SIMILAR PATTERNS OF AMINO ACIDS FOR 2AB2_A_SNLA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C 115
ALA C 220
GLN C 222
ARG C 210
MET C 135
 None
 1.43A 2ab2A-1t3qC:
undetectable		 2ab2A-1t3qC:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
ASN A 705
GLN A 711
MET A 742
ARG A 752
PHE A 764
MET A 780
MET A 787
PHE A 891
 None
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.6A)
None
 0.72A 2ab2A-2ax9A:
35.8		 2ab2A-2ax9A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
PHE A  98
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.15A 2ab2A-2q3yA:
38.5		 2ab2A-2q3yA:
68.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  28
GLN A  39
ARG A  80
PHE A  92
MET A 115
 None
1CA  A 247 (-3.1A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
 1.48A 2ab2A-2q3yA:
38.5		 2ab2A-2q3yA:
68.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		12 LEU A  29
ASN A  33
ALA A  36
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 108
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
None
1CA  A 247 (-3.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.38A 2ab2A-2q3yA:
38.5		 2ab2A-2q3yA:
68.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 ALA A 361
GLN A 362
MET A 460
CYH A 431
THR A 435
 None
 1.36A 2ab2A-3a9sA:
undetectable		 2ab2A-3a9sA:
17.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.82A 2ab2A-3kbaA:
35.2		 2ab2A-3kbaA:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
ASN A 719
MET A 756
ARG A 766
PHE A 778
MET A 801
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.58A 2ab2A-3kbaA:
35.2		 2ab2A-3kbaA:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  29
ASN A  33
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 108
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.33A 2ab2A-3ry9A:
37.8		 2ab2A-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 LEU A  29
PHE A  98
MET A 108
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.40A 2ab2A-3ry9A:
37.8		 2ab2A-3ry9A:
65.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Polaromonas sp.
JS666) 		no annotation 5 LEU C  68
ALA C  59
GLN C  58
CYH C 119
PHE C  71
 None
 1.39A 2ab2A-4iqgC:
undetectable		 2ab2A-4iqgC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 280
ALA A 287
MET A 321
ARG A 331
PHE A 342
MET A 358
PHE A 462
 None
 0.67A 2ab2A-4n1yA:
28.2		 2ab2A-4n1yA:
28.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 564
GLN A 570
MET A 601
ARG A 611
PHE A 623
MET A 646
CYH A 736
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.72A 2ab2A-4p6wA:
34.4		 2ab2A-4p6wA:
56.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
ARG A 817
PHE A 829
MET A 852
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.35A 2ab2A-4udbA:
36.6		 2ab2A-4udbA:
91.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ALA A 773
GLN A 776
MET A 807
ARG A 817
PHE A 829
MET A 852
CYH A 942
 ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 (-3.7A)
ECV  A1101 (-4.0A)
 0.75A 2ab2A-5mwpA:
39.4		 2ab2A-5mwpA:
72.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
ARG A 817
PHE A 829
MET A 845
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.38A 2ab2A-5mwpA:
39.4		 2ab2A-5mwpA:
72.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 LEU L 104
ALA L  74
ARG L  54
PHE L  62
THR L  13
 None
 1.40A 2ab2A-5tr1L:
undetectable		 2ab2A-5tr1L:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 ASN A 560
GLN A 566
ARG A 607
PHE A 619
MET A 635
 486  A 801 (-4.2A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 ( 4.7A)
 1.28A 2ab2A-5uc1A:
23.2		 2ab2A-5uc1A:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
GLN A 566
MET A 597
ARG A 607
PHE A 619
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 ( 3.8A)
 0.82A 2ab2A-5uc1A:
23.2		 2ab2A-5uc1A:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 ASN A  33
GLN A  39
ARG A  80
PHE A  92
MET A 108
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.09A 2ab2A-5ufsA:
36.7		 2ab2A-5ufsA:
59.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 115
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.53A 2ab2A-5ufsA:
36.7		 2ab2A-5ufsA:
59.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  28
GLN A  39
ARG A  80
PHE A  92
MET A 115
 None
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 2.8A)
 1.49A 2ab2A-5ufsA:
36.7		 2ab2A-5ufsA:
59.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A 373
PHE A 365
MET A 385
MET A 396
CYH A 381
 None
 1.48A 2ab2A-6ei1A:
undetectable		 2ab2A-6ei1A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 5 LEU A   2
ALA A  18
GLN A  17
PHE A 409
THR A  83
 None
 1.36A 2ab2A-6gdtA:
undetectable		 2ab2A-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1af5 I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 LEU A  91
LEU A  88
LEU A  78
LEU A  58
 None
 0.90A 2ab2A-1af5A:
undetectable		 2ab2A-1af5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		4 LEU A  82
LEU A  17
LEU A  18
LEU A  89
 None
 0.82A 2ab2A-1b5lA:
undetectable		 2ab2A-1b5lA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 LEU A 254
LEU A 282
LEU A 274
LEU A 246
 None
 1.00A 2ab2A-1lzkA:
undetectable		 2ab2A-1lzkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii;
Desulfurococcus
mucosus) 		PF00961
(LAGLIDADG_1)
PF14528
(LAGLIDADG_3) 		4 LEU A 188
LEU A 185
LEU A 175
LEU A 155
 None
 0.80A 2ab2A-1mowA:
undetectable		 2ab2A-1mowA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU E 227
LEU E 232
LEU E 221
LEU E 256
 None
 0.97A 2ab2A-1nfiE:
undetectable		 2ab2A-1nfiE:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
LEU A 349
LEU A 387
LEU A 391
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
 0.36A 2ab2A-1pcgA:
27.1		 2ab2A-1pcgA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE

