (-3.3A)NoneNoneNone | 0.98A | 2aclE-1jneA:undetectable | 2aclE-1jneA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7h | ALKALINE PHOSPHATASE (Pandalusborealis) |
PF00245(Alk_phosphatase) | 5 | ILE A 350ALA A 28GLN A 27ARG A 137ILE A 458 | None | 1.12A | 2aclE-1k7hA:undetectable | 2aclE-1k7hA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nmo | HYPOTHETICAL PROTEINYBGI (Escherichiacoli) |
PF01784(NIF3) | 5 | ILE A 179ALA A 182ALA A 183ALA A 169ILE A 200 | None | 0.96A | 2aclE-1nmoA:undetectable | 2aclE-1nmoA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovm | INDOLE-3-PYRUVATEDECARBOXYLASE (Enterobactercloacae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 457ASN A 461LEU A 460ALA A 381ILE A 489 | None | 1.05A | 2aclE-1ovmA:undetectable | 2aclE-1ovmA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl0 | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Homo sapiens) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | ALA A 262ALA A 263ASN A 245LEU A 249ALA A 261 | None | 1.04A | 2aclE-1pl0A:undetectable | 2aclE-1pl0A:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgd | PROTEIN(TRANSKETOLASE) (Escherichiacoli) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ALA A 135ALA A 134GLN A 136LEU A 133ALA A 401 | None | 1.12A | 2aclE-1qgdA:undetectable | 2aclE-1qgdA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tt4 | PUTATIVE CYTOPLASMICPROTEIN (Salmonellaenterica) |
PF04107(GCS2) | 5 | ILE A 83ALA A 86ALA A 87LEU A 92ALA A 40 | None | 1.04A | 2aclE-1tt4A:undetectable | 2aclE-1tt4A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u6g | TIP120 PROTEIN (Homo sapiens) |
PF08623(TIP120) | 5 | ILE C1081ALA C1084ALA C1085ASN C1054LEU C1052 | None | 0.95A | 2aclE-1u6gC:undetectable | 2aclE-1u6gC:12.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uhl | RETINOIC ACIDRECEPTOR RXR-BETA (Homo sapiens) |
PF00104(Hormone_recep) | 11 | ILE A 339ALA A 342ALA A 343GLN A 346ASN A 377LEU A 380PHE A 384ARG A 387ALA A 398ILE A 416CYH A 503 | MEI A1001 (-3.8A)MEI A1001 (-3.1A)MEI A1001 (-3.3A)NoneNoneMEI A1001 (-3.8A)MEI A1001 (-4.5A)MEI A1001 (-3.6A)MEI A1001 (-3.4A)NoneMEI A1001 (-4.0A) | 0.89A | 2aclE-1uhlA:30.0 | 2aclE-1uhlA:88.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xa0 | PUTATIVE NADPHDEPENDENTOXIDOREDUCTASES (Geobacillusstearothermophilus) |
PF00107(ADH_zinc_N) | 5 | ALA A 134ALA A 135LEU A 291ALA A 166ILE A 87 | None | 1.07A | 2aclE-1xa0A:undetectable | 2aclE-1xa0A:24.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xiu | RXR-LIKE PROTEIN (Biomphalariaglabrata) |
PF00104(Hormone_recep) | 11 | ILE A 242ALA A 245ALA A 246GLN A 249ASN A 280LEU A 283PHE A 287ARG A 290ALA A 301ILE A 319CYH A 406 | 9CR A 201 ( 4.4A)9CR A 201 (-3.6A)9CR A 201 (-3.6A)9CR A 201 (-4.1A)None9CR A 201 ( 4.1A)9CR A 201 (-4.7A)9CR A 201 (-2.8A)9CR A 201 (-3.4A)None9CR A 201 (-3.6A) | 0.51A | 2aclE-1xiuA:30.6 | 2aclE-1xiuA:81.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xls | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 11 | ILE A 268ALA A 271ALA A 272GLN A 275ASN A 306LEU A 309PHE A 313ARG A 316ALA A 327ILE A 345CYH A 432 | 9CR A 801 (-3.9A)9CR A 801 (-3.6A)9CR A 801 (-3.5A)9CR A 801 (-4.7A)None9CR A 801 (-4.2A)9CR A 801 (-4.3A)9CR A 801 (-2.6A)9CR A 801 (-3.3A)9CR A 801 ( 4.5A)9CR A 801 ( 3.7A) | 0.58A | 2aclE-1xlsA:29.6 | 2aclE-1xlsA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwd | FOLLICLE STIMULATINGHORMONE RECEPTOR (Homo sapiens) |
