SIMILAR PATTERNS OF AMINO ACIDS FOR 2A1M_B_CAMB2422_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		4 TYR A 120
THR A 137
VAL A  63
GLY A  62
 None
 0.82A 2a1mB-1dj0A:
undetectable		 2a1mB-1dj0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 THR A  54
VAL A 164
GLY A 165
ILE A 187
 ADP  A 398 (-4.5A)
None
None
None
 0.74A 2a1mB-1fnnA:
undetectable		 2a1mB-1fnnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 VAL A 163
GLY A 162
VAL A 312
ILE A 308
 None
 0.73A 2a1mB-1l1lA:
0.0		 2a1mB-1l1lA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 THR A 283
VAL A 205
THR A 180
ILE A 187
 None
 0.78A 2a1mB-1ldjA:
0.0		 2a1mB-1ldjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mh6 BLEOMYCIN RESISTANCE
PROTEIN

(Klebsiella
pneumoniae) 		no annotation 4 PHE A 220
GLY A 287
THR A 284
ILE A 281
 None
 0.82A 2a1mB-1mh6A:
undetectable		 2a1mB-1mh6A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ

(Escherichia
coli) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 VAL A 423
GLY A 345
VAL A 411
ILE A 404
 None
 0.80A 2a1mB-1ni5A:
0.0		 2a1mB-1ni5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.80A 2a1mB-1ofuA:
0.0		 2a1mB-1ofuA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0u PROTEIN YWIB

(Bacillus
subtilis) 		PF09148
(DUF1934) 		4 PHE A  77
TYR A 118
THR A  54
VAL A  56
 None
None
GOL  A 301 ( 4.1A)
None
 0.78A 2a1mB-1r0uA:
undetectable		 2a1mB-1r0uA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLY A 973
THR A 971
VAL A1092
ILE A 995
 None
 0.79A 2a1mB-1rpmA:
undetectable		 2a1mB-1rpmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		4 THR A 182
VAL A 246
GLY A 245
ILE A  39
 None
 0.78A 2a1mB-1t71A:
undetectable		 2a1mB-1t71A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 PHE A 148
VAL A 205
VAL A 155
ILE A 152
 None
 0.77A 2a1mB-1t8qA:
undetectable		 2a1mB-1t8qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 THR Y  64
VAL Y  19
GLY Y  20
ILE Y  86
 None
GDP  Y1207 (-4.1A)
GDP  Y1207 (-2.9A)
None
 0.82A 2a1mB-1ukvY:
undetectable		 2a1mB-1ukvY:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 THR A 170
VAL A 380
VAL A 295
ILE A 291
 None
 0.78A 2a1mB-1vdkA:
undetectable		 2a1mB-1vdkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 VAL A 475
GLY A 410
THR A 479
VAL A 487
 None
 0.81A 2a1mB-1w6sA:
undetectable		 2a1mB-1w6sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k GTP-BINDING PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		4 PHE A   9
VAL A  52
GLY A  53
ILE A 169
 None
 0.78A 2a1mB-1z0kA:
undetectable		 2a1mB-1z0kA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 TYR A 164
VAL A 303
GLY A 304
ILE A 221
 ACT  A2005 (-4.6A)
None
None
None
 0.82A 2a1mB-2e3jA:
undetectable		 2a1mB-2e3jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 VAL A  47
GLY A  48
VAL A  27
ILE A  31
 None
 0.79A 2a1mB-2ftpA:
undetectable		 2a1mB-2ftpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 THR A  94
VAL A 322
GLY A 323
ILE A 357
 None
 0.72A 2a1mB-2ftwA:
undetectable		 2a1mB-2ftwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		4 VAL A 202
GLY A 201
VAL A 196
ILE A   3
 None
 0.80A 2a1mB-2h6rA:
undetectable		 2a1mB-2h6rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		4 TYR A  17
THR A 111
THR A  35
VAL A  37
 None
 0.74A 2a1mB-2hngA:
undetectable		 2a1mB-2hngA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqn CRK-LIKE PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		4 THR A 289
VAL A 266
GLY A 277
ILE A 263
 None
 0.79A 2a1mB-2lqnA:
undetectable		 2a1mB-2lqnA:
21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
GLY A 248
THR A 252
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
 1.25A 2a1mB-2m56A:
69.3		 2a1mB-2m56A:
99.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
TYR A  96
THR A 101
VAL A 247
GLY A 248
THR A 252
ILE A 395
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
 0.61A 2a1mB-2m56A:
69.3		 2a1mB-2m56A:
99.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
TYR A  96
THR A 101
VAL A 247
GLY A 248
VAL A 295
ILE A 395
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
None
 0.45A 2a1mB-2m56A:
69.3		 2a1mB-2m56A:
99.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB

(Nitrosomonas
europaea) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		4 PHE A  63
VAL A  95
GLY A  96
VAL A  55
 None
 0.77A 2a1mB-2pn0A:
undetectable		 2a1mB-2pn0A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A  20
THR A  99
VAL A  13
ILE A  38
 None
 0.82A 2a1mB-2q1yA:
undetectable		 2a1mB-2q1yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 149
GLY A 150
VAL A 252
ILE A 309
 None
 0.81A 2a1mB-2qz9A:
undetectable		 2a1mB-2qz9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN

(Oceanicola
granulosus) 		PF13759
(2OG-FeII_Oxy_5) 		4 VAL A 175
GLY A 176
THR A 130
ILE A 199
 None
 0.62A 2a1mB-2rg4A:
undetectable		 2a1mB-2rg4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 PHE A  98
GLY A  37
THR A 111
VAL A 101
 None
 0.81A 2a1mB-2uu7A:
undetectable		 2a1mB-2uu7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.80A 2a1mB-2vawA:
undetectable		 2a1mB-2vawA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 THR A 496
VAL A 660
GLY A 661
ILE A 696
 None
 0.72A 2a1mB-2wjvA:
undetectable		 2a1mB-2wjvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 THR A 434
VAL A 596
GLY A 597
ILE A 632
 ADP  A1854 (-4.3A)
None
None
1PE  A1866 ( 4.0A)
 0.73A 2a1mB-2xzlA:
undetectable		 2a1mB-2xzlA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 THR A 496
VAL A 660
GLY A 661
ILE A 696
 ADP  A1004 ( 4.4A)
None
None
None
 0.74A 2a1mB-2xzoA:
undetectable		 2a1mB-2xzoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bd1 CRO PROTEIN

(Xylella
fastidiosa) 		PF15943
(YdaS_antitoxin) 		4 VAL A  23
GLY A  22
VAL A  48
ILE A  45
 None
 0.76A 2a1mB-3bd1A:
undetectable		 2a1mB-3bd1A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		4 VAL A 175
GLY A 176
THR A 130
ILE A 199
 None
 0.56A 2a1mB-3bvcA:
undetectable		 2a1mB-3bvcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crl DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		4 VAL C 156
GLY C 157
VAL C 208
ILE C 206
 None
 0.76A 2a1mB-3crlC:
undetectable		 2a1mB-3crlC:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 PHE A 232
GLY A 220
VAL A 310
ILE A 306
 None
 0.69A 2a1mB-3dh4A:
undetectable		 2a1mB-3dh4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 THR A 364
VAL A 461
GLY A 462
ILE A 486
 None
 0.83A 2a1mB-3e1sA:
undetectable		 2a1mB-3e1sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A 275
VAL A 147
GLY A 146
ILE A 117
 None
 0.51A 2a1mB-3gvhA:
undetectable		 2a1mB-3gvhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE

(Trypanosoma
brucei) 		no annotation 4 PHE A 336
THR A 186
GLY A  53
ILE A 144
 None
 0.78A 2a1mB-3hj4A:
undetectable		 2a1mB-3hj4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw PSEUDOURIDINE
SYNTHASE CBF5

(Pyrococcus
furiosus) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 VAL A 196
GLY A 195
VAL A 131
ILE A 128
 None
 0.60A 2a1mB-3hjwA:
undetectable		 2a1mB-3hjwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyj PROTEIN DUF199/WHIA

