SIMILAR PATTERNS OF AMINO ACIDS FOR 2AA6_A_STRA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		5 LEU A 190
ASN A 191
LEU A 193
LEU A 207
MET A 211
 None
 1.36A 2aa6A-1alqA:
undetectable		 2aa6A-1alqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ASN B 200
ALA B 230
LEU B 235
MET B 270
THR B 170
 KCX  B 219 ( 4.2A)
None
None
None
None
 1.36A 2aa6A-1e9yB:
undetectable		 2aa6A-1e9yB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 LEU A 591
ASN A 592
LEU A 594
GLN A 598
LEU A 619
 None
 1.08A 2aa6A-1kblA:
undetectable		 2aa6A-1kblA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldd ANAPHASE PROMOTING
COMPLEX

(Saccharomyces
cerevisiae) 		PF08672
(ANAPC2) 		5 LEU A 826
ASN A 827
LEU A 829
ALA A 830
LEU A 789
 None
 0.79A 2aa6A-1lddA:
undetectable		 2aa6A-1lddA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		5 LEU A 132
ASN A 131
LEU A 129
ALA A 128
LEU A  21
 None
 1.30A 2aa6A-1nrkA:
undetectable		 2aa6A-1nrkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		5 LEU A 187
ASN A 188
LEU A 190
MET A 159
THR A 478
 None
 1.27A 2aa6A-1ohfA:
undetectable		 2aa6A-1ohfA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
LEU A 349
ALA A 350
LEU A 391
ARG A 394
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.50A 2aa6A-1pcgA:
27.0		 2aa6A-1pcgA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		5 LEU A 308
ASN A 309
LEU A 311
ALA A 312
THR A 320
 None
 1.28A 2aa6A-1pxyA:
undetectable		 2aa6A-1pxyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ASN A 748
LEU A 745
ALA A 752
LEU A 499
MET A 359
 None
 1.19A 2aa6A-1rrhA:
undetectable		 2aa6A-1rrhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu9 HYPOTHETICAL PROTEIN
PA3967

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  51
ALA A  53
LEU A  58
MET A 119
CYH A  15
 PPI  A 302 ( 4.3A)
None
HEM  A 301 (-4.5A)
None
None
 1.25A 2aa6A-1tu9A:
undetectable		 2aa6A-1tu9A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		5 LEU B 830
ASN B 829
LEU B 831
ALA B 828
LEU B 779
 None
 1.26A 2aa6A-1uw4B:
undetectable		 2aa6A-1uw4B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 LEU A 194
LEU A  36
ALA A  35
LEU A  29
THR A 212
 None
 1.25A 2aa6A-1vbmA:
undetectable		 2aa6A-1vbmA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus) 		PF01085
(HH_signal) 		5 LEU A 107
ASN A 108
LEU A 110
ALA A 111
MET A  99
 None
 1.16A 2aa6A-1vhhA:
undetectable		 2aa6A-1vhhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		5 LEU A 189
ASN A 190
LEU A 192
ALA A 193
THR A 309
 None
 1.36A 2aa6A-1xmxA:
undetectable		 2aa6A-1xmxA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 780
MET A 787
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.6A)
 0.69A 2aa6A-2ax9A:
35.8		 2aa6A-2ax9A:
48.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 LEU A  21
ASN A  25
ALA A  24
LEU A 274
THR A  35
 None
 1.43A 2aa6A-2dbyA:
undetectable		 2aa6A-2dbyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		5 ASN A 120
LEU A 122
ALA A 119
LEU A  54
MET A  56
 None
 1.29A 2aa6A-2e18A:
undetectable		 2aa6A-2e18A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		5 LEU A 159
LEU A  73
GLN A 181
LEU A  21
CYH A 139
 None
 1.27A 2aa6A-2ebjA:
undetectable		 2aa6A-2ebjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		5 LEU A  54
LEU A  83
ALA A  84
LEU A  41
MET A  44
 None
 1.37A 2aa6A-2f6kA:
undetectable		 2aa6A-2f6kA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnu AMINOTRANSFERASE