PF01462(LRRNT)PF13306(LRR_5) | 5 | ILE C 185ALA C 189ASN C 211PHE C 214ILE C 230 | None | 1.11A | 2aclE-1xwdC:undetectable | 2aclE-1xwdC:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yt5 | INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Thermotogamaritima) |
PF01513(NAD_kinase) | 5 | ILE A 134ALA A 148ASN A 210ALA A 184ILE A 224 | None | 1.04A | 2aclE-1yt5A:undetectable | 2aclE-1yt5A:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkj | EXTENDED-SPECTRUMBETA-LACTAMASE (Klebsiellaaerogenes) |
PF00144(Beta-lactamase) | 5 | ALA A 163ALA A 164LEU A 174ALA A 78ILE A 225 | None | 0.97A | 2aclE-1zkjA:undetectable | 2aclE-1zkjA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a87 | THIOREDOXINREDUCTASE (Mycobacteriumtuberculosis) |
PF07992(Pyr_redox_2) | 5 | ILE A 309ALA A 308ALA A 311LEU A 315ALA A 33 | None | 1.10A | 2aclE-2a87A:undetectable | 2aclE-2a87A:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4m | GLYCOGENPHOSPHORYLASE (Corynebacteriumcallunae) |
PF00343(Phosphorylase) | 6 | ILE A 405ALA A 402ALA A 330ASN A 295LEU A 294ALA A 401 | None | 1.13A | 2aclE-2c4mA:undetectable | 2aclE-2c4mA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dc1 | L-ASPARTATEDEHYDROGENASE (Archaeoglobusfulgidus) |
PF01958(DUF108)PF03447(NAD_binding_3) | 5 | ILE A 6ALA A 58ALA A 57LEU A 80ILE A 75 | NoneNAD A 242 (-3.5A)NAD A 242 ( 4.9A)NAD A 242 (-4.1A)None | 1.08A | 2aclE-2dc1A:undetectable | 2aclE-2dc1A:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ebd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Aquifexaeolicus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ILE A 174ALA A 176LEU A 292ALA A 223ILE A 5 | None | 1.07A | 2aclE-2ebdA:undetectable | 2aclE-2ebdA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fow | RIBOSOMAL PROTEINL11 (Geobacillusstearothermophilus) |
PF00298(Ribosomal_L11) | 5 | ILE A 56ALA A 58ALA A 59LEU A 51ALA A 54 | None | 1.07A | 2aclE-2fowA:undetectable | 2aclE-2fowA:16.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gl8 | RETINOIC ACIDRECEPTOR RXR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 88PHE A 92ARG A 95ALA A 106ILE A 124CYH A 211 | None | 0.94A | 2aclE-2gl8A:27.7 | 2aclE-2gl8A:85.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hk3 | DIPHOSPHOMEVALONATEDECARBOXYLASE (Staphylococcusaureus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | ILE A 323ALA A 112ALA A 115LEU A 134ALA A 142 | None | 1.07A | 2aclE-2hk3A:undetectable | 2aclE-2hk3A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iu3 | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Gallus gallus) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | ALA A 263ALA A 264ASN A 246LEU A 250ALA A 262 | None | 0.98A | 2aclE-2iu3A:undetectable | 2aclE-2iu3A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mxa | NDH-1 COMPLEXSENSORY SUBUNIT CUPS (Thermosynechococcuselongatus) |