(Thermotoga
maritima) 		PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA) 		4 PHE A 181
THR A 147
GLY A  34
ILE A 185
 None
 0.79A 2a1mB-3hyjA:
undetectable		 2a1mB-3hyjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		4 THR A 296
GLY A  13
THR A  17
VAL A 324
 None
FAD  A 441 (-3.4A)
None
None
 0.74A 2a1mB-3hyvA:
undetectable		 2a1mB-3hyvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Sulfurisphaera
tokodaii) 		PF00994
(MoCF_biosynth) 		4 PHE A  73
THR A 102
GLY A  90
ILE A  21
 None
 0.79A 2a1mB-3iwtA:
undetectable		 2a1mB-3iwtA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 PHE X 433
TYR X 427
THR X 423
GLY X1026
 None
 0.81A 2a1mB-3jb9X:
undetectable		 2a1mB-3jb9X:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 PHE A  66
THR A  80
GLY A  12
ILE A  27
 None
 0.78A 2a1mB-3js6A:
undetectable		 2a1mB-3js6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		4 VAL B  68
GLY B  69
THR B  51
ILE B 175
 None
 0.75A 2a1mB-3kydB:
undetectable		 2a1mB-3kydB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1

(Saccharomyces
cerevisiae) 		PF02383
(Syja_N) 		4 THR X 162
VAL X 182
THR X 133
ILE X 209
 None
 0.79A 2a1mB-3lwtX:
undetectable		 2a1mB-3lwtX:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		4 PHE A 274
TYR A 273
GLY A  20
ILE A 200
 None
 0.83A 2a1mB-3m5wA:
undetectable		 2a1mB-3m5wA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 284
GLY A 283
VAL A  74
ILE A 117
 None
 0.82A 2a1mB-3p7mA:
undetectable		 2a1mB-3p7mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 103
GLY A 104
THR A  89
ILE A   6
 None
 0.66A 2a1mB-3pi7A:
undetectable		 2a1mB-3pi7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 THR A 305
VAL A 313
GLY A 288
ILE A 127
 None
 0.81A 2a1mB-3q6dA:
undetectable		 2a1mB-3q6dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE

(Ovis aries) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 333
GLY A 125
VAL A  40
ILE A  42
 None
 0.80A 2a1mB-3qe3A:
undetectable		 2a1mB-3qe3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A 236
VAL A 287
GLY A 286
ILE A 254
 None
 0.81A 2a1mB-3tiaA:
undetectable		 2a1mB-3tiaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up6 HYPOTHETICAL PROTEIN
BACOVA_04078

(Bacteroides
ovatus) 		no annotation 4 PHE A 213
TYR A 132
GLY A 149
ILE A 107
 None
 0.77A 2a1mB-3up6A:
undetectable		 2a1mB-3up6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.74A 2a1mB-3wgkA:
undetectable		 2a1mB-3wgkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		4 THR A 174
VAL A 237
GLY A 236
ILE A  35
 None
 0.80A 2a1mB-4b2oA:
undetectable		 2a1mB-4b2oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6c DNA GYRASE SUBUNIT B

(Mycolicibacterium
smegmatis) 		PF02518
(HATPase_c) 		4 VAL A 125
GLY A 124
VAL A  98
ILE A  96
 None
 0.74A 2a1mB-4b6cA:
undetectable		 2a1mB-4b6cA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqq INTEGRASE

