SIMILAR PATTERNS OF AMINO ACIDS FOR 2A3B_A_CFFA1435_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		11 TYR A  43
PHE A  71
GLY A 130
TRP A 131
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
 None
 0.47A 2a3bA-1d2kA:
65.0		 2a3bA-1d2kA:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  10
PHE A  51
GLY A  96
ASP A 142
TYR A 214
TYR A 292
TRP A 403
 NGO  A 502 (-3.2A)
NGO  A 502 (-4.7A)
NGO  A 502 ( 3.8A)
NGO  A 502 (-3.1A)
NGO  A 502 (-4.5A)
NGO  A 502 (-4.8A)
NGO  A 502 (-3.5A)
 0.81A 2a3bA-1e6zA:
39.4		 2a3bA-1e6zA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  10
PHE A  51
GLY A  96
GLU A 144
MET A 212
TYR A 214
TRP A 403
 NGO  A 502 (-3.2A)
NGO  A 502 (-4.7A)
NGO  A 502 ( 3.8A)
NGO  A 502 (-3.4A)
NGO  A 502 (-3.4A)
NGO  A 502 (-4.5A)
NGO  A 502 (-3.5A)
 0.71A 2a3bA-1e6zA:
39.4		 2a3bA-1e6zA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  10
PHE A  51
GLY A  96
MET A 212
TYR A 214
ASP A 215
TYR A 292
TRP A 403
 NGO  A 502 (-3.2A)
NGO  A 502 (-4.7A)
NGO  A 502 ( 3.8A)
NGO  A 502 (-3.4A)
NGO  A 502 (-4.5A)
NGO  A 502 ( 3.1A)
NGO  A 502 (-4.8A)
NGO  A 502 (-3.5A)
 0.44A 2a3bA-1e6zA:
39.4		 2a3bA-1e6zA:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  27
PHE A  58
GLY A  98
MET A 204
TYR A 206
ASP A 207
TRP A 352
 NAG  A  -1 (-3.8A)
NAG  A  -2 (-4.7A)
NAG  A  -2 ( 4.2A)
NAG  A   1 (-3.7A)
NAG  A  -1 (-4.6A)
NAG  A  -1 (-3.7A)
NAG  A  -1 (-3.5A)
 0.66A 2a3bA-1hjvA:
43.4		 2a3bA-1hjvA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  27
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.74A 2a3bA-1hkkA:
43.8		 2a3bA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		8 PHE A  77
GLY A 163
TRP A 164
ASP A 202
GLU A 204
MET A 277
TYR A 279
TRP A 433
 GOL  A1007 (-4.8A)
GOL  A1007 ( 3.9A)
None
GOL  A1007 (-3.6A)
GOL  A1007 (-3.7A)
GOL  A1007 ( 3.3A)
GOL  A1007 ( 4.8A)
GOL  A1007 (-4.8A)
 0.87A 2a3bA-1itxA:
47.8		 2a3bA-1itxA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		9 PHE A  77
GLY A 163
TRP A 164
ASP A 202
MET A 277
TYR A 279
ASP A 280
TYR A 338
TRP A 433
 GOL  A1007 (-4.8A)
GOL  A1007 ( 3.9A)
None
GOL  A1007 (-3.6A)
GOL  A1007 ( 3.3A)
GOL  A1007 ( 4.8A)
None
None
GOL  A1007 (-4.8A)
 0.65A 2a3bA-1itxA:
47.8		 2a3bA-1itxA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		8 TYR A  49
PHE A  77
GLY A 163
ASP A 202
GLU A 204
MET A 277
TYR A 279
TRP A 433
 GOL  A1007 (-4.1A)
GOL  A1007 (-4.8A)
GOL  A1007 ( 3.9A)
GOL  A1007 (-3.6A)
GOL  A1007 (-3.7A)
GOL  A1007 ( 3.3A)
GOL  A1007 ( 4.8A)
GOL  A1007 (-4.8A)
 0.74A 2a3bA-1itxA:
47.8		 2a3bA-1itxA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		9 TYR A  49
PHE A  77
GLY A 163
ASP A 202
MET A 277
TYR A 279
ASP A 280
TYR A 338
TRP A 433
 GOL  A1007 (-4.1A)
GOL  A1007 (-4.8A)
GOL  A1007 ( 3.9A)
GOL  A1007 (-3.6A)
GOL  A1007 ( 3.3A)
GOL  A1007 ( 4.8A)
None
None
GOL  A1007 (-4.8A)
 0.43A 2a3bA-1itxA:
