SIMILAR PATTERNS OF AMINO ACIDS FOR 2A3C_A_PNXA1434_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		11 TYR A  43
TRP A  47
PHE A  71
GLY A 130
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
 None
 0.45A 2a3cA-1d2kA:
65.1		 2a3cA-1d2kA:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  10
PHE A  51
GLY A  96
ASP A 142
GLU A 144
TYR A 214
TRP A 403
 NGO  A 502 (-3.2A)
NGO  A 502 (-4.7A)
NGO  A 502 ( 3.8A)
NGO  A 502 (-3.1A)
NGO  A 502 (-3.4A)
NGO  A 502 (-4.5A)
NGO  A 502 (-3.5A)
 0.96A 2a3cA-1e6zA:
12.6		 2a3cA-1e6zA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  10
PHE A  51
GLY A  96
ASP A 142
TYR A 214
TYR A 292
TRP A 403
 NGO  A 502 (-3.2A)
NGO  A 502 (-4.7A)
NGO  A 502 ( 3.8A)
NGO  A 502 (-3.1A)
NGO  A 502 (-4.5A)
NGO  A 502 (-4.8A)
NGO  A 502 (-3.5A)
 0.81A 2a3cA-1e6zA:
12.6		 2a3cA-1e6zA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  10
PHE A  51
GLY A  96
GLU A 144
MET A 212
TYR A 214
TRP A 403
 NGO  A 502 (-3.2A)
NGO  A 502 (-4.7A)
NGO  A 502 ( 3.8A)
NGO  A 502 (-3.4A)
NGO  A 502 (-3.4A)
NGO  A 502 (-4.5A)
NGO  A 502 (-3.5A)
 0.71A 2a3cA-1e6zA:
12.6		 2a3cA-1e6zA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  10
PHE A  51
GLY A  96
MET A 212
TYR A 214
ASP A 215
TYR A 292
TRP A 403
 NGO  A 502 (-3.2A)
NGO  A 502 (-4.7A)
NGO  A 502 ( 3.8A)
NGO  A 502 (-3.4A)
NGO  A 502 (-4.5A)
NGO  A 502 ( 3.1A)
NGO  A 502 (-4.8A)
NGO  A 502 (-3.5A)
 0.44A 2a3cA-1e6zA:
12.6		 2a3cA-1e6zA:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 204
TYR A 206
ASP A 207
TRP A 352
 NAG  A  -1 (-3.8A)
NAG  A  -2 (-4.2A)
NAG  A  -2 (-4.7A)
NAG  A  -2 ( 4.2A)
NAG  A   1 (-3.7A)
NAG  A  -1 (-4.6A)
NAG  A  -1 (-3.7A)
NAG  A  -1 (-3.5A)
 0.76A 2a3cA-1hjvA:
16.0		 2a3cA-1hjvA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		7 TRP A  31
PHE A  58
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 358
 NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 1.17A 2a3cA-1hkkA:
13.9		 2a3cA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 358
 AMI  A1388 (-3.6A)
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.98A 2a3cA-1hkkA:
13.9		 2a3cA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		9 TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-3.6A)
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.73A 2a3cA-1hkkA:
13.9		 2a3cA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		9 TYR A  49
TRP A  53
PHE A  77
GLY A 163
ASP A 202
GLU A 204
MET A 277
TYR A 279
TRP A 433
 GOL  A1007 (-4.1A)
None
GOL  A1007 (-4.8A)
GOL  A1007 ( 3.9A)
GOL  A1007 (-3.6A)
GOL  A1007 (-3.7A)
GOL  A1007 ( 3.3A)
GOL  A1007 ( 4.8A)
GOL  A1007 (-4.8A)
 0.72A 2a3cA-1itxA:
16.8		 2a3cA-1itxA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		10 TYR A  49
TRP A  53
PHE A  77
GLY A 163
ASP A 202
MET A 277
TYR A 279
ASP A 280
TYR A 338
TRP A 433
 GOL  A1007 (-4.1A)
None
GOL  A1007 (-4.8A)
GOL  A1007 ( 3.9A)
GOL  A1007 (-3.6A)
GOL  A1007 ( 3.3A)
GOL  A1007 ( 4.8A)
None
None
GOL  A1007 (-4.8A)
 0.40A 2a3cA-1itxA:
16.8		 2a3cA-1itxA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		8 TYR A  23
TRP A  27
PHE A  55
GLY A 135
ASP A 190
GLU A 192
TYR A 271
TRP A 412
 None
None
None
None
None
GOL  A 530 (-3.9A)
GOL  A 530 (-4.8A)
None
 0.65A 2a3cA-1kfwA:
45.9		 2a3cA-1kfwA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		9 TYR A  23
TRP A  27
PHE A  55
GLY A 135
ASP A 190
TYR A 271
ASP A 272
TYR A 328
TRP A 412
 None
None
None
None
None
GOL  A 530 (-4.8A)
GOL  A 530 (-3.7A)
None
None
 0.39A 2a3cA-1kfwA:
45.9		 2a3cA-1kfwA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		8 TYR A   6
TRP A  10
PHE A  37
GLY A  77
ASP A 117
MET A 189
TYR A 191
TYR A 246
 None
 0.89A 2a3cA-1vf8A:
13.8		 2a3cA-1vf8A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		8 TYR A   6
TRP A  10
PHE A  37
GLY A  77
MET A 189
TYR A 191
ASP A 192
TYR A 246
 None
 0.61A 2a3cA-1vf8A:
13.8		 2a3cA-1vf8A:
26.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
 None
 1.06A 2a3cA-1wb0A:
14.5		 2a3cA-1wb0A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 None
 0.87A 2a3cA-1wb0A:
14.5		 2a3cA-1wb0A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
 None
 0.92A 2a3cA-1wb0A:
14.5		 2a3cA-1wb0A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		9 TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
 0.60A 2a3cA-1wb0A:
14.5		 2a3cA-1wb0A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		10 TYR A  10
TRP A  14
PHE A  38
GLY A  98
ASP A 137
GLU A 139
MET A 205
TYR A 207
ASP A 208
TRP A 346
 None
 0.67A 2a3cA-1wnoA:
69.6		 2a3cA-1wnoA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		10 TYR A  10
TRP A  14
PHE A  38
GLY A  98
ASP A 137
MET A 205
TYR A 207
ASP A 208
TYR A 261
TRP A 346
 None
 0.41A 2a3cA-1wnoA:
69.6		 2a3cA-1wnoA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		7 TYR A   6
PHE A  32
GLY A  80
ASP A 125
GLU A 127
TYR A 182
TRP A 253
 None
 1.14A 2a3cA-2gsjA:
19.7		 2a3cA-2gsjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae) 		PF00704
(Glyco_hydro_18) 		7 TYR A  32
PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 1.14A 2a3cA-2uy3A:
20.2		 2a3cA-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		8 TYR A 163
TRP A 167
PHE A 191
ASP A 313
GLU A 315
MET A 388
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 1.01A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		8 TYR A 163
TRP A 167
PHE A 191
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.84A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		8 TYR A 163
TRP A 167
PHE A 191
GLY A 274
GLU A 315
MET A 388
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.74A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		9 TYR A 163
TRP A 167
PHE A 191
GLY A 274
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1563 ( 4.0A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.40A 2a3cA-2wk2A:
13.3		 2a3cA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvn ASPERGILLUS
FUMIGATUS CHITINASE
A1

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		7 TYR A  34
PHE A  60
GLY A 123
ASP A 172
GLU A 174
TYR A 232
TRP A 312
 KLS  A1338 (-3.4A)
None
None
KLS  A1338 (-2.8A)
KLS  A1338 (-2.9A)
KLS  A1338 (-4.8A)
KLS  A1338 (-3.5A)
 1.18A 2a3cA-2xvnA:
21.2		 2a3cA-2xvnA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
 CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 1.07A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
 0.86A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
 None
