SIMILAR PATTERNS OF AMINO ACIDS FOR 2A3C_A_PNXA1435_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 TYR A 319
PHE A 285
SER A 286
ARG A 284
 None
 1.31A 2a3cA-1jqoA:
3.9		 2a3cA-1jqoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		4 TYR A6214
GLY A6165
PHE A6163
SER A6164
 None
 1.36A 2a3cA-1koaA:
undetectable		 2a3cA-1koaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 GLY A 137
PHE A  43
SER A 139
ARG A 109
 None
 1.31A 2a3cA-1ns3A:
undetectable		 2a3cA-1ns3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TYR A  34
GLY A 109
PHE A 111
SER A 112
 None
 1.28A 2a3cA-1q20A:
undetectable		 2a3cA-1q20A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		4 TYR D 308
GLY D 359
PHE D 360
SER D 361
 None
 1.10A 2a3cA-1r20D:
undetectable		 2a3cA-1r20D:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		4 TYR A 352
GLY A 342
PHE A 346
SER A 343
 None
 1.19A 2a3cA-1sxjA:
undetectable		 2a3cA-1sxjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tul TLP20

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF06088
(TLP-20) 		4 TYR A  33
GLY A  70
PHE A 102
SER A  65
 None
 1.33A 2a3cA-1tulA:
undetectable		 2a3cA-1tulA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 TYR A 716
GLY A 597
SER A 605
ARG A 596
 TYR  A 716 ( 1.3A)
GLY  A 597 ( 0.0A)
SER  A 605 ( 0.0A)
ARG  A 596 ( 0.6A)
 1.24A 2a3cA-1v0fA:
undetectable		 2a3cA-1v0fA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 TYR A 140
GLY A 211
SER A 214
ARG A 263
 None
 0.40A 2a3cA-1wnoA:
69.6		 2a3cA-1wnoA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 TYR A 299
GLY A 548
PHE A 546
SER A 547
 None
 1.23A 2a3cA-1z8lA:
2.1		 2a3cA-1z8lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd1 SULFOTRANSFERASE 4A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TYR A 172
GLY A  57
PHE A 145
SER A 141
 None
 1.39A 2a3cA-1zd1A:
undetectable		 2a3cA-1zd1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 TYR A 255
GLY A 267
PHE A 262
SER A 264
 None
 1.31A 2a3cA-2aaaA:
9.5		 2a3cA-2aaaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmy RIPENING-ASSOCIATED
PROTEIN

(Musa acuminata) 		PF01419
(Jacalin) 		4 TRP A  10
GLY A  75
PHE A  94
SER A  95
 None
 0.93A 2a3cA-2bmyA:
undetectable		 2a3cA-2bmyA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjl SECRETED CHITINASE

(Streptomyces
coelicolor) 		PF00182
(Glyco_hydro_19) 		4 TRP A 147
TYR A  42
GLY A 154
SER A 176
 None
 1.11A 2a3cA-2cjlA:
undetectable		 2a3cA-2cjlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		4 TYR A  50
GLY A 266
PHE A 309
SER A 265
 None
 1.25A 2a3cA-2cygA:
8.0		 2a3cA-2cygA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 GLY A 263
PHE A 261
SER A 260
ARG A 143
 None
 1.25A 2a3cA-2go4A:
undetectable		 2a3cA-2go4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		4 TYR A  92
GLY A  98
PHE A 108
ARG A 156
 None
 1.35A 2a3cA-2im9A:
undetectable		 2a3cA-2im9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lz0 UNCHARACTERIZED
PROTEIN

