SIMILAR PATTERNS OF AMINO ACIDS FOR 2A3B_A_CFFA1434
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a87 | COLICIN N (Escherichiacoli) |
PF01024(Colicin) | 3 | TRP A 270THR A 362TYR A 365 | None | 1.24A | 2a3bA-1a87A:undetectable | 2a3bA-1a87A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cja | PROTEIN(ACTIN-FRAGMINKINASE) (Physarumpolycephalum) |
PF09192(Act-Frag_cataly) | 3 | TRP A 66THR A 90TYR A 58 | None | 1.06A | 2a3bA-1cjaA:undetectable | 2a3bA-1cjaA:23.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1d2k | CHITINASE 1 (Coccidioidesimmitis) |
PF00704(Glyco_hydro_18) | 3 | TRP A 47THR A 132TYR A 133 | None | 0.27A | 2a3bA-1d2kA:65.0 | 2a3bA-1d2kA:59.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eom | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F3 (Elizabethkingiameningoseptica) |
PF00704(Glyco_hydro_18) | 3 | TRP A 151THR A 146TYR A 226 | None | 0.87A | 2a3bA-1eomA:18.5 | 2a3bA-1eomA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gju | MALTODEXTRINGLYCOSYLTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09083(DUF1923) | 3 | TRP A 545THR A 501TYR A 87 | None | 1.23A | 2a3bA-1gjuA:9.7 | 2a3bA-1gjuA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i71 | APOLIPOPROTEIN(A) (Homo sapiens) |
PF00051(Kringle) | 3 | TRP A 32THR A 36TYR A 39 | None | 0.84A | 2a3bA-1i71A:undetectable | 2a3bA-1i71A:8.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1f | GLUTAMATEDEHYDROGENASE 1 (Homo sapiens) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TRP A 182THR A 175TYR A 99 | None | 0.70A | 2a3bA-1l1fA:undetectable | 2a3bA-1l1fA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mvl | PPC DECARBOXYLASEATHAL3A (Arabidopsisthaliana) |
PF02441(Flavoprotein) | 3 | TRP A 96THR A 70TYR A 72 | None | 1.17A | 2a3bA-1mvlA:undetectable | 2a3bA-1mvlA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP1)HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP2) (Rhinovirus A) |
PF00073(Rhv) | 3 | TRP 2 220THR 1 117TYR 1 118 | None | 1.24A | 2a3bA-1r1a2:undetectable | 2a3bA-1r1a2:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry2 | ACETYL-COENZYME ASYNTHETASE 1 (Saccharomycescerevisiae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 3 | TRP A 365THR A 359TYR A 411 | None | 1.13A | 2a3bA-1ry2A:undetectable | 2a3bA-1ry2A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukv | GTP-BINDING PROTEINYPT1 (Saccharomycescerevisiae) |
PF00071(Ras) | 3 | TRP Y 102THR Y 64TYR Y 77 | None | 1.14A | 2a3bA-1ukvY:3.4 | 2a3bA-1ukvY:19.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wno | CHITINASE (Aspergillusfumigatus) |
PF00704(Glyco_hydro_18) | 3 | TRP A 14THR A 100TYR A 101 | None | 0.14A | 2a3bA-1wnoA:69.7 | 2a3bA-1wnoA:99.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xf1 | C5A PEPTIDASE (Streptococcuspyogenes) |
PF00082(Peptidase_S8)PF02225(PA)PF06280(fn3_5)PF13585(CHU_C) | 3 | TRP A 650THR A 627TYR A 564 | None | 1.29A | 2a3bA-1xf1A:2.2 | 2a3bA-1xf1A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xl8 | PEROXISOMALCARNITINEO-OCTANOYLTRANSFERASE (Mus musculus) |