47.8		 2a3bA-1itxA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		7 TYR A  23
PHE A  55
GLY A 135
ASP A 190
GLU A 192
TYR A 271
TRP A 412
 None
None
None
None
GOL  A 530 (-3.9A)
GOL  A 530 (-4.8A)
None
 0.67A 2a3bA-1kfwA:
46.1		 2a3bA-1kfwA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		8 TYR A  23
PHE A  55
GLY A 135
ASP A 190
TYR A 271
ASP A 272
TYR A 328
TRP A 412
 None
None
None
None
GOL  A 530 (-4.8A)
GOL  A 530 (-3.7A)
None
None
 0.38A 2a3bA-1kfwA:
46.1		 2a3bA-1kfwA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		8 TYR A  23
PHE A  55
GLY A 135
TRP A 136
ASP A 190
ASP A 272
TYR A 328
TRP A 412
 None
None
None
None
None
GOL  A 530 (-3.7A)
None
None
 0.59A 2a3bA-1kfwA:
46.1		 2a3bA-1kfwA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		7 TYR A  23
PHE A  55
GLY A 135
TRP A 136
ASP A 190
GLU A 192
TRP A 412
 None
None
None
None
None
GOL  A 530 (-3.9A)
None
 0.80A 2a3bA-1kfwA:
46.1		 2a3bA-1kfwA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		7 TYR A   6
PHE A  37
GLY A  77
MET A 189
TYR A 191
ASP A 192
TYR A 246
 None
 0.63A 2a3bA-1vf8A:
44.1		 2a3bA-1vf8A:
26.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		7 PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 None
 0.84A 2a3bA-1wb0A:
43.5		 2a3bA-1wb0A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  27
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
 None
 0.82A 2a3bA-1wb0A:
43.5		 2a3bA-1wb0A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  27
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
 0.56A 2a3bA-1wb0A:
43.5		 2a3bA-1wb0A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		10 TYR A  10
PHE A  38
GLY A  98
TRP A  99
ASP A 137
GLU A 139
MET A 205
TYR A 207
ASP A 208
TRP A 346
 None
 0.73A 2a3bA-1wnoA:
69.7		 2a3bA-1wnoA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		10 TYR A  10
PHE A  38
GLY A  98
TRP A  99
ASP A 137
MET A 205
TYR A 207
ASP A 208
TYR A 261
TRP A 346
 None
 0.50A 2a3bA-1wnoA:
69.7		 2a3bA-1wnoA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 TYR A 163
PHE A 191
ASP A 313
MET A 388
TYR A 390
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 (-3.4A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.86A 2a3bA-2wk2A:
43.4		 2a3bA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 TYR A 163
PHE A 191
GLY A 274
GLU A 315
MET A 388
TYR A 390
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
SN5  A1566 ( 2.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 ( 3.5A)
 0.73A 2a3bA-2wk2A:
43.4		 2a3bA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		8 TYR A 163
PHE A 191
GLY A 274
MET A 388
TYR A 390
ASP A 391
TYR A 444
TRP A 539
 NGT  A1565 (-3.6A)
SN5  A1564 (-4.6A)
NGT  A1565 ( 3.9A)
NGT  A1565 (-3.7A)
NGT  A1565 (-4.7A)
NGT  A1565 (-2.9A)
NGT  A1565 ( 4.9A)
NGT  A1565 ( 3.5A)
 0.39A 2a3bA-2wk2A:
43.4		 2a3bA-2wk2A:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		7 PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
