SIMILAR PATTERNS OF AMINO ACIDS FOR 2A3C_B_PNXB2434_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		4 TYR A  22
GLY A 233
PHE A 274
SER A 232
 None
 1.23A 2a3cB-1ghsA:
4.7		 2a3cB-1ghsA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 TYR A 698
GLY A 736
SER A 735
ARG A 718
 None
 1.28A 2a3cB-1h54A:
undetectable		 2a3cB-1h54A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 TYR A 541
GLY A 244
PHE A 359
ARG A  20
 None
 1.35A 2a3cB-1j2bA:
10.1		 2a3cB-1j2bA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 GLY A 137
PHE A  43
SER A 139
ARG A 109
 None
 1.29A 2a3cB-1ns3A:
undetectable		 2a3cB-1ns3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TYR A  34
GLY A 109
PHE A 111
SER A 112
 None
 1.35A 2a3cB-1q20A:
undetectable		 2a3cB-1q20A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		4 TYR D 308
GLY D 359
PHE D 360
SER D 361
 None
 1.09A 2a3cB-1r20D:
undetectable		 2a3cB-1r20D:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		4 TYR A 352
GLY A 342
PHE A 346
SER A 343
 None
 1.16A 2a3cB-1sxjA:
undetectable		 2a3cB-1sxjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 TYR A 716
GLY A 597
SER A 605
ARG A 596
 TYR  A 716 ( 1.3A)
GLY  A 597 ( 0.0A)
SER  A 605 ( 0.0A)
ARG  A 596 ( 0.6A)
 1.22A 2a3cB-1v0fA:
undetectable		 2a3cB-1v0fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w63 ADAPTER-RELATED
PROTEIN COMPLEX 1
SIGMA 1A SUBUNIT

(Mus musculus) 		PF01217
(Clat_adaptor_s) 		4 TYR Q 111
GLY Q  12
PHE Q   8
SER Q   9
 None
 1.32A 2a3cB-1w63Q:
undetectable		 2a3cB-1w63Q:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 TRP A 230
TYR A 530
PHE A 696
SER A 699
 None
None
R71  A1733 (-3.6A)
None
 1.39A 2a3cB-1w6jA:
undetectable		 2a3cB-1w6jA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 TYR A 140
GLY A 211
SER A 214
ARG A 263
 None
 0.36A 2a3cB-1wnoA:
69.9		 2a3cB-1wnoA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 TRP E 512
GLY E 526
PHE E 527
SER E 528
 None
 1.35A 2a3cB-1ye9E:
undetectable		 2a3cB-1ye9E:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 TYR A 299
GLY A 548
PHE A 546
SER A 547
 None
 1.19A 2a3cB-1z8lA:
2.1		 2a3cB-1z8lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd1 SULFOTRANSFERASE 4A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TYR A 172
GLY A  57
PHE A 145
SER A 141
 None
 1.39A 2a3cB-1zd1A:
undetectable		 2a3cB-1zd1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 TYR A 255
GLY A 267
PHE A 262
SER A 264
 None
 1.36A 2a3cB-2aaaA:
9.3		 2a3cB-2aaaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmy RIPENING-ASSOCIATED
PROTEIN

(Musa acuminata) 		PF01419
(Jacalin) 		4 TRP A  10
GLY A  75
PHE A  94
SER A  95
 None
 1.01A 2a3cB-2bmyA:
undetectable		 2a3cB-2bmyA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjl SECRETED CHITINASE