(Streptomyces
virus phiC31) 		PF00239
(Resolvase) 		4 PHE A  94
GLY A   6
VAL A 114
ILE A 116
 None
 0.64A 2a1mB-4bqqA:
undetectable		 2a1mB-4bqqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		4 VAL A2046
GLY A2043
THR A1999
ILE A1869
 None
 0.78A 2a1mB-4by6A:
undetectable		 2a1mB-4by6A:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TYR A  98
THR A 103
GLY A 256
THR A 260
VAL A 303
ILE A 403
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
None
 0.76A 2a1mB-4c9mA:
59.0		 2a1mB-4c9mA:
45.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		4 VAL A 323
GLY A 320
VAL A 373
ILE A  62
 None
 0.80A 2a1mB-4d9iA:
undetectable		 2a1mB-4d9iA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PHE A  87
GLY A 254
THR A 258
VAL A 301
 None
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
 0.41A 2a1mB-4dxyA:
52.3		 2a1mB-4dxyA:
46.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 THR A 101
GLY A 254
THR A 258
VAL A 301
ILE A 401
 HEM  A 501 ( 4.8A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
 0.76A 2a1mB-4dxyA:
52.3		 2a1mB-4dxyA:
46.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A  20
THR A  99
VAL A  13
ILE A  38
 None
 0.82A 2a1mB-4e6eA:
undetectable		 2a1mB-4e6eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl4 GLYCOSIDE HYDROLASE
FAMILY 9
CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum;
Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1)
PF00963
(Cohesin) 		4 PHE C  87
THR A  37
GLY C  94
ILE C  98
 None
 0.82A 2a1mB-4fl4C:
undetectable		 2a1mB-4fl4C:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn4 SHORT CHAIN
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF13561
(adh_short_C2) 		4 THR A  82
VAL A  62
GLY A  61
ILE A  12
 None
 0.79A 2a1mB-4fn4A:
undetectable		 2a1mB-4fn4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A 236
VAL A 287
GLY A 286
ILE A 254
 None
 0.82A 2a1mB-4h53A:
undetectable		 2a1mB-4h53A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 PHE A 314
GLY A  15
THR A 244
ILE A 276
 None
 0.75A 2a1mB-4ictA:
37.3		 2a1mB-4ictA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 PHE A 396
VAL A 354
GLY A 353
VAL A 423
 PHE  A 396 ( 1.3A)
VAL  A 354 ( 0.6A)
GLY  A 353 ( 0.0A)
VAL  A 423 ( 0.5A)
 0.74A 2a1mB-4kqnA:
undetectable		 2a1mB-4kqnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		5 TYR A  30
VAL A  89
GLY A  84
VAL A  41
ILE A  37
 None
None
None
6NA  A 301 ( 4.2A)
None
 1.26A 2a1mB-4kvsA:
undetectable		 2a1mB-4kvsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6r VELB

(Aspergillus
nidulans) 		PF11754
(Velvet) 		4 VAL B 258
GLY B 257
VAL B  64
ILE B  89
 None
 0.79A 2a1mB-4n6rB:
undetectable		 2a1mB-4n6rB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A 291
VAL A 166
GLY A 165
ILE A 136
 None
 0.56A 2a1mB-4nd4A:
undetectable		 2a1mB-4nd4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 PHE A 224
TYR A 256
THR A 258
ILE A 197
 None
 0.69A 2a1mB-4q1zA:
undetectable		 2a1mB-4q1zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2w PUTATIVE
ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Streptococcus
pneumoniae) 		PF01832
(Glucosaminidase) 		4 PHE A 169
GLY A 194
VAL A 225
ILE A 229
 None
 0.81A 2a1mB-4q2wA:
undetectable		 2a1mB-4q2wA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 4 VAL B 496
GLY B 437
THR B 500
VAL B 508
 None
 0.78A 2a1mB-4tqoB:
undetectable		 2a1mB-4tqoB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy4 SPINDLIN-4

(Homo sapiens) 		PF02513
(Spin-Ssty) 		4 VAL A  41
GLY A  42
THR A  62
ILE A  75
 None
None
None
GOL  A1237 ( 4.0A)
 0.79A 2a1mB-4uy4A:
undetectable		 2a1mB-4uy4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14) 		PF17515
(CPV_Polyhedrin) 		4 THR A 142
VAL A 177
GLY A 176
VAL A  32
 None
 0.75A 2a1mB-5a96A:
undetectable		 2a1mB-5a96A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq0 CARBOXYPEPTIDASE D