PF00755(Carn_acyltransf) | 3 | TRP A 85THR A 441TYR A 439 | 152 A 613 (-4.7A)152 A 613 (-2.8A)152 A 613 (-4.3A) | 1.23A | 2a3bA-1xl8A:undetectable | 2a3bA-1xl8A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yiq | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Pseudomonasputida) |
PF01011(PQQ)PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 3 | TRP A 352THR A 293TYR A 332 | None | 1.25A | 2a3bA-1yiqA:undetectable | 2a3bA-1yiqA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z2a | RAS-RELATED PROTEINRAB-23 (Mus musculus) |
PF00071(Ras) | 3 | TRP A 103THR A 65TYR A 78 | None | 1.07A | 2a3bA-1z2aA:undetectable | 2a3bA-1z2aA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5j | RAS-RELATED PROTEINRAB-2B (Homo sapiens) |
PF00071(Ras) | 3 | TRP A 105THR A 67TYR A 80 | None | 1.02A | 2a3bA-2a5jA:3.2 | 2a3bA-2a5jA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glo | BRINKER CG9653-PA (Drosophilamelanogaster) |
PF09607(BrkDBD) | 3 | TRP A 87THR A 73TYR A 77 | None | 1.18A | 2a3bA-2gloA:undetectable | 2a3bA-2gloA:8.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgz | G2/MITOTIC-SPECIFICCYCLIN-B1 (Homo sapiens) |
PF00134(Cyclin_N)PF02984(Cyclin_C) | 3 | TRP B 208THR B 276TYR B 277 | None | 0.80A | 2a3bA-2jgzB:undetectable | 2a3bA-2jgzB:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k60 | PROTEIN (STROMALINTERACTION MOLECULE1) (Homo sapiens) |
PF07647(SAM_2) | 3 | TRP A 132THR A 143TYR A 144 | None | 1.29A | 2a3bA-2k60A:undetectable | 2a3bA-2k60A:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kl2 | AIG2-LIKEDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
PF06094(GGACT) | 3 | TRP A 124THR A 117TYR A 88 | None | 1.14A | 2a3bA-2kl2A:undetectable | 2a3bA-2kl2A:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mqi | TYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF00017(SH2) | 3 | TRP A 149THR A 223TYR A 213 | None | 1.18A | 2a3bA-2mqiA:undetectable | 2a3bA-2mqiA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n1b | GTP-BINDING NUCLEARPROTEIN RAN (Homo sapiens) |
PF00071(Ras) | 3 | TRP A 104THR A 66TYR A 79 | None | 1.19A | 2a3bA-2n1bA:3.6 | 2a3bA-2n1bA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o52 | RAS-RELATED PROTEINRAB-4B (Homo sapiens) |
PF00071(Ras) | 3 | TRP A 102THR A 64TYR A 77 | None | 1.01A | 2a3bA-2o52A:3.0 | 2a3bA-2o52A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfg | ENDOGLUCANASE 1 (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9) | 3 | TRP A 260THR A 152TYR A 199 | None CA A1447 ( 4.7A)None | 1.23A | 2a3bA-2xfgA:undetectable | 2a3bA-2xfgA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyd | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 3 | TRP A 198THR A 179TYR A 175 | None | 1.23A | 2a3bA-2xydA:undetectable | 2a3bA-2xydA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y32 | BLR5658 PROTEIN (Bradyrhizobiumjaponicum) |
PF01382(Avidin) | 3 | TRP A 5THR A 58TYR A 53 | None | 0.98A | 2a3bA-2y32A:undetectable | 2a3bA-2y32A:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4l | MANNOSYLGLYCERATESYNTHASE (Rhodothermusmarinus) |
no annotation | 3 | TRP A 344THR A 274TYR A 269 | None | 1.03A | 2a3bA-2y4lA:undetectable | 2a3bA-2y4lA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5p | HAEMAGGLUTININ I (Physarumpolycephalum) |