(Streptomyces
coelicolor) 		PF00182
(Glyco_hydro_19) 		4 TRP A 147
TYR A  42
GLY A 154
SER A 176
 None
 1.11A 2a3cB-2cjlA:
undetectable		 2a3cB-2cjlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		4 TYR A  50
GLY A 266
PHE A 309
SER A 265
 None
 1.25A 2a3cB-2cygA:
11.1		 2a3cB-2cygA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 TRP A 115
GLY A 145
PHE A 144
SER A 142
 None
 1.37A 2a3cB-2e3jA:
undetectable		 2a3cB-2e3jA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 GLY A 263
PHE A 261
SER A 260
ARG A 143
 None
 1.28A 2a3cB-2go4A:
undetectable		 2a3cB-2go4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		4 TYR A  92
GLY A  98
PHE A 108
ARG A 156
 None
 1.33A 2a3cB-2im9A:
undetectable		 2a3cB-2im9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 TRP A 900
PHE A 539
SER A 538
ARG A 540
 GOL  A3006 (-4.3A)
None
None
None
 1.29A 2a3cB-2okxA:
undetectable		 2a3cB-2okxA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A  34
GLY A  53
PHE A  23
SER A  55
 None
 1.17A 2a3cB-2panA:
undetectable		 2a3cB-2panA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		4 TYR A 163
GLY A  24
SER A  23
ARG A 135
 None
 1.31A 2a3cB-2pjqA:
undetectable		 2a3cB-2pjqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 TYR A 552
GLY A 423
PHE A 422
ARG A 611
 None
 1.24A 2a3cB-2pziA:
undetectable		 2a3cB-2pziA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 987
GLY A 622
SER A 666
ARG A 621
 None
 1.27A 2a3cB-2qf7A:
7.5		 2a3cB-2qf7A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A 322
GLY A  41
SER A 111
ARG A  38
 None
 1.29A 2a3cB-2qn0A:
undetectable		 2a3cB-2qn0A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		4 TRP A 233
GLY A 123
PHE A 142
SER A 141
 GOL  A1259 ( 4.8A)
None
None
None
 1.36A 2a3cB-2uz0A:
undetectable		 2a3cB-2uz0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 TYR A  96
GLY A  62
PHE A  61
SER A  63
 None
 1.36A 2a3cB-2vg9A:
undetectable		 2a3cB-2vg9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 TRP A 527
TYR A 579
GLY A 641
SER A  39
 None
 1.06A 2a3cB-2wzsA:
undetectable		 2a3cB-2wzsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 4 TYR A 308
GLY A  63
PHE A  62
SER A  66
 TRH  A 416 (-3.6A)
TRH  A 416 (-3.7A)
None
TRH  A 416 (-3.6A)
 1.05A 2a3cB-2x0fA:
undetectable		 2a3cB-2x0fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 TRP A  69
TYR B 273
GLY A 225
SER B 254
 None
 1.39A 2a3cB-3ayxA:
undetectable		 2a3cB-3ayxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 TRP A  69
TYR B 273
GLY A 226
SER B 254
 None
 1.29A 2a3cB-3ayxA:
undetectable		 2a3cB-3ayxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 TYR B 151
PHE B  76
SER B  96
ARG B  77
 None
 1.28A 2a3cB-3draB:
undetectable		 2a3cB-3draB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtd INVASION-ASSOCIATED
PROTEIN B

(Bartonella
henselae) 		PF06776
(IalB) 		4 TRP A  50
GLY A  92
PHE A 135
SER A  91
 None
 1.17A 2a3cB-3dtdA:
undetectable		 2a3cB-3dtdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		4 TYR A 190
GLY A 164
PHE A 170
SER A 163
 None
 1.36A 2a3cB-3efeA:
undetectable		 2a3cB-3efeA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 TYR A 512
GLY A 400
PHE A 546
SER A 399
 None
 1.33A 2a3cB-3f41A:
undetectable		 2a3cB-3f41A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjn THYMIDYLATE KINASE

(Thermotoga
maritima) 		PF02223
(Thymidylate_kin) 		4 TYR A  97
GLY A  38
SER A  67
ARG A  47
 TYD  A 401 (-3.8A)
None
None
TYD  A 401 (-2.9A)
 1.35A 2a3cB-3hjnA:
undetectable		 2a3cB-3hjnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		4 TYR A 129
GLY A 251
SER A 249
ARG A 278
 None
SO4  A 328 ( 4.5A)
SO4  A 328 (-2.5A)
None
 1.16A 2a3cB-3kaoA:
8.2		 2a3cB-3kaoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 TYR A 291
GLY A  89
PHE A 306
SER A 307
 None
 1.31A 2a3cB-3ll8A:
undetectable		 2a3cB-3ll8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE

(Sus scrofa) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 133
GLY A 242
PHE A 194
SER A 182
 None
 1.37A 2a3cB-3mdeA:
undetectable		 2a3cB-3mdeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		4 TYR A 216
GLY A 104
PHE A 250
SER A 103
 None
 1.31A 2a3cB-3mozA:
undetectable		 2a3cB-3mozA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 TRP A 221
GLY A 155
PHE A 154
SER A  84
 None
 1.27A 2a3cB-3oajA:
undetectable		 2a3cB-3oajA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 TYR A 244
GLY A 282
SER A 279
ARG A 255
 None
 1.40A 2a3cB-3op0A:
undetectable		 2a3cB-3op0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens) 		PF02263
(GBP) 		4 TYR A 328
GLY A 410
PHE A 413
SER A 414
 None
 1.06A 2a3cB-3q5eA:
undetectable		 2a3cB-3q5eA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A  92
GLY A 216
PHE A 218
SER A 219
 None
 0.83A 2a3cB-3vnsA:
undetectable		 2a3cB-3vnsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		4 TRP A 197
GLY A 242
PHE A 229
SER A 230
 None
 0.94A 2a3cB-3wmyA:
undetectable		 2a3cB-3wmyA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avr PA4485

(Pseudomonas
aeruginosa) 		PF03330
(DPBB_1) 		4 TYR A   9
GLY A  39
PHE A  38
ARG A  56
 None
 1.31A 2a3cB-4avrA:
undetectable		 2a3cB-4avrA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 TYR A 273
GLY A 512
PHE A 513
ARG A 483
 None
 1.29A 2a3cB-4b9yA:
12.5		 2a3cB-4b9yA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		4 TYR A 262
GLY A 133
PHE A 134
SER A 190
 None
 1.25A 2a3cB-4db3A:
undetectable		 2a3cB-4db3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 TRP A 192
GLY A 249
PHE A 253
SER A 248
 None
 1.31A 2a3cB-4fchA:
undetectable		 2a3cB-4fchA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 TRP A 192
GLY A 249
PHE A 253
SER A 248
 ACX  A 401 (-3.9A)
None
None
None
 1.34A 2a3cB-4femA:
undetectable		 2a3cB-4femA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		4 TYR A 444
GLY A 352
PHE A 421
SER A 417
 None
 1.34A 2a3cB-4fnmA:
undetectable		 2a3cB-4fnmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		4 TRP A 315
TYR A 311
PHE A 336
SER A 335
 None
 1.24A 2a3cB-4gdnA:
undetectable		 2a3cB-4gdnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE

(Solanum
tuberosum) 		PF00332
(Glyco_hydro_17) 		4 TYR A  47
GLY A 261
PHE A 305
SER A 260
 None
None
BGC  A 401 (-3.8A)
None
 1.24A 2a3cB-4gziA:
8.0		 2a3cB-4gziA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 TRP A 549
GLY A 590
PHE A 588
SER A 587
 None
 1.20A 2a3cB-4iegA:
undetectable		 2a3cB-4iegA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'

