SIMILAR PATTERNS OF AMINO ACIDS FOR 2A1O_B_CAMB2422

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 5 VAL P 227
GLY P 157
VAL P 239
ASP P 235
ILE P 236
 None
 1.09A 2a1oB-1cf2P:
undetectable		 2a1oB-1cf2P:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		5 THR A 381
LEU A 385
GLY A 440
VAL C 238
ILE A 435
 None
 1.08A 2a1oB-1e6vA:
undetectable		 2a1oB-1e6vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		5 THR A 105
LEU A 124
GLY A  88
VAL A  57
ILE A  22
 None
 1.14A 2a1oB-1ejbA:
undetectable		 2a1oB-1ejbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		5 THR A 751
VAL A 791
GLY A 790
VAL A 821
ASP A 783
 None
 1.21A 2a1oB-1hu3A:
0.0		 2a1oB-1hu3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00497
(SBP_bac_3) 		5 PHE A 192
TYR A  91
GLY A  29
VAL A  10
ILE A  70
 None
 1.14A 2a1oB-1iiwA:
undetectable		 2a1oB-1iiwA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		5 TYR A1181
LEU A1103
VAL A1063
GLY A 997
ILE A1151
 None
 1.17A 2a1oB-1k7yA:
0.0		 2a1oB-1k7yA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 437
VAL A 438
GLY A 436
ASP A 428
ILE A 426
 None
 1.34A 2a1oB-1m2wA:
0.0		 2a1oB-1m2wA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		5 TYR A1181
LEU A1103
VAL A1063
GLY A 997
ILE A1151
 None
 1.12A 2a1oB-1mskA:
0.0		 2a1oB-1mskA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		5 PHE A  34
VAL A 439
GLY A 442
VAL A 414
ILE A 401
 None
 1.18A 2a1oB-1rdrA:
undetectable		 2a1oB-1rdrA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rv9 CONSERVED
HYPOTHETICAL PROTEIN
NMB0706

