SIMILAR PATTERNS OF AMINO ACIDS FOR 2A8T_B_ADNB252

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 GLY A 292
ILE A 153
SER D  62
GLN D  63
 None
 1.05A 2a8tB-1e08A:
0.0		 2a8tB-1e08A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lba T7 LYSOZYME

(Escherichia
virus T7) 		PF01510
(Amidase_2) 		4 GLY A  54
PHE A 133
ILE A  50
SER A 102
 None
 1.05A 2a8tB-1lbaA:
0.0		 2a8tB-1lbaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 HIS A 256
GLY A 251
THR A 274
ILE A 247
 FE  A 900 (-4.4A)
None
None
None
 0.96A 2a8tB-1o2dA:
0.0		 2a8tB-1o2dA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 HIS A 270
THR A 263
ILE A 149
ASN A  69
 FE  A 900 ( 3.4A)
None
NAP  A1800 (-3.9A)
NAP  A1800 (-4.2A)
 0.90A 2a8tB-1o2dA:
0.0		 2a8tB-1o2dA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 405
THR A 380
ILE A 404
ASN A 343
 None
 0.97A 2a8tB-1pxtA:
undetectable		 2a8tB-1pxtA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		4 GLY A  53
THR A  13
ILE A  55
GLN A  49
 None
 1.03A 2a8tB-1qozA:
0.0		 2a8tB-1qozA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 GLY A  60
THR A  42
ILE A  59
GLN A  50
 None
 0.98A 2a8tB-1rp1A:
0.0		 2a8tB-1rp1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		4 GLY A 215
PHE A 127
THR A  36
ILE A 197
 None
 0.83A 2a8tB-1uh9A:
undetectable		 2a8tB-1uh9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 GLY A 572
THR A 647
ILE A 587
GLN A 629
 None
 0.90A 2a8tB-1ulvA:
0.0		 2a8tB-1ulvA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w SISTER CHROMATID
COHESION PROTEIN 1
STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04824
(Rad21_Rec8) 		4 GLY A  33
PHE E 504
ILE A  32
ASN A1192
 None
 1.04A 2a8tB-1w1wA:
undetectable		 2a8tB-1w1wA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 GLY A 125
PHE A 178
THR A 144
SER A 122
 None
 1.06A 2a8tB-1wd3A:
undetectable		 2a8tB-1wd3A:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a8q U8 SNORNA-BINDING
PROTEIN X29

(Xenopus laevis) 		PF00293
(NUDIX) 		8 HIS A  37
GLY A  69
PHE A  74
THR A 122
ILE A 178
ASN A 180
SER A 181
GLN A 184
 POP  A1307 (-4.1A)
None
POP  A1307 (-4.1A)
None
None
None
None
None
 0.44A 2a8tB-2a8qA:
33.3		 2a8tB-2a8qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anv LYSOZYME

(Salmonella
virus P22) 		PF00959
(Phage_lysozyme) 		4 HIS A  36
GLY A  33
ILE A  51
SER A  56
 None
 1.05A 2a8tB-2anvA:
undetectable		 2a8tB-2anvA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		4 GLY A 504
PHE A 271
THR A 330
ILE A 480
 None
 0.96A 2a8tB-2bf6A:
undetectable		 2a8tB-2bf6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 HIS A 520
GLY A 517
PHE A 682
ASN A 470
 CU  A1737 (-3.4A)
None
None
PAQ  A 471 ( 3.3A)
 0.88A 2a8tB-2c11A:
undetectable		 2a8tB-2c11A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 HIS A 126
GLY A 275
ILE A 121
SER A 124
 NDP  A2510 (-4.0A)
None
None
None
 0.97A 2a8tB-2cwfA:
undetectable		 2a8tB-2cwfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		4 GLY A 299
PHE A 130
ILE A 298
ASN A 204
 None
 1.06A 2a8tB-2d2xA:
undetectable		 2a8tB-2d2xA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzc UDP-N-ACETYLGLUCOSAM
INE TRANSFERASE
SUBUNIT ALG13

(Saccharomyces
cerevisiae) 		PF04101
(Glyco_tran_28_C) 		4 GLY A 194
PHE A  53
SER A 198
GLN A 199
 None
 1.04A 2a8tB-2jzcA:
undetectable		 2a8tB-2jzcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lw7 HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00458
(WHEP-TRS)
PF03129
(HGTP_anticodon) 		4 GLY A 128
ILE A 127
SER A  76
GLN A 112
 None
 0.88A 2a8tB-2lw7A:
undetectable		 2a8tB-2lw7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqb PROBABLE
BETA-LACTAMASE

