SIMILAR PATTERNS OF AMINO ACIDS FOR 2A3A_A_TEPA1436

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		3 ASP B  40
PHE B 147
ARG B  43
 None
 0.67A 2a3aA-1d2zB:
undetectable		 2a3aA-1d2zB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN

(Escherichia
coli) 		PF03548
(LolA) 		3 ASP A   5
PHE A 113
ARG A   9
 None
 0.68A 2a3aA-1iwlA:
undetectable		 2a3aA-1iwlA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		3 ASP A 246
PHE A  10
ARG A  20
 None
 0.78A 2a3aA-1j2bA:
10.4		 2a3aA-1j2bA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP A 263
PHE A 343
ARG A 261
 2PG  A 801 ( 4.4A)
None
2PG  A 801 (-2.9A)
 0.73A 2a3aA-1o99A:
3.0		 2a3aA-1o99A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A  37
PHE A   7
ARG A 140
 None
 0.78A 2a3aA-1q1nA:
undetectable		 2a3aA-1q1nA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 ASP A  71
PHE A 452
ARG A 456
 None
 0.86A 2a3aA-1rqbA:
9.7		 2a3aA-1rqbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Escherichia
coli) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		3 ASP A  90
PHE A  55
ARG A  92
 None
 0.81A 2a3aA-1sfeA:
undetectable		 2a3aA-1sfeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txu RAB5 GDP/GTP
EXCHANGE FACTOR

(Homo sapiens) 		PF02204
(VPS9) 		3 ASP A 279
PHE A 224
ARG A 330
 ASP  A 279 ( 0.6A)
PHE  A 224 ( 1.3A)
ARG  A 330 ( 0.6A)
 0.82A 2a3aA-1txuA:
undetectable		 2a3aA-1txuA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		3 ASP A 266
PHE A  61
ARG A 147
 None
 0.88A 2a3aA-1uarA:
undetectable		 2a3aA-1uarA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 ASP A 397
PHE A 256
ARG A  21
 None
 0.70A 2a3aA-1uedA:
undetectable		 2a3aA-1uedA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl7 HYPOTHETICAL PROTEIN
ALR5027

(Nostoc sp. PCC
7120) 		PF01243
(Putative_PNPOx) 		3 ASP A  73
PHE A  14
ARG A  85
 None
 0.91A 2a3aA-1vl7A:
undetectable		 2a3aA-1vl7A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn0 HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN

(Zea mays) 		PF01627
(Hpt) 		3 ASP A  55
PHE A 124
ARG A 128
 None
 0.86A 2a3aA-1wn0A:
undetectable		 2a3aA-1wn0A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn9 THE HYPOTHETICAL
PROTEIN (TT1805)

(Thermus
thermophilus) 		PF11432
(DUF3197) 		3 ASP A  61
PHE A  67
ARG A  45
 None
 0.90A 2a3aA-1wn9A:
undetectable		 2a3aA-1wn9A:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		3 ASP A 208
PHE A 213
ARG A 263
 None
 0.24A 2a3aA-1wnoA:
69.7		 2a3aA-1wnoA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woi AGMATINASE

