SIMILAR PATTERNS OF AMINO ACIDS FOR 2A69_C_RPTC8001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		5 PHE A  33
ASP A  22
ARG A  38
SER A  40
ILE A  45
 AMP  A 307 (-4.8A)
None
None
None
None
 1.25A 2a69C-1obgA:
0.0
2a69F-1obgA:
0.0		 2a69C-1obgA:
14.55
2a69F-1obgA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
 None
 0.88A 2a69C-3hkzB:
20.6
2a69F-3hkzB:
0.0		 2a69C-3hkzB:
30.01
2a69F-3hkzB:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uss PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF05995
(CDO_I) 		5 GLN A 107
PHE A 171
HIS A  89
SER A 145
ILE A  85
 None
None
FE2  A 212 ( 3.2A)
None
None
 1.49A 2a69C-3ussA:
0.0
2a69F-3ussA:
0.0		 2a69C-3ussA:
11.51
2a69F-3ussA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he4 YELLOW FLUORESCENT
PROTEIN

(Phialidium sp.
SL-2003) 		PF01353
(GFP) 		5 GLN A  69
PHE A  71
SER A 161
PRO A 196
ILE A 150
 CRO  A  65 ( 4.2A)
None
None
None
None
 1.46A 2a69C-4he4A:
0.0
2a69F-4he4A:
undetectable		 2a69C-4he4A:
11.88
2a69F-4he4A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ARG B 166
GLN B 425
ASP B 428
HIS B 438
PRO B 472
 None
 0.71A 2a69C-4qiwB:
22.5
2a69F-4qiwB:
0.0		 2a69C-4qiwB:
31.05
2a69F-4qiwB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLN X 327
GLN X 368
ASP X 297
ARG X 372
SER X 371
 None
 1.42A 2a69C-5evyX:
0.0
2a69F-5evyX:
1.7		 2a69C-5evyX:
18.33
2a69F-5evyX:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 ARG C 164
GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ILE C 488
 None
 0.76A 2a69C-5tw1C:
38.0
2a69F-5tw1C:
1.3		 2a69C-5tw1C:
50.41
2a69F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		5 GLN C 169
HIS C 442
ARG C 445
PRO C 480
ILE C 488
 None
 1.28A 2a69C-5tw1C:
38.0
2a69F-5tw1C:
1.3		 2a69C-5tw1C:
50.41
2a69F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		7 GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
PRO C 480
ILE C 488
 None
 0.97A 2a69C-5tw1C:
38.0
2a69F-5tw1C:
1.3		 2a69C-5tw1C:
50.41
2a69F-5tw1C:
18.80