(Staphylococcus
aureus) 		PF16229
(DUF4888) 		4 GLY A  26
THR A  83
ILE A  24
ASN A  22
 None
 0.94A 2a8tB-2mqbA:
undetectable		 2a8tB-2mqbA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Shigella
flexneri) 		PF03009
(GDPD) 		4 GLY A 241
THR A 214
ILE A 237
ASN A 216
 None
 1.06A 2a8tB-2otdA:
undetectable		 2a8tB-2otdA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLY A 271
THR A 139
ILE A 269
SER A 273
 None
 0.97A 2a8tB-2vmjA:
undetectable		 2a8tB-2vmjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE

(Nipah
henipavirus) 		PF00423
(HN) 		4 GLY A 400
THR A 308
ILE A 401
SER A 405
 None
 0.98A 2a8tB-2vsmA:
undetectable		 2a8tB-2vsmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 445
THR A 183
ILE A 252
ASN A 220
 None
 0.86A 2a8tB-2w40A:
undetectable		 2a8tB-2w40A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd6 AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		4 GLY A 641
PHE A 646
ILE A 726
GLN A 492
 None
 1.03A 2a8tB-2wd6A:
undetectable		 2a8tB-2wd6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlt L-ASPARAGINASE

(Helicobacter
pylori) 		PF00710
(Asparaginase) 		4 HIS A  93
GLY A  14
THR A  97
ILE A  60
 None
 0.84A 2a8tB-2wltA:
undetectable		 2a8tB-2wltA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		4 GLY A  14
THR A  22
ILE A  15
SER A 218
 FAD  A 600 (-3.6A)
None
None
None
 0.94A 2a8tB-2yg6A:
undetectable		 2a8tB-2yg6A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLY A 199
PHE B 427
THR B 430
SER A 217
 None
 1.05A 2a8tB-2z2mA:
undetectable		 2a8tB-2z2mA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bal ACETYLACETONE-CLEAVI
NG ENZYME

(Acinetobacter
johnsonii) 		no annotation 4 GLY A  31
THR A 107
ILE A  33
SER A  29
 None
 0.99A 2a8tB-3balA:
undetectable		 2a8tB-3balA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv)
no annotation 		4 GLY C 279
PHE C 109
THR C 232
SER A 202
 None
 1.03A 2a8tB-3cjiC:
undetectable		 2a8tB-3cjiC:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cou NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 16

(Homo sapiens) 		PF00293
(NUDIX) 		5 HIS A  24
GLY A  56
PHE A  61
ILE A 164
GLN A 170
 None
 0.30A 2a8tB-3couA:
28.9		 2a8tB-3couA:
54.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		4 GLY A 242
ILE A 243
ASN A  23
GLN A  19
 None
 1.02A 2a8tB-3ctkA:
undetectable		 2a8tB-3ctkA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633

(Methanosarcina
mazei) 		PF13649
(Methyltransf_25) 		4 GLY A 150
THR A 161
ILE A 155
ASN A 157
 None
 0.90A 2a8tB-3dtnA:
undetectable		 2a8tB-3dtnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fza GLUTAREDOXIN

(Populus tremula
x Populus
tremuloides) 		PF00462
(Glutaredoxin) 		4 THR A  69
ILE A  84
ASN A  76
GLN A  71
 None
 0.92A 2a8tB-3fzaA:
undetectable		 2a8tB-3fzaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 HIS A 510
GLY A 507
PHE A 673
ASN A 460
 CU  A 801 (-3.3A)
None
None
TPQ  A 461 ( 3.3A)
 0.78A 2a8tB-3higA:
undetectable		 2a8tB-3higA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjg PUTATIVE
ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
COBC

