SIMILAR PATTERNS OF AMINO ACIDS FOR 2A1O_A_CAMA1422

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 PHE A 531
VAL A 504
GLY A 505
VAL A 513
 None
 0.90A 2a1oA-1dedA:
undetectable		 2a1oA-1dedA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LEU P 276
VAL P 310
GLY P 311
ASP P 290
 None
 0.77A 2a1oA-1h71P:
0.0		 2a1oA-1h71P:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00497
(SBP_bac_3) 		4 PHE A 192
TYR A  91
GLY A  29
VAL A  10
 None
 0.84A 2a1oA-1iiwA:
undetectable		 2a1oA-1iiwA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 PHE A 526
VAL A 417
GLY A 418
VAL A 534
 None
 0.91A 2a1oA-1kspA:
0.4		 2a1oA-1kspA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4t PUTATIVE OXALATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		4 PHE A 114
TYR A  70
GLY A  59
VAL A  29
 None
OXL  A 400 (-4.7A)
None
None
 0.79A 2a1oA-1o4tA:
undetectable		 2a1oA-1o4tA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE

(Xenopus laevis) 		no annotation 4 PHE A 156
VAL A 224
GLY A 223
VAL A  90
 None
 0.86A 2a1oA-1oe5A:
0.0		 2a1oA-1oe5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 PHE A 249
THR A 238
VAL A  11
GLY A  10
 None
 0.92A 2a1oA-1qyiA:
0.0		 2a1oA-1qyiA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5a HYPOTHETICAL PROTEIN
YESE

(Bacillus
subtilis) 		PF12680
(SnoaL_2) 		4 TYR A  64
LEU A  70
GLY A  95
VAL A 130
 ACT  A 801 (-4.8A)
None
None
None
 0.78A 2a1oA-1s5aA:
0.0		 2a1oA-1s5aA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 THR B 706
LEU B 703
VAL B 112
GLY B 113
 None
 0.92A 2a1oA-1t3qB:
0.0		 2a1oA-1t3qB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 THR A 105
LEU A  44
VAL A  47
GLY A  48
 None
 0.84A 2a1oA-1tj7A:
undetectable		 2a1oA-1tj7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		4 LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 0.90A 2a1oA-1u05A:
undetectable		 2a1oA-1u05A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		4 LEU A 101
VAL A  37
GLY A  38
VAL A  85
 None
 0.91A 2a1oA-1ufrA:
undetectable		 2a1oA-1ufrA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 PHE A  65
VAL A 118
GLY A 119
VAL A 176
 None
 0.91A 2a1oA-1v6mA:
undetectable		 2a1oA-1v6mA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553