 0.84A 2a3bA-2ybuA:
44.5		 2a3bA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		7 TYR A  27
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 0.84A 2a3bA-2ybuA:
44.5		 2a3bA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		8 TYR A  27
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.51A 2a3bA-2ybuA:
44.5		 2a3bA-2ybuA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		8 TYR A   7
PHE A  31
GLY A  73
ASP A 113
GLU A 115
MET A 181
TYR A 183
TRP A 326
 EDO  A 357 ( 4.5A)
EDO  A 357 (-4.8A)
EDO  A 357 ( 4.2A)
EDO  A 357 (-4.2A)
EDO  A 357 (-2.8A)
EDO  A 357 ( 3.3A)
EDO  A 359 ( 4.7A)
EDO  A 357 (-4.4A)
 0.72A 2a3bA-3alfA:
41.4		 2a3bA-3alfA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		9 TYR A   7
PHE A  31
GLY A  73
ASP A 113
MET A 181
TYR A 183
ASP A 184
TYR A 234
TRP A 326
 EDO  A 357 ( 4.5A)
EDO  A 357 (-4.8A)
EDO  A 357 ( 4.2A)
EDO  A 357 (-4.2A)
EDO  A 357 ( 3.3A)
EDO  A 359 ( 4.7A)
EDO  A 359 (-4.5A)
None
EDO  A 357 (-4.4A)
 0.55A 2a3bA-3alfA:
41.4		 2a3bA-3alfA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		8 TYR A   8
PHE A  32
GLY A  74
ASP A 114
GLU A 116
MET A 182
TYR A 184
TRP A 324
 None
 0.68A 2a3bA-3aquA:
41.3		 2a3bA-3aquA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		9 TYR A   8
PHE A  32
GLY A  74
ASP A 114
MET A 182
TYR A 184
ASP A 185
TYR A 235
TRP A 324
 None
 0.50A 2a3bA-3aquA:
41.3		 2a3bA-3aquA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 PHE A 192
GLY A 274
TRP A 275
ASP A 313
ASP A 392
TYR A 461
TRP A 570
 None
 0.75A 2a3bA-3b9eA:
39.7		 2a3bA-3b9eA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		9 TYR A 164
PHE A 192
GLY A 274
ASP A 313
MET A 389
TYR A 391
ASP A 392
TYR A 461
TRP A 570
 None
 0.47A 2a3bA-3b9eA:
39.7		 2a3bA-3b9eA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		7 TYR A  52
PHE A  79
MET A 211
TYR A 213
ASP A 214
TYR A 256
TRP A 322
 None
None
None
None
None
GOL  A 356 (-4.3A)
None
 0.44A 2a3bA-3fndA:
31.4		 2a3bA-3fndA:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		10 TYR A  46
PHE A  74
GLY A 133
TRP A 134
ASP A 172
GLU A 174
MET A 240
TYR A 242
TYR A 296
TRP A 381
 None
 0.61A 2a3bA-3g6lA:
63.7		 2a3bA-3g6lA:
54.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		10 TYR A  46
PHE A  74
GLY A 133
TRP A 134
ASP A 172
MET A 240
TYR A 242
ASP A 243
TYR A 296
TRP A 381
 None
 0.39A 2a3bA-3g6lA:
63.7		 2a3bA-3g6lA:
54.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		8 PHE A  58
GLY A 113
TRP A 114
ASP A 151
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
 0.79A 2a3bA-3qokA:
37.7		 2a3bA-3qokA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		9 PHE A  58
GLY A 113
TRP A 114
ASP A 151
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
 0.57A 2a3bA-3qokA:
37.7		 2a3bA-3qokA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		8 TYR A  28