(Vibrio
parahaemolyticus) 		PF00300
(His_Phos_1) 		4 GLY A 175
THR A 146
ILE A 174
SER A 178
 None
 1.05A 2a8tB-3hjgA:
undetectable		 2a8tB-3hjgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		4 GLY A  12
ASN A  37
SER A  38
GLN A  42
 None
 1.04A 2a8tB-3k5hA:
undetectable		 2a8tB-3k5hA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		4 GLY A  13
ASN A  37
SER A  38
GLN A  42
 None
 0.88A 2a8tB-3k5hA:
undetectable		 2a8tB-3k5hA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN ALPHA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		4 GLY A  89
ILE A  88
ASN A  53
GLN A  49
 None
 0.77A 2a8tB-3kvsA:
undetectable		 2a8tB-3kvsA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 GLY A 832
PHE A 683
ILE A 833
SER A 838
 None
 1.01A 2a8tB-3l4kA:
undetectable		 2a8tB-3l4kA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		4 GLY A 165
PHE A 180
ILE A 172
SER A 170
 None
 0.99A 2a8tB-3lflA:
undetectable		 2a8tB-3lflA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 278
ILE A  51
ASN A  49
GLN A  45
 None
 0.81A 2a8tB-3mcxA:
undetectable		 2a8tB-3mcxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 GLY A 670
THR A 726
ILE A 668
GLN A 682
 None
 0.88A 2a8tB-3nawA:
undetectable		 2a8tB-3nawA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		4 HIS A  93
GLY A  14
THR A  97
ILE A  61
 None
 0.84A 2a8tB-3nxkA:
undetectable		 2a8tB-3nxkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 HIS A 244
GLY A 214
ASN A 247
SER A 246
 None
 0.92A 2a8tB-3om8A:
undetectable		 2a8tB-3om8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 GLY B 344
THR A 390
ILE B 332
SER B 193
 None
 0.94A 2a8tB-3opyB:
undetectable		 2a8tB-3opyB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 4 HIS A 409
GLY A 407
PHE A 414
ILE A 406
 None
 1.05A 2a8tB-3picA:
undetectable		 2a8tB-3picA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q19 GLUTATHIONE
S-TRANSFERASE
OMEGA-2

(Homo sapiens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 GLY A 167
PHE A 182
ILE A 174
SER A 172
 None
 1.03A 2a8tB-3q19A:
undetectable		 2a8tB-3q19A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhc GLUTAREDOXIN-C5,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00462
(Glutaredoxin) 		4 THR A  69
ILE A  84
ASN A  76
GLN A  71
 None
 0.93A 2a8tB-3rhcA:
undetectable		 2a8tB-3rhcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		4 GLY A 158
THR A 131
ILE A 176
SER A 154
 None
 1.00A 2a8tB-3s55A:
undetectable		 2a8tB-3s55A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skq MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
38

(Saccharomyces
cerevisiae) 		PF07766
(LETM1) 		4 GLY A 394
PHE A 222
ILE A 395
SER A 354
 None
 0.97A 2a8tB-3skqA:
undetectable		 2a8tB-3skqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 GLY A  45
PHE A 253
THR A 101
ASN A  97
 None
 1.07A 2a8tB-3stoA:
undetectable		 2a8tB-3stoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz6 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF05031
(NEAT) 		4 PHE A 146
ILE A 142
ASN A  56
SER A  53
 None
 0.90A 2a8tB-3sz6A:
undetectable		 2a8tB-3sz6A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50

(Plasmodium
falciparum) 		PF00149
(Metallophos) 		4 GLY A 298
ILE A 297
ASN A 258
SER A 275
 None
 0.95A 2a8tB-3tghA:
undetectable		 2a8tB-3tghA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 487
ILE A 488
SER A 358
GLN A 392
 0GV  A 602 ( 4.1A)
HEM  A 601 (-4.8A)
None
None
 1.05A 2a8tB-3v8dA:
undetectable		 2a8tB-3v8dA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 GLY A 233
ILE A 283
SER A 236
GLN A 240
 PLP  A 500 (-3.8A)
None
None
None
 1.07A 2a8tB-3vbeA:
undetectable		 2a8tB-3vbeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcx SPHINGOMYELINASE C

(Streptomyces
griseocarneus) 		PF03372
(Exo_endo_phos) 		4 GLY A 172
ILE A 158
ASN A 160
GLN A 214
 None
EPE  A 401 (-4.9A)
None
None
 1.02A 2a8tB-3wcxA:
undetectable		 2a8tB-3wcxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 GLY A 707
ILE A 706
ASN A 713
SER A 712
 None
 0.91A 2a8tB-3zqjA:
undetectable		 2a8tB-3zqjA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1