(Pseudoflavonifractor
capillosus) 		no annotation 4 TYR A  91
GLY A  37
PHE A  39
SER A  40
 None
 1.09A 2a3cA-2lz0A:
undetectable		 2a3cA-2lz0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 TYR A 863
GLY A 807
PHE A 806
SER A 805
 None
None
NAP  A 903 (-4.0A)
None
 1.34A 2a3cA-2o2qA:
undetectable		 2a3cA-2o2qA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A  34
GLY A  53
PHE A  23
SER A  55
 None
 1.10A 2a3cA-2panA:
undetectable		 2a3cA-2panA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		4 TYR A 163
GLY A  24
SER A  23
ARG A 135
 None
 1.29A 2a3cA-2pjqA:
undetectable		 2a3cA-2pjqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 987
GLY A 622
SER A 666
ARG A 621
 None
 1.29A 2a3cA-2qf7A:
8.3		 2a3cA-2qf7A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A 322
GLY A  41
SER A 111
ARG A  38
 None
 1.22A 2a3cA-2qn0A:
undetectable		 2a3cA-2qn0A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		4 TRP A 233
GLY A 123
PHE A 142
SER A 141
 GOL  A1259 ( 4.8A)
None
None
None
 1.37A 2a3cA-2uz0A:
undetectable		 2a3cA-2uz0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 TYR A  96
GLY A  62
PHE A  61
SER A  63
 None
 1.31A 2a3cA-2vg9A:
undetectable		 2a3cA-2vg9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE

(Staphylococcus
aureus) 		PF00884
(Sulfatase) 		4 TYR A 621
GLY A 548
PHE A 547
SER A 310
 None
 1.13A 2a3cA-2w5sA:
undetectable		 2a3cA-2w5sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 TRP A 527
TYR A 579
GLY A 641
SER A  39
 None
 1.16A 2a3cA-2wzsA:
undetectable		 2a3cA-2wzsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 4 TYR A 308
GLY A  63
PHE A  62
SER A  66
 TRH  A 416 (-3.6A)
TRH  A 416 (-3.7A)
None
TRH  A 416 (-3.6A)
 1.10A 2a3cA-2x0fA:
undetectable		 2a3cA-2x0fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 TYR A 177
GLY A  84
PHE A  30
SER A  88
 None
 1.37A 2a3cA-3ailA:
undetectable		 2a3cA-3ailA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 TRP A  69
TYR B 273
GLY A 225
SER B 254
 None
 1.37A 2a3cA-3ayxA:
undetectable		 2a3cA-3ayxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 TRP A  69
TYR B 273
GLY A 226
SER B 254
 None
 1.32A 2a3cA-3ayxA:
undetectable		 2a3cA-3ayxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 TYR B 151
PHE B  76
SER B  96
ARG B  77
 None
 1.28A 2a3cA-3draB:
undetectable		 2a3cA-3draB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtd INVASION-ASSOCIATED
PROTEIN B

(Bartonella
henselae) 		PF06776
(IalB) 		4 TRP A  50
GLY A  92
PHE A 135
SER A  91
 None
 1.15A 2a3cA-3dtdA:
undetectable		 2a3cA-3dtdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		4 TYR A  28
GLY A  68
PHE A  69
SER A  36
 None
 1.21A 2a3cA-3dwvA:
undetectable		 2a3cA-3dwvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		4 TYR A 190
GLY A 164
PHE A 170
SER A 163
 None
 1.28A 2a3cA-3efeA:
undetectable		 2a3cA-3efeA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 TYR A 512
GLY A 400
PHE A 546
SER A 399
 None
 1.39A 2a3cA-3f41A:
undetectable		 2a3cA-3f41A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		4 GLY A 219
PHE A 212
SER A 218
ARG A 220
 GOL  A 403 (-4.4A)
None
None
None
 1.33A 2a3cA-3i58A:
undetectable		 2a3cA-3i58A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 TYR A 215
GLY A 195
PHE A 196
SER A 197
 None
 1.25A 2a3cA-3iecA:
undetectable		 2a3cA-3iecA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 TYR A 291
GLY A  89
PHE A 306
SER A 307
 None
 1.28A 2a3cA-3ll8A:
undetectable		 2a3cA-3ll8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		4 TYR A 216
GLY A 104
PHE A 250
SER A 103
 None
 1.37A 2a3cA-3mozA:
undetectable		 2a3cA-3mozA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 TRP A 221
GLY A 155
PHE A 154
SER A  84
 None
 1.31A 2a3cA-3oajA:
undetectable		 2a3cA-3oajA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 TYR A 244
GLY A 282
SER A 279
ARG A 255
 None
 1.39A 2a3cA-3op0A:
undetectable		 2a3cA-3op0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens) 		PF02263
(GBP) 		4 TYR A 328
GLY A 410
PHE A 413
SER A 414
 None
 1.10A 2a3cA-3q5eA:
undetectable		 2a3cA-3q5eA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A  92
GLY A 216
PHE A 218
SER A 219
 None
 0.85A 2a3cA-3vnsA:
undetectable		 2a3cA-3vnsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		4 TRP A 197
GLY A 242
PHE A 229
SER A 230
 None
 0.96A 2a3cA-3wmyA:
undetectable		 2a3cA-3wmyA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avr PA4485