(Deinococcus
radiodurans) 		PF00491
(Arginase) 		3 ASP A  30
PHE A 301
ARG A 112
 None
 0.81A 2a3aA-1woiA:
undetectable		 2a3aA-1woiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ASP A 545
PHE A 361
ARG A 543
 None
 0.89A 2a3aA-1xpgA:
7.1		 2a3aA-1xpgA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 ASP A 539
PHE A 736
ARG A 740
 None
 0.57A 2a3aA-2c4mA:
3.8		 2a3aA-2c4mA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		3 ASP A 218
PHE A 178
ARG A 221
 None
 0.90A 2a3aA-2dpmA:
undetectable		 2a3aA-2dpmA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ASP A  36
PHE A 102
ARG A  38
 None
FAD  A1200 ( 3.9A)
None
 0.84A 2a3aA-2e0iA:
undetectable		 2a3aA-2e0iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 821
PHE A 700
ARG A 698
 None
 0.88A 2a3aA-2faqA:
undetectable		 2a3aA-2faqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn5 NEURABIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 ASP A  58
PHE A   6
ARG A  93
 None
 0.91A 2a3aA-2fn5A:
undetectable		 2a3aA-2fn5A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 ASP A 237
PHE A 204
ARG A 241
 None
 0.90A 2a3aA-2gwcA:
undetectable		 2a3aA-2gwcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		3 ASP C 159
PHE C 252
ARG C  88
 None
 0.70A 2a3aA-2inpC:
undetectable		 2a3aA-2inpC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 359
PHE A 347
ARG A 351
 None
 0.66A 2a3aA-2nqlA:
4.0		 2a3aA-2nqlA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 ASP A  65
PHE A 450
ARG A 454
 None
 0.84A 2a3aA-2nx9A:
10.4		 2a3aA-2nx9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		3 ASP A 353
PHE A 118
ARG A 133
 None
 0.85A 2a3aA-2o0rA:
undetectable		 2a3aA-2o0rA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohf GTP-BINDING PROTEIN
9

(Homo sapiens) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		3 ASP A  68
PHE A 309
ARG A  70
 None
 0.75A 2a3aA-2ohfA:
2.7		 2a3aA-2ohfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		3 ASP X 233
PHE X 303
ARG X 236
 None
 0.86A 2a3aA-2p4hX:
2.1		 2a3aA-2p4hX:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ASP A 982
PHE A 960
ARG A 987
 MR9  A 301 (-4.2A)
MR9  A 301 ( 4.7A)
None
 0.83A 2a3aA-2p4iA:
undetectable		 2a3aA-2p4iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT

(Sulfolobus
shibatae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 ASP D  42
PHE D 156
ARG D 146
 None
 0.89A 2a3aA-2wb1D:
undetectable		 2a3aA-2wb1D:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 ASP A 391
PHE A 396
ARG A 446
 NGT  A1565 (-2.9A)
SN5  A1567 ( 4.1A)
SN5  A1566 ( 3.5A)
 0.47A 2a3aA-2wk2A:
13.3		 2a3aA-2wk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 ASP A 252
PHE A 360
ARG A 254
 None
 0.81A 2a3aA-2x3kA:
undetectable		 2a3aA-2x3kA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 ASP A  27
PHE B 485
ARG B 525
 None
 0.77A 2a3aA-2y3aA:
undetectable		 2a3aA-2y3aA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		3 ASP A 438
PHE A 436
ARG A 420
 None
 0.81A 2a3aA-2yeqA:
2.3		 2a3aA-2yeqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		3 ASP A  37
PHE A  68
ARG A  91
 None
 0.71A 2a3aA-2ywrA:
undetectable		 2a3aA-2ywrA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN

(Solanum
tuberosum) 		PF00225
(Kinesin) 		3 ASP A 950
PHE A 938
ARG A 936
 None
 0.83A 2a3aA-3cobA:
undetectable		 2a3aA-3cobA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		3 ASP A 183
PHE A 209
ARG A 187
 GOL  A 401 (-3.7A)
GOL  A 401 ( 3.8A)
GOL  A 401 (-2.6A)
 0.78A 2a3aA-3cs3A:
undetectable		 2a3aA-3cs3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewe NUCLEOPORIN NUP85

(Saccharomyces
cerevisiae) 		PF07575
(Nucleopor_Nup85) 		3 ASP B  99
PHE B 158
ARG B 171
 None
 0.78A 2a3aA-3eweB:
undetectable		 2a3aA-3eweB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		3 ASP A1259
PHE A1324
ARG A1328
 None
 0.67A 2a3aA-3f5fA:
undetectable		 2a3aA-3f5fA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grf ORNITHINE
CARBAMOYLTRANSFERASE

(Giardia
intestinalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ASP A 235
PHE A 148
ARG A 275
 None
 0.67A 2a3aA-3grfA:
undetectable		 2a3aA-3grfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxx TRANSCRIPTION
ELONGATION FACTOR
SPT6