PF02469(Fasciclin) | 5 | ILE A 123ALA A 114ALA A 113ASN A 42ALA A 79 | None | 1.12A | 2aclE-2mxaA:undetectable | 2aclE-2mxaA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nty | RAC-LIKE GTP-BINDINGPROTEIN ARAC5 (Arabidopsisthaliana) |
PF00071(Ras) | 5 | ILE C 82ALA C 173ALA C 172ASN C 165PHE C 170 | None | 1.11A | 2aclE-2ntyC:undetectable | 2aclE-2ntyC:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nty | RAC-LIKE GTP-BINDINGPROTEIN ARAC5 (Arabidopsisthaliana) |
PF00071(Ras) | 5 | ILE C 82ALA C 173ALA C 172PHE C 170CYH C 158 | None | 1.03A | 2aclE-2ntyC:undetectable | 2aclE-2ntyC:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pzi | PROBABLESERINE/THREONINE-PROTEIN KINASE PKNG (Mycobacteriumtuberculosis) |
PF00069(Pkinase)PF16918(PknG_TPR)PF16919(PknG_rubred) | 5 | ILE A 661ALA A 664ALA A 665LEU A 704ALA A 644 | None | 0.92A | 2aclE-2pziA:undetectable | 2aclE-2pziA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q5c | NTRC FAMILYTRANSCRIPTIONALREGULATOR (Clostridiumacetobutylicum) |
PF06506(PrpR_N) | 5 | ILE A 175ALA A 178ASN A 26LEU A 3ALA A 52 | None | 1.01A | 2aclE-2q5cA:undetectable | 2aclE-2q5cA:22.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q60 | RETINOID X RECEPTOR (Polyandrocarpamisakiensis) |
PF00104(Hormone_recep) | 7 | ASN A 181LEU A 184PHE A 188ARG A 191ALA A 202ILE A 220CYH A 307 | None | 0.88A | 2aclE-2q60A:28.1 | 2aclE-2q60A:71.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qz6 | BETA-LACTAMASE (Pseudomonasfluorescens) |
PF00144(Beta-lactamase) | 5 | ALA A 162ALA A 163LEU A 173ALA A 77ILE A 224 | None | 1.08A | 2aclE-2qz6A:undetectable | 2aclE-2qz6A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhh | CG3027-PA (Drosophilamelanogaster) |
PF00795(CN_hydrolase) | 5 | ILE A 105ALA A 108ALA A 109ASN A 160ILE A 185 | None | 1.10A | 2aclE-2vhhA:undetectable | 2aclE-2vhhA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vjt | ALLOPHYCOCYANIN BETASUBUNIT (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 5 | ILE B 52ALA B 55ALA B 56LEU B 60ALA B 132 | NoneNoneNoneCYC B1081 (-4.7A)None | 1.11A | 2aclE-2vjtB:3.2 | 2aclE-2vjtB:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w37 | ORNITHINECARBAMOYLTRANSFERASE, CATABOLIC (Lactobacillushilgardii) |
PF00185(OTCace)PF02729(OTCace_N) | 6 | ILE A 183ALA A 182ALA A 206ASN A 175LEU A 178ALA A 215 | None | 1.48A | 2aclE-2w37A:undetectable | 2aclE-2w37A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0f | WSAF (Geobacillusstearothermophilus) |
no annotation | 5 | ILE A 168ALA A 138ASN A 50LEU A 52ALA A 140 | None | 1.11A | 2aclE-2x0fA:undetectable | 2aclE-2x0fA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5v | ALPHA-GALACTOSIDASE (Umbelopsisvinacea) |