(Hevea
brasiliensis) 		PF00332
(Glyco_hydro_17) 		4 TYR A  23
GLY A 242
PHE A 284
SER A 241
 None
 1.25A 2a3cB-4iisA:
7.9		 2a3cB-4iisA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 TYR A 624
GLY A 422
PHE A 639
SER A 640
 None
 1.37A 2a3cB-4il1A:
undetectable		 2a3cB-4il1A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 4 TRP B  50
GLY B 266
PHE B 268
SER B 267
 None
 1.16A 2a3cB-4iu9B:
undetectable		 2a3cB-4iu9B:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 TYR A 499
GLY A 544
SER A 569
ARG A 235
 None
 1.10A 2a3cB-4jeuA:
2.4		 2a3cB-4jeuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 4 TYR D 176
GLY D 551
PHE D 553
SER D 547
 None
 1.36A 2a3cB-4jf7D:
undetectable		 2a3cB-4jf7D:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 TYR A 252
PHE A  35
SER A  63
ARG A 200
 None
 1.22A 2a3cB-4l9aA:
undetectable		 2a3cB-4l9aA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		4 TYR A  79
GLY A 107
PHE A 103
SER A 104
 None
 0.81A 2a3cB-4ld7A:
undetectable		 2a3cB-4ld7A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TRP A 679
GLY A 600
PHE A 609
SER A 605
 None
 1.26A 2a3cB-4lixA:
undetectable		 2a3cB-4lixA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TYR A 254
GLY A 230
PHE A 228
SER A 232
 None
 1.28A 2a3cB-4lxlA:
undetectable		 2a3cB-4lxlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 TYR A 362
GLY A 231
PHE A 230
SER A 234
 None
None
GOL  A 503 ( 4.8A)
None
 1.16A 2a3cB-4maaA:
undetectable		 2a3cB-4maaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbg TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE

(Janthinobacterium
sp. J3) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 TRP A 285
GLY A 131
PHE A  34
SER A  35
 None
 0.76A 2a3cB-4nbgA:
undetectable		 2a3cB-4nbgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2

(Bdellovibrio
bacteriovorus) 		PF14566
(PTPlike_phytase) 		4 TYR A 170
GLY A  72
PHE A 204
SER A  71
 None
 1.31A 2a3cB-4nx8A:
undetectable		 2a3cB-4nx8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 TYR A 300
GLY A  98
PHE A 315
SER A 316
 None
 1.33A 2a3cB-4oraA:
undetectable		 2a3cB-4oraA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A 291
GLY A  89
PHE A 306
SER A 307
 None
 1.40A 2a3cB-4orbA:
undetectable		 2a3cB-4orbA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 TRP A 260
GLY A 194
PHE A 181
SER A 182
 TEC  A 404 (-4.0A)
None
None
None
 1.22A 2a3cB-4q38A:
undetectable		 2a3cB-4q38A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		4 TRP A  53
TYR A 140
GLY A  90
SER A  88
 None
 1.29A 2a3cB-4rafA:
undetectable		 2a3cB-4rafA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1

(Homo sapiens) 		PF02214
(BTB_2) 		4 TYR A 123
GLY A  72
PHE A  70
SER A  71
 None
 1.23A 2a3cB-4uijA:
undetectable		 2a3cB-4uijA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 TYR A1389
GLY A1214
PHE A1223
SER A1221
 None
 0.93A 2a3cB-4xqkA:
undetectable		 2a3cB-4xqkA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xw3 ATP-DEPENDENT RNA
HELICASE DDX1

(Homo sapiens) 		PF00622
(SPRY) 		4 TYR A 135
GLY A 159
PHE A 165
SER A 174
 None
 0.84A 2a3cB-4xw3A:
undetectable		 2a3cB-4xw3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		4 GLY A 441
PHE A 381
SER A 382
ARG A 447
 None
 1.37A 2a3cB-4y7iA:
undetectable		 2a3cB-4y7iA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a11 THIOCYANATE FORMING
PROTEIN

(Thlaspi arvense) 		PF01344
(Kelch_1) 		4 TRP A 234
GLY A 188
PHE A 189
SER A 132
 None
None
None
IOD  A1350 ( 4.3A)
 1.40A 2a3cB-5a11A:
undetectable		 2a3cB-5a11A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		4 TYR A 309
GLY A 107
PHE A 324
SER A 325
 None
 1.35A 2a3cB-5b8iA:
undetectable		 2a3cB-5b8iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		4 TYR A 535
GLY A 469
PHE A 477
SER A 474
 None
 1.04A 2a3cB-5d3oA:
undetectable		 2a3cB-5d3oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TYR A 479
GLY A 518
PHE A 519
SER A 522
 None
 0.94A 2a3cB-5f7sA:
3.0		 2a3cB-5f7sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 TRP A 137
GLY A 109
PHE A 110
SER A 112
 None
 1.23A 2a3cB-5h2vA:
undetectable		 2a3cB-5h2vA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5b THYMIDYLATE KINASE