([Candida]
glabrata) 		PF14633
(SH2_2) 		3 ASP A  54
PHE A  56
ARG A  26
 None
 0.89A 2a3aA-3gxxA:
undetectable		 2a3aA-3gxxA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		3 ASP A 212
PHE A 245
ARG A 284
 None
 0.90A 2a3aA-3i1aA:
undetectable		 2a3aA-3i1aA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj8 TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc) 		3 ASP A 259
PHE A 333
ARG A 296
 None
 0.82A 2a3aA-3lj8A:
undetectable		 2a3aA-3lj8A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 ASP A  42
PHE A 125
ARG A  46
 None
 0.78A 2a3aA-3ml0A:
undetectable		 2a3aA-3ml0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp2 NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF08715
(Viral_protease) 		3 ASP A  29
PHE A  14
ARG A  75
 None
 0.80A 2a3aA-3mp2A:
undetectable		 2a3aA-3mp2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwb PREPHENATE
DEHYDRATASE

(Paenarthrobacter
aurescens) 		PF00800
(PDT)
PF01842
(ACT) 		3 ASP A  69
PHE A 243
ARG A 233
 None
 0.89A 2a3aA-3mwbA:
undetectable		 2a3aA-3mwbA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9u CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 7

(Homo sapiens) 		PF00076
(RRM_1) 		3 ASP C 156
PHE C 168
ARG C 158
 None
 0.91A 2a3aA-3n9uC:
undetectable		 2a3aA-3n9uC:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nn2 CHLORITE DISMUTASE

(Nitrospira
defluvii) 		PF06778
(Chlor_dismutase) 		3 ASP A  66
PHE A 236
ARG A  59
 None
 0.78A 2a3aA-3nn2A:
undetectable		 2a3aA-3nn2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		3 ASP A 233
PHE A 240
ARG A 238
 None
 0.89A 2a3aA-3nomA:
undetectable		 2a3aA-3nomA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72

(Homo sapiens) 		PF04722
(Ssu72) 		3 ASP B 103
PHE B  36
ARG B  34
 None
 0.84A 2a3aA-3o2sB:
undetectable		 2a3aA-3o2sB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 336
PHE A 369
ARG A 340
 None
 0.71A 2a3aA-3ozyA:
6.8		 2a3aA-3ozyA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6

([Candida]
glabrata) 		PF14633
(SH2_2) 		3 ASP A1299
PHE A1301
ARG A1271
 None
 0.90A 2a3aA-3pjpA:
undetectable		 2a3aA-3pjpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk FUSION OF UREASE
BETA AND GAMMA
SUBUNITS
UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 ASP C  24
PHE A 105
ARG C 564
 None
 0.81A 2a3aA-3qgkC:
2.8		 2a3aA-3qgkC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0h INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 ASP A 627
PHE A 583
ARG A 662
 None
 0.90A 2a3aA-3r0hA:
undetectable		 2a3aA-3r0hA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0r PORCINE CIRCOVIRUS 2
(PCV2) CAPSID
PROTEIN

(Porcine
circovirus 2) 		PF02443
(Circo_capsid) 		3 ASP A 122
PHE A 124
ARG A  68
 None
 0.91A 2a3aA-3r0rA:
undetectable		 2a3aA-3r0rA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		3 ASP A  48
PHE A 289
ARG A  51
 ASP  A  48 ( 0.6A)
PHE  A 289 ( 1.3A)
ARG  A  51 ( 0.6A)
 0.85A 2a3aA-3r9rA:
undetectable		 2a3aA-3r9rA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		3 ASP A  98
PHE A 124
ARG A 128
 None
 0.68A 2a3aA-3rc3A:
undetectable		 2a3aA-3rc3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqf E3 UBIQUITIN-PROTEIN
LIGASE LNX