PF16499(Melibiase_2) | 5 | ILE A 28ALA A 31ALA A 32LEU A 88ILE A 76 | None | 0.85A | 2aclE-3a5vA:undetectable | 2aclE-3a5vA:20.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 9 | ALA A 271ALA A 272GLN A 275ASN A 306LEU A 309PHE A 313ARG A 316ILE A 345CYH A 432 | 9CR A7223 (-3.5A)9CR A7223 (-4.2A)9CR A7223 (-4.6A)9CR A7223 (-3.9A)9CR A7223 ( 4.4A)9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 ( 4.9A)9CR A7223 (-3.8A) | 0.84A | 2aclE-3dzuA:29.9 | 2aclE-3dzuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 10 | ILE A 268ALA A 271ALA A 272GLN A 275LEU A 309PHE A 313ARG A 316ALA A 327ILE A 345CYH A 432 | 9CR A7223 (-3.9A)9CR A7223 (-3.5A)9CR A7223 (-4.2A)9CR A7223 (-4.6A)9CR A7223 ( 4.4A)9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 ( 4.7A)9CR A7223 ( 4.9A)9CR A7223 (-3.8A) | 0.87A | 2aclE-3dzuA:29.9 | 2aclE-3dzuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e35 | UNCHARACTERIZEDPROTEIN SCO1997 (Streptomycescoelicolor) |
PF09754(PAC2) | 5 | ILE A 224ALA A 227ALA A 226ARG A 136ILE A 235 | None | 1.11A | 2aclE-3e35A:undetectable | 2aclE-3e35A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewb | 2-ISOPROPYLMALATESYNTHASE (Listeriamonocytogenes) |
PF00682(HMGL-like) | 5 | ILE X 4ALA X 221ALA X 199ALA X 216ILE X 260 | None | 1.07A | 2aclE-3ewbX:undetectable | 2aclE-3ewbX:23.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3eyb | NUCLEAR HORMONERECEPTOR RXR (Branchiostomafloridae) |
PF00104(Hormone_recep) | 5 | ASN A 335LEU A 338PHE A 342ALA A 356CYH A 461 | None | 0.94A | 2aclE-3eybA:27.8 | 2aclE-3eybA:84.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f4n | PYRIDOXINE5'-PHOSPHATESYNTHASE (Yersinia pestis) |
PF03740(PdxJ) | 5 | ILE A 141ALA A 143ALA A 144LEU A 132ALA A 110 | None | 1.08A | 2aclE-3f4nA:undetectable | 2aclE-3f4nA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic6 | PUTATIVE METHYLASEFAMILY PROTEIN (Neisseriagonorrhoeae) |
PF00588(SpoU_methylase) | 5 | ILE A 28ALA A 31ALA A 32ASN A 89ILE A 92 | None | 1.06A | 2aclE-3ic6A:undetectable | 2aclE-3ic6A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ius | UNCHARACTERIZEDCONSERVED PROTEIN (Ruegeriapomeroyi) |
no annotation | 5 | ILE A 216ALA A 219ALA A 220GLN A 223LEU A 225 | None | 1.02A | 2aclE-3iusA:undetectable | 2aclE-3iusA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j0l | RIBOSOMAL PROTEINS14 (Oryctolaguscuniculus) |
PF00411(Ribosomal_S11) | 5 | ILE K 42ALA K 77ALA K 74GLN K 76ILE K 95 | None | 1.07A | 2aclE-3j0lK:undetectable | 2aclE-3j0lK:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kf8 | PROTEIN STN1 (Candidatropicalis) |
PF10451(Stn1) | 5 | ALA A 40GLN A 39LEU A 36PHE A 37ILE A 63 | None | 1.09A | 2aclE-3kf8A:undetectable | 2aclE-3kf8A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3klj | NAD(FAD)-DEPENDENTDEHYDROGENASE,NIRB-FAMILY(N-TERMINAL DOMAIN) (Clostridiumacetobutylicum) |
PF07992(Pyr_redox_2) | 6 | ILE A 160ALA A 166ALA A 156ASN A 46LEU A 155ALA A 143 | None | 1.47A | 2aclE-3kljA:undetectable | 2aclE-3kljA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lqy | PUTATIVEISOCHORISMATASEHYDROLASE (Oleispiraantarctica) |