(Pseudomonas
aeruginosa) 		PF03330
(DPBB_1) 		4 TYR A   9
GLY A  39
PHE A  38
ARG A  56
 None
 1.31A 2a3cA-4avrA:
undetectable		 2a3cA-4avrA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		4 TYR A 177
GLY A 192
PHE A 193
ARG A 252
 TYR  A 177 ( 1.3A)
GLY  A 192 (-0.0A)
PHE  A 193 (-1.3A)
ARG  A 252 (-0.6A)
 1.38A 2a3cA-4c9gA:
undetectable		 2a3cA-4c9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 TYR A 320
GLY A 190
SER A 166
ARG A 191
 MLI  A1466 (-4.5A)
None
None
None
 1.38A 2a3cA-4cp8A:
undetectable		 2a3cA-4cp8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Lactobacillus
brevis) 		PF12849
(PBP_like_2) 		4 TYR A 271
GLY A 186
SER A 184
ARG A 189
 None
None
None
ACT  A 301 (-3.1A)
 1.39A 2a3cA-4ecfA:
undetectable		 2a3cA-4ecfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 TRP A 192
GLY A 249
PHE A 253
SER A 248
 ACX  A 401 (-3.9A)
None
None
None
 1.32A 2a3cA-4femA:
undetectable		 2a3cA-4femA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		4 TYR A 444
GLY A 352
PHE A 421
SER A 417
 None
 1.37A 2a3cA-4fnmA:
undetectable		 2a3cA-4fnmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		4 TRP A 315
TYR A 311
PHE A 336
SER A 335
 None
 1.16A 2a3cA-4gdnA:
undetectable		 2a3cA-4gdnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 TRP A 549
GLY A 590
PHE A 588
SER A 587
 None
 1.18A 2a3cA-4iegA:
undetectable		 2a3cA-4iegA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 TYR A 624
GLY A 422
PHE A 639
SER A 640
 None
 1.34A 2a3cA-4il1A:
undetectable		 2a3cA-4il1A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 4 TRP B  50
GLY B 266
PHE B 268
SER B 267
 None
 1.09A 2a3cA-4iu9B:
undetectable		 2a3cA-4iu9B:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 TYR A 499
GLY A 544
SER A 569
ARG A 235
 None
 1.20A 2a3cA-4jeuA:
2.3		 2a3cA-4jeuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 4 TYR D 176
GLY D 551
PHE D 553
SER D 547
 None
 1.33A 2a3cA-4jf7D:
undetectable		 2a3cA-4jf7D:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		4 TRP A  52
GLY A 268
PHE A 270
SER A 269
 None
None
None
GYP  A 502 ( 4.8A)
 1.23A 2a3cA-4jreA:
undetectable		 2a3cA-4jreA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 TRP A 123
TYR A 127
PHE A 120
ARG A  64
 OPE  A 501 ( 3.8A)
SAH  A 502 (-4.9A)
None
SAH  A 502 (-3.9A)
 1.39A 2a3cA-4krgA:
undetectable		 2a3cA-4krgA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 TYR A 252
PHE A  35
SER A  63
ARG A 200
 None
 1.15A 2a3cA-4l9aA:
undetectable		 2a3cA-4l9aA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		4 TYR A  79
GLY A 107
PHE A 103
SER A 104
 None
 0.84A 2a3cA-4ld7A:
undetectable		 2a3cA-4ld7A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TRP A 679
GLY A 600
PHE A 609
SER A 605
 None
 1.18A 2a3cA-4lixA:
undetectable		 2a3cA-4lixA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 154
GLY A  35
PHE A  33
SER A 236
 None
ZN  A 505 ( 4.8A)
None
None
 1.31A 2a3cA-4lr2A:
undetectable		 2a3cA-4lr2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 TYR A 362
GLY A 231
PHE A 230
SER A 234
 None
None
GOL  A 503 ( 4.8A)
None
 1.09A 2a3cA-4maaA:
undetectable		 2a3cA-4maaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbg TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE

(Janthinobacterium
sp. J3) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 TRP A 285
GLY A 131
PHE A  34
SER A  35
 None
 0.74A 2a3cA-4nbgA:
undetectable		 2a3cA-4nbgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2

(Bdellovibrio
bacteriovorus) 		PF14566
(PTPlike_phytase) 		4 TYR A 170
GLY A  72
PHE A 204
SER A  71
 None
 1.37A 2a3cA-4nx8A:
undetectable		 2a3cA-4nx8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 TYR A 300
GLY A  98
PHE A 315
SER A 316
 None
 1.31A 2a3cA-4oraA:
undetectable		 2a3cA-4oraA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A 291
GLY A  89
PHE A 306
SER A 307
 None
 1.38A 2a3cA-4orbA:
undetectable		 2a3cA-4orbA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 GLY A 265
PHE A 267
SER A 263
ARG A 127
 None
 1.39A 2a3cA-4ow8A:
undetectable		 2a3cA-4ow8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 TRP A 260
GLY A 194
PHE A 181
SER A 182
 TEC  A 404 (-4.0A)
None
None
None
 1.19A 2a3cA-4q38A:
undetectable		 2a3cA-4q38A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		4 TRP A  53
TYR A 140
GLY A  90
SER A  88
 None
 1.30A 2a3cA-4rafA:
undetectable		 2a3cA-4rafA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 TYR A 627
GLY A 554
PHE A 553
SER A 317
 None
 1.16A 2a3cA-4uooA:
undetectable		 2a3cA-4uooA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 TYR A1389
GLY A1214
PHE A1223
SER A1221
 None
 0.99A 2a3cA-4xqkA:
undetectable		 2a3cA-4xqkA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xw3 ATP-DEPENDENT RNA
HELICASE DDX1

(Homo sapiens) 		PF00622
(SPRY) 		4 TYR A 135
GLY A 159
PHE A 165
SER A 174
 None
 0.76A 2a3cA-4xw3A:
undetectable		 2a3cA-4xw3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apm VP1
VP3

(Parechovirus A) 		no annotation 4 TYR B  61
GLY A  73
PHE A  72
SER A 200
 None
 1.32A 2a3cA-5apmB:
undetectable		 2a3cA-5apmB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		4 TYR A 309
GLY A 107
PHE A 324
SER A 325
 None
 1.32A 2a3cA-5b8iA:
undetectable		 2a3cA-5b8iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TRP A 421
TYR A 398
GLY A 414
PHE A 137
 None
 0.99A 2a3cA-5dmyA:
5.6		 2a3cA-5dmyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TYR A 479
GLY A 518
PHE A 519
SER A 522
 None
 0.96A 2a3cA-5f7sA:
2.9		 2a3cA-5f7sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 TRP A 137
GLY A 109
PHE A 110
SER A 112
 None
 1.21A 2a3cA-5h2vA:
undetectable		 2a3cA-5h2vA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5b THYMIDYLATE KINASE