(Thermotoga
maritima) 		PF02424
(ApbE) 		4 LEU A 335
VAL A 289
GLY A 288
ASP A 316
 None
 0.80A 2a1oA-1vrmA:
undetectable		 2a1oA-1vrmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 THR A  81
LEU A 280
VAL A 250
GLY A 278
 None
 0.89A 2a1oA-1wkyA:
undetectable		 2a1oA-1wkyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 530
VAL A 574
GLY A 528
ASP A 565
 None
 0.90A 2a1oA-1xpgA:
undetectable		 2a1oA-1xpgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 PHE A 150
LEU A  72
VAL A  77
GLY A  78
 None
 0.83A 2a1oA-1y8pA:
undetectable		 2a1oA-1y8pA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 THR A 157
VAL A 133
GLY A 134
VAL A 125
 None
 0.91A 2a1oA-2aa4A:
undetectable		 2a1oA-2aa4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 THR A 332
LEU A 388
VAL A 384
GLY A 383
 None
 0.74A 2a1oA-2cb1A:
undetectable		 2a1oA-2cb1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djw PROBABLE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Thermus
thermophilus) 		PF01037
(AsnC_trans_reg) 		4 THR A  69
LEU A  61
GLY A  59
VAL A  44
 None
 0.82A 2a1oA-2djwA:
undetectable		 2a1oA-2djwA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 THR A  64
VAL A 227
GLY A 226
ASP A 294
 None
None
None
ZN  A 921 ( 2.3A)
 0.84A 2a1oA-2dkdA:
undetectable		 2a1oA-2dkdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 THR A 106
LEU A  46
VAL A  49
GLY A  50
 None
 0.78A 2a1oA-2e9fA:
undetectable		 2a1oA-2e9fA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 387
VAL A 355
GLY A 354
ASP A  31
 None
 0.79A 2a1oA-2hneA:
undetectable		 2a1oA-2hneA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 TYR A 289
LEU A 250
VAL A 247
GLY A 248
 None
 0.89A 2a1oA-2j1nA:
undetectable		 2a1oA-2j1nA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
LEU A 244
GLY A 248
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
None
 0.93A 2a1oA-2m56A:
68.5		 2a1oA-2m56A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		8 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
GLY A 248
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.46A 2a1oA-2m56A:
68.5		 2a1oA-2m56A:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		4 PHE A  62
THR A   6
LEU A  52
GLY A  97
 None
None
NAD  A1118 (-4.0A)
None
 0.85A 2a1oA-2p5uA:
undetectable		 2a1oA-2p5uA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 LEU A 221
VAL A 224
GLY A 225
VAL A  89
 None
 0.20A 2a1oA-2pd3A:
undetectable		 2a1oA-2pd3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB

(Nitrosomonas
europaea) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		4 PHE A  63
VAL A  95
GLY A  96
VAL A  55
 None
 0.74A 2a1oA-2pn0A:
undetectable		 2a1oA-2pn0A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A 121
ASP A 147
 None
 0.87A 2a1oA-2r8rA:
undetectable		 2a1oA-2r8rA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2van DNA POLYMERSE BETA

(Rattus
norvegicus) 		PF10391
(DNA_pol_lambd_f)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 THR A 196
VAL A 269
GLY A 268
VAL A 313
 None
 0.89A 2a1oA-2vanA:
undetectable		 2a1oA-2vanA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 PHE A 311
THR A 292
LEU A 162
GLY A  85
 None
 0.87A 2a1oA-3b9tA:
undetectable		 2a1oA-3b9tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5x CYCLIN-A2

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 LEU B 253
VAL B 256
GLY B 257
ASP B 240
 None
 0.51A 2a1oA-3f5xB:
undetectable		 2a1oA-3f5xB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnt HAP PROTEIN

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 TYR A 313
THR A 311
GLY A 302
VAL A 212
 None
 0.89A 2a1oA-3fntA:
undetectable		 2a1oA-3fntA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 LEU A  53
VAL A  57
GLY A  58
ASP A 282
 None
 0.82A 2a1oA-3iibA:
undetectable		 2a1oA-3iibA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 PHE X 433
TYR X 427
THR X 423
GLY X1026
 None
 0.74A 2a1oA-3jb9X:
undetectable		 2a1oA-3jb9X:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		4 LEU A 224
VAL A 227
GLY A 228
VAL A  92
 None
 0.68A 2a1oA-3k31A:
undetectable		 2a1oA-3k31A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 PHE A 297
THR A 279
VAL A 240
GLY A 239
 None
 0.89A 2a1oA-3m6xA:
undetectable		 2a1oA-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		4 PHE A  85
TYR A  98
VAL A 292
GLY A 293
 None
None
None
PLP  A1001 ( 4.3A)
 0.84A 2a1oA-3n2oA:
undetectable		 2a1oA-3n2oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 PHE A 107
TYR A 120
VAL A 309
GLY A 310
 None
 0.87A 2a1oA-3nzqA:
undetectable		 2a1oA-3nzqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN

(Brucella
abortus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 163
VAL A 159
GLY A 376
VAL A 339
 None
 0.91A 2a1oA-3oceA:
undetectable		 2a1oA-3oceA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 THR A1278
VAL A1234
GLY A1233
ASP A1225
 None
 0.88A 2a1oA-3opuA:
undetectable		 2a1oA-3opuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		4 LEU A 221
VAL A 224
GLY A 225
ASP A 172
 None
 0.80A 2a1oA-3pkmA:
undetectable		 2a1oA-3pkmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		4 THR A  75
VAL A  26
GLY A  25
VAL A 119
 None
 0.83A 2a1oA-3pp6A:
undetectable		 2a1oA-3pp6A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 TYR A 185
THR A 187
GLY A  16
ASP A  62
 None
 0.83A 2a1oA-3py6A:
undetectable		 2a1oA-3py6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.91A 2a1oA-3t6gA:
undetectable		 2a1oA-3t6gA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		4 LEU A 249
VAL A  49
VAL A  61
ASP A  43
 None
 0.90A 2a1oA-3tovA:
undetectable		 2a1oA-3tovA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni) 		PF00406
(ADK) 		4 PHE A  13
TYR A  96
LEU A  74
VAL A 110
 None
 0.82A 2a1oA-3umfA:
undetectable		 2a1oA-3umfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		4 PHE A 225
LEU A 159
GLY A 217
VAL A 239
 None
 0.89A 2a1oA-3v8vA:
undetectable		 2a1oA-3v8vA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 LEU A 279
VAL A 313
GLY A 314
ASP A 293
 None
 0.82A 2a1oA-3vi1A:
undetectable		 2a1oA-3vi1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		4 THR A  98
LEU A 301
VAL A 270
GLY A 299
 None
 0.92A 2a1oA-3wsuA:
undetectable		 2a1oA-3wsuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans) 		PF10140
(YukC) 		4 LEU A 103
VAL A 127
GLY A 126
VAL A  62
 None
 0.65A 2a1oA-4anoA:
undetectable		 2a1oA-4anoA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asm BETA-AGARASE D

(Zobellia
galactanivorans) 		no annotation 4 TYR B 194
LEU B 271
VAL B 262
GLY B 261
 None
 0.83A 2a1oA-4asmB:
undetectable		 2a1oA-4asmB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 THR A  67
VAL A 220
GLY A 219
ASP A 288
 SEP  A  69 ( 3.4A)
None
None
MG  A 998 (-2.3A)
 0.85A 2a1oA-4bjuA:
undetectable		 2a1oA-4bjuA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
LEU A 252
GLY A 256
VAL A 404
 None
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.5A)
 0.80A 2a1oA-4c9mA:
58.9		 2a1oA-4c9mA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TYR A  98
THR A 103
LEU A 252
GLY A 256
VAL A 303
ASP A 305
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.60A 2a1oA-4c9mA:
58.9		 2a1oA-4c9mA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PHE A  87
LEU A 250
GLY A 254
VAL A 301
 None
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
PEG  A 502 ( 4.5A)
 0.60A 2a1oA-4dxyA:
52.1		 2a1oA-4dxyA:
45.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 THR A 101
LEU A 250
GLY A 254
VAL A 301
 HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
PEG  A 502 ( 4.5A)
 0.77A 2a1oA-4dxyA:
52.1		 2a1oA-4dxyA:
45.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 LEU A 164
VAL A 143
GLY A 144
VAL A 111
 None
 0.81A 2a1oA-4f4wA:
undetectable		 2a1oA-4f4wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		4 THR A 159
LEU A  64
VAL A 172
GLY A 171
 None
 0.91A 2a1oA-4kqkA:
undetectable		 2a1oA-4kqkA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 PHE A 396
VAL A 354
GLY A 353
VAL A 423
 PHE  A 396 ( 1.3A)
VAL  A 354 ( 0.6A)
GLY  A 353 ( 0.0A)
VAL  A 423 ( 0.5A)
 0.77A 2a1oA-4kqnA:
undetectable		 2a1oA-4kqnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus) 		PF03328
(HpcH_HpaI) 		4 LEU A  59
VAL A  91
GLY A  57
VAL A  78
 None
 0.79A 2a1oA-4l7zA:
undetectable		 2a1oA-4l7zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 LEU A 412
VAL A 148
GLY A 147
ASP A  68
 None
 0.79A 2a1oA-4mguA:
undetectable		 2a1oA-4mguA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsp ENDONUCLEASE V