no annotation | 3 | TRP A 3THR A 41TYR A 31 | None | 1.28A | 2a3bA-3a5pA:undetectable | 2a3bA-3a5pA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cji | POLYPROTEIN (Senecavirus A) |
PF00073(Rhv)no annotation | 3 | TRP C 236THR A 117TYR A 118 | None | 1.23A | 2a3bA-3cjiC:undetectable | 2a3bA-3cjiC:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmg | PUTATIVEBETA-GALACTOSIDASE (Bacteroidesfragilis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 3 | TRP A 604THR A 559TYR A 511 | None | 0.85A | 2a3bA-3cmgA:5.2 | 2a3bA-3cmgA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cph | RAS-RELATED PROTEINSEC4 (Saccharomycescerevisiae) |
PF00071(Ras) | 3 | TRP A 114THR A 76TYR A 89 | None | 1.08A | 2a3bA-3cphA:3.2 | 2a3bA-3cphA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctm | CARBONYL REDUCTASE (Candidaparapsilosis) |
PF13561(adh_short_C2) | 3 | TRP A 48THR A 80TYR A 81 | None | 0.98A | 2a3bA-3ctmA:3.6 | 2a3bA-3ctmA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epd | PROTEIN VP1PROTEIN VP2 (Enterovirus C) |
PF00073(Rhv) | 3 | TRP 2 226THR 1 126TYR 1 127 | None | 1.27A | 2a3bA-3epd2:undetectable | 2a3bA-3epd2:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f5x | CYCLIN-A2 (Homo sapiens) |
PF00134(Cyclin_N)PF02984(Cyclin_C) | 3 | TRP B 217THR B 285TYR B 286 | None | 0.71A | 2a3bA-3f5xB:undetectable | 2a3bA-3f5xB:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fz4 | PUTATIVE ARSENATEREDUCTASE (Streptococcusmutans) |
PF03960(ArsC) | 3 | TRP A 45THR A 3TYR A 5 | None | 1.27A | 2a3bA-3fz4A:undetectable | 2a3bA-3fz4A:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib3 | COCE/NOND FAMILYHYDROLASE (Staphylococcusaureus) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 3 | TRP A 138THR A 218TYR A 214 | None | 1.07A | 2a3bA-3ib3A:undetectable | 2a3bA-3ib3A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ics | COENZYME A-DISULFIDEREDUCTASE (Bacillusanthracis) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | TRP A 303THR A 327TYR A 324 | None | 1.16A | 2a3bA-3icsA:undetectable | 2a3bA-3icsA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 3 | TRP A1478THR A1215TYR A1114 | None | 1.26A | 2a3bA-3jb9A:undetectable | 2a3bA-3jb9A:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kv4 | PHD FINGER PROTEIN 8 (Homo sapiens) |
PF00628(PHD)PF02373(JmjC) | 3 | TRP A 282THR A 82TYR A 243 | None | 1.22A | 2a3bA-3kv4A:undetectable | 2a3bA-3kv4A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lho | PUTATIVE HYDROLASE (Shewanellafrigidimarina) |
PF07063(DUF1338) | 3 | TRP A 154THR A 20TYR A 16 | None | 1.20A | 2a3bA-3lhoA:undetectable | 2a3bA-3lhoA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lnp | AMIDOHYDROLASEFAMILY PROTEINOLEI01672_1_465 (Oleispiraantarctica) |
PF01979(Amidohydro_1) | 3 | TRP A 115THR A 220TYR A 219 | None | 0.65A | 2a3bA-3lnpA:6.6 | 2a3bA-3lnpA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3meb | ASPARTATEAMINOTRANSFERASE (Giardiaintestinalis) |
PF00155(Aminotran_1_2) | 3 | TRP A 203THR A 171TYR A 155 | EDO A 506 (-4.3A)NoneNone | 1.10A | 2a3bA-3mebA:undetectable | 2a3bA-3mebA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbh | RECQ-MEDIATED GENOMEINSTABILITY PROTEIN1RECQ-MEDIATED GENOMEINSTABILITY PROTEIN2 (Homo sapiens) |