(Helicobacter
pylori) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 LEU A  97
LEU A 100
LEU A  69
LEU A  61
 None
 0.89A 2ab2A-1pu7A:
undetectable		 2ab2A-1pu7A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 508
LEU A 504
LEU A 456
LEU A  27
 None
 0.97A 2ab2A-1rqgA:
undetectable		 2ab2A-1rqgA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9i DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 LEU A  91
LEU A  88
LEU A  78
LEU A  58
 None
 0.86A 2ab2A-1t9iA:
undetectable		 2ab2A-1t9iA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end) 		4 LEU A 640
LEU A 642
LEU A 633
LEU A 590
 None
 1.04A 2ab2A-1um2A:
undetectable		 2ab2A-1um2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 189
LEU A 235
LEU A 246
LEU A 256
 None
 1.01A 2ab2A-1x87A:
undetectable		 2ab2A-1x87A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9z DNA MISMATCH REPAIR
PROTEIN MUTL

(Escherichia
coli) 		PF08676
(MutL_C) 		4 LEU A 460
LEU A 457
LEU A 449
LEU A 599
 None
 1.04A 2ab2A-1x9zA:
undetectable		 2ab2A-1x9zA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yke RNA POLYMERASE II
MEDIATOR COMPLEX
PROTEIN MED7

(Saccharomyces
cerevisiae) 		PF05983
(Med7) 		4 LEU A 155
LEU A 122
LEU A 123
LEU A 162
 None
 0.96A 2ab2A-1ykeA:
undetectable		 2ab2A-1ykeA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 118
LEU A  91
LEU A  87
LEU A  96
 None
 0.94A 2ab2A-1yrgA:
undetectable		 2ab2A-1yrgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 LEU A 304
LEU A 300
LEU A 110
LEU A 106
 None
WO4  A 773 (-4.6A)
None
None
 1.04A 2ab2A-1z26A:
undetectable		 2ab2A-1z26A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxq INTERCELLULAR
ADHESION MOLECULE-2