(Neisseria
meningitidis) 		PF02578
(Cu-oxidase_4) 		5 PHE A 123
LEU A 141
VAL A 145
GLY A 144
ILE A 150
 None
 1.30A 2a1oB-1rv9A:
undetectable		 2a1oB-1rv9A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 TYR A 459
THR A 567
VAL A 612
GLY A 611
VAL A 625
 None
 1.30A 2a1oB-1s5jA:
undetectable		 2a1oB-1s5jA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		5 THR A 777
VAL A 716
GLY A 722
VAL A 759
ILE A 757
 None
 1.32A 2a1oB-1suuA:
undetectable		 2a1oB-1suuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans) 		PF13277
(YmdB) 		5 PHE A 144
THR A 172
VAL A 235
GLY A 234
ILE A  33
 None
 1.15A 2a1oB-1t70A:
undetectable		 2a1oB-1t70A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans) 		PF13277
(YmdB) 		5 PHE A 144
VAL A 235
GLY A 234
ASP A 146
ILE A  33
 None
 1.17A 2a1oB-1t70A:
undetectable		 2a1oB-1t70A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		5 LEU A  57
VAL A  53
GLY A  80
VAL A 171
ILE A 116
 None
 1.29A 2a1oB-1txoA:
undetectable		 2a1oB-1txoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		5 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.18A 2a1oB-1u05A:
undetectable		 2a1oB-1u05A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 PHE A  31
TYR A  32
GLY A 316
VAL A 270
ILE A 266
 NH3  A 401 ( 4.3A)
None
None
None
NH3  A 401 (-3.9A)
 1.04A 2a1oB-1u7gA:
undetectable		 2a1oB-1u7gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 PHE A 236
THR A 263
LEU A 303
VAL A 307
VAL A 244
 None
 1.33A 2a1oB-1vbmA:
undetectable		 2a1oB-1vbmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A  58
LEU A 204
VAL A 206
GLY A 205
ASP A 199
 None
 1.13A 2a1oB-1xdiA:
undetectable		 2a1oB-1xdiA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yn9 POLYNUCLEOTIDE
5'-PHOSPHATASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00782
(DSPc) 		5 TYR A 133
VAL A 117
GLY A 116
VAL A  15
ILE A  16
 None
 1.11A 2a1oB-1yn9A:
undetectable		 2a1oB-1yn9A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		5 LEU A 302
VAL A 343
GLY A 342
VAL A 406
ILE A 408
 None
 1.36A 2a1oB-2a8iA:
undetectable		 2a1oB-2a8iA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 PHE A  11
LEU A  77
VAL A  34
VAL A  38
ILE A  43
 None
 1.17A 2a1oB-2awaA:
undetectable		 2a1oB-2awaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 PHE A 437
VAL A 177
GLY A 176
VAL A 428
ILE A 430
 None
FAD  A 525 (-4.1A)
FAD  A 525 (-3.5A)
None
None
 1.26A 2a1oB-2exrA:
undetectable		 2a1oB-2exrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		5 PHE X 130
THR X 151
VAL X 204
GLY X 202
ILE X 227
 None
 1.01A 2a1oB-2h3gX:
undetectable		 2a1oB-2h3gX:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 THR A 133
LEU A 239
VAL A 236
GLY A 237
ILE A 189
 None
 1.35A 2a1oB-2hrzA:
undetectable		 2a1oB-2hrzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 PHE A 307
LEU A 241
GLY A 240
VAL A 258
ILE A 262
 None
 1.27A 2a1oB-2inpA:
undetectable		 2a1oB-2inpA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 PHE D 292
LEU D 301
GLY D 264
VAL D 270
ILE D 277
 None
 1.32A 2a1oB-2j7pD:
undetectable		 2a1oB-2j7pD:
24.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
LEU A 244
GLY A 248
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
None
 0.92A 2a1oB-2m56A:
69.4		 2a1oB-2m56A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		9 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
GLY A 248
VAL A 295
ASP A 297
ILE A 395
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.36A 2a1oB-2m56A:
69.4		 2a1oB-2m56A:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olt HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF01865
(PhoU_div) 		5 THR A 172
VAL A 205
GLY A 207
VAL A 132
ILE A 129
 None
 1.33A 2a1oB-2oltA:
undetectable		 2a1oB-2oltA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 THR A 202
LEU A 269
VAL A 134
GLY A 272
ILE A 152
 None
 1.15A 2a1oB-2pfzA:
undetectable		 2a1oB-2pfzA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 TYR A 344
THR A 230
VAL A 338
GLY A 234
ILE A 416
 GOL  A 804 (-4.7A)
None
None
None
None
 1.26A 2a1oB-2qk4A:
undetectable		 2a1oB-2qk4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ts1 TYROSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		5 PHE A 231
THR A 258
LEU A 298
VAL A 302
ILE A  46
 None
 1.32A 2a1oB-2ts1A:
undetectable		 2a1oB-2ts1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 TYR A 182
THR A 186
VAL A 144
GLY A 143
ILE A 138
 None
 1.26A 2a1oB-2xkrA:
45.1		 2a1oB-2xkrA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PHE A  26
LEU A 126
VAL A 125
GLY A 124
ILE A 157
 None
 1.19A 2a1oB-2z0fA:
undetectable		 2a1oB-2z0fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		5 PHE A  62
TYR A  63
VAL A 209
GLY A 211
ILE A  59
 None
 1.18A 2a1oB-3axiA:
undetectable		 2a1oB-3axiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		5 THR A 130
LEU A 195
VAL A 192
VAL A 168
ILE A 220
 None
 1.16A 2a1oB-3bexA:
undetectable		 2a1oB-3bexA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		5 PHE A 268
LEU A  52
VAL A  72
GLY A  71
ILE A  25
 None
 1.32A 2a1oB-3cpgA:
undetectable		 2a1oB-3cpgA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbx CD1-2 ANTIGEN

(Gallus gallus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		5 PHE A 214
LEU A 242
GLY A 239
VAL A 221
ILE A 219
 None
 1.32A 2a1oB-3dbxA:
undetectable		 2a1oB-3dbxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF00480
(ROK) 		5 THR A 542
LEU A 540
VAL A 653
GLY A 652
ILE A 678
 None
 1.14A 2a1oB-3eo3A:
undetectable		 2a1oB-3eo3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A  24
THR A 376
VAL A 409
GLY A 410
ILE A 231
 None
None
GOL  A1002 (-3.6A)
None
None
 1.19A 2a1oB-3etcA:
undetectable		 2a1oB-3etcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Sulfurisphaera
tokodaii) 		PF00994
(MoCF_biosynth) 		5 PHE A  73
THR A 102
GLY A  90
VAL A  62
ILE A  21
 None
 1.02A 2a1oB-3iwtA:
undetectable		 2a1oB-3iwtA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2i ACYL-COENZYME A
THIOESTERASE 4