(Caenorhabditis
elegans) 		PF10250
(O-FucT) 		4 GLY A 165
PHE A 192
ILE A 163
SER A 174
 None
 1.03A 2a8tB-3zy3A:
undetectable		 2a8tB-3zy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k DNA DAMAGE-BINDING
PROTEIN 2

(Danio rerio) 		PF00400
(WD40) 		4 GLY D 197
THR D 375
ILE D 195
SER D 152
 None
 0.85A 2a8tB-4a0kD:
undetectable		 2a8tB-4a0kD:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLY A 113
ILE A 117
ASN A 239
SER A 199
 PO4  A 601 (-3.2A)
None
None
None
 0.92A 2a8tB-4c13A:
undetectable		 2a8tB-4c13A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A  19
ILE A  17
ASN A 432
GLN A 436
 None
 0.97A 2a8tB-4c23A:
undetectable		 2a8tB-4c23A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Bacillus
anthracis) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		4 GLY A  17
ASN A  42
SER A  43
GLN A  47
 GLY  A  17 ( 0.0A)
ASN  A  42 ( 0.6A)
SER  A  43 ( 0.0A)
GLN  A  47 (-0.6A)
 0.93A 2a8tB-4dlkA:
undetectable		 2a8tB-4dlkA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 GLY A 739
THR A 591
ILE A 682
GLN A 576
 None
 0.70A 2a8tB-4duuA:
undetectable		 2a8tB-4duuA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		4 HIS A 261
GLY A 265
ILE A 230
ASN A 221
 PO4  A 605 (-3.6A)
None
None
None
 0.91A 2a8tB-4fj6A:
undetectable		 2a8tB-4fj6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		4 GLY A 150
PHE A  41
THR A 138
ILE A 118
 None
 0.98A 2a8tB-4g0bA:
undetectable		 2a8tB-4g0bA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 HIS A 220
GLY A 222
ASN A 245
SER A 244
 ZN  A 602 (-3.3A)
None
ZN  A 603 ( 4.6A)
None
 1.03A 2a8tB-4h1sA:
undetectable		 2a8tB-4h1sA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum) 		PF01036
(Bac_rhodopsin) 		4 GLY A 143
THR A  79
ILE A 133
SER A 132
 None
 1.05A 2a8tB-4hyjA:
undetectable		 2a8tB-4hyjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		4 GLY A 173
THR A 155
ILE A 174
SER A 192
 None
 1.06A 2a8tB-4j1lA:
undetectable		 2a8tB-4j1lA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcn GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
epidermidis) 		PF13365
(Trypsin_2) 		4 GLY A 175
ILE A 174
ASN A 168
GLN A 172
 None
 0.90A 2a8tB-4jcnA:
undetectable		 2a8tB-4jcnA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwc CHAPERONE PROTEIN
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 GLY A 461
ILE A 462
ASN A 492
SER A 493
 None
 0.88A 2a8tB-4jwcA:
undetectable		 2a8tB-4jwcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lss ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 GLY G 222
THR G 244
ILE G 491
GLN G 246
 None
 1.04A 2a8tB-4lssG:
undetectable		 2a8tB-4lssG:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		4 GLY A 132
THR A 137
ILE A 133
ASN A 342
 None
 1.04A 2a8tB-4ovjA:
undetectable		 2a8tB-4ovjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6k SOLUTE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF13416
(SBP_bac_8) 		4 GLY A 170
PHE A 180
ILE A 248
SER A 246
 None
 1.06A 2a8tB-4r6kA:
undetectable		 2a8tB-4r6kA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		4 GLY A  51
PHE A 247
ILE A 239
GLN A  58
 AGS  A 303 (-3.2A)
None
AGS  A 303 ( 3.9A)
None
 0.96A 2a8tB-4tl9A:
undetectable		 2a8tB-4tl9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 PHE A  81
ILE A  35
ASN A  44
GLN A  40
 None
 0.84A 2a8tB-4trrA:
undetectable		 2a8tB-4trrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		4 GLY C 220
ILE C 205
ASN C 229
SER C 228
 None
 1.03A 2a8tB-4u9sC:
undetectable		 2a8tB-4u9sC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 251
THR A 358
ILE A  14
SER A  12
 None
 0.89A 2a8tB-4ubtA:
undetectable		 2a8tB-4ubtA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		4 GLY A  12
PHE A  83
ASN A  46
SER A  43
 FAD  A 401 (-3.2A)
None
FAD  A 401 (-3.7A)
FAD  A 401 (-2.5A)
 0.85A 2a8tB-4x9nA:
undetectable		 2a8tB-4x9nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		4 GLY A  82
ILE A 106
SER A  79
GLN A  60
 None
 1.04A 2a8tB-4ys6A:
undetectable		 2a8tB-4ys6A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 GLY A 347
PHE A 274
ILE A  59
ASN A 236
 None
 1.03A 2a8tB-5cerA:
undetectable		 2a8tB-5cerA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLY A 189
ILE A 279
SER A 287
GLN A 290
 None
 0.96A 2a8tB-5f9sA:
undetectable		 2a8tB-5f9sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 GLY A 428
ILE A 425
ASN A 434
SER A 431
 None
 1.06A 2a8tB-5flzA:
undetectable		 2a8tB-5flzA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY B 345
ILE B 344
ASN B 244
SER B 342
 None
 0.80A 2a8tB-5fq6B:
undetectable		 2a8tB-5fq6B:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtx BUCKWHEAT
GLUTAREDOXIN