PF16099(RMI1_C)PF16100(RMI2) | 3 | TRP B 59THR A 538TYR A 493 | None | 1.24A | 2a3bA-3nbhB:undetectable | 2a3bA-3nbhB:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ncy | ADIC (Salmonellaenterica) |
PF13520(AA_permease_2) | 3 | TRP A 202THR A 361TYR A 365 | None | 1.15A | 2a3bA-3ncyA:undetectable | 2a3bA-3ncyA:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no5 | UNCHARACTERIZEDPROTEIN (Cupriaviduspinatubonensis) |
PF05853(BKACE) | 3 | TRP A 128THR A 135TYR A 136 | None | 1.05A | 2a3bA-3no5A:4.8 | 2a3bA-3no5A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3op7 | AMINOTRANSFERASECLASS I AND II (Streptococcussuis) |
PF00155(Aminotran_1_2) | 3 | TRP A 232THR A 222TYR A 223 | NoneLLP A 221 ( 4.3A)None | 1.11A | 2a3bA-3op7A:undetectable | 2a3bA-3op7A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a39 | METALLO-CARBOXYPEPTIDASE (Pseudomonasaeruginosa) |
PF00246(Peptidase_M14) | 3 | TRP A 230THR A 326TYR A 327 | None | 1.28A | 2a3bA-4a39A:undetectable | 2a3bA-4a39A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b56 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 1 (Mus musculus) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 3 | TRP A 289THR A 247TYR A 243 | None | 1.20A | 2a3bA-4b56A:undetectable | 2a3bA-4b56A:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bbo | BLR5658 PROTEIN (Bradyrhizobiumjaponicum) |
PF01382(Avidin) | 3 | TRP A 5THR A 58TYR A 53 | GOL A1114 (-3.8A)GOL A1114 ( 4.5A)None | 1.16A | 2a3bA-4bboA:undetectable | 2a3bA-4bboA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bvw | APOLIPOPROTEIN(A) (Homo sapiens) |
PF00051(Kringle) | 3 | TRP A 32THR A 36TYR A 39 | None | 0.89A | 2a3bA-4bvwA:undetectable | 2a3bA-4bvwA:9.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzi | SEC23P (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 3 | TRP A 551THR A 587TYR A 583 | None | 1.06A | 2a3bA-4bziA:2.3 | 2a3bA-4bziA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c2t | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 3 | TRP A 88THR A 102TYR A 103 | None | 1.13A | 2a3bA-4c2tA:undetectable | 2a3bA-4c2tA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c90 | ALPHA-GLUCURONIDASEGH115 (Bacteroidesovatus) |
PF15979(Glyco_hydro_115) | 3 | TRP A 172THR A 218TYR A 219 | None | 1.02A | 2a3bA-4c90A:9.8 | 2a3bA-4c90A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvq | GLUTAMATE-PYRUVATEAMINOTRANSFERASEALAA (Escherichiacoli) |
PF00155(Aminotran_1_2) | 3 | TRP A 251THR A 241TYR A 242 | None | 0.80A | 2a3bA-4cvqA:undetectable | 2a3bA-4cvqA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4djt | GTP-BINDING NUCLEARPROTEIN GSP1 (Encephalitozooncuniculi) |
PF00071(Ras) | 3 | TRP A 102THR A 64TYR A 77 | None | 1.15A | 2a3bA-4djtA:undetectable | 2a3bA-4djtA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doe | 1,4-BETA-GLUCANASE (Caldicellulosiruptorbescii) |
PF00759(Glyco_hydro_9) | 3 | TRP A 281THR A 173TYR A 220 | CT3 A 504 ( 4.0A) CA A 502 ( 4.5A)None | 1.22A | 2a3bA-4doeA:undetectable | 2a3bA-4doeA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dyk | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 3 | TRP A 98THR A 198TYR A 197 | None | 0.63A | 2a3bA-4dykA:6.7 | 2a3bA-4dykA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzh | AMIDOHYDROLASE (Xanthomonascampestris) |
