SIMILAR PATTERNS OF AMINO ACIDS FOR 2A69_M_RPTM8002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLN B 472
ASP B  10
ARG B 223
HIS B 493
ARG B 222
 None
 1.34A 2a69M-2w55B:
0.0		 2a69M-2w55B:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum) 		PF00190
(Cupin_1) 		5 GLN A 172
GLN A 174
ARG A 158
ASN A 151
GLU A   9
 None
 1.22A 2a69M-3kscA:
0.3		 2a69M-3kscA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 ASP A 593
ARG A 327
HIS A 594
ILE A 330
GLU A 282
 None
CL  A 816 (-3.1A)
None
CSO  A 316 ( 4.4A)
TRS  A 824 ( 4.6A)
 1.27A 2a69M-5mfaA:
0.0		 2a69M-5mfaA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		8 ARG C 164
GLN C 426
GLN C 429
ASP C 432
ARG C 604
HIS C 442
ARG C 445
ILE C 488
 None
 1.20A 2a69M-5tw1C:
39.0		 2a69M-5tw1C:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 GLN C 426
GLN C 429
ASP C 432
ARG C 604
HIS C 442
ARG C 445
SER C 447
ILE C 488
ASN C 601
 None
 1.23A 2a69M-5tw1C:
39.0		 2a69M-5tw1C:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		5 GLN C 426
GLN C 429
ASP C 432
HIS C 442
GLU C 481
 None
 1.41A 2a69M-5tw1C:
39.0		 2a69M-5tw1C:
50.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ARG C 150
HIS C 160
ARG C 163
ASN Q  99
GLU Q  27
 None
 1.39A 2a69M-6g2jC:
undetectable		 2a69M-6g2jC:
5.36