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU A  40
LEU A  55
LEU A  20
LEU A  36
 None
 0.90A 2ab2A-1zxqA:
undetectable		 2ab2A-1zxqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0t SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 LEU A 101
LEU A 124
LEU A  93
LEU A  48
 None
 0.89A 2ab2A-2a0tA:
undetectable		 2ab2A-2a0tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 LEU A 310
LEU A 265
LEU A 267
LEU A 258
 None
 1.05A 2ab2A-2acvA:
undetectable		 2ab2A-2acvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		4 LEU A 285
LEU A 314
LEU A 275
LEU A 251
 None
 0.98A 2ab2A-2bexA:
undetectable		 2ab2A-2bexA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 LEU A 567
LEU A 568
LEU A 518
LEU A 520
 None
 0.85A 2ab2A-2dkhA:
undetectable		 2ab2A-2dkhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 LEU A 204
LEU A 207
LEU A 179
LEU A 133
 None
 0.91A 2ab2A-2eg3A:
undetectable		 2ab2A-2eg3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 LEU A 211
LEU A 128
LEU A 136
LEU A 169
 None
 1.03A 2ab2A-2eyqA:
undetectable		 2ab2A-2eyqA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbh TRANSCRIPTIONAL
REGULATOR PA3341

(Pseudomonas
aeruginosa) 		PF12802
(MarR_2) 		4 LEU A  42
LEU A  39
LEU A  28
LEU A 103
 None
 1.06A 2ab2A-2fbhA:
undetectable		 2ab2A-2fbhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 LEU A 166
LEU A 163
LEU A 489
LEU A 289
 None
 0.93A 2ab2A-2hb6A:
undetectable		 2ab2A-2hb6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		4 LEU A 103
LEU A  54
LEU A 111
LEU A  15
 None
 1.01A 2ab2A-2ie8A:
undetectable		 2ab2A-2ie8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'

(Homo sapiens) 		PF03095
(PTPA) 		4 LEU A 139
LEU A 119
LEU A  81
LEU A 163
 None
 1.02A 2ab2A-2ixmA:
undetectable		 2ab2A-2ixmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
LEU A 349
LEU A 387
LEU A 391
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
 0.32A 2ab2A-2ocfA:
28.4		 2ab2A-2ocfA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 LEU B 306
LEU B 309
LEU B 319
LEU B 330
 None
 0.88A 2ab2A-2p1nB:
undetectable		 2ab2A-2p1nB:
18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
LEU A  35
LEU A  77
CYH A 112
LEU A 201
 1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 ( 3.9A)
None
1CA  A 247 ( 4.2A)
 0.19A 2ab2A-2q3yA:
38.5		 2ab2A-2q3yA:
68.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		4 LEU A 899
LEU A 902
LEU A 929
LEU A 880
 None
 1.02A 2ab2A-2qmaA:
undetectable		 2ab2A-2qmaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzg UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 33

(Homo sapiens) 		PF02148
(zf-UBP) 		4 LEU A  71
LEU A 107
LEU A  58
CYH A  64
 None
None
None
ZN  A 132 (-2.3A)
 1.05A 2ab2A-2uzgA:
undetectable		 2ab2A-2uzgA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm8 MAGNESIUM-DEPENDENT
PHOSPHATASE 1