(Mus musculus) 		PF00595
(PDZ) 		3 ASP A  51
PHE A   4
ARG A  86
 None
 0.82A 2a3aA-3vqfA:
undetectable		 2a3aA-3vqfA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvw CALCIUM-BINDING AND
COILED-COIL
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07888
(CALCOCO1) 		3 ASP A 111
PHE A  48
ARG A 117
 None
 0.60A 2a3aA-3vvwA:
undetectable		 2a3aA-3vvwA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		3 ASP A 114
PHE A  82
ARG A 170
 None
 0.74A 2a3aA-3wp5A:
undetectable		 2a3aA-3wp5A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 ASP A 128
PHE A  71
ARG A 121
 None
 0.83A 2a3aA-3zdpA:
undetectable		 2a3aA-3zdpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A 430
PHE A 438
ARG A 420
 None
 0.89A 2a3aA-4d8mA:
undetectable		 2a3aA-4d8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		3 ASP A  81
PHE A 161
ARG A  80
 None
None
ATP  A 502 ( 4.7A)
 0.88A 2a3aA-4gniA:
undetectable		 2a3aA-4gniA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 ASP A 349
PHE A 371
ARG A 362
 None
 0.84A 2a3aA-4gqoA:
undetectable		 2a3aA-4gqoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id0 GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF

(Pseudomonas
fluorescens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 ASP A  47
PHE A   4
ARG A  57
 None
 0.79A 2a3aA-4id0A:
undetectable		 2a3aA-4id0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 ASP A 139
PHE A  61
ARG A  56
 None
 0.86A 2a3aA-4j3qA:
undetectable		 2a3aA-4j3qA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvh PROTEIN QUAKING

(Homo sapiens) 		PF00013
(KH_1)
PF16544
(STAR_dimer) 		3 ASP A 187
PHE A  96
ARG A 101
 None
 0.85A 2a3aA-4jvhA:
undetectable		 2a3aA-4jvhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki3 OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Yersinia pestis) 		PF03548
(LolA) 		3 ASP A  26
PHE A 134
ARG A  30
 None
 0.79A 2a3aA-4ki3A:
undetectable		 2a3aA-4ki3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhu ECTOINE HYDROXYLASE

(Sphingopyxis
alaskensis) 		PF05721
(PhyH) 		3 ASP A 108
PHE A  53
ARG A 110
 None
 0.87A 2a3aA-4mhuA:
undetectable		 2a3aA-4mhuA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmi ECTD

(Virgibacillus
salexigens) 		PF05721
(PhyH) 		3 ASP A 110
PHE A  54
ARG A 112
 None
 0.84A 2a3aA-4nmiA:
undetectable		 2a3aA-4nmiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		3 ASP A 282
PHE A 190
ARG A 280
 None
 0.86A 2a3aA-4oalA:
undetectable		 2a3aA-4oalA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oib INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		3 ASP A 345
PHE A 350
ARG A 348
 None
 0.88A 2a3aA-4oibA:
undetectable		 2a3aA-4oibA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		3 ASP A 176
PHE A 291
ARG A 161
 None
 0.76A 2a3aA-4opuA:
undetectable		 2a3aA-4opuA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		3 ASP A  85
PHE A 242
ARG A  44
 None
 0.76A 2a3aA-4rgpA:
undetectable		 2a3aA-4rgpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		3 ASP A 220
PHE A 191
ARG A 223
 None
 0.89A 2a3aA-4rgyA:
undetectable		 2a3aA-4rgyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		3 ASP A 595
PHE A 556
ARG A 598
 None
 0.83A 2a3aA-4wrnA:
undetectable		 2a3aA-4wrnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 ASP A 121
PHE A 133
ARG A 125
 None
None
GOL  A 502 ( 2.9A)
 0.61A 2a3aA-4x4wA:
undetectable		 2a3aA-4x4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 ASP A 777
PHE A 763
ARG A 762
 None
 0.80A 2a3aA-4xjxA:
undetectable		 2a3aA-4xjxA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		3 ASP A1259
PHE A1196
ARG A1263
 None
 0.82A 2a3aA-4ziuA:
undetectable		 2a3aA-4ziuA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		3 ASP A  68
PHE A  24
ARG A  70
 None
 0.90A 2a3aA-4zpiA:
undetectable		 2a3aA-4zpiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zut CLASSICAL MHC CLASS
I ANTIGEN