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		5 PHE A 208
TYR A 207
LEU A 196
GLY A 169
ILE A 163
 None
 1.27A 2a1oB-3k2iA:
undetectable		 2a1oB-3k2iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00696
(AA_kinase) 		5 LEU A 162
VAL A  10
GLY A   7
VAL A  84
ILE A  25
 None
None
ADP  A 246 (-3.2A)
None
None
 1.38A 2a1oB-3ll5A:
undetectable		 2a1oB-3ll5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.37A 2a1oB-3lpdA:
undetectable		 2a1oB-3lpdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 THR A 456
LEU A 460
VAL A 413
GLY A 416
ILE A 251
 None
 1.27A 2a1oB-3mpnA:
undetectable		 2a1oB-3mpnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		5 PHE A  34
LEU A 117
GLY A 262
VAL A 129
ILE A 121
 None
 1.29A 2a1oB-3p8tA:
undetectable		 2a1oB-3p8tA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 LEU A 141
VAL A 189
GLY A 190
VAL A 202
ILE A 231
 None
 1.35A 2a1oB-3qanA:
undetectable		 2a1oB-3qanA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 TYR A 324
THR A 436
LEU A 437
VAL A 312
ILE A 344
 None
GLU  A 501 (-3.8A)
GLU  A 501 ( 4.1A)
None
None
 1.27A 2a1oB-3s6hA:
undetectable		 2a1oB-3s6hA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		5 THR A  34
VAL A  24
GLY A  26
VAL A 150
ASP A 146
 None
None
None
None
CXS  A 171 (-4.7A)
 1.36A 2a1oB-3tfzA:
undetectable		 2a1oB-3tfzA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to4 NKT VBETA2 (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR D 115
LEU D  12
GLY D 219
VAL D 158
ASP D 156
 None
 1.24A 2a1oB-3to4D:
undetectable		 2a1oB-3to4D:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 THR A  55
LEU A  35
VAL A  30
GLY A  31
ILE A   9
 None
 1.20A 2a1oB-3w3aA:
undetectable		 2a1oB-3w3aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans) 		PF10140
(YukC) 		5 LEU A 103
VAL A 127
GLY A 126
VAL A  62
ILE A  53
 None
 0.88A 2a1oB-4anoA:
undetectable		 2a1oB-4anoA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		5 PHE A 146
THR A 174
VAL A 237
GLY A 236
ILE A  35
 None
 1.13A 2a1oB-4b2oA:
undetectable		 2a1oB-4b2oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		5 PHE A 146
VAL A 237
GLY A 236
ASP A 148
ILE A  35
 None
 1.15A 2a1oB-4b2oA:
undetectable		 2a1oB-4b2oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		5 TYR A 112
VAL A 218
GLY A 217
ASP A 121
ILE A 268
 None
 1.34A 2a1oB-4b4oA:
undetectable		 2a1oB-4b4oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 NOP5/NOP56 RELATED
PROTEIN