(Polygonaceae) 		PF00462
(Glutaredoxin) 		4 THR A  78
ILE A  93
ASN A  85
GLN A  80
 None
 0.86A 2a8tB-5gtxA:
undetectable		 2a8tB-5gtxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 HIS A 228
PHE A 236
THR A 231
ILE A 250
 None
 1.03A 2a8tB-5k04A:
undetectable		 2a8tB-5k04A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLY A 733
ILE A 734
ASN A 747
SER A 492
 None
 1.01A 2a8tB-5l1bA:
undetectable		 2a8tB-5l1bA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 GLY A   5
ILE A   7
ASN A   2
GLN A  76
 None
 1.00A 2a8tB-5mrrA:
undetectable		 2a8tB-5mrrA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLY A 173
THR A 155
ILE A 174
SER A 192
 None
 1.03A 2a8tB-5n0cA:
undetectable		 2a8tB-5n0cA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 4 HIS A 460
GLY A 190
SER A 458
GLN A 457
 None
 0.78A 2a8tB-5oevA:
undetectable		 2a8tB-5oevA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 GLY A 205
THR A 132
ASN A 211
SER A 208
 None
 0.98A 2a8tB-5oynA:
undetectable		 2a8tB-5oynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcv 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 1

(Petunia x
hybrida) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A 117
THR A  53
ASN A 161
SER A 160
 None
 1.05A 2a8tB-5tcvA:
undetectable		 2a8tB-5tcvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		4 GLY A 370
ILE A 369
ASN A 374
SER A 373
 None
 0.93A 2a8tB-5vmkA:
undetectable		 2a8tB-5vmkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 GLY A 470
THR A 478
ILE A 599
SER A 474
 None
ATP  A1501 (-3.6A)
None
ATP  A1501 ( 4.8A)
 0.95A 2a8tB-5yudA:
undetectable		 2a8tB-5yudA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 4 PHE A 332
THR A 305
ASN A 172
GLN A 402
 None
 0.76A 2a8tB-6c62A:
undetectable		 2a8tB-6c62A:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6co2 NUDT16-TUDOR-INTERAC
TING (NUDT16TI)

(Homo sapiens) 		no annotation 5 HIS A  24
GLY A  56
PHE A  61
ILE A 165
GLN A 171
 None
 0.57A 2a8tB-6co2A:
28.6		 2a8tB-6co2A:
53.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 HIS A 668
GLY A 763
ILE A 765
ASN A 666
 None
 1.00A 2a8tB-6eonA:
undetectable		 2a8tB-6eonA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1j -

(-) 		no annotation 4 HIS A 180
GLY A 176
ILE A 151
SER A 154
 ZN  A 406 (-3.3A)
None
None
None
 1.03A 2a8tB-6f1jA:
undetectable		 2a8tB-6f1jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 GLY A 504
THR A 808
ILE A 549
SER A 555
 None
 0.97A 2a8tB-6fikA:
undetectable		 2a8tB-6fikA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 GLY A  32
THR A 188
ASN A 367
SER A 366
 None
 0.95A 2a8tB-6gbnA:
undetectable		 2a8tB-6gbnA:
undetectable