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 0.91A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		9 TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.59A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		9 TYR A   7
PHE A  31
GLY A  73
ASP A 113
GLU A 115
MET A 181
TYR A 183
ASP A 184
TRP A 326
 EDO  A 357 ( 4.5A)
EDO  A 357 (-4.8A)
EDO  A 357 ( 4.2A)
EDO  A 357 (-4.2A)
EDO  A 357 (-2.8A)
EDO  A 357 ( 3.3A)
EDO  A 359 ( 4.7A)
EDO  A 359 (-4.5A)
EDO  A 357 (-4.4A)
 0.71A 2a3cA-3alfA:
41.4		 2a3cA-3alfA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		9 TYR A   7
PHE A  31
GLY A  73
ASP A 113
MET A 181
TYR A 183
ASP A 184
TYR A 234
TRP A 326
 EDO  A 357 ( 4.5A)
EDO  A 357 (-4.8A)
EDO  A 357 ( 4.2A)
EDO  A 357 (-4.2A)
EDO  A 357 ( 3.3A)
EDO  A 359 ( 4.7A)
EDO  A 359 (-4.5A)
None
EDO  A 357 (-4.4A)
 0.54A 2a3cA-3alfA:
41.4		 2a3cA-3alfA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		9 TYR A   8
PHE A  32
GLY A  74
ASP A 114
GLU A 116
MET A 182
TYR A 184
ASP A 185
TRP A 324
 None
 0.69A 2a3cA-3aquA:
41.2		 2a3cA-3aquA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		9 TYR A   8
PHE A  32
GLY A  74
ASP A 114
MET A 182
TYR A 184
ASP A 185
TYR A 235
TRP A 324
 None
 0.50A 2a3cA-3aquA:
41.2		 2a3cA-3aquA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		10 TYR A 164
TRP A 168
PHE A 192
GLY A 274
ASP A 313
MET A 389
TYR A 391
ASP A 392
TYR A 461
TRP A 570
 None
 0.50A 2a3cA-3b9eA:
39.5		 2a3cA-3b9eA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		7 TYR A  10
PHE A  37
GLY A  84
ASP A 119
GLU A 121
TYR A 181
TRP A 271
 None
 1.11A 2a3cA-3ebvA:
22.9		 2a3cA-3ebvA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		7 TYR A  52
PHE A  79
ASP A 155
GLU A 157
MET A 211
TYR A 213
TRP A 322
 None
 1.12A 2a3cA-3fndA:
31.4		 2a3cA-3fndA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		7 TYR A  52
PHE A  79
ASP A 155
MET A 211
TYR A 213
TYR A 256
TRP A 322
 None
None
None
None
None
GOL  A 356 (-4.3A)
None
 0.97A 2a3cA-3fndA:
31.4		 2a3cA-3fndA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		7 TYR A  52
PHE A  79
MET A 211
TYR A 213
ASP A 214
TYR A 256
TRP A 322
 None
None
None
None
None
GOL  A 356 (-4.3A)
None
 0.44A 2a3cA-3fndA:
31.4		 2a3cA-3fndA:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		11 TYR A  46
TRP A  50
PHE A  74
GLY A 133
ASP A 172
GLU A 174
MET A 240
TYR A 242
ASP A 243
TYR A 296
TRP A 381
 None
 0.53A 2a3cA-3g6lA:
63.8		 2a3cA-3g6lA:
54.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		7 TYR A  48
TRP A  52
PHE A  84
GLY A 126
ASP A 160
TYR A 229
TRP A 321
 EDO  A 361 ( 4.2A)
None
None
EDO  A 369 ( 3.7A)
EDO  A 361 ( 2.7A)
EDO  A 361 (-4.5A)
EDO  A 361 (-4.5A)
 1.03A 2a3cA-3ianA:
21.7		 2a3cA-3ianA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		8 TYR A  28
PHE A  58
GLY A 113
ASP A 151
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
 0.72A 2a3cA-3qokA:
37.7		 2a3cA-3qokA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		9 TYR A  28
PHE A  58
GLY A 113
ASP A 151
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
 0.47A 2a3cA-3qokA:
37.7		 2a3cA-3qokA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		9 TYR A  30
TRP A  34
PHE A  61
GLY A 106
ASP A 146
GLU A 148
MET A 215
