SIMILAR PATTERNS OF AMINO ACIDS FOR 2A15_A_NCAA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 SER A 365
VAL A 534
LEU A 304
LEU A 410
TYR A 361
 CLL  A 801 (-3.3A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.7A)
CLL  A 801 (-4.5A)
CLL  A 801 ( 4.8A)
 1.18A 2a15A-1cleA:
0.0		 2a15A-1cleA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 SER A 365
VAL A 534
LEU A 304
LEU A 410
TYR A 361
 None
 1.19A 2a15A-1crlA:
0.0		 2a15A-1crlA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3y DNA TOPOISOMERASE VI
A SUBUNIT

(Methanocaldococcus
jannaschii) 		PF04406
(TP6A_N) 		5 VAL A 148
ILE A 217
LEU A 152
LEU A 184
LEU A 186
 None
 1.28A 2a15A-1d3yA:
undetectable		 2a15A-1d3yA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3r CELL DIVISION
INHIBITOR

(Pyrococcus
furiosus) 		PF13614
(AAA_31) 		5 SER A 133
ILE A 115
LEU A  35
LEU A  59
LEU A  84
 None
 1.09A 2a15A-1g3rA:
0.0		 2a15A-1g3rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 SER A 365
VAL A 534
LEU A 304
LEU A 410
TYR A 361
 None
 1.16A 2a15A-1gz7A:
0.0		 2a15A-1gz7A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 VAL A 530
ILE A 477
LEU A 481
LEU A 578
LEU A 538
 None
 1.21A 2a15A-1hn0A:
0.0		 2a15A-1hn0A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4s RIBONUCLEASE III

(Aquifex
aeolicus) 		PF14622
(Ribonucleas_3_3) 		5 VAL A 108
ILE A  93
LEU A  25
LEU A  87
LEU A   7
 None
 1.22A 2a15A-1i4sA:
undetectable		 2a15A-1i4sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		5 SER A 133
ILE A 115
LEU A  35
LEU A  59
LEU A  84
 None
 1.08A 2a15A-1ionA:
0.0		 2a15A-1ionA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 VAL A  11
ILE A  88
LEU A   9
LEU A 215
LEU A 219
 None
 1.23A 2a15A-1jnyA:
0.0		 2a15A-1jnyA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqv CYTOCHROME C'

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		5 SER A  40
VAL A  37
ILE A  96
LEU A 102
LEU A  26
 None
 1.21A 2a15A-1mqvA:
undetectable		 2a15A-1mqvA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 SER A 223
VAL A 221
LEU A 252
LEU A 245
LEU A 249
 None
None
None
None
EDO  A 503 (-4.7A)
 1.23A 2a15A-1n0wA:
undetectable		 2a15A-1n0wA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk0 CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA) 		5 SER A 355
ILE A 418
LEU A 413
LEU A 403
LEU A 405
 None
 1.21A 2a15A-1pk0A:
undetectable		 2a15A-1pk0A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		5 SER A 252
VAL A 254
ILE A 241
LEU A 218
LEU A  83
 None
 1.29A 2a15A-1pv5A:
undetectable		 2a15A-1pv5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE

(Thuja plicata) 		PF05368
(NmrA) 		6 SER A  82
VAL A  80
ILE A 103
LEU A  74
LEU A  64
LEU A  70
 None
 1.26A 2a15A-1qydA:
undetectable		 2a15A-1qydA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3g X-LINKED
INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		PF01582
(TIR) 		5 VAL A 507
LEU A 534
LEU A 527
TYR A 481
MET A 477
 None
 1.25A 2a15A-1t3gA:
undetectable		 2a15A-1t3gA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5t DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
VPS36P

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		5 SER B 489
VAL B 487
ILE B 435
LEU B 440
LEU B 420
 None
 1.21A 2a15A-1u5tB:
undetectable		 2a15A-1u5tB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Methanocaldococcus
jannaschii) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		5 VAL A 208
ILE A 158
LEU A 160
LEU A 227
LEU A 184
 None
 1.23A 2a15A-1u9zA:
undetectable		 2a15A-1u9zA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v98 THIOREDOXIN