(Homo sapiens) 		PF04493
(Endonuclease_5) 		4 LEU A  70
VAL A  48
GLY A  49
VAL A 153
 None
 0.91A 2a1oA-4nspA:
undetectable		 2a1oA-4nspA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 PHE A 125
LEU A  57
VAL A  40
GLY A  39
 None
None
None
PO4  A 403 ( 4.4A)
 0.90A 2a1oA-4oc8A:
undetectable		 2a1oA-4oc8A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		4 LEU B 400
VAL B 372
GLY B 373
ASP B 350
 None
 0.92A 2a1oA-4peqB:
undetectable		 2a1oA-4peqB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 4 THR A  85
LEU A 249
VAL A 264
VAL A  39
 None
 0.84A 2a1oA-4txdA:
undetectable		 2a1oA-4txdA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  89
VAL A  53
GLY A  54
ASP A  74
 None
None
None
P6G  A 705 ( 3.5A)
 0.44A 2a1oA-4uzsA:
undetectable		 2a1oA-4uzsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 4 THR A 210
VAL A 315
GLY A 316
VAL A 375
 None
 0.84A 2a1oA-4yubA:
undetectable		 2a1oA-4yubA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae) 		no annotation 4 THR A 184
LEU A 142
VAL A 243
VAL A 194
 None
 0.91A 2a1oA-4z8tA:
undetectable		 2a1oA-4z8tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TYR A 564
THR A 913
GLY A 752
VAL A 654
 None
 0.91A 2a1oA-4zdnA:
undetectable		 2a1oA-4zdnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14) 		PF17515
(CPV_Polyhedrin) 		4 THR A 142
VAL A 177
GLY A 176
VAL A  32
 None
 0.73A 2a1oA-5a96A:
undetectable		 2a1oA-5a96A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoy ENDONUCLEASE V

(Mus musculus) 		PF04493
(Endonuclease_5) 		4 LEU A  70
VAL A  48
GLY A  49
VAL A 153
 None
 0.91A 2a1oA-5aoyA:
undetectable		 2a1oA-5aoyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PHE A 870
TYR A 869
VAL A 792
GLY A 796
 None
 0.79A 2a1oA-5aw4A:
undetectable		 2a1oA-5aw4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
CALCINEURIN SUBUNIT
B, VARIANT

(Coccidioides
immitis;
Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 PHE B 153
THR B 160
VAL A 375
GLY A 376
 None
 0.91A 2a1oA-5b8iB:
undetectable		 2a1oA-5b8iB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 PHE A 244
VAL A 280
GLY A 281
VAL A 110
 None
 0.87A 2a1oA-5bwyA:
undetectable		 2a1oA-5bwyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		4 LEU A 200
VAL A 203
GLY A 204
ASP A 225
 None
 0.80A 2a1oA-5cdhA:
undetectable		 2a1oA-5cdhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  87
VAL A  51
GLY A  52
ASP A  72
 None
 0.68A 2a1oA-5dfaA:
undetectable		 2a1oA-5dfaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  85
VAL A  49
GLY A  50
ASP A  70
 None
 0.64A 2a1oA-5e9aA:
undetectable		 2a1oA-5e9aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 THR A 220
LEU A 319
VAL A 322
GLY A 323
 None
 0.87A 2a1oA-5h80A:
undetectable		 2a1oA-5h80A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PHE A 825
VAL A 787
GLY A 786
ASP A 800
 None
 0.91A 2a1oA-5hjrA:
undetectable		 2a1oA-5hjrA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioo AVPA