TYR A 217
TRP A 372
 None
 0.85A 2a3cA-3w4rA:
11.2		 2a3cA-3w4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		10 TYR A  30
TRP A  34
PHE A  61
GLY A 106
ASP A 146
MET A 215
TYR A 217
ASP A 218
TYR A 272
TRP A 372
 None
 0.68A 2a3cA-3w4rA:
11.2		 2a3cA-3w4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		9 TYR A  30
TRP A  34
PHE A  61
GLY A 106
ASP A 146
GLU A 148
MET A 215
TYR A 217
TRP A 372
 NAG  A 501 (-3.8A)
NAG  A 503 ( 4.0A)
NAG  A 501 (-4.5A)
NAG  A 501 (-3.6A)
NAG  A 501 (-3.0A)
NAG  A 501 (-2.7A)
NAG  A 501 (-3.5A)
NAG  A 501 (-4.6A)
NAG  A 501 (-3.7A)
 1.08A 2a3cA-3wl1A:
10.9		 2a3cA-3wl1A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		9 TYR A  30
TRP A  34
PHE A  61
GLY A 106
ASP A 146
MET A 215
TYR A 217
ASP A 218
TRP A 372
 NAG  A 501 (-3.8A)
NAG  A 503 ( 4.0A)
NAG  A 501 (-4.5A)
NAG  A 501 (-3.6A)
NAG  A 501 (-3.0A)
NAG  A 501 (-3.5A)
NAG  A 501 (-4.6A)
NAG  A 501 ( 3.2A)
NAG  A 501 (-3.7A)
 0.97A 2a3cA-3wl1A:
10.9		 2a3cA-3wl1A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		9 TYR A  30
TRP A  34
PHE A  61
GLY A 106
MET A 215
TYR A 217
ASP A 218
TYR A 272
TRP A 372
 NAG  A 501 (-3.8A)
NAG  A 503 ( 4.0A)
NAG  A 501 (-4.5A)
NAG  A 501 (-3.6A)
NAG  A 501 (-3.5A)
NAG  A 501 (-4.6A)
NAG  A 501 ( 3.2A)
NAG  A 502 (-3.9A)
NAG  A 501 (-3.7A)
 0.70A 2a3cA-3wl1A:
10.9		 2a3cA-3wl1A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		7 TYR A  73
PHE A 117
GLY A 214
ASP A 254
ASP A 326
TYR A 379
TRP A 486
 None
 0.89A 2a3cA-4a5qA:
7.2		 2a3cA-4a5qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		8 TYR A  73
TRP A  77
PHE A 117
ASP A 254
MET A 323
TYR A 325
ASP A 326
TYR A 379
 None
 1.04A 2a3cA-4a5qA:
7.2		 2a3cA-4a5qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		8 TYR A  73
TRP A  77
PHE A 117
GLY A 214
ASP A 254
GLU A 256
MET A 323
ASP A 326
 None
 0.95A 2a3cA-4a5qA:
7.2		 2a3cA-4a5qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		8 TYR A  73
TRP A  77
PHE A 117
GLY A 214
ASP A 254
MET A 323
ASP A 326
TYR A 379
 None
 0.83A 2a3cA-4a5qA:
7.2		 2a3cA-4a5qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  32
TRP A  36
PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 NAG  A 401 (-3.9A)
NAG  A 400 (-4.3A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.76A 2a3cA-4ay1A:
15.0		 2a3cA-4ay1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		7 TYR A 156
PHE A 200
GLY A 307
ASP A 347
ASP A 425
TYR A 482
TRP A 582
 None
None
None
None
None
None
GOL  A 701 (-4.2A)
 0.88A 2a3cA-4dwsA:
12.6		 2a3cA-4dwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		7 TYR A 156
TRP A 160
PHE A 200
GLY A 307
ASP A 347
GLU A 349
MET A 422
 None
GOL  A 701 (-3.9A)
None
None
None
None
None
 0.79A 2a3cA-4dwsA:
12.6		 2a3cA-4dwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		9 TYR A 156
TRP A 160
PHE A 200
GLY A 307
ASP A 347
MET A 422
TYR A 424
ASP A 425
TYR A 482
 None
GOL  A 701 (-3.9A)
None
None
None
None
None
None
None
 0.55A 2a3cA-4dwsA:
12.6		 2a3cA-4dwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		7 TYR A  36
TRP A  40
PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 NAG  A 608 ( 3.8A)
PEG  A 614 (-3.7A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.99A 2a3cA-4mb5A:
20.8		 2a3cA-4mb5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		7 PHE A  34
GLY A  76
ASP A 117
MET A 189
TYR A 191
ASP A 192
TRP A 327
 None
 0.90A 2a3cA-4mnmA:
40.8		 2a3cA-4mnmA:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		8 TYR A  28
PHE A  58
GLY A 113
ASP A 151
GLU A 153
MET A 220
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 1.02A 2a3cA-4q22A:
37.6		 2a3cA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		8 TYR A  28
PHE A  58
GLY A 113
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.56A 2a3cA-4q22A:
37.6		 2a3cA-4q22A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		10 TYR A 159
TRP A 163
PHE A 190
GLY A 254
ASP A 312
GLU A 314
MET A 395
TYR A 397
ASP A 398
TRP A 603
 None
None
None
None
None
CS  A 803 (-2.9A)
CS  A 803 (-3.5A)
CS  A 812 (-4.4A)
CS  A 812 (-4.0A)
CS  A 812 ( 4.2A)
 0.93A 2a3cA-4txgA:
34.8		 2a3cA-4txgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		10 TYR A 159
TRP A 163
PHE A 190
GLY A 254
ASP A 312
MET A 395
TYR A 397
ASP A 398
TYR A 464
TRP A 603
 None
None
None
None
None
CS  A 803 (-3.5A)
CS  A 812 (-4.4A)
CS  A 812 (-4.0A)
CS  A 812 (-4.5A)
CS  A 812 ( 4.2A)
 0.79A 2a3cA-4txgA:
34.8		 2a3cA-4txgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		8 TYR A   6
PHE A  30
GLY A  72
ASP A 114
GLU A 116
MET A 183
TYR A 185
TRP A 317
 MPD  A 401 (-3.5A)
None
MPD  A 401 ( 4.6A)
MPD  A 401 (-4.3A)
MPD  A 401 (-2.7A)
MPD  A 401 (-3.0A)
MPD  A 401 (-4.8A)
MPD  A 401 (-3.8A)
 0.86A 2a3cA-4uriA:
40.3		 2a3cA-4uriA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		9 TYR A   6
PHE A  30
GLY A  72
ASP A 114
MET A 183
TYR A 185
ASP A 186
TYR A 236
TRP A 317
 MPD  A 401 (-3.5A)
None
MPD  A 401 ( 4.6A)
MPD  A 401 (-4.3A)
MPD  A 401 (-3.0A)
MPD  A 401 (-4.8A)
None
None
MPD  A 401 (-3.8A)
 0.69A 2a3cA-4uriA:
40.3		 2a3cA-4uriA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 9 TYR B  46
PHE B  78
GLY B 141
ASP B 181
GLU B 183
TYR B 250
ASP B 251
TYR B 305
TRP B 388
 None
None
None
None
None
None
MLI  B 501 ( 4.7A)
None
None
 1.02A 2a3cA-4w5uB:
17.2		 2a3cA-4w5uB:
32.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 10 TYR B  46
TRP B  50
PHE B  78
GLY B 141
ASP B 181
GLU B 183
MET B 248
TYR B 250
ASP B 251
TYR B 305
 None
None
None
None
None
None
None
None
MLI  B 501 ( 4.7A)
None
 0.84A 2a3cA-4w5uB:
17.2		 2a3cA-4w5uB:
32.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		7 TYR A  36
TRP A  40
PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 ACT  A 404 (-2.7A)
CL  A 408 (-4.3A)
None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.99A 2a3cA-4w5zA:
20.7		 2a3cA-4w5zA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		9 TYR A 153
TRP A 157
PHE A 181
GLY A 264
ASP A 303
GLU A 305
MET A 379
TYR A 381
TRP A 528
 58Y  A 605 (-3.6A)
None
58Y  A 605 (-4.5A)
58Y  A 605 ( 4.2A)
None
58Y  A 605 (-3.1A)
58Y  A 605 (-3.3A)
58Y  A 605 (-4.9A)
58Y  A 605 (-3.7A)
 0.69A 2a3cA-5df0A:
12.2		 2a3cA-5df0A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		10 TYR A 153
TRP A 157
PHE A 181
GLY A 264
ASP A 303
MET A 379
TYR A 381
ASP A 382
TYR A 435
TRP A 528
 58Y  A 605 (-3.6A)
None
58Y  A 605 (-4.5A)
58Y  A 605 ( 4.2A)
None
58Y  A 605 (-3.3A)
58Y  A 605 (-4.9A)
58Y  A 605 ( 3.0A)
None