PHE A  58
GLY A 113
ASP A 151
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
 0.72A 2a3bA-3qokA:
37.7		 2a3bA-3qokA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		9 TYR A  28
PHE A  58
GLY A 113
ASP A 151
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
 0.47A 2a3bA-3qokA:
37.7		 2a3bA-3qokA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		8 PHE A  61
GLY A 106
TRP A 107
ASP A 146
GLU A 148
MET A 215
TYR A 217
TRP A 372
 None
 0.81A 2a3bA-3w4rA:
44.0		 2a3bA-3w4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		9 PHE A  61
GLY A 106
TRP A 107
ASP A 146
MET A 215
TYR A 217
ASP A 218
TYR A 272
TRP A 372
 None
 0.65A 2a3bA-3w4rA:
44.0		 2a3bA-3w4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		8 TYR A  30
PHE A  61
GLY A 106
ASP A 146
GLU A 148
MET A 215
TYR A 217
TRP A 372
 None
 0.77A 2a3bA-3w4rA:
44.0		 2a3bA-3w4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		9 TYR A  30
PHE A  61
GLY A 106
ASP A 146
MET A 215
TYR A 217
ASP A 218
TYR A 272
TRP A 372
 None
 0.65A 2a3bA-3w4rA:
44.0		 2a3bA-3w4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		7 PHE A  61
GLY A 106
TRP A 107
TYR A 217
ASP A 218
TYR A 272
TRP A 372
 NAG  A 501 (-4.5A)
NAG  A 501 (-3.6A)
NAG  A 505 ( 3.4A)
NAG  A 501 (-4.6A)
NAG  A 501 ( 3.2A)
NAG  A 502 (-3.9A)
NAG  A 501 (-3.7A)
 0.72A 2a3bA-3wl1A:
44.1		 2a3bA-3wl1A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		7 TYR A  30
PHE A  61
GLY A 106
GLU A 148
MET A 215
TYR A 217
TRP A 372
 NAG  A 501 (-3.8A)
NAG  A 501 (-4.5A)
NAG  A 501 (-3.6A)
NAG  A 501 (-2.7A)
NAG  A 501 (-3.5A)
NAG  A 501 (-4.6A)
NAG  A 501 (-3.7A)
 0.84A 2a3bA-3wl1A:
44.1		 2a3bA-3wl1A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		8 TYR A  30
PHE A  61
GLY A 106
MET A 215
TYR A 217
ASP A 218
TYR A 272
TRP A 372
 NAG  A 501 (-3.8A)
NAG  A 501 (-4.5A)
NAG  A 501 (-3.6A)
NAG  A 501 (-3.5A)
NAG  A 501 (-4.6A)
NAG  A 501 ( 3.2A)
NAG  A 502 (-3.9A)
NAG  A 501 (-3.7A)
 0.66A 2a3bA-3wl1A:
44.1		 2a3bA-3wl1A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		7 TYR A  73
PHE A 117
GLY A 214
ASP A 254
MET A 323
ASP A 326
TYR A 379
 None
 0.84A 2a3bA-4a5qA:
7.4		 2a3bA-4a5qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		8 TYR A  73
PHE A 117
GLY A 214
TRP A 215
ASP A 254
ASP A 326
TYR A 379
TRP A 486
 None
 0.92A 2a3bA-4a5qA:
7.4		 2a3bA-4a5qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		7 TYR A  73
PHE A 117
GLY A 214
TRP A 215
ASP A 254
GLU A 256
ASP A 326
 None
 0.86A 2a3bA-4a5qA:
7.4		 2a3bA-4a5qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		8 TYR A 156
PHE A 200
GLY A 307
TRP A 308
ASP A 347
ASP A 425
TYR A 482
TRP A 582
 None
None
None
None
None
None
None
GOL  A 701 (-4.2A)
 0.89A 2a3bA-4dwsA:
33.9		 2a3bA-4dwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		7 TYR A 156
PHE A 200
GLY A 307
TRP A 308
ASP A 347
GLU A 349
MET A 422
 None
 0.82A 2a3bA-4dwsA:
33.9		 2a3bA-4dwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		9 TYR A 156
PHE A 200
GLY A 307
TRP A 308
ASP A 347
MET A 422
TYR A 424
ASP A 425
TYR A 482
 None
 0.62A 2a3bA-4dwsA:
33.9		 2a3bA-4dwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		7 PHE A  34
GLY A  76
ASP A 117
MET A 189
TYR A 191
ASP A 192
TRP A 327
 None
 0.88A 2a3bA-4mnmA:
40.9		 2a3bA-4mnmA:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		7 PHE A  58
GLY A 113
TRP A 114
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
ACT  A 502 ( 4.6A)
None
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.80A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		8 PHE A  58
GLY A 113
TRP A 114
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
ACT  A 502 ( 4.6A)
None
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.59A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		7 TYR A  28
PHE A  58
GLY A 113
GLU A 153
MET A 220
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.82A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		8 TYR A  28
PHE A  58
GLY A 113
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.57A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		8 TYR A 159
PHE A 190
GLY A 254
ASP A 312
GLU A 314
MET A 395
TYR A 397
TRP A 603
 None
None
None
None
CS  A 803 (-2.9A)
CS  A 803 (-3.5A)
CS  A 812 (-4.4A)
CS  A 812 ( 4.2A)
 0.99A 2a3bA-4txgA:
34.8		 2a3bA-4txgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		9 TYR A 159
PHE A 190
GLY A 254
ASP A 312
MET A 395
TYR A 397
ASP A 398
TYR A 464
TRP A 603
 None
None
None
None
CS  A 803 (-3.5A)
CS  A 812 (-4.4A)
CS  A 812 (-4.0A)
CS  A 812 (-4.5A)
CS  A 812 ( 4.2A)
 0.83A 2a3bA-4txgA:
34.8		 2a3bA-4txgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		8 TYR A   6
PHE A  30
GLY A  72
ASP A 114
GLU A 116
MET A 183
TYR A 185
TRP A 317
 MPD  A 401 (-3.5A)
None
MPD  A 401 ( 4.6A)
MPD  A 401 (-4.3A)
MPD  A 401 (-2.7A)
MPD  A 401 (-3.0A)
MPD  A 401 (-4.8A)
MPD  A 401 (-3.8A)
 0.86A 2a3bA-4uriA:
40.4		 2a3bA-4uriA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		9 TYR A   6
PHE A  30
GLY A  72
ASP A 114
MET A 183
TYR A 185
ASP A 186
TYR A 236
TRP A 317
 MPD  A 401 (-3.5A)
None
MPD  A 401 ( 4.6A)
MPD  A 401 (-4.3A)
MPD  A 401 (-3.0A)
MPD  A 401 (-4.8A)
None
None
MPD  A 401 (-3.8A)
 0.69A 2a3bA-4uriA:
40.4		 2a3bA-4uriA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 8 PHE B  78
GLY B 141
TRP B 142
ASP B 181
GLU B 183
ASP B 251
TYR B 305
TRP B 388
 None
None
MLI  B 501 ( 3.8A)
None
None
MLI  B 501 ( 4.7A)
None
None
 1.11A 2a3bA-4w5uB:
44.4		 2a3bA-4w5uB:
32.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 9 TYR B  46
PHE B  78
GLY B 141
ASP B 181
GLU B 183
MET B 248
TYR B 250
ASP B 251
TYR B 305
 None
None
None
None
None
None
None
MLI  B 501 ( 4.7A)
None
 0.86A 2a3bA-4w5uB:
44.4		 2a3bA-4w5uB:
32.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 9 TYR B  46