PF00857(Isochorismatase) | 5 | ALA A 146ALA A 35GLN A 38ALA A 182ILE A 77 | None | 1.05A | 2aclE-3lqyA:undetectable | 2aclE-3lqyA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mr7 | ADENYLATE/GUANYLATECYCLASE/HYDROLASE,ALPHA/BETA FOLDFAMILY (Ruegeriapomeroyi) |
PF00211(Guanylate_cyc) | 5 | ALA A 66ALA A 67LEU A 8ALA A 45ILE A 102 | None | 1.04A | 2aclE-3mr7A:undetectable | 2aclE-3mr7A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvt | 3-DEOXY-D-ARABINO-HEPTULOSONATE7-PHOSPHATE SYNTHASE (Listeriamonocytogenes) |
PF00793(DAHP_synth_1)PF01817(CM_2) | 5 | ILE A 248ALA A 245ALA A 244ASN A 211ILE A 195 | None | 1.11A | 2aclE-3nvtA:undetectable | 2aclE-3nvtA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiq | KOJIBIOSEPHOSPHORYLASE (Caldicellulosiruptorsaccharolyticus) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | ALA A 360ALA A 361ASN A 434LEU A 350ILE A 718 | None | 0.98A | 2aclE-3wiqA:undetectable | 2aclE-3wiqA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiq | KOJIBIOSEPHOSPHORYLASE (Caldicellulosiruptorsaccharolyticus) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | ALA A 360ALA A 361LEU A 350ALA A 318ILE A 718 | None | 0.91A | 2aclE-3wiqA:undetectable | 2aclE-3wiqA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ILE A 333ALA A 336GLN A 340LEU A 368ALA A 427 | None | 0.54A | 2aclE-3zyvA:undetectable | 2aclE-3zyvA:10.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b7x | PROBABLEOXIDOREDUCTASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | ILE A 178ALA A 179ALA A 157ILE A 217CYH A 213 | NoneNAP A 400 (-3.7A)NoneNoneNone | 1.06A | 2aclE-4b7xA:undetectable | 2aclE-4b7xA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpy | MEVALONATEDIPHOSPHATEDECARBOXYLASE (Staphylococcusepidermidis) |
PF00288(GHMP_kinases_N) | 5 | ILE A 146ALA A 116ALA A 115LEU A 114ALA A 7 | None | 1.09A | 2aclE-4dpyA:undetectable | 2aclE-4dpyA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g0o | PROTEIN ARGONAUTE 5 (Arabidopsisthaliana) |
PF02171(Piwi) | 5 | ILE A 629ALA A 633ALA A 611ILE A 653CYH A 657 | None | 1.08A | 2aclE-4g0oA:undetectable | 2aclE-4g0oA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g0y | PROTEIN ARGONAUTE 1 (Arabidopsisthaliana) |
PF02171(Piwi) | 5 | ILE A 610ALA A 650GLN A 654ILE A 704CYH A 698 | None | 1.13A | 2aclE-4g0yA:undetectable | 2aclE-4g0yA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 11 | ILE D 268ALA D 271ALA D 272GLN D 275ASN D 306LEU D 309PHE D 313ARG D 316ALA D 327ILE D 345CYH D 432 | None | 0.80A | 2aclE-4j5xD:28.3 | 2aclE-4j5xD:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 171ALA A 201ASN A 345LEU A 348ALA A 204 | None | 1.11A | 2aclE-4jlwA:undetectable | 2aclE-4jlwA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9a | ACYL-COADEHYDROGENASE (Burkholderiathailandensis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 244ALA A 316ALA A 319GLN A 318LEU A 298 | None | 1.10A | 2aclE-4m9aA:undetectable | 2aclE-4m9aA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n5f | PUTATIVE ACYL-COADEHYDROGENASE (Burkholderiacenocepacia) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 244ALA A 316ALA A 319GLN A 318LEU A 298 | None | 1.09A | 2aclE-4n5fA:undetectable | 2aclE-4n5fA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nn1 | TRANSCRIPTIONALREGULATOR (Mycobacteriumtuberculosis) |