58Y  A 605 (-3.7A)
 0.41A 2a3cA-5df0A:
12.2		 2a3cA-5df0A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		9 TYR A 156
TRP A 160
PHE A 184
GLY A 267
ASP A 306
GLU A 308
MET A 381
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
TRP  A 160 ( 0.5A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.72A 2a3cA-5gprA:
12.4		 2a3cA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		10 TYR A 156
TRP A 160
PHE A 184
GLY A 267
ASP A 306
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 TYR  A 156 ( 1.3A)
TRP  A 160 ( 0.5A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.44A 2a3cA-5gprA:
12.4		 2a3cA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR B 564
TRP B 568
PHE B 590
GLY B 651
ASP B 689
GLU B 691
MET B 764
TYR B 766
ASP B 767
TRP B 905
 None
 0.72A 2a3cA-5gztB:
41.1		 2a3cA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR B 564
TRP B 568
PHE B 590
GLY B 651
ASP B 689
MET B 764
TYR B 766
ASP B 767
TYR B 816
TRP B 905
 None
 0.49A 2a3cA-5gztB:
41.1		 2a3cA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR B1051
TRP B1055
PHE B1077
GLY B1137
ASP B1175
GLU B1177
MET B1250
TYR B1252
ASP B1253
TRP B1396
 None
 0.74A 2a3cA-5gztB:
41.1		 2a3cA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR B1051
TRP B1055
PHE B1077
GLY B1137
ASP B1175
MET B1250
TYR B1252
ASP B1253
TYR B1304
TRP B1396
 None
 0.56A 2a3cA-5gztB:
41.1		 2a3cA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR A 564
TRP A 568
PHE A 590
GLY A 651
ASP A 689
GLU A 691
MET A 764
TYR A 766
ASP A 767
TRP A 905
 None
 0.72A 2a3cA-5gzuA:
9.6		 2a3cA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR A 564
TRP A 568
PHE A 590
GLY A 651
ASP A 689
MET A 764
TYR A 766
ASP A 767
TYR A 816
TRP A 905
 None
 0.54A 2a3cA-5gzuA:
9.6		 2a3cA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR A1051
TRP A1055
PHE A1077
GLY A1137
ASP A1175
GLU A1177
MET A1250
TYR A1252
ASP A1253
TRP A1396
 None
 0.73A 2a3cA-5gzuA:
9.6		 2a3cA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR A1051
TRP A1055
PHE A1077
GLY A1137
ASP A1175
MET A1250
TYR A1252
ASP A1253
TYR A1304
TRP A1396
 None
 0.60A 2a3cA-5gzuA:
9.6		 2a3cA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 10 TYR A  98
TRP A 102
PHE A 129
GLY A 175
ASP A 215
MET A 283
TYR A 285
ASP A 286
TYR A 340
TRP A 433
 NAG  A 504 (-3.7A)
NAG  A 506 ( 4.3A)
NAG  A 505 (-4.5A)
NAG  A 504 (-3.7A)
NAG  A 504 (-3.8A)
NAG  A 503 (-4.0A)
NAG  A 504 (-4.5A)
NAG  A 504 (-3.5A)
NAG  A 505 (-4.1A)
NAG  A 504 (-3.6A)
 0.65A 2a3cA-5wvbA:
11.9		 2a3cA-5wvbA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 10 TYR A 534
TRP A 538
PHE A 565
GLY A 605
ASP A 645
MET A 713
TYR A 715
ASP A 716
TYR A 770
TRP A 864
 NAG  A1003 ( 4.2A)
NAG  A1001 (-4.0A)
NAG  A1003 ( 4.8A)
NAG  A1003 (-3.5A)
NAG  A1003 (-3.9A)
NAG  A1003 (-3.6A)
NAG  A1003 (-4.5A)
NAG  A1003 (-3.1A)
NAG  A1002 (-4.2A)
NAG  A1003 (-3.4A)
 0.59A 2a3cA-5wvgA:
11.8		 2a3cA-5wvgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 7 TYR A  27
TRP A  31
PHE A  58
GLY A  99
MET A 205
TYR A 207
TRP A 353
 None
 0.82A 2a3cA-5xepA:
12.0		 2a3cA-5xepA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 8 TYR A  82
TRP A  86
PHE A 104
GLY A 141
ASP A 180
GLU A 182
TYR A 256
TRP A 425
 None