(Homo sapiens) 		PF12689
(Acid_PPase) 		4 LEU A  17
LEU A  48
LEU A  81
LEU A  82
 None
 0.97A 2ab2A-2wm8A:
undetectable		 2ab2A-2wm8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 LEU A 376
LEU A 379
LEU A 428
LEU A 409
 None
 0.93A 2ab2A-2wqdA:
undetectable		 2ab2A-2wqdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		4 LEU A 165
LEU A 192
LEU A 177
LEU A 160
 None
 1.02A 2ab2A-2xotA:
undetectable		 2ab2A-2xotA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 LEU A 371
LEU A 101
LEU A 107
LEU A 122
 None
 1.05A 2ab2A-2y4fA:
undetectable		 2ab2A-2y4fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 174
LEU A 152
LEU A 180
LEU A 198
 None
 1.05A 2ab2A-2z65A:
undetectable		 2ab2A-2z65A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 LEU A 581
LEU A 593
LEU A 540
LEU A 604
 None
 0.86A 2ab2A-2ziuA:
undetectable		 2ab2A-2ziuA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ad9 SARCOSINE OXIDASE
GAMMA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04268
(SoxG) 		4 LEU C 163
LEU C 156
LEU C 122
LEU C 124
 None
 0.99A 2ab2A-3ad9C:
undetectable		 2ab2A-3ad9C:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 346
LEU A 343
LEU A 248
LEU A 298
 None
 0.87A 2ab2A-3co8A:
undetectable		 2ab2A-3co8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 127
LEU A 116
LEU A 112
LEU A  91
 None
 0.99A 2ab2A-3e6eA:
undetectable		 2ab2A-3e6eA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 290
LEU A 315
LEU A 303
LEU A 280
 None
 1.02A 2ab2A-3fxiA:
undetectable		 2ab2A-3fxiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		4 LEU A 324
LEU A 304
LEU A 305
LEU A 331
 None
 0.67A 2ab2A-3glgA:
undetectable		 2ab2A-3glgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		4 LEU A  14
LEU A 106
LEU A 115
LEU A 117
 None
 1.00A 2ab2A-3heeA:
undetectable		 2ab2A-3heeA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF03177
(Nucleoporin_C) 		4 LEU B 938
LEU B 935
LEU B 956
LEU B 973
 None
 0.95A 2ab2A-3i4rB:
undetectable		 2ab2A-3i4rB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 LEU 3 355
LEU 3 351
LEU 3 544
LEU 3 369
 None
 1.03A 2ab2A-3i9v3:
undetectable		 2ab2A-3i9v3:
15.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 718
LEU A 721
LEU A 763
CYH A 798
LEU A 887
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.0A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.0A)
 0.29A 2ab2A-3kbaA:
35.2		 2ab2A-3kbaA:
52.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 LEU A 267
LEU A 266
LEU A 281
LEU A 444
 None
 0.90A 2ab2A-3kbhA:
undetectable		 2ab2A-3kbhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxy EXOENZYME S
SYNTHESIS PROTEIN C

(Pseudomonas
aeruginosa) 		PF05932
(CesT) 		4 LEU A  25
LEU A  46
LEU A  52
LEU A   3
 None
 0.95A 2ab2A-3kxyA:
undetectable		 2ab2A-3kxyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 LEU A 409
LEU A 412
LEU A 449
LEU A 456
 None
 0.96A 2ab2A-3m1cA:
undetectable		 2ab2A-3m1cA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON

(Bos taurus) 		PF04733
(Coatomer_E) 		4 LEU A 216
LEU A 219
LEU A 239
LEU A 253
 None
 0.79A 2ab2A-3mkrA:
undetectable		 2ab2A-3mkrA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 LEU A  91
LEU A  88
LEU A  78
LEU A  58
 None
 0.85A 2ab2A-3mx9A:
undetectable		 2ab2A-3mx9A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 LEU A 282
LEU A 279
LEU A 269
LEU A 249
 None
 0.74A 2ab2A-3mx9A:
undetectable		 2ab2A-3mx9A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oun PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		4 LEU A  61
LEU A  71
LEU A  93
LEU A  34
 None
 1.03A 2ab2A-3ounA:
undetectable		 2ab2A-3ounA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		4 LEU A  14
LEU A 106
LEU A 115
LEU A 117
 None
 1.02A 2ab2A-3ph3A:
undetectable		 2ab2A-3ph3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4r HYPOTHETICAL
FIMBRIAL ASSEMBLY
PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 LEU A  40
LEU A  43
LEU A 187
CYH A  69
 None
 0.99A 2ab2A-3r4rA:
undetectable		 2ab2A-3r4rA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  32
LEU A  35
LEU A  77
CYH A 112
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.1A)
None
1CA  A 249 ( 4.2A)
 0.18A 2ab2A-3ry9A:
37.8		 2ab2A-3ry9A:
65.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 LEU A 266
LEU A 269
LEU A 282
LEU A 198
 IOD  A 962 ( 4.6A)
IOD  A 962 ( 4.3A)
None
None
 0.74A 2ab2A-3s1sA:
undetectable		 2ab2A-3s1sA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1