PHE B  78
GLY B 141
ASP B 181
GLU B 183
TYR B 250
ASP B 251
TYR B 305
TRP B 388
 None
None
None
None
None
None
MLI  B 501 ( 4.7A)
None
None
 1.02A 2a3bA-4w5uB:
44.4		 2a3bA-4w5uB:
32.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 PHE A 181
GLY A 264
TRP A 265
ASP A 303
GLU A 305
TYR A 381
TRP A 528
 58Y  A 605 (-4.5A)
58Y  A 605 ( 4.2A)
NAG  A 603 ( 3.9A)
None
58Y  A 605 (-3.1A)
58Y  A 605 (-4.9A)
58Y  A 605 (-3.7A)
 0.85A 2a3bA-5df0A:
43.3		 2a3bA-5df0A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		8 PHE A 181
GLY A 264
TRP A 265
ASP A 303
TYR A 381
ASP A 382
TYR A 435
TRP A 528
 58Y  A 605 (-4.5A)
58Y  A 605 ( 4.2A)
NAG  A 603 ( 3.9A)
None
58Y  A 605 (-4.9A)
58Y  A 605 ( 3.0A)
None
58Y  A 605 (-3.7A)
 0.61A 2a3bA-5df0A:
43.3		 2a3bA-5df0A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		8 TYR A 153
PHE A 181
GLY A 264
ASP A 303
GLU A 305
MET A 379
TYR A 381
TRP A 528
 58Y  A 605 (-3.6A)
58Y  A 605 (-4.5A)
58Y  A 605 ( 4.2A)
None
58Y  A 605 (-3.1A)
58Y  A 605 (-3.3A)
58Y  A 605 (-4.9A)
58Y  A 605 (-3.7A)
 0.69A 2a3bA-5df0A:
43.3		 2a3bA-5df0A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		9 TYR A 153
PHE A 181
GLY A 264
ASP A 303
MET A 379
TYR A 381
ASP A 382
TYR A 435
TRP A 528
 58Y  A 605 (-3.6A)
58Y  A 605 (-4.5A)
58Y  A 605 ( 4.2A)
None
58Y  A 605 (-3.3A)
58Y  A 605 (-4.9A)
58Y  A 605 ( 3.0A)
None
58Y  A 605 (-3.7A)
 0.39A 2a3bA-5df0A:
43.3		 2a3bA-5df0A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		9 TYR A 156
PHE A 184
GLY A 267
TRP A 268
ASP A 306
GLU A 308
MET A 381
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.78A 2a3bA-5gprA:
43.0		 2a3bA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		10 TYR A 156
PHE A 184
GLY A 267
TRP A 268
ASP A 306
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
ASP  A 306 ( 0.5A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.57A 2a3bA-5gprA:
43.0		 2a3bA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 PHE B 590
GLY B 651
TRP B 652
ASP B 689
GLU B 691
MET B 764
TYR B 766
ASP B 767
TRP B 905
 None
 0.82A 2a3bA-5gztB:
41.5		 2a3bA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 PHE B 590
GLY B 651
TRP B 652
ASP B 689
MET B 764
TYR B 766
ASP B 767
TYR B 816
TRP B 905
 None
 0.66A 2a3bA-5gztB:
41.5		 2a3bA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 TYR B 564
PHE B 590
GLY B 651
ASP B 689
GLU B 691
MET B 764
TYR B 766
ASP B 767
TRP B 905
 None
 0.73A 2a3bA-5gztB:
41.5		 2a3bA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 TYR B 564
PHE B 590
GLY B 651
ASP B 689
MET B 764
TYR B 766
ASP B 767
TYR B 816
TRP B 905
 None
 0.50A 2a3bA-5gztB:
41.5		 2a3bA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 TYR B1051
PHE B1077
GLY B1137
ASP B1175
GLU B1177
MET B1250
TYR B1252
ASP B1253
TRP B1396
 None
 0.75A 2a3bA-5gztB:
41.5		 2a3bA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 TYR B1051