(Thermus
thermophilus) 		PF00085
(Thioredoxin) 		5 SER A 124
VAL A  68
ILE A  71
LEU A  72
LEU A  54
 None
 1.25A 2a15A-1v98A:
undetectable		 2a15A-1v98A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 VAL A 173
ILE A 176
LEU A 177
LEU A  81
LEU A 158
 None
 1.30A 2a15A-1vplA:
undetectable		 2a15A-1vplA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		5 VAL A 120
ILE A  23
LEU A 118
LEU A  15
LEU A  17
 None
 1.25A 2a15A-1yggA:
undetectable		 2a15A-1yggA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		5 VAL A 304
ILE A 349
LEU A 285
LEU A 278
LEU A 282
 None
None
None
A  G  10 ( 4.3A)
None
 1.23A 2a15A-1yvpA:
undetectable		 2a15A-1yvpA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 SER A 118
ILE A 157
LEU A 101
LEU A 111
LEU A 105
 None
 1.21A 2a15A-1zwsA:
undetectable		 2a15A-1zwsA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 VAL A 176
ILE A 109
LEU A 256
LEU A 237
LEU A 253
 None
 1.16A 2a15A-2bihA:
undetectable		 2a15A-2bihA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 VAL A 176
ILE A 109
LEU A 256
LEU A 237
LEU A 253
 None
 1.18A 2a15A-2biiA:
undetectable		 2a15A-2biiA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		5 VAL A 159
ILE A 124
LEU A 183
LEU A 190
MET A 137
 None
 1.23A 2a15A-2cygA:
undetectable		 2a15A-2cygA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpe BPSL1050

(Burkholderia
pseudomallei) 		no annotation 5 ILE A  51
LEU A  68
LEU A 126
LEU A 123
TYR A  92
 None
 1.28A 2a15A-2mpeA:
undetectable		 2a15A-2mpeA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nar EFFECTOR PROTEIN
AVR3A

(Phytophthora
infestans) 		PF16810
(RXLR) 		5 VAL A  50
TRP A  45
ILE A  55
LEU A  52
LEU A  82
 None
 1.17A 2a15A-2narA:
undetectable		 2a15A-2narA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		5 SER A  81
VAL A  79
ILE A  98
LEU A  63
LEU A  69
 None
 1.24A 2a15A-2qw8A:
undetectable		 2a15A-2qw8A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		5 VAL A 312
ILE A 293
LEU A 297
LEU A  57
LEU A 253
 None
 1.30A 2a15A-2rinA:
undetectable		 2a15A-2rinA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum) 		PF00696
(AA_kinase) 		5 SER A  39
VAL A  44
ILE A   8
LEU A  88
LEU A  84
 None
 1.22A 2a15A-2va1A:
undetectable		 2a15A-2va1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF00156
(Pribosyltran) 		5 VAL A 173
ILE A  56
LEU A  11
LEU A  40
LEU A  15
 None
 1.29A 2a15A-2wnsA:
undetectable		 2a15A-2wnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 VAL A 328
ILE A 331
LEU A 332
LEU A  68
LEU A 102
 None
 1.26A 2a15A-2x24A:
undetectable		 2a15A-2x24A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgv PSIV CAPSID
N-TERMINAL DOMAIN

(Microcebus
murinus) 		PF00607
(Gag_p24) 		5 VAL A 116
TRP A 120
ASP A  81
ILE A  95
LEU A  88
 None
 1.21A 2a15A-2xgvA:
undetectable		 2a15A-2xgvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xig FERRIC UPTAKE
REGULATION PROTEIN