PF01979(Amidohydro_1) | 3 | TRP A 104THR A 204TYR A 203 | None | 0.46A | 2a3bA-4dzhA:5.3 | 2a3bA-4dzhA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kma | GM14141P (Drosophilamelanogaster) |
PF05076(SUFU)PF12470(SUFU_C) | 3 | TRP A 45THR A 39TYR A 54 | None | 0.99A | 2a3bA-4kmaA:undetectable | 2a3bA-4kmaA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lh7 | DNA LIGASE (Enterococcusfaecalis) |
PF01653(DNA_ligase_aden) | 3 | TRP A 310THR A 228TYR A 227 | NoneNone1X8 A 401 (-3.6A) | 1.19A | 2a3bA-4lh7A:undetectable | 2a3bA-4lh7A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lnp | SORBIN AND SH3DOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF07653(SH3_2) | 3 | TRP A 830THR A 845TYR A 846 | None | 1.27A | 2a3bA-4lnpA:undetectable | 2a3bA-4lnpA:10.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mgg | MUCONATE LACTONIZINGENZYME (Labrenziaaggregata) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TRP A 295THR A 320TYR A 136 | None | 1.21A | 2a3bA-4mggA:5.3 | 2a3bA-4mggA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0r | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesvulgatus) |
PF13204(DUF4038)PF16586(DUF5060) | 3 | TRP A 365THR A 137TYR A 139 | UNL A 601 ( 3.7A)NoneUNL A 601 ( 4.7A) | 1.19A | 2a3bA-4n0rA:5.4 | 2a3bA-4n0rA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q4y | COXSACKIEVIRUSCAPSID PROTEIN VP1COXSACKIEVIRUSCAPSID PROTEIN VP2 (Enterovirus C) |
PF00073(Rhv) | 3 | TRP 2 226THR 1 128TYR 1 129 | None | 1.23A | 2a3bA-4q4y2:undetectable | 2a3bA-4q4y2:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi4 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C) | 3 | TRP A 325THR A 421TYR A 422 | None | 0.67A | 2a3bA-4qi4A:undetectable | 2a3bA-4qi4A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi6 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C)PF16010(CDH-cyt) | 3 | TRP A 325THR A 421TYR A 422 | None | 0.74A | 2a3bA-4qi6A:undetectable | 2a3bA-4qi6A:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi7 | CELLOBIOSEDEHYDROGENASE (Neurosporacrassa) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C)PF16010(CDH-cyt) | 3 | TRP A 325THR A 421TYR A 422 | None | 0.75A | 2a3bA-4qi7A:undetectable | 2a3bA-4qi7A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rft | COAT PROTEIN (Redspottedgrouper nervousnecrosis virus) |
no annotation | 3 | TRP A 152THR A 72TYR A 77 | None | 1.18A | 2a3bA-4rftA:undetectable | 2a3bA-4rftA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk2 | PUTATIVE SUGAR ABCTRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Rhizobium etli) |
PF01547(SBP_bac_1) | 3 | TRP A 37THR A 45TYR A 47 | None | 0.90A | 2a3bA-4rk2A:undetectable | 2a3bA-4rk2A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Pisum sativum) |
PF00223(PsaA_PsaB) | 3 | TRP B 596THR B 614TYR B 615 | None | 0.98A | 2a3bA-4rkuB:undetectable | 2a3bA-4rkuB:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkt | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 3 | TRP A3200THR A3196TYR A3197 | None | 1.05A | 2a3bA-4tktA:undetectable | 2a3bA-4tktA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ur2 | TETRACHLOROETHENEREDUCTIVEDEHALOGENASECATALYTIC SUBUNITPCEA (Sulfurospirillummultivorans) |