(Nanoarchaeota
archaeon JGI
OTU-1) 		no annotation 4 LEU A  53
VAL A 186
GLY A 187
VAL A 162
 None
 0.85A 2a1oA-5iooA:
undetectable		 2a1oA-5iooA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr9 NEQ131

(Nanoarchaeum
equitans) 		PF01997
(Translin) 		4 PHE B  77
LEU B 162
GLY B 116
VAL B  84
 None
 0.92A 2a1oA-5jr9B:
undetectable		 2a1oA-5jr9B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE

(Aspergillus
terreus) 		PF11991
(Trp_DMAT) 		4 LEU A 265
VAL A 255
GLY A 254
VAL A 152
 None
 0.70A 2a1oA-5kd0A:
undetectable		 2a1oA-5kd0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvp ZOOCIN A
ENDOPEPTIDASE

(Streptococcus
equi) 		PF01551
(Peptidase_M23) 		4 TYR A  87
THR A  85
VAL A 101
GLY A  53
 None
 0.84A 2a1oA-5kvpA:
undetectable		 2a1oA-5kvpA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 THR A  92
LEU A 311
VAL A 276
GLY A 309
 None
 0.92A 2a1oA-5m7rA:
undetectable		 2a1oA-5m7rA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 PHE B 169
THR B 239
LEU B 252
GLY B 134
 None
 0.92A 2a1oA-5n5nB:
undetectable		 2a1oA-5n5nB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opz CHIX

(Serratia
marcescens) 		no annotation 4 LEU A  26
VAL A  22
GLY A  72
ASP A  76
 None
None
None
ZN  A 201 (-2.2A)
 0.79A 2a1oA-5opzA:
undetectable		 2a1oA-5opzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		no annotation 4 PHE A  86
LEU A  54
GLY A  58
VAL A  75
 None
 0.91A 2a1oA-5swkA:
undetectable		 2a1oA-5swkA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF13420
(Acetyltransf_4) 		4 LEU A 148
VAL A 161
GLY A 162
VAL A 123
 None
 0.88A 2a1oA-5t7dA:
undetectable		 2a1oA-5t7dA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 THR A  92
LEU A 311
VAL A 276
GLY A 309
 None
 0.85A 2a1oA-5uhkA:
undetectable		 2a1oA-5uhkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 THR A  92
LEU A 311
VAL A 276
GLY A 309
 None
 0.93A 2a1oA-5vvoA:
undetectable		 2a1oA-5vvoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
 0.55A 2a1oA-5wu3A:
undetectable		 2a1oA-5wu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
None
None
MG  A1001 (-3.9A)
 0.56A 2a1oA-5wu6A:
undetectable		 2a1oA-5wu6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 PHE A   7
TYR A 459
THR A 651
LEU A 435
 None
 0.87A 2a1oA-5x2gA:
undetectable		 2a1oA-5x2gA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S5,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 THR e 282
VAL e 187
GLY e 188
VAL e 157
 None
 0.75A 2a1oA-5x8re:
undetectable		 2a1oA-5x8re:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9u THERMOSOME, ALPHA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		no annotation 4 THR A  91
VAL A  85
GLY A  86
ASP A 476
 ADP  A 601 (-3.9A)
None
None
ADP  A 601 (-2.6A)
 0.83A 2a1oA-5x9uA:
undetectable		 2a1oA-5x9uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		4 TYR B 212
LEU B 201
VAL B 184
GLY B 183
 None
 0.93A 2a1oA-5xeqB:
undetectable		 2a1oA-5xeqB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		4 PHE A 185
THR A 301
GLY A 267
ASP A 184
 None
 0.88A 2a1oA-5xw5A:
undetectable		 2a1oA-5xw5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 PHE A 453
THR A 443
GLY A 377
VAL A 267
 None
 0.93A 2a1oA-6fylA:
undetectable		 2a1oA-6fylA:
undetectable