(Burkholderia
ambifaria) 		PF00793
(DAHP_synth_1) 		4 LEU A 235
LEU A  16
LEU A 262
LEU A 269
 None
 0.73A 2ab2A-3t4cA:
undetectable		 2ab2A-3t4cA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		4 LEU A 180
LEU A 183
LEU A 241
LEU A 233
 GOL  A 305 (-3.7A)
None
None
None
 0.94A 2ab2A-3vc1A:
undetectable		 2ab2A-3vc1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		4 LEU A 298
LEU A 293
LEU A 318
LEU A 320
 None
 1.02A 2ab2A-3wwxA:
undetectable		 2ab2A-3wwxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 LEU A 459
LEU A 462
LEU A 475
LEU A 484
 None
 1.03A 2ab2A-4b8bA:
undetectable		 2ab2A-4b8bA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsx TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 1

(Homo sapiens) 		no annotation 4 LEU A   8
LEU A  43
LEU A  42
LEU A  49
 None
 1.02A 2ab2A-4bsxA:
undetectable		 2ab2A-4bsxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnm TROPHOBLAST
GLYCOPROTEIN

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 233
LEU A 212
LEU A 239
LEU A 257
 None
 0.94A 2ab2A-4cnmA:
undetectable		 2ab2A-4cnmA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e10 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		4 LEU A 365
LEU A 368
LEU A 304
CYH A 235
 None
 0.68A 2ab2A-4e10A:
undetectable		 2ab2A-4e10A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f41 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		4 LEU A 365
LEU A 368
LEU A 304
CYH A 235
 None
 0.77A 2ab2A-4f41A:
undetectable		 2ab2A-4f41A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 373
LEU A  19
LEU A  17
LEU A 291
 None
 1.05A 2ab2A-4ga7A:
undetectable		 2ab2A-4ga7A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas sp.
C18) 		PF00866
(Ring_hydroxyl_B) 		4 LEU B  37
LEU B  36
LEU B 172
LEU B  44
 None
 0.94A 2ab2A-4hjlB:
undetectable		 2ab2A-4hjlB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 4 LEU B  97
LEU B  93
LEU B  85
LEU B  45
 None
 1.05A 2ab2A-4k5uB:
undetectable		 2ab2A-4k5uB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		4 LEU A  81
LEU A  80
LEU A 293
CYH A 216
 None
 0.82A 2ab2A-4lcmA:
undetectable		 2ab2A-4lcmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maf ATP SULFURYLASE

(Glycine max) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  93
LEU A  60
LEU A 164
LEU A  82
 None
 0.91A 2ab2A-4mafA:
undetectable		 2ab2A-4mafA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU A 174
LEU A 111
LEU A  87
LEU A 323
 None
 1.01A 2ab2A-4p4sA:
undetectable		 2ab2A-4p4sA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU B 174
LEU B 111
LEU B  87
LEU B 323
 None
 1.03A 2ab2A-4p4sB:
undetectable		 2ab2A-4p4sB:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 563
LEU A 566
LEU A 608
CYH A 643
LEU A 732
 MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 ( 4.6A)
MOF  A 801 ( 3.7A)
MOF  A 801 ( 4.2A)
 0.65A 2ab2A-4p6wA:
34.4		 2ab2A-4p6wA:
56.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvq PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 LEU A 381
LEU A 378
LEU A 402
LEU A 406
 None
 0.97A 2ab2A-4rvqA:
undetectable		 2ab2A-4rvqA:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 769
LEU A 772
LEU A 810
LEU A 814
CYH A 849
LEU A 938
 CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.9A)
 0.58A 2ab2A-4udbA:
36.6		 2ab2A-4udbA:
91.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 299
LEU A 332
LEU A 305
LEU A 325
 None
 0.83A 2ab2A-4v2dA:
undetectable		 2ab2A-4v2dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 LEU B 443
LEU B 446
LEU B 522
LEU B 381
 None
 0.74A 2ab2A-4ydoB:
undetectable		 2ab2A-4ydoB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		4 LEU A 161
LEU A   7
LEU A 184
LEU A 142
 None
 0.90A 2ab2A-5a60A:
undetectable		 2ab2A-5a60A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 LEU A 644
LEU A 636
LEU A 544
LEU A 524
 None
 0.83A 2ab2A-5b3hA:
undetectable		 2ab2A-5b3hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		4 LEU A 352
LEU A 349
LEU A 445
LEU A 438
 None
 1.01A 2ab2A-5b5rA:
undetectable		 2ab2A-5b5rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 333
LEU A 334
LEU A 327
LEU A 270
 None
 0.97A 2ab2A-5cekA:
undetectable		 2ab2A-5cekA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A 576
LEU A 579
LEU A 405
LEU A 143
 None
 1.02A 2ab2A-5eawA:
undetectable		 2ab2A-5eawA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 386
LEU B 390
CYH B 317
LEU B 298
 None
 0.88A 2ab2A-5ip9B:
undetectable		 2ab2A-5ip9B:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Trichormus
variabilis) 		PF00701
(DHDPS) 		4 LEU A 240
LEU A 237
LEU A 195
LEU A 193
 None
 0.90A 2ab2A-5ktlA:
undetectable		 2ab2A-5ktlA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
LEU A 772
LEU A 814
CYH A 849
LEU A 938
 ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-3.8A)
ECV  A1101 ( 4.3A)
 0.20A 2ab2A-5mwpA:
39.4		 2ab2A-5mwpA:
72.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 LEU A 355
LEU A 353
LEU A 941
LEU A 933
 None
 1.05A 2ab2A-5mzoA:
undetectable		 2ab2A-5mzoA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 4 LEU A 189
LEU A 122
LEU A 197
LEU A 234
 None
PLM  A 401 ( 4.1A)
None
None
 1.01A 2ab2A-5oceA:
undetectable		 2ab2A-5oceA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7