PF00440(TetR_N) | 5 | ILE A 12ALA A 15ALA A 16GLN A 19ALA A 35 | None | 0.58A | 2aclE-4nn1A:undetectable | 2aclE-4nn1A:26.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5a | LACI FAMILYTRANSCRIPTIONREGULATOR (Bifidobacteriumanimalis) |
PF13377(Peripla_BP_3) | 5 | ALA A 309ALA A 308GLN A 310LEU A 307ALA A 95 | NoneNoneSO4 A 404 (-3.4A)NoneNone | 1.04A | 2aclE-4o5aA:undetectable | 2aclE-4o5aA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qji | PHOSPHOPANTOTHENOYLCYSTEINEDECARBOXYLASE/PHOSPHOPANTOTHENATE--CYSTEINE LIGASE (Mycolicibacteriumsmegmatis) |
PF04127(DFP) | 5 | ALA A 277ALA A 196PHE A 332ALA A 278ILE A 405 | CTP A 500 (-4.8A)NoneNoneNoneNone | 1.04A | 2aclE-4qjiA:undetectable | 2aclE-4qjiA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkx | LYS-GINGIPAIN W83 (Porphyromonasgingivalis) |
PF01364(Peptidase_C25)PF03785(Peptidase_C25_C) | 5 | ALA L 564ALA L 563LEU L 562ALA L 578ILE L 473 | None | 1.05A | 2aclE-4tkxL:undetectable | 2aclE-4tkxL:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr2 | SUBTILISIN-LIKE 1SERINE PROTEASE (Plasmodiumvivax) |
PF00082(Peptidase_S8) | 5 | ILE A 558ALA A 581ASN A 605LEU A 606ILE A 302 | None | 1.03A | 2aclE-4tr2A:undetectable | 2aclE-4tr2A:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4utg | SUGAR KINASE (Burkholderiapseudomallei) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | ALA A 10ALA A 43LEU A 122ALA A 167ILE A 47 | None | 1.09A | 2aclE-4utgA:undetectable | 2aclE-4utgA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynv | ACL4 (Chaetomiumthermophilum) |
PF13432(TPR_16) | 5 | ILE A 46ALA A 49ALA A 50LEU A 74ALA A 37 | None | 0.85A | 2aclE-4ynvA:undetectable | 2aclE-4ynvA:25.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3y | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | ILE A 237ALA A 240ALA A 241LEU A 263ALA A 309 | None | 1.08A | 2aclE-5a3yA:undetectable | 2aclE-5a3yA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dm6 | 50S RIBOSOMALPROTEIN L1 (Deinococcusradiodurans) |
PF00687(Ribosomal_L1) | 5 | ILE 0 18ALA 0 21ALA 0 22ASN 0 180LEU 0 181 | None | 0.87A | 2aclE-5dm60:undetectable | 2aclE-5dm60:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | SUSC/RAGA FAMILYTONB-LINKED OUTERMEMBRANE PROTEIN (Bacteroidesthetaiotaomicron) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ILE B 777ALA B 769GLN B 767ASN B 780ILE B 855 | None | 1.12A | 2aclE-5fq6B:undetectable | 2aclE-5fq6B:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxn | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | ILE A 237ALA A 240ALA A 241LEU A 263ALA A 309 | None | 1.09A | 2aclE-5fxnA:undetectable | 2aclE-5fxnA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hra | ASPARTATE/GLUTAMATERACEMASE (Escherichiacoli) |