PHE B1077
GLY B1137
ASP B1175
MET B1250
TYR B1252
ASP B1253
TYR B1304
TRP B1396
 None
 0.55A 2a3bA-5gztB:
41.5		 2a3bA-5gztB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 TYR A 564
PHE A 590
GLY A 651
TRP A 652
ASP A 689
GLU A 691
MET A 764
TYR A 766
TRP A 905
 None
 0.76A 2a3bA-5gzuA:
41.2		 2a3bA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		10 TYR A 564
PHE A 590
GLY A 651
TRP A 652
ASP A 689
MET A 764
TYR A 766
ASP A 767
TYR A 816
TRP A 905
 None
 0.66A 2a3bA-5gzuA:
41.2		 2a3bA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		8 TYR A1051
PHE A1077
GLY A1137
ASP A1175
GLU A1177
MET A1250
TYR A1252
TRP A1396
 None
 0.68A 2a3bA-5gzuA:
41.2		 2a3bA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		9 TYR A1051
PHE A1077
GLY A1137
ASP A1175
MET A1250
TYR A1252
ASP A1253
TYR A1304
TRP A1396
 None
 0.58A 2a3bA-5gzuA:
41.2		 2a3bA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		8 TYR A1051
PHE A1077
GLY A1137
TRP A1138
ASP A1175
ASP A1253
TYR A1304
TRP A1396
 None
 0.83A 2a3bA-5gzuA:
41.2		 2a3bA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		7 TYR A1051
PHE A1077
GLY A1137
TRP A1138
ASP A1175
GLU A1177
TRP A1396
 None
 0.81A 2a3bA-5gzuA:
41.2		 2a3bA-5gzuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 8 PHE A 129
GLY A 175
TRP A 176
ASP A 215
TYR A 285
ASP A 286
TYR A 340
TRP A 433
 NAG  A 505 (-4.5A)
NAG  A 504 (-3.7A)
NAG  A 503 (-3.3A)
NAG  A 504 (-3.8A)
NAG  A 504 (-4.5A)
NAG  A 504 (-3.5A)
NAG  A 505 (-4.1A)
NAG  A 504 (-3.6A)
 0.69A 2a3bA-5wvbA:
45.3		 2a3bA-5wvbA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 9 TYR A  98
PHE A 129
GLY A 175
ASP A 215
MET A 283
TYR A 285
ASP A 286
TYR A 340
TRP A 433
 NAG  A 504 (-3.7A)
NAG  A 505 (-4.5A)
NAG  A 504 (-3.7A)
NAG  A 504 (-3.8A)
NAG  A 503 (-4.0A)
NAG  A 504 (-4.5A)
NAG  A 504 (-3.5A)
NAG  A 505 (-4.1A)
NAG  A 504 (-3.6A)
 0.64A 2a3bA-5wvbA:
45.3		 2a3bA-5wvbA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 8 PHE A 565
GLY A 605
TRP A 606
ASP A 645
TYR A 715
ASP A 716
TYR A 770
TRP A 864
 NAG  A1003 ( 4.8A)
NAG  A1003 (-3.5A)
NAG  A1004 (-3.4A)
NAG  A1003 (-3.9A)
NAG  A1003 (-4.5A)
NAG  A1003 (-3.1A)
NAG  A1002 (-4.2A)
NAG  A1003 (-3.4A)
 0.64A 2a3bA-5wvgA:
43.6		 2a3bA-5wvgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 9 TYR A 534
PHE A 565
GLY A 605
ASP A 645
MET A 713
TYR A 715
ASP A 716
TYR A 770
TRP A 864
 NAG  A1003 ( 4.2A)
NAG  A1003 ( 4.8A)
NAG  A1003 (-3.5A)
NAG  A1003 (-3.9A)
NAG  A1003 (-3.6A)
NAG  A1003 (-4.5A)
NAG  A1003 (-3.1A)
NAG  A1002 (-4.2A)
NAG  A1003 (-3.4A)
 0.56A 2a3bA-5wvgA:
43.6		 2a3bA-5wvgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 7 TYR A  82
PHE A 104
GLY A 141
ASP A 180
TYR A 256
TYR A 310
TRP A 425
 None
 0.92A 2a3bA-5xwqA:
36.1		 2a3bA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 7 TYR A  82
PHE A 104
GLY A 141
GLU A 182
MET A 254
TYR A 256
TRP A 425
 None