(Helicobacter
pylori) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 152
ALA A 172
LEU A 200
MET A 204
THR A  87
 None
None
None
None
PMP  A 901 (-4.6A)
 1.29A 2aa6A-2fnuA:
undetectable		 2aa6A-2fnuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 268
LEU A 271
ALA A 272
MET A 306
ARG A 316
 OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.29A 2aa6A-2gpvA:
25.7		 2aa6A-2gpvA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		5 LEU A 171
ASN A 170
LEU A 172
ALA A 169
LEU A 163
 None
 1.18A 2aa6A-2hoeA:
undetectable		 2aa6A-2hoeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibg PROTEIN HEDGEHOG

(Drosophila
melanogaster) 		PF01085
(HH_signal) 		5 LEU E 166
ASN E 167
LEU E 169
ALA E 170
MET E 158
 None
 1.08A 2aa6A-2ibgE:
undetectable		 2aa6A-2ibgE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 259
LEU A  78
ALA A  74
LEU A 224
MET A 222
 None
 1.40A 2aa6A-2nmpA:
undetectable		 2aa6A-2nmpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 LEU A 218
LEU A 215
LEU A 201
MET A 264
THR A 428
 None
None
None
None
ADP  A 600 (-4.5A)
 1.37A 2aa6A-2obmA:
undetectable		 2aa6A-2obmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
LEU A 349
ALA A 350
LEU A 391
ARG A 394
MET A 421
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.53A 2aa6A-2ocfA:
28.3		 2aa6A-2ocfA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		5 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 1.14A 2aa6A-2pl2A:
undetectable		 2aa6A-2pl2A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		12 LEU A  32
ASN A  33
LEU A  35
ALA A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
CYH A 205
THR A 208
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.36A 2aa6A-2q3yA:
38.5		 2aa6A-2q3yA:
68.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 343
LEU A 294
LEU A  16
CYH A 319
THR A 322
 None
 1.40A 2aa6A-2r3vA:
undetectable		 2aa6A-2r3vA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 728
ASN A 731
LEU A 729
ALA A 730
GLN A 766
 None
 1.14A 2aa6A-2vcaA:
undetectable		 2aa6A-2vcaA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		5 LEU A  28
ASN A  29
LEU A  31
ALA A  32
LEU A 338
 None
 1.19A 2aa6A-2w6dA:
undetectable		 2aa6A-2w6dA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ym9 CELL INVASION
PROTEIN SIPD

(Salmonella
enterica) 		PF06511
(IpaD) 		5 LEU A  87
ASN A  88
LEU A  90
ALA A  91
LEU A 105
 None
SO4  A1340 (-3.7A)
None
None
None
 0.65A 2aa6A-2ym9A:
undetectable		 2aa6A-2ym9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 LEU A 124
LEU A 115
ALA A 122
ARG A 351
THR A 482
 None
 1.36A 2aa6A-2yr5A:
undetectable		 2aa6A-2yr5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 ALA A 361
GLN A 362
MET A 460
CYH A 431
THR A 435
 None
 1.42A 2aa6A-3a9sA:
undetectable		 2aa6A-3a9sA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		5 ALA A 327
LEU A  69
MET A 284
MET A  71
THR A 235
 None
 1.39A 2aa6A-3d3aA:
undetectable		 2aa6A-3d3aA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		5 LEU A 202
ASN A 203
LEU A 205
ALA A 206
THR A 111
 None
 1.36A 2aa6A-3d62A:
undetectable		 2aa6A-3d62A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 LEU A 290
ASN A 291
LEU A 293
ALA A 294
GLN A 297
 None
 0.74A 2aa6A-3d6kA:
undetectable		 2aa6A-3d6kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		5 LEU A 705
LEU A 702
ALA A 701
LEU A 647
MET A 676
 None
 1.00A 2aa6A-3ebbA:
undetectable		 2aa6A-3ebbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz4 PUTATIVE ARSENATE
REDUCTASE