PF01177(Asp_Glu_race) | 6 | ILE A 182ALA A 186ALA A 190GLN A 188LEU A 147ILE A 200 | None | 1.20A | 2aclE-5hraA:undetectable | 2aclE-5hraA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbw | 3-HYDROXYBUTYRYL-COADEHYDRATASE (Myxococcusxanthus) |
PF00378(ECH_1) | 5 | ILE A 102ALA A 101ALA A 100ALA A 190ILE A 166 | None | 1.10A | 2aclE-5jbwA:undetectable | 2aclE-5jbwA:26.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6m | RIBONUCLEASE VAPC (Caulobactervibrioides) |
PF01850(PIN) | 5 | ILE B 82ALA B 100ALA B 99GLN B 101ALA B 75 | None | 1.02A | 2aclE-5l6mB:undetectable | 2aclE-5l6mB:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5maw | FLAGELLAR PROTEINFLIS (Bacillussubtilis) |
no annotation | 5 | ILE E 35ALA E 39ALA E 38GLN E 40ILE E 60 | None | 1.11A | 2aclE-5mawE:undetectable | 2aclE-5mawE:25.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg5 | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Pseudomonasprotegens) |
no annotation | 5 | ALA A 164ALA A 13LEU A 329ALA A 278ILE A 174 | None | 1.06A | 2aclE-5mg5A:undetectable | 2aclE-5mg5A:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mza | ERYTHROCYTE MEMBRANEPROTEIN 1 (PFEMP1) (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 5 | ALA A 878ALA A 877LEU A 876ALA A 974ILE A 935 | None | 0.96A | 2aclE-5mzaA:undetectable | 2aclE-5mzaA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0g | PRECORRIN-8XMETHYLMUTASE (Rhodobactercapsulatus) |
no annotation | 5 | ILE A 196ALA A 44ALA A 43ASN A 202ILE A 160 | NoneNone8F5 A 301 ( 4.1A)8F5 A 301 (-3.8A)None | 1.11A | 2aclE-5n0gA:undetectable | 2aclE-5n0gA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojl | IMINE REDUCTASE (Aspergillusterreus) |
no annotation | 6 | ILE A 137ALA A 135ALA A 125ALA A 132ILE A 68CYH A 70 | NoneNone9X5 A 301 ( 4.8A)NoneNoneNone | 1.22A | 2aclE-5ojlA:undetectable | 2aclE-5ojlA:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txr | 5-AMINOLEVULINATESYNTHASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
no annotation | 5 | ILE B 331ALA B 347ALA B 348ALA B 168ILE B 264 | None | 1.07A | 2aclE-5txrB:undetectable | 2aclE-5txrB:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2o | J30 CCH (Thermobacilluscomposti) |
no annotation | 5 | ILE A 200ALA A 160GLN A 161LEU A 164ALA A 530 | None | 1.12A | 2aclE-5u2oA:undetectable | 2aclE-5u2oA:15.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
no annotation | 10 | ILE A 268ALA A 271ALA A 272ASN A 306LEU A 309PHE A 313ARG A 316ALA A 327ILE A 345CYH A 432 | 9CR A 503 (-4.0A)9CR A 503 (-3.5A)9CR A 503 (-3.5A)None9CR A 503 (-3.7A)9CR A 503 (-4.7A)9CR A 503 (-3.0A)9CR A 503 (-3.4A)None9CR A 503 (-3.3A) | 0.69A | 2aclE-5uanA:29.6 | 2aclE-5uanA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
no annotation | 10 | ILE A 268ALA A 271ALA A 272GLN A 275ASN A 306LEU A 309PHE A 313ARG A 316ALA A 327ILE A 345 | 9CR A 503 (-4.0A)9CR A 503 (-3.5A)9CR A 503 (-3.5A)9CR A 503 (-3.8A)None9CR A 503 (-3.7A)9CR A 503 (-4.7A)9CR A 503 (-3.0A)9CR A 503 (-3.4A)None | 0.65A | 2aclE-5uanA:29.6 | 2aclE-5uanA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uvm | HISTIDINE TRIAD(HIT) PROTEIN (Ruminiclostridiumthermocellum) |