 0.82A 2a3bA-5xwqA:
36.1		 2a3bA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 8 TYR A  82
PHE A 104
GLY A 141
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
 None
 0.50A 2a3bA-5xwqA:
36.1		 2a3bA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 PHE A1648
GLY A1690
TRP A1691
ASP A1731
TYR A1803
TYR A1856
TRP A1961
 None
 0.86A 2a3bA-5y29A:
43.4		 2a3bA-5y29A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 PHE A1648
GLY A1690
TRP A1691
TYR A1803
ASP A1804
TYR A1856
TRP A1961
 None
 0.59A 2a3bA-5y29A:
43.4		 2a3bA-5y29A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 8 TYR A1617
PHE A1648
GLY A1690
ASP A1731
GLU A1733
MET A1801
TYR A1803
TRP A1961
 None
 1.01A 2a3bA-5y29A:
43.4		 2a3bA-5y29A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 8 TYR A1617
PHE A1648
GLY A1690
ASP A1731
MET A1801
TYR A1803
TYR A1856
TRP A1961
 None
 0.88A 2a3bA-5y29A:
43.4		 2a3bA-5y29A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 8 TYR A1617
PHE A1648
GLY A1690
MET A1801
TYR A1803
ASP A1804
TYR A1856
TRP A1961
 None
 0.52A 2a3bA-5y29A:
43.4		 2a3bA-5y29A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 7 TYR A2063
PHE A2094
GLY A2137
MET A2248
TYR A2250
ASP A2251
TYR A2303
 None
 0.60A 2a3bA-5y2aA:
43.2		 2a3bA-5y2aA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 7 PHE A 191
GLY A 274
TRP A 275
ASP A 313
TYR A 392
TYR A 446
TRP A 541
 GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
None
GOL  A 706 (-3.5A)
GOL  A 706 (-4.8A)
GOL  A 703 (-3.5A)
GOL  A 706 ( 3.8A)
 0.93A 2a3bA-5zl9A:
43.0		 2a3bA-5zl9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 7 PHE A 191
GLY A 274
TRP A 275
TYR A 392
ASP A 393
TYR A 446
TRP A 541
 GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
None
GOL  A 706 (-4.8A)
GOL  A 703 (-3.0A)
GOL  A 703 (-3.5A)
GOL  A 706 ( 3.8A)
 0.69A 2a3bA-5zl9A:
43.0		 2a3bA-5zl9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 8 TYR A 163
PHE A 191
GLY A 274
ASP A 313
GLU A 315
MET A 390
TYR A 392
TRP A 541
 GOL  A 706 (-4.1A)
GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
GOL  A 706 (-3.5A)
GOL  A 706 (-3.3A)
GOL  A 706 (-3.3A)
GOL  A 706 (-4.8A)
GOL  A 706 ( 3.8A)
 1.03A 2a3bA-5zl9A:
43.0		 2a3bA-5zl9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 8 TYR A 163
PHE A 191
GLY A 274
ASP A 313
MET A 390
TYR A 392
TYR A 446
TRP A 541
 GOL  A 706 (-4.1A)
GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
GOL  A 706 (-3.5A)
GOL  A 706 (-3.3A)
GOL  A 706 (-4.8A)
GOL  A 703 (-3.5A)
GOL  A 706 ( 3.8A)
 0.84A 2a3bA-5zl9A:
43.0		 2a3bA-5zl9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 8 TYR A 163
PHE A 191
GLY A 274
MET A 390
TYR A 392
ASP A 393
TYR A 446
TRP A 541
 GOL  A 706 (-4.1A)
GOL  A 706 (-4.9A)
GOL  A 706 ( 4.1A)
GOL  A 706 (-3.3A)
GOL  A 706 (-4.8A)
GOL  A 703 (-3.0A)
GOL  A 703 (-3.5A)
GOL  A 706 ( 3.8A)
 0.42A 2a3bA-5zl9A:
43.0		 2a3bA-5zl9A:
10.86