PF13484(Fer4_16)PF13486(Dehalogenase) | 3 | TRP A 376THR A 242TYR A 246 | BVQ A 503 (-4.2A)BVQ A 503 (-3.6A)BVQ A 503 (-4.2A) | 1.13A | 2a3bA-4ur2A:undetectable | 2a3bA-4ur2A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwq | SULFUR OXIDATIONPROTEIN SOXB (Thermusthermophilus) |
PF02872(5_nucleotid_C) | 3 | TRP A 417THR A 439TYR A 440 | None | 0.82A | 2a3bA-4uwqA:2.1 | 2a3bA-4uwqA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzz | PUTATIVE SUGAR ABCTRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Lachnoclostridiumphytofermentans) |
PF13407(Peripla_BP_4) | 3 | TRP A 192THR A 245TYR A 64 | NoneRAM A 401 (-3.1A)RAM A 401 (-3.1A) | 1.21A | 2a3bA-4wzzA:undetectable | 2a3bA-4wzzA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aca | VP1VP2 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | TRP 2 177THR 1 70TYR 1 71 | None | 1.26A | 2a3bA-5aca2:undetectable | 2a3bA-5aca2:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnn | CAPSID PROTEIN VP1CAPSID PROTEIN VP2 (Enterovirus D) |
PF00073(Rhv) | 3 | TRP B 207THR A 111TYR A 112 | None | 1.20A | 2a3bA-5bnnB:undetectable | 2a3bA-5bnnB:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czw | MYROILYSIN (Myroidesprofundi) |
PF01400(Astacin) | 3 | TRP A 179THR A 191TYR A 192 | None | 1.16A | 2a3bA-5czwA:undetectable | 2a3bA-5czwA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5r | HEAT SHOCK PROTEIN75 KDA,MITOCHONDRIAL (Homo sapiens) |
PF13589(HATPase_c_3) | 3 | TRP A 231THR A 94TYR A 206 | None | 1.29A | 2a3bA-5f5rA:undetectable | 2a3bA-5f5rA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fuc | INTERLEUKIN-6RECEPTOR SUBUNITALPHA, INTERLEUKIN-6RECEPTOR (Homo sapiens) |
PF09240(IL6Ra-bind) | 3 | TRP C 264THR C 247TYR C 238 | None | 1.29A | 2a3bA-5fucC:undetectable | 2a3bA-5fucC:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k59 | UNCHARACTERIZEDLEUKOCIDIN-LIKEPROTEIN 1UNCHARACTERIZEDLEUKOCIDIN-LIKEPROTEIN 2 (Staphylococcusaureus) |
no annotation | 3 | TRP B 80THR B 183TYR D 233 | None | 1.26A | 2a3bA-5k59B:undetectable | 2a3bA-5k59B:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7v | GLYCOSIDE HYDROLASE (Bacteroidesvulgatus) |
PF13320(DUF4091) | 3 | TRP A 448THR A 428TYR A 426 | None | 0.95A | 2a3bA-5l7vA:5.2 | 2a3bA-5l7vA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lzl | DELTA-AMINOLEVULINICACID DEHYDRATASE (Pyrobaculumcalidifontis) |
PF00490(ALAD) | 3 | TRP A 145THR A 228TYR A 229 | None | 1.23A | 2a3bA-5lzlA:5.9 | 2a3bA-5lzlA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpo | MOLYBDOPTERINSYNTHASE SULFURCARRIER SUBUNIT (Homo sapiens) |
PF02597(ThiS) | 3 | TRP A 38THR A 19TYR A 11 | None | 1.29A | 2a3bA-5mpoA:undetectable | 2a3bA-5mpoA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncc | FATTY ACIDPHOTODECARBOXYLASE (Chlorellavariabilis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | TRP A 479THR A 131TYR A 466 | PLM A 702 ( 4.6A)NonePLM A 702 (-4.2A) | 1.10A | 2a3bA-5nccA:undetectable | 2a3bA-5nccA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nno | ALDEHYDEDEHYDROGENASE (Trypanosomabrucei) |