(Aquifex
aeolicus) 		no annotation 4 TYR B  98
GLY B  38
SER B  67
ARG B  47
 None
 1.38A 2a3cA-5h5bB:
undetectable		 2a3cA-5h5bB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 GLY A 206
PHE A 367
SER A 207
ARG A 396
 None
None
None
PLP  A 501 ( 4.6A)
 1.36A 2a3cA-5hh9A:
3.1		 2a3cA-5hh9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 4 TRP B   8
GLY B 143
PHE B 147
SER B 142
 None
 1.35A 2a3cA-5i61B:
undetectable		 2a3cA-5i61B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 TYR A 726
GLY A 763
PHE A 739
SER A 762
 None
EPE  A1101 ( 4.7A)
None
None
 1.33A 2a3cA-5j44A:
undetectable		 2a3cA-5j44A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jym ANTIBODY SCFV TSP11

(Mus musculus) 		PF07686
(V-set) 		4 TYR B 236
GLY B 173
SER B 171
ARG B 192
 None
 1.18A 2a3cA-5jymB:
undetectable		 2a3cA-5jymB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 TRP A 237
GLY A 203
PHE A 205
SER A 206
 None
 1.18A 2a3cA-5l51A:
3.4		 2a3cA-5l51A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		4 TRP A 282
GLY A 157
PHE A 160
SER A 159
 None
 1.29A 2a3cA-5mapA:
undetectable		 2a3cA-5mapA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj3 INTERLEUKIN-12
SUBUNIT BETA

(Homo sapiens) 		PF10420
(IL12p40_C) 		4 TYR A 315
PHE A 227
SER A 226
ARG A 160
 None
 1.38A 2a3cA-5mj3A:
undetectable		 2a3cA-5mj3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR D 771
GLY D 946
PHE D 948
SER D 947
 None
 1.20A 2a3cA-5t4yD:
undetectable		 2a3cA-5t4yD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 4 TYR A 331
GLY A 215
PHE A 252
ARG A 280
 None
 1.37A 2a3cA-5u2oA:
undetectable		 2a3cA-5u2oA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		4 TYR A 530
GLY A 464
PHE A 472
SER A 469
 None
 0.98A 2a3cA-5uqeA:
undetectable		 2a3cA-5uqeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 157
GLY A  37
PHE A  35
SER A 237
 None
ZN  A 501 ( 4.9A)
None
None
 1.21A 2a3cA-5vemA:
undetectable		 2a3cA-5vemA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		4 TYR A 157
GLY A  37
PHE A  35
SER A 237
 AMP  A 524 ( 3.5A)
ZN  A 502 ( 4.6A)
None
None
 1.29A 2a3cA-5veoA:
undetectable		 2a3cA-5veoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 GLY B 219
PHE B 216
SER B 218
ARG B 249
 None
 1.07A 2a3cA-5vipB:
undetectable		 2a3cA-5vipB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 TYR A 463
GLY A 502
PHE A 503
SER A 506
 None
 0.91A 2a3cA-5x3jA:
1.9		 2a3cA-5x3jA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00001
(7tm_1)
PF00258
(Flavodoxin_1) 		4 TRP A 356
GLY A 166
PHE A 170
SER A 167
 None
None
8D3  A 602 ( 4.4A)
None
 1.24A 2a3cA-5xraA:
undetectable		 2a3cA-5xraA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 TYR A 395
GLY A  71
PHE A  31
SER A  70
 None
None
GOL  A 602 (-4.8A)
None
 1.30A 2a3cA-5z5dA:
undetectable		 2a3cA-5z5dA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3o SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2) 		4 TYR A1111
GLY A 758
PHE A1115
SER A1116
 None
 0.88A 2a3cA-6b3oA:
undetectable		 2a3cA-6b3oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 4 TRP A 199
TYR A 496
GLY A 144
SER A  96
 None
 1.29A 2a3cA-6bf6A:
undetectable		 2a3cA-6bf6A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PROTEIN FAM126A

(Homo sapiens) 		no annotation 4 TYR C 109
GLY C 235
PHE C 236
SER C 233
 None
 1.06A 2a3cA-6bq1C:
undetectable		 2a3cA-6bq1C:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 TYR A 148
GLY A  88
PHE A  93
SER A  91
 None
 1.13A 2a3cA-6cwpA:
undetectable		 2a3cA-6cwpA:
11.53