(Homo sapiens) 		PF13620
(CarboxypepD_reg) 		4 PHE A 457
GLY A 383
VAL A 404
ILE A 402
 None
 0.79A 2a1mB-5aq0A:
undetectable		 2a1mB-5aq0A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PHE A 870
TYR A 869
VAL A 792
GLY A 796
 None
 0.80A 2a1mB-5aw4A:
undetectable		 2a1mB-5aw4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyf PUTATIVE URIDINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 GLY A 235
THR A 239
VAL A 165
ILE A 250
 None
 0.76A 2a1mB-5cyfA:
undetectable		 2a1mB-5cyfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TYR A 656
VAL A 176
GLY A 177
ILE A 548
 None
 0.66A 2a1mB-5f7sA:
undetectable		 2a1mB-5f7sA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TYR A 411
VAL A 284
GLY A 283
ILE A 301
 None
 0.65A 2a1mB-5jo7A:
undetectable		 2a1mB-5jo7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 TYR A  17
VAL A  76
GLY A  71
VAL A  28
ILE A  24
 None
None
None
OCD  A 500 ( 4.6A)
OCD  A 500 (-4.6A)
 1.29A 2a1mB-5k52A:
undetectable		 2a1mB-5k52A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		5 TYR A  17
VAL A  76
GLY A  71
VAL A  28
ILE A  24
 None
None
None
STE  A 502 ( 4.8A)
STE  A 502 (-4.4A)
 1.24A 2a1mB-5k53A:
undetectable		 2a1mB-5k53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		4 THR A 142
VAL A  15
GLY A  16
ILE A 162
 None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.2A)
None
 0.77A 2a1mB-5k5zA:
undetectable		 2a1mB-5k5zA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 TYR A 628
VAL A 575
GLY A 576
ILE A 649
 None
 0.81A 2a1mB-5k8fA:
undetectable		 2a1mB-5k8fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		4 VAL A  19
GLY A  20
VAL A 146
ILE A 121
 None
 0.72A 2a1mB-5kh0A:
undetectable		 2a1mB-5kh0A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		5 VAL A 249
GLY A 250
THR A 254
VAL A 297
ILE A 397
 None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.5A)
HEM  A 501 (-4.3A)
None
 0.56A 2a1mB-5kyoA:
50.3		 2a1mB-5kyoA:
40.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 TYR A 441
VAL A 401
GLY A 402
THR A 506
 None
 0.80A 2a1mB-5lykA:
undetectable		 2a1mB-5lykA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.75A 2a1mB-5mn5A:
undetectable		 2a1mB-5mn5A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 VAL A 554
GLY A 555
VAL A 269
ILE A 533
 None
 0.63A 2a1mB-5oc1A:
undetectable		 2a1mB-5oc1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 THR B  92
VAL B  99
GLY B 100
ILE B 417
 MGD  B 503 ( 4.9A)
None
None
None
 0.79A 2a1mB-5t5iB:
undetectable		 2a1mB-5t5iB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL A  12
GLY A  29
THR A  54
ILE A  49
 None
 0.78A 2a1mB-5vm1A:
undetectable		 2a1mB-5vm1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		4 THR A 404
VAL A 414
GLY A 415
THR A 418
 None
 0.74A 2a1mB-5wgxA:
undetectable		 2a1mB-5wgxA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		4 GLY A1048
THR A1050
VAL A1015
ILE A 986
 None
 0.77A 2a1mB-5wqwA:
undetectable		 2a1mB-5wqwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S5,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 THR e 282
VAL e 187
GLY e 188
VAL e 157
 None
 0.74A 2a1mB-5x8re:
undetectable		 2a1mB-5x8re:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 THR A 555
VAL A 501
GLY A 500
THR A 649
 None
 0.72A 2a1mB-5xapA:
undetectable		 2a1mB-5xapA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 4 THR A 236
VAL A 287
GLY A 286
ILE A 254
 None
 0.82A 2a1mB-6br6A:
undetectable		 2a1mB-6br6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 PHE D 430
VAL D 449
GLY D 450
ILE D 480
 None
 0.69A 2a1mB-6fkhD:
undetectable		 2a1mB-6fkhD:
undetectable