(Pyrococcus
furiosus) 		PF01798
(Nop) 		5 LEU C 253
VAL C 257
GLY C 258
VAL C 307
ILE C 308
 None
 1.13A 2a1oB-4by9C:
undetectable		 2a1oB-4by9C:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		7 TYR A  98
THR A 103
LEU A 252
GLY A 256
VAL A 303
ASP A 305
ILE A 403
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
None
 0.64A 2a1oB-4c9mA:
58.9		 2a1oB-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		5 THR A  78
LEU A  70
GLY A 137
VAL A 140
ILE A 122
 None
ATP  A 400 (-3.8A)
None
None
None
 1.20A 2a1oB-4ctaA:
undetectable		 2a1oB-4ctaA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF05207
(zf-CSL) 		5 THR A  52
VAL A  49
GLY A  59
VAL A  85
ILE A 101
 None
 1.34A 2a1oB-4d4pA:
undetectable		 2a1oB-4d4pA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 PHE A  87
THR A 101
GLY A 254
VAL A 301
ILE A 401
 None
HEM  A 501 ( 4.8A)
PEG  A 502 (-3.8A)
PEG  A 502 ( 4.5A)
None
 0.84A 2a1oB-4dxyA:
52.2		 2a1oB-4dxyA:
45.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 PHE A  87
THR A 101
LEU A 250
GLY A 254
VAL A 301
 None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
PEG  A 502 ( 4.5A)
 0.89A 2a1oB-4dxyA:
52.2		 2a1oB-4dxyA:
45.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 164
VAL A 171
GLY A 172
VAL A 240
ILE A  31
 None
 1.18A 2a1oB-4h1sA:
undetectable		 2a1oB-4h1sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A 998
VAL A 954
GLY A 937
VAL A1023
ILE A1024
 None
 1.18A 2a1oB-4h6yA:
undetectable		 2a1oB-4h6yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		5 PHE A 354
TYR A 283
GLY A 289
VAL A 344
ILE A 358
 None
 1.34A 2a1oB-4haqA:
undetectable		 2a1oB-4haqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		5 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.19A 2a1oB-4kvsA:
undetectable		 2a1oB-4kvsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		5 TYR A  30
VAL A  89
GLY A  84
VAL A  41
ILE A  37
 None
None
None
6NA  A 301 ( 4.2A)
None
 1.21A 2a1oB-4kvsA:
undetectable		 2a1oB-4kvsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2

(Saccharomyces
cerevisiae) 		PF02854
(MIF4G) 		5 PHE U  40
LEU U  57
GLY U  99
VAL U  76
ILE U  72
 None
 1.32A 2a1oB-4lunU:
undetectable		 2a1oB-4lunU:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovx XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		5 TYR A 267
THR A 301
LEU A 305
VAL A 283
GLY A 284
 None
 1.36A 2a1oB-4ovxA:
undetectable		 2a1oB-4ovxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		5 PHE A 131
VAL A 180
GLY A 177
VAL A 151
ILE A 149
 None
 1.30A 2a1oB-4p6vA:
undetectable		 2a1oB-4p6vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 TYR A 271
VAL A 172
GLY A 171
VAL A 161
ILE A 289
 None
 1.33A 2a1oB-4pl0A:
undetectable		 2a1oB-4pl0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 PHE A 113
THR A 192
LEU A 212
GLY A 213
ILE A 136
 None
 1.26A 2a1oB-4q05A:
undetectable		 2a1oB-4q05A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 PHE A 476
TYR A 484
LEU A 512
GLY A 464
ILE A 470
 None
 1.36A 2a1oB-4q9zA:
undetectable		 2a1oB-4q9zA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2

(Saccharomyces
cerevisiae) 		PF06470
(SMC_hinge) 		5 PHE A 626
LEU A 552
VAL A 527
GLY A 528
ILE A 612
 None
 1.24A 2a1oB-4rsiA:
undetectable		 2a1oB-4rsiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		5 PHE A 131
VAL A 180
GLY A 177
VAL A 151
ILE A 149
 None
 1.29A 2a1oB-4u9oA:
undetectable		 2a1oB-4u9oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 THR A 483
LEU A 509
VAL A 507
GLY A 508
ILE A 500
 None
 1.36A 2a1oB-4ypjA:
undetectable		 2a1oB-4ypjA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		5 TYR A 120
LEU A 150
VAL A 148
GLY A 157
VAL A 210
 None
 1.28A 2a1oB-4yw5A:
undetectable		 2a1oB-4yw5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5s ALDEHYDE
DECARBONYLASE

(Synechocystis
sp. PCC 6803) 		PF11266
(Ald_deCOase) 		6 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
ILE A  24
 None
 1.29A 2a1oB-4z5sA:
undetectable		 2a1oB-4z5sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 PHE A 396
LEU A 160
VAL A 159
GLY A 162
ASP A 398
 None
 1.36A 2a1oB-5du3A:
undetectable		 2a1oB-5du3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans) 		PF00344
(SecY) 		5 PHE Y 374
VAL Y 406
GLY Y 407
VAL Y 266
ILE Y 234
 None
 0.93A 2a1oB-5eulY:
undetectable		 2a1oB-5eulY:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 PHE C 204
LEU C 139
VAL C  17
GLY C  18
ILE C 234
 None
 1.33A 2a1oB-5flzC:
undetectable		 2a1oB-5flzC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy2 FLAGELLIN