(Saccharomyces
cerevisiae) 		PF05983
(Med7) 		4 LEU U 155
LEU U 122
LEU U 123
LEU U 162
 None
 0.95A 2ab2A-5svaU:
undetectable		 2ab2A-5svaU:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
LEU A 301
LEU A 339
LEU A 343
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
 0.34A 2ab2A-5toaA:
25.6		 2ab2A-5toaA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 LEU E 258
LEU E 259
LEU E  45
LEU E 123
 None
 0.82A 2ab2A-5u8sE:
undetectable		 2ab2A-5u8sE:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Escherichia
coli) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 LEU A  85
LEU A  88
LEU A 100
LEU A 102
 None
 0.97A 2ab2A-5uagA:
undetectable		 2ab2A-5uagA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 4 LEU A 559
LEU A 562
LEU A 604
CYH A 639
 486  A 801 (-4.7A)
486  A 801 ( 4.8A)
486  A 801 ( 3.8A)
486  A 801 ( 3.9A)
 0.74A 2ab2A-5uc1A:
23.2		 2ab2A-5uc1A:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
LEU A  35
LEU A  77
CYH A 112
LEU A 201
 1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.4A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.8A)
 0.40A 2ab2A-5ufsA:
36.7		 2ab2A-5ufsA:
59.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 4 LEU A  28
LEU A  25
LEU A  55
LEU A  38
 None
 0.88A 2ab2A-5w1eA:
undetectable		 2ab2A-5w1eA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 LEU A 511
LEU A 520
LEU A 530
LEU A 547
 None
 1.05A 2ab2A-5wu3A:
undetectable		 2ab2A-5wu3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00866
(Ring_hydroxyl_B) 		4 LEU C  37
LEU C  36
LEU C 172
LEU C  44
 None
 0.90A 2ab2A-5xbpC:
undetectable		 2ab2A-5xbpC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 379
LEU B 383
CYH B 309
LEU B 290
 None
 0.84A 2ab2A-5xogB:
undetectable		 2ab2A-5xogB:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 LEU B 569
LEU B 568
LEU B 477
LEU B 478
 None
 1.03A 2ab2A-6bcqB:
undetectable		 2ab2A-6bcqB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 LEU A 201
LEU A 203
LEU A 278
LEU A 381
 None
 0.89A 2ab2A-6cgmA:
undetectable		 2ab2A-6cgmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A  17
LEU A  30
LEU A  78
LEU A 123
 None
 0.98A 2ab2A-6eojA:
undetectable		 2ab2A-6eojA:
11.56