(Helicobacter
pylori) 		PF01475
(FUR) 		5 VAL A  32
ILE A  67
LEU A  71
LEU A  11
LEU A  14
 None
 1.30A 2a15A-2xigA:
undetectable		 2a15A-2xigA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 VAL A  27
ILE A  24
LEU A  36
LEU A  58
LEU A  54
 None
 1.25A 2a15A-2xr1A:
undetectable		 2a15A-2xr1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A 275
LEU A 266
LEU A 320
LEU A 330
TYR A 307
 None
 1.05A 2a15A-2yh0A:
undetectable		 2a15A-2yh0A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		5 VAL A 241
ILE A 202
LEU A 243
LEU A 306
LEU A 302
 None
 1.10A 2a15A-2yx0A:
undetectable		 2a15A-2yx0A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 VAL A  22
ILE A 258
LEU A 262
LEU A  31
LEU A   6
 None
None
None
NDP  A3003 (-4.4A)
None
 1.13A 2a15A-3a14A:
undetectable		 2a15A-3a14A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bci DISULFIDE BOND
PROTEIN A

(Staphylococcus
aureus) 		PF13462
(Thioredoxin_4) 		5 SER A  71
VAL A  74
ILE A 110
LEU A 113
TYR A  24
 None
 1.17A 2a15A-3bciA:
undetectable		 2a15A-3bciA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 VAL A 326
ILE A 348
LEU A 322
LEU A 299
TYR A 390
 None
 1.08A 2a15A-3cmmA:
undetectable		 2a15A-3cmmA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 VAL A 203
ILE A 205
LEU A 196
LEU A 173
LEU A 169
 None
 1.17A 2a15A-3dwiA:
undetectable		 2a15A-3dwiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efc OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		5 SER A 117
VAL A 119
LEU A 165
LEU A 137
LEU A 167
 None
 1.25A 2a15A-3efcA:
undetectable		 2a15A-3efcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 VAL A 148
ILE A  97
LEU A 150
LEU A 175
LEU A 170
 None
 1.23A 2a15A-3ezxA:
undetectable		 2a15A-3ezxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		5 VAL A 313
ILE A  15
LEU A 186
LEU A 182
TYR A  59
 None
 1.16A 2a15A-3fj1A:
undetectable		 2a15A-3fj1A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fok UNCHARACTERIZED
PROTEIN CGL0159

(Corynebacterium
glutamicum) 		no annotation 5 VAL A  88
ILE A  95
LEU A  98
LEU A  72
LEU A  73
 None
 1.26A 2a15A-3fokA:
undetectable		 2a15A-3fokA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		5 VAL A  35
ILE A  52
LEU A  74
LEU A  23
LEU A  58
 None
 1.22A 2a15A-3godA:
undetectable		 2a15A-3godA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 5 SER A  11
ILE A  37
LEU A  34
LEU A   5
LEU A  29
 None
 1.12A 2a15A-3gozA:
undetectable		 2a15A-3gozA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		5 SER A  35
VAL A  38
LEU A  48
LEU A  26
LEU A 100
 None
 1.29A 2a15A-3gqmA:
undetectable		 2a15A-3gqmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A  26
ILE A   5
LEU A  28
LEU A  45
LEU A  43
 None
 1.29A 2a15A-3hwrA:
undetectable		 2a15A-3hwrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iir TRYPSIN INHIBITOR