(Bacillus
subtilis) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		5 LEU C 175
VAL C 172
GLY C 171
ASP C 193
ILE C 196
 None
 1.33A 2a1oB-5gy2C:
undetectable		 2a1oB-5gy2C:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA 1

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 PHE B  12
TYR B  15
GLY B 114
VAL B 108
ILE B  80
 None
 1.18A 2a1oB-5hbtB:
undetectable		 2a1oB-5hbtB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
None
None
None
OCD  A 500 ( 4.6A)
 1.21A 2a1oB-5k52A:
undetectable		 2a1oB-5k52A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 TYR A  17
VAL A  76
GLY A  71
VAL A  28
ILE A  24
 None
None
None
OCD  A 500 ( 4.6A)
OCD  A 500 (-4.6A)
 1.23A 2a1oB-5k52A:
undetectable		 2a1oB-5k52A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		6 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
ILE A  24
 None
None
None
None
STE  A 502 ( 4.8A)
STE  A 502 (-4.4A)
 1.18A 2a1oB-5k53A:
undetectable		 2a1oB-5k53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7f TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Myxococcus
xanthus) 		PF00440
(TetR_N) 		5 PHE A  72
TYR A 134
VAL A 167
GLY A 165
ILE A 110
 None
 1.38A 2a1oB-5k7fA:
undetectable		 2a1oB-5k7fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 5 TYR A 325
LEU A 306
VAL A 288
GLY A 287
ILE A 282
 None
 1.16A 2a1oB-5mlgA:
undetectable		 2a1oB-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mll DNA PROCESSING CHAIN
A (DPRA)

(Helicobacter
pylori) 		no annotation 5 THR A 192
VAL A  84
GLY A  50
VAL A 154
ILE A 155
 None
 1.30A 2a1oB-5mllA:
undetectable		 2a1oB-5mllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 LEU A 271
GLY A 264
VAL A 126
ASP A 128
ILE A 241
 None
 1.33A 2a1oB-5ugfA:
undetectable		 2a1oB-5ugfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Naegleria
gruberi) 		no annotation 5 PHE A   9
LEU A  58
VAL A  67
VAL A  74
ILE A  31
 None
 1.25A 2a1oB-5ur0A:
undetectable		 2a1oB-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxi ALDEHYDE
DECARBONYLASE

(Nostoc
punctiforme) 		no annotation 5 TYR A  18
LEU A  75
VAL A  77
GLY A  72
ILE A  25
 None
None
None
None
DDQ  A 302 (-4.3A)
 1.12A 2a1oB-5uxiA:
undetectable		 2a1oB-5uxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii) 		no annotation 5 LEU A 307
VAL A 308
GLY A 309
VAL A 210
ILE A 233
 None
 1.12A 2a1oB-5wa2A:
undetectable		 2a1oB-5wa2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woy PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Caldanaerobacter
subterraneus) 		no annotation 5 LEU A 130
VAL A 133
GLY A 134
VAL A  89
ILE A  86
 None
 1.19A 2a1oB-5woyA:
undetectable		 2a1oB-5woyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 THR A 269
VAL A 275
GLY A 274
VAL A 288
ILE A 257
 None
 1.24A 2a1oB-5xdrA:
undetectable		 2a1oB-5xdrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 5 PHE A  51
VAL A  41
GLY A  42
VAL A 316
ILE A 318
 None
 1.26A 2a1oB-5ybwA:
undetectable		 2a1oB-5ybwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 THR A 196
VAL A 213
GLY A 169
VAL A 209
ILE A 219
 None
 1.33A 2a1oB-6apeA:
undetectable		 2a1oB-6apeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 5 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.15A 2a1oB-6d35A:
undetectable		 2a1oB-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 PHE A  34
TYR A  30
THR A 213
LEU A 274
VAL A 325
 None
 1.32A 2a1oB-6eu6A:
undetectable		 2a1oB-6eu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A 648
TYR A 658
GLY A 715
VAL A 670
ILE A 646
 None
 1.24A 2a1oB-6f91A:
undetectable		 2a1oB-6f91A:
undetectable