(Equus caballus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASP A 116
PHE A  74
ARG A  97
 None
 0.73A 2a3aA-4zutA:
undetectable		 2a3aA-4zutA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 ASP A1259
PHE A1196
ARG A1263
 None
 0.83A 2a3aA-5a42A:
undetectable		 2a3aA-5a42A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a49 MATERNAL EFFECT
PROTEIN OSKAR

(Drosophila
melanogaster) 		PF12872
(OST-HTH) 		3 ASP A 157
PHE A 198
ARG A 150
 None
 0.80A 2a3aA-5a49A:
undetectable		 2a3aA-5a49A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum) 		PF00252
(Ribosomal_L16) 		3 ASP F  83
PHE F  46
ARG F  38
 None
 0.64A 2a3aA-5anbF:
undetectable		 2a3aA-5anbF:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g HEAT-LABILE
ENTEROTOXIN B CHAIN

(Clostridium
perfringens) 		PF03505
(Clenterotox) 		3 ASP B 288
PHE B 319
ARG B 252
 None
 0.85A 2a3aA-5b2gB:
undetectable		 2a3aA-5b2gB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF03466
(LysR_substrate) 		3 ASP A 149
PHE A 290
ARG A 286
 None
 0.80A 2a3aA-5b7dA:
undetectable		 2a3aA-5b7dA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd8 MATERNAL EFFECT
PROTEIN OSKAR

(Drosophila
melanogaster) 		PF12872
(OST-HTH) 		3 ASP A 157
PHE A 198
ARG A 150
 None
 0.89A 2a3aA-5cd8A:
undetectable		 2a3aA-5cd8A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		3 ASP A 486
PHE A 534
ARG A  53
 None
ADP  A 902 (-3.8A)
None
 0.89A 2a3aA-5e7pA:
undetectable		 2a3aA-5e7pA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		3 ASP A  70
PHE A 308
ARG A  72
 None
 0.81A 2a3aA-5ee0A:
2.3		 2a3aA-5ee0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PREPROTEIN
TRANSLOCASE SECE
SUBUNIT
PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans) 		PF00344
(SecY)
PF00584
(SecE) 		3 ASP E  48
PHE Y  33
ARG Y  29
 None
 0.84A 2a3aA-5eulE:
undetectable		 2a3aA-5eulE:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 ASP A 109
PHE A  89
ARG A  93
 None
 0.74A 2a3aA-5g5zA:
undetectable		 2a3aA-5g5zA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		3 ASP A 392
PHE A  59
ARG A 403
 None
 0.91A 2a3aA-5hh9A:
3.1		 2a3aA-5hh9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 ASP A 452
PHE A 498
ARG A 455
 None
 0.86A 2a3aA-5ik2A:
undetectable		 2a3aA-5ik2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 ASP A 857
PHE A 692
ARG A 839
 None
 0.87A 2a3aA-5o1pA:
undetectable		 2a3aA-5o1pA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 3 ASP A 139
PHE A  61
ARG A  56
 None
 0.89A 2a3aA-5or4A:
undetectable		 2a3aA-5or4A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ASP A 547
PHE A 752
ARG A 585
 None
 0.90A 2a3aA-5vniA:
undetectable		 2a3aA-5vniA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus) 		no annotation 3 ASP D  39
PHE D  33
ARG D  89
 CA  D 304 (-3.3A)
None
CA  D 304 (-4.3A)
 0.90A 2a3aA-5x2bD:
undetectable		 2a3aA-5x2bD:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN

(Felis catus) 		no annotation 3 ASP A 117
PHE A  75
ARG A  98
 None
 0.89A 2a3aA-5xmmA:
undetectable		 2a3aA-5xmmA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 3 ASP A 393
PHE A 398
ARG A 448
 GOL  A 703 (-3.0A)
None
GOL  A 703 (-4.0A)
 0.39A 2a3aA-5zl9A:
6.1		 2a3aA-5zl9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 3 ASP A 969
PHE A 490
ARG A 997
 None
 0.80A 2a3aA-6f9nA:
undetectable		 2a3aA-6f9nA:
12.68