(Streptococcus
mutans) 		PF03960
(ArsC) 		5 LEU A  84
ASN A  83
LEU A  85
ALA A  82
LEU A  73
 None
 1.33A 2aa6A-3fz4A:
undetectable		 2aa6A-3fz4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 LEU A 389
LEU A 386
LEU A  66
MET A  28
THR A  32
 None
 1.25A 2aa6A-3g05A:
undetectable		 2aa6A-3g05A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 114
LEU A 117
ALA A 118
MET A  93
THR A 281
 None
 1.30A 2aa6A-3i6eA:
undetectable		 2aa6A-3i6eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibp CHROMOSOME PARTITION
PROTEIN MUKB

(Escherichia
coli) 		PF16330
(MukB_hinge) 		5 LEU A 674
ASN A 675
LEU A 677
ALA A 678
LEU A 736
 None
 1.29A 2aa6A-3ibpA:
undetectable		 2aa6A-3ibpA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH

(Pseudomonas
aeruginosa) 		PF04984
(Phage_sheath_1)
PF17482
(Phage_sheath_1C) 		5 LEU A 249
ASN A 248
LEU A 250
ALA A 247
ARG A 234
 None
 1.35A 2aa6A-3j9qA:
undetectable		 2aa6A-3j9qA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7h INDIAN HEDGEHOG
PROTEIN

(Homo sapiens) 		PF01085
(HH_signal) 		5 LEU B 111
ASN B 112
LEU B 114
ALA B 115
MET B 103
 None
 1.15A 2aa6A-3k7hB:
undetectable		 2aa6A-3k7hB:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 718
ASN A 719
LEU A 721
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
THR A 894
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.54A 2aa6A-3kbaA:
35.2		 2aa6A-3kbaA:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 721
GLN A 725
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
 0.82A 2aa6A-3kbaA:
35.2		 2aa6A-3kbaA:
52.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ASN A 167
LEU A 169
ALA A 166
GLN A 176
LEU A  54
 None
 1.19A 2aa6A-3mq4A:
undetectable		 2aa6A-3mq4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o01 CELL INVASION
PROTEIN SIPD

(Salmonella
enterica) 		PF06511
(IpaD) 		5 LEU A  87
ASN A  88
LEU A  90
ALA A  91
LEU A 105
 None
 0.71A 2aa6A-3o01A:
undetectable		 2aa6A-3o01A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ASN A 208
ALA A 196
LEU A  13
MET A   9
THR A 184
 None
 1.37A 2aa6A-3pv4A:
undetectable		 2aa6A-3pv4A:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
CYH A 205
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.26A 2aa6A-3ry9A:
37.6		 2aa6A-3ry9A:
65.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT

([Eubacterium]
rectale) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A  10
ASN A   9
LEU A  11
ALA A   8
LEU A  81
 None
 1.12A 2aa6A-3t0pA:
undetectable		 2aa6A-3t0pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.38A 2aa6A-3zxsA:
undetectable		 2aa6A-3zxsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA

(Salmonella
enterica) 		PF03193
(RsgA_GTPase) 		5 LEU V 232
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.18A 2aa6A-4a2iV:
undetectable		 2aa6A-4a2iV:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		5 LEU A  39
LEU A  42
ALA A  43
GLN A  46
CYH A  63
 None
 0.73A 2aa6A-4am9A:
undetectable		 2aa6A-4am9A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 LEU A 590
ASN A 593
LEU A 591
ALA A 592
THR A 609
 None
 1.21A 2aa6A-4dwsA:
undetectable		 2aa6A-4dwsA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		5 LEU A 104
ASN A  56
LEU A 108
ALA A 106
LEU A 460
 None
 1.25A 2aa6A-4e8dA:
undetectable		 2aa6A-4e8dA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.10A 2aa6A-4fdhA:
undetectable		 2aa6A-4fdhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A3339
ASN A3484
LEU A3342
ALA A3343
GLN A3346
 None
 1.22A 2aa6A-4kc5A:
undetectable		 2aa6A-4kc5A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A  88
ASN A  89
LEU A  91
ALA A  92
LEU A 179
 None
 1.36A 2aa6A-4kwgA:
undetectable		 2aa6A-4kwgA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
LEU A 286
ALA A 287
MET A 321
ARG A 331
MET A 358
 None
 0.48A 2aa6A-4n1yA:
28.2		 2aa6A-4n1yA:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oud TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 LEU B 194
LEU B  36
ALA B  35
LEU B  29
THR B 212
 LEU  B 194 ( 0.6A)
LEU  B  36 ( 0.6A)
ALA  B  35 ( 0.0A)
LEU  B  29 ( 0.6A)
THR  B 212 ( 0.8A)
 1.23A 2aa6A-4oudB:
undetectable		 2aa6A-4oudB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		5 LEU E 432
LEU E 431
ALA E 434
LEU E 458
CYH E 367
 None
 1.36A 2aa6A-4oztE:
21.7		 2aa6A-4oztE:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
LEU A 608
ARG A 611
MET A 646
CYH A 736
THR A 739
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.74A 2aa6A-4p6wA:
34.5		 2aa6A-4p6wA:
56.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		5 LEU A 201
LEU A 202
ALA A 199
GLN A  58
LEU A 190
 None
 1.44A 2aa6A-4q16A:
undetectable		 2aa6A-4q16A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A1500
ASN A1501
LEU A1503
ALA A1504
LEU A1457
 None
 1.37A 2aa6A-4rh7A:
undetectable		 2aa6A-4rh7A:
6.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
CYH A 942
THR A 945
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.26A 2aa6A-4udbA:
36.7		 2aa6A-4udbA:
91.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 LEU A 773
ASN A 774
LEU A 776
ALA A 777
LEU A 826
 None
 1.07A 2aa6A-4uvkA:
undetectable		 2aa6A-4uvkA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw7 L-SHAPED TAIL FIBER
PROTEIN

(Escherichia
virus T5) 		no annotation 5 LEU A1045
ASN A1018
LEU A1020
LEU A1062
THR A1105
 None
 1.18A 2aa6A-4uw7A:
undetectable		 2aa6A-4uw7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw8 L-SHAPED TAIL FIBER
PROTEIN

(Escherichia
virus T5) 		no annotation 5 LEU A1045
ASN A1018
LEU A1020
LEU A1062
THR A1105
 None
 1.25A 2aa6A-4uw8A:
undetectable		 2aa6A-4uw8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq5 L-SHAPED TAIL FIBER
PROTEIN PB8

(Escherichia
virus T5) 		no annotation 5 LEU A1045
ASN A1018
LEU A1020
LEU A1062
THR A1105
 None
 1.25A 2aa6A-5aq5A:
undetectable		 2aa6A-5aq5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		5 LEU A 400
ASN A 401
LEU A 399
ALA A 402
LEU A 477
 None
 1.28A 2aa6A-5dgqA:
undetectable		 2aa6A-5dgqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN B 155
LEU B 157
ALA B 154
GLN B 164
LEU B  37
 None
 1.21A 2aa6A-5fbhB:
undetectable		 2aa6A-5fbhB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU B 156
ASN B 155
LEU B 157
ALA B 154
GLN B 164
 None
 1.38A 2aa6A-5fbhB:
undetectable		 2aa6A-5fbhB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		5 LEU A 229
MET A 417
LEU A 331
MET A 334
THR A 385
 None
 1.38A 2aa6A-5fulA:
undetectable		 2aa6A-5fulA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 303
LEU A 317
ALA A 318
LEU A  10
MET A 361
 None
 1.44A 2aa6A-5hwqA:
undetectable		 2aa6A-5hwqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ASN A 155
LEU A 157
ALA A 154
GLN A 164
LEU A  37
 None
 1.27A 2aa6A-5k5tA:
undetectable		 2aa6A-5k5tA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A 156
ASN A 155
LEU A 157
ALA A 154
GLN A 164
 None
 1.39A 2aa6A-5k5tA:
undetectable		 2aa6A-5k5tA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ASN A 153
LEU A 155
ALA A 152
GLN A 162
LEU A  37
 None
 1.15A 2aa6A-5kznA:
undetectable		 2aa6A-5kznA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A 154
ASN A 153
LEU A 155
ALA A 152
GLN A 162
 None
 1.37A 2aa6A-5kznA:
undetectable		 2aa6A-5kznA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 5 LEU A 311
LEU A 310
ALA A 430
MET A 348
MET A 255
 None
 1.32A 2aa6A-5m3xA:
undetectable		 2aa6A-5m3xA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m50 CALMODULIN-REGULATED
SPECTRIN-ASSOCIATED
PROTEIN 3