PF11969(DcpS_C) | 5 | ILE A 64ALA A 67ALA A 68LEU A 103ALA A 27 | None | 1.00A | 2aclE-5uvmA:undetectable | 2aclE-5uvmA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2m | MEVALONATEDIPHOSPHATEDECARBOXYLASE (Enterococcusfaecalis) |
no annotation | 5 | ILE A 321ALA A 111ALA A 114LEU A 133ALA A 141 | None | 1.04A | 2aclE-5v2mA:undetectable | 2aclE-5v2mA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xnz | CRED (Streptomycescremeus) |
no annotation | 5 | ILE A 54ALA A 57ALA A 58LEU A 30ALA A 89 | None | 0.96A | 2aclE-5xnzA:undetectable | 2aclE-5xnzA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS14 (Trichomonasvaginalis) |
PF00411(Ribosomal_S11) | 5 | ALA O 86ALA O 85GLN O 87LEU O 84ALA O 126 | None | 0.99A | 2aclE-5xyiO:undetectable | 2aclE-5xyiO:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xym | 50S RIBOSOMALPROTEIN L22 (Mycolicibacteriumsmegmatis) |
PF00237(Ribosomal_L22) | 5 | ILE S 58ALA S 61ALA S 62LEU S 76ALA S 10 | None | 1.10A | 2aclE-5xymS:undetectable | 2aclE-5xymS:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xym | 50S RIBOSOMALPROTEIN L22 (Mycolicibacteriumsmegmatis) |
PF00237(Ribosomal_L22) | 5 | ILE S 58ALA S 61ALA S 62LEU S 76ILE S 42 | None | 0.74A | 2aclE-5xymS:undetectable | 2aclE-5xymS:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bma | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Campylobacterjejuni) |
no annotation | 5 | ILE A 184ALA A 182LEU A 140ALA A 177ILE A 54 | None | 1.03A | 2aclE-6bmaA:undetectable | 2aclE-6bmaA:25.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cbo | C-6'AMINOTRANSFERASE (Micromonosporaechinospora) |
no annotation | 5 | ILE A 45ALA A 34PHE A 353ALA A 352ILE A 365 | None | 1.06A | 2aclE-6cboA:undetectable | 2aclE-6cboA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6j | HIT FAMILY HYDROLASE (Legionellapneumophila) |
no annotation | 5 | ILE A 63ALA A 67LEU A 102ALA A 26ILE A 49 | None | 1.11A | 2aclE-6d6jA:undetectable | 2aclE-6d6jA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d95 | - (-) |
no annotation | 5 | ILE A 129ALA A 132ALA A 133ALA A 266ILE A 180 | None | 1.02A | 2aclE-6d95A:undetectable | 2aclE-6d95A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d95 | - (-) |
no annotation | 5 | ILE A 129ALA A 132ALA A 133LEU A 138ALA A 266 | None | 0.90A | 2aclE-6d95A:undetectable | 2aclE-6d95A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6et9 | ACETYL-COAACETYLTRANSFERASETHIOLASE (Methanothermococcusthermolithotrophicus) |
no annotation | 5 | ILE A 26ALA A 29ALA A 215GLN A 11ILE A 63 | None | 1.09A | 2aclE-6et9A:undetectable | 2aclE-6et9A:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gdg | TRXA,ADENOSINERECEPTOR A2A (Escherichiacoli;Homo sapiens) |
no annotation | 5 | ILE A 200ALA A 203ALA A 204GLN A 207ILE A 238 | None | 0.98A | 2aclE-6gdgA:undetectable | 2aclE-6gdgA:14.16 |