SIMILAR PATTERNS OF AMINO ACIDS FOR 2A3R_B_LDPB297

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g3m ESTROGEN
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 PHE A  23
PRO A  46
PHE A  80
LYS A 105
HIS A 107
 PCQ  A 712 ( 4.6A)
PCQ  A 712 ( 4.3A)
PCQ  A 712 (-4.6A)
PCQ  A 712 (-3.0A)
PCQ  A 712 (-3.9A)
 0.62A 2a3rB-1g3mA:
43.3		 2a3rB-1g3mA:
49.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g3m ESTROGEN
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 PRO A  46
PHE A  80
LYS A 105
HIS A 107
HIS A 148
 PCQ  A 712 ( 4.3A)
PCQ  A 712 (-4.6A)
PCQ  A 712 (-3.0A)
PCQ  A 712 (-3.9A)
None
 0.62A 2a3rB-1g3mA:
43.3		 2a3rB-1g3mA:
49.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		5 PHE X  81
LYS X 106
HIS X 108
ALA X 146
HIS X 149
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
NPO  X1601 (-4.0A)
 1.46A 2a3rB-2zyvX:
45.6		 2a3rB-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		5 PRO X  47
PHE X  81
LYS X 106
HIS X 108
HIS X 149
 PPS  X1501 (-4.3A)
NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 (-4.0A)
 0.34A 2a3rB-2zyvX:
45.6		 2a3rB-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		6 PHE A  24
PRO A  47
PHE A  81
LYS A 106
HIS A 108
HIS A 149
 None
None
NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.6A)
 0.39A 2a3rB-3qvuA:
48.8		 2a3rB-3qvuA:
91.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 PHE A  81
LYS A 106
HIS A 108
ALA A 146
HIS A 149
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.6A)
 1.44A 2a3rB-3qvuA:
48.8		 2a3rB-3qvuA:
91.53