PF00171(Aldedh) | 3 | TRP A 249THR A 258TYR A 129 | None92N A 602 (-3.8A)92N A 602 (-4.0A) | 1.29A | 2a3bA-5nnoA:undetectable | 2a3bA-5nnoA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oee | LARGE SUBUNITTERMINASE (Phage D6E) |
no annotation | 3 | TRP A 275THR A 375TYR A 379 | None | 1.24A | 2a3bA-5oeeA:undetectable | 2a3bA-5oeeA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oup | PERFORIN-LIKEPROTEIN 1 (Toxoplasmagondii) |
no annotation | 3 | TRP A 754THR A 734TYR A 677 | None | 0.89A | 2a3bA-5oupA:undetectable | 2a3bA-5oupA:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Synechocystissp. PCC 6803) |
no annotation | 3 | TRP b 593THR b 611TYR b 612 | None | 1.13A | 2a3bA-5oy0b:undetectable | 2a3bA-5oy0b:10.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ub8 | LIKELY RAB FAMILYGTP-BINDING PROTEIN (Candidaalbicans) |
PF00071(Ras) | 3 | TRP A 109THR A 71TYR A 84 | None | 1.20A | 2a3bA-5ub8A:2.9 | 2a3bA-5ub8A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5utv | PAPAIN-LIKEPROTEINASE (Rousettus batcoronavirusHKU9) |
no annotation | 3 | TRP A 21THR A 37TYR A 45 | None | 1.17A | 2a3bA-5utvA:undetectable | 2a3bA-5utvA:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vem | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 5 (Homo sapiens) |
PF01663(Phosphodiest) | 3 | TRP A 124THR A 81TYR A 77 | None | 1.16A | 2a3bA-5vemA:undetectable | 2a3bA-5vemA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veo | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 5 (Mus musculus) |
PF01663(Phosphodiest) | 3 | TRP A 124THR A 81TYR A 77 | None | 1.20A | 2a3bA-5veoA:undetectable | 2a3bA-5veoA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp6 | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Homo sapiens) |
no annotation | 3 | TRP A 152THR A 107TYR A 103 | None | 1.00A | 2a3bA-5wp6A:undetectable | 2a3bA-5wp6A:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x5y | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF03739(YjgP_YjgQ) | 3 | TRP G 149THR G 172TYR G 174 | None | 1.28A | 2a3bA-5x5yG:undetectable | 2a3bA-5x5yG:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xc3 | PROBABLE RAB-RELATEDGTPASE (Acanthamoebapolyphagamimivirus) |
no annotation | 3 | TRP A 100THR A 62TYR A 75 | None | 1.14A | 2a3bA-5xc3A:3.2 | 2a3bA-5xc3A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zc3 | - (-) |
no annotation | 3 | TRP B 206THR B 231TYR B 232 | None | 0.81A | 2a3bA-5zc3B:undetectable | 2a3bA-5zc3B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bcq | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Mus musculus) |
no annotation | 3 | TRP B 153THR B 108TYR B 104 | None | 1.25A | 2a3bA-6bcqB:2.1 | 2a3bA-6bcqB:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk1 | UDP-GLYCOSYLTRANSFERASE 79 (Oryza sativa) |
no annotation | 3 | TRP A 364THR A 388TYR A 392 | None | 1.18A | 2a3bA-6bk1A:3.3 | 2a3bA-6bk1A:10.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ekt | P-47 PROTEIN (Clostridiumbotulinum) |
no annotation | 3 | TRP A 188THR A 410TYR A 31 | None | 1.29A | 2a3bA-6ektA:undetectable | 2a3bA-6ektA:22.57 |