 1.05A 2a3cA-5xwqA:
10.6		 2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 8 TYR A  82
TRP A  86
PHE A 104
GLY A 141
ASP A 180
TYR A 256
TYR A 310
TRP A 425
 None
 0.89A 2a3cA-5xwqA:
10.6		 2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 8 TYR A  82
TRP A  86
PHE A 104
GLY A 141
GLU A 182
MET A 254
TYR A 256
TRP A 425
 None
 0.81A 2a3cA-5xwqA:
10.6		 2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 9 TYR A  82
TRP A  86
PHE A 104
GLY A 141
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
 None
 0.48A 2a3cA-5xwqA:
10.6		 2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 9 TYR A1617
TRP A1621
PHE A1648
GLY A1690
ASP A1731
GLU A1733
MET A1801
TYR A1803
TRP A1961
 None
 1.06A 2a3cA-5y29A:
14.5		 2a3cA-5y29A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 10 TYR A1617
TRP A1621
PHE A1648
GLY A1690
ASP A1731
MET A1801
TYR A1803
ASP A1804
TYR A1856
TRP A1961
 None
 0.87A 2a3cA-5y29A:
14.5		 2a3cA-5y29A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 TYR A2063
TRP A2067
PHE A2094
GLY A2137
ASP A2178
GLU A2180
TRP A2398
 None
 1.31A 2a3cA-5y2aA:
12.0		 2a3cA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 TYR A2063
TRP A2067
PHE A2094
GLY A2137
ASP A2178
GLU A2180
TYR A2250
 None
 1.20A 2a3cA-5y2aA:
12.0		 2a3cA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 TYR A2063
TRP A2067
PHE A2094
GLY A2137
ASP A2178
TYR A2250
TYR A2303
 None
 1.03A 2a3cA-5y2aA:
12.0		 2a3cA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 TYR A2063
TRP A2067
PHE A2094
GLY A2137
ASP A2178
TYR A2303
TRP A2398
 None
 1.16A 2a3cA-5y2aA:
12.0		 2a3cA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 TYR A2063
TRP A2067
PHE A2094
GLY A2137
ASP A2251
TYR A2303
TRP A2398
 None
 0.85A 2a3cA-5y2aA:
12.0		 2a3cA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 TYR A2063
TRP A2067
PHE A2094
GLY A2137
GLU A2180
MET A2248
TYR A2250
 None
 0.98A 2a3cA-5y2aA:
12.0		 2a3cA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 8 TYR A2063
TRP A2067
PHE A2094
GLY A2137
MET A2248
TYR A2250
ASP A2251
TYR A2303
 None
 0.65A 2a3cA-5y2aA:
12.0		 2a3cA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 9 TYR A 163
TRP A 167
PHE A 191
GLY A 274
ASP A 313
GLU A 315
MET A 390
TYR A 392
TRP A 541
 GOL  A 706 (-4.1A)
GOL  A 707 (-4.0A)
GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
GOL  A 706 (-3.5A)
GOL  A 706 (-3.3A)
GOL  A 706 (-3.3A)
GOL  A 706 (-4.8A)
GOL  A 706 ( 3.8A)
 1.03A 2a3cA-5zl9A:
13.0		 2a3cA-5zl9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 9 TYR A 163
TRP A 167
PHE A 191
GLY A 274
ASP A 313
MET A 390
TYR A 392
TYR A 446
TRP A 541
 GOL  A 706 (-4.1A)
GOL  A 707 (-4.0A)
GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
GOL  A 706 (-3.5A)
GOL  A 706 (-3.3A)
GOL  A 706 (-4.8A)
GOL  A 703 (-3.5A)
GOL  A 706 ( 3.8A)
 0.83A 2a3cA-5zl9A:
13.0		 2a3cA-5zl9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 9 TYR A 163
TRP A 167
PHE A 191
GLY A 274
MET A 390
TYR A 392
ASP A 393
TYR A 446
TRP A 541
 GOL  A 706 (-4.1A)
GOL  A 707 (-4.0A)
GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
GOL  A 706 (-3.3A)
GOL  A 706 (-4.8A)
GOL  A 703 (-3.0A)
GOL  A 703 (-3.5A)
GOL  A 706 ( 3.8A)
 0.46A 2a3cA-5zl9A:
13.0		 2a3cA-5zl9A:
10.86