(Aquifex
aeolicus) 		no annotation 4 TYR B  98
GLY B  38
SER B  67
ARG B  47
 None
 1.33A 2a3cB-5h5bB:
undetectable		 2a3cB-5h5bB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 4 TRP B   8
GLY B 143
PHE B 147
SER B 142
 None
 1.34A 2a3cB-5i61B:
undetectable		 2a3cB-5i61B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 TYR A 726
GLY A 763
PHE A 739
SER A 762
 None
EPE  A1101 ( 4.7A)
None
None
 1.38A 2a3cB-5j44A:
undetectable		 2a3cB-5j44A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		4 TRP A 443
TYR A 440
GLY A 463
SER A 459
 None
 1.38A 2a3cB-5j5uA:
undetectable		 2a3cB-5j5uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jym ANTIBODY SCFV TSP11

(Mus musculus) 		PF07686
(V-set) 		4 TYR B 236
GLY B 173
SER B 171
ARG B 192
 None
 1.22A 2a3cB-5jymB:
undetectable		 2a3cB-5jymB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 TRP A 237
GLY A 203
PHE A 205
SER A 206
 None
 1.10A 2a3cB-5l51A:
3.3		 2a3cB-5l51A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 TRP A  93
GLY A  20
PHE A 427
SER A 407
 None
 1.40A 2a3cB-5neuA:
undetectable		 2a3cB-5neuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 TRP B 483
TYR B 535
GLY B 597
SER B  21
 None
 1.10A 2a3cB-5swiB:
undetectable		 2a3cB-5swiB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR D 771
GLY D 946
PHE D 948
SER D 947
 None
 1.22A 2a3cB-5t4yD:
undetectable		 2a3cB-5t4yD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		4 TYR A 530
GLY A 464
PHE A 472
SER A 469
 None
 0.98A 2a3cB-5uqeA:
undetectable		 2a3cB-5uqeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 157
GLY A  37
PHE A  35
SER A 237
 None
ZN  A 501 ( 4.9A)
None
None
 1.30A 2a3cB-5vemA:
undetectable		 2a3cB-5vemA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 GLY B 219
PHE B 216
SER B 218
ARG B 249
 None
 1.15A 2a3cB-5vipB:
undetectable		 2a3cB-5vipB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 4 TYR A 292
GLY A 427
PHE A 426
SER A 429
 GOL  A 501 (-4.3A)
None
None
None
 1.36A 2a3cB-5wkaA:
8.1		 2a3cB-5wkaA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 TYR A 463
GLY A 502
PHE A 503
SER A 506
 None
 0.90A 2a3cB-5x3jA:
7.3		 2a3cB-5x3jA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 4 TYR A  80
GLY A 437
PHE A 440
SER A 441
 None
 1.33A 2a3cB-5xgzA:
5.4		 2a3cB-5xgzA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00001
(7tm_1)
PF00258
(Flavodoxin_1) 		4 TRP A 356
GLY A 166
PHE A 170
SER A 167
 None
None
8D3  A 602 ( 4.4A)
None
 1.32A 2a3cB-5xraA:
undetectable		 2a3cB-5xraA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3o SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2) 		4 TYR A1111
GLY A 758
PHE A1115
SER A1116
 None
 0.81A 2a3cB-6b3oA:
undetectable		 2a3cB-6b3oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PROTEIN FAM126A

(Homo sapiens) 		no annotation 4 TYR C 109
GLY C 235
PHE C 236
SER C 233
 None
 1.09A 2a3cB-6bq1C:
undetectable		 2a3cB-6bq1C:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 4 TYR C 354
GLY C 274
PHE C 277
SER C 278
 None
 1.37A 2a3cB-6f0kC:
undetectable		 2a3cB-6f0kC:
12.83