(Mus musculus) 		PF08683
(CAMSAP_CKK) 		5 LEU C1137
LEU C1132
ALA C1131
LEU C1175
CYH C1170
 None
 1.41A 2aa6A-5m50C:
undetectable		 2aa6A-5m50C:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C)
PF07719
(TPR_2) 		5 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.55A 2aa6A-5mgxE:
undetectable		 2aa6A-5mgxE:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 845
CYH A 942
THR A 945
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.33A 2aa6A-5mwpA:
39.4		 2aa6A-5mwpA:
72.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
ASN A 770
LEU A 827
CYH A 942
THR A 945
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 1.39A 2aa6A-5mwpA:
39.4		 2aa6A-5mwpA:
72.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 9 LEU A 769
LEU A 772
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
CYH A 942
 ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 (-4.0A)
 0.68A 2aa6A-5mwpA:
39.4		 2aa6A-5mwpA:
72.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.23A 2aa6A-5nagA:
undetectable		 2aa6A-5nagA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 LEU A 431
ASN A 430
LEU A 428
ALA A 427
LEU A 313
 None
 1.30A 2aa6A-5nqdA:
undetectable		 2aa6A-5nqdA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 559
ASN A 560
LEU A 562
ALA A 563
MET A 545
 None
 1.06A 2aa6A-5o7eA:
undetectable		 2aa6A-5o7eA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 298
LEU A 301
ALA A 302
MET A 336
LEU A 343
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 0.34A 2aa6A-5toaA:
25.5		 2aa6A-5toaA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		5 LEU A  20
ASN A  21
LEU A  23
ALA A  24
LEU A  59
 None
 0.70A 2aa6A-5tz8A:
undetectable		 2aa6A-5tz8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzk GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		5 LEU C  20
ASN C  21
LEU C  23
ALA C  24
LEU C  59
 None
 0.75A 2aa6A-5tzkC:
undetectable		 2aa6A-5tzkC:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.12A 2aa6A-5uc1A:
23.2		 2aa6A-5uc1A:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 8 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.85A 2aa6A-5uc1A:
23.2		 2aa6A-5uc1A:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
LEU A  77
ARG A  80
MET A 108
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-3.0A)
 0.92A 2aa6A-5ufsA:
36.8		 2aa6A-5ufsA:
59.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
CYH A 205
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
 0.40A 2aa6A-5ufsA:
36.8		 2aa6A-5ufsA:
59.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A1015
ASN A1016
LEU A1018
ALA A1019
THR A1227
 None
 1.43A 2aa6A-5welA:
undetectable		 2aa6A-5welA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo sapiens) 		no annotation 5 ASN A 164
LEU A 166
ALA A 163
GLN A 173
LEU A  51
 None
 1.14A 2aa6A-6bszA:
undetectable		 2aa6A-6bszA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 5 LEU C 543
ASN C 542
LEU C 544
ALA C 541
THR C 355
 None
 1.14A 2aa6A-6c08C:
undetectable		 2aa6A-6c08C:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfp UBIQUITIN-LIKE
PROTEIN
SMT3,POLYMERASE
ACIDIC PROTEIN

(Influenza A
virus;
Saccharomyces
cerevisiae) 		no annotation 5 LEU A 470
ASN A 471
LEU A 469
ALA A 472
LEU A 511
 None
None
DMS  A 802 (-4.0A)
None
None
 1.38A 2aa6A-6cfpA:
undetectable		 2aa6A-6cfpA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 5 LEU A 246
LEU A 175
ALA A 176
LEU A 135
CYH A 192
 None
 1.36A 2aa6A-6cxdA:
undetectable		 2aa6A-6cxdA:
15.10