(Murraya
koenigii) 		PF00197
(Kunitz_legume) 		5 VAL A 154
ILE A 105
LEU A 164
LEU A  19
LEU A  31
 None
 1.10A 2a15A-3iirA:
undetectable		 2a15A-3iirA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 VAL A 262
ILE A 201
LEU A 196
LEU A 770
LEU A 203
 None
 1.24A 2a15A-3ne5A:
undetectable		 2a15A-3ne5A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A 241
ILE A 162
LEU A 235
LEU A 259
TYR A 220
 None
 1.14A 2a15A-3pkoA:
undetectable		 2a15A-3pkoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 SER A 584
ILE A 570
LEU A 630
LEU A 654
MET A 574
 None
 1.14A 2a15A-3pxiA:
undetectable		 2a15A-3pxiA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 206
ILE A 214
LEU A 208
LEU A 165
LEU A 164
 None
 1.12A 2a15A-3qfvA:
undetectable		 2a15A-3qfvA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		5 VAL A 230
ILE A 259
LEU A 250
LEU A 193
LEU A 239
 None
 1.16A 2a15A-3scyA:
undetectable		 2a15A-3scyA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 TRP A 210
VAL A 303
ILE A 253
LEU A 269
LEU A 289
 None
 1.23A 2a15A-3sutA:
undetectable		 2a15A-3sutA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		5 SER A  95
ILE A 106
LEU A 110
LEU A  45
LEU A 137
 None
 1.24A 2a15A-3t66A:
undetectable		 2a15A-3t66A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqq METHIONYL-TRNA
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 TRP A 215
ILE A 273
LEU A 263
LEU A 306
MET A 244
 None
 1.19A 2a15A-3tqqA:
undetectable		 2a15A-3tqqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 VAL A 360
ILE A 341
LEU A 338
LEU A 386
LEU A 380
 None
 1.21A 2a15A-3ufbA:
undetectable		 2a15A-3ufbA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 VAL A 358
ILE A 357
LEU A 378
LEU A 391
LEU A 380
 None
 1.06A 2a15A-3vfdA:
undetectable		 2a15A-3vfdA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 155
ASP A 148
ILE A 379
LEU A 375
LEU A 198
 None
None
None
None
ANP  A 401 (-4.8A)
 1.05A 2a15A-3wigA:
undetectable		 2a15A-3wigA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi1 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		no annotation 5 TRP A 155
ILE A 253
LEU A 245
LEU A 217
LEU A 214
 None
 1.29A 2a15A-3zi1A:
undetectable		 2a15A-3zi1A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 VAL A 365
ILE A 370
LEU A 445
LEU A 401
LEU A 346
 None
 1.19A 2a15A-4cyjA:
undetectable		 2a15A-4cyjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER A 104
VAL A 263
LEU A 261
LEU A 392
LEU A 363
 None
 1.13A 2a15A-4dd5A:
undetectable		 2a15A-4dd5A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		5 VAL A 328
ILE A 322
LEU A 325
LEU A 386
LEU A 389
 None
None
None
0K3  A 501 (-3.5A)
0K3  A 501 (-4.5A)
 1.15A 2a15A-4de8A:
undetectable		 2a15A-4de8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 VAL B 661
ILE B 889
LEU B 620
LEU B 614
LEU B 628
 None
 1.29A 2a15A-4f92B:
undetectable		 2a15A-4f92B:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TRP A 306
VAL A 319
ILE A 365
LEU A 109
LEU A 113
 None
 1.26A 2a15A-4hnlA:
undetectable		 2a15A-4hnlA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrt HEMOGLOBIN B CHAIN

(Scapharca
inaequivalvis) 		PF00042
(Globin) 		5 SER B 142
VAL B 146
LEU B  92
LEU B  20
LEU B  86
 None
 1.21A 2a15A-4hrtB:
undetectable		 2a15A-4hrtB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		5 VAL B 200
ILE B  50
LEU B  53
LEU B  28
MET B 219
 None
 1.25A 2a15A-4hzuB:
undetectable		 2a15A-4hzuB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 VAL A 471
ILE A 418
LEU A 482
LEU A  78
LEU A  81
 None
 1.24A 2a15A-4lxfA:
undetectable		 2a15A-4lxfA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		6 SER B 203
VAL B 207
ILE B 222
LEU B 264
LEU B 231
LEU B 266
 None
 1.40A 2a15A-4mbgB:
undetectable		 2a15A-4mbgB:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 VAL A 620
ILE A 646
LEU A 622
LEU A 627
MET A 659
 None
 1.14A 2a15A-4nurA:
undetectable		 2a15A-4nurA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermoplasma
volcanium) 		PF14890
(Intein_splicing) 		5 VAL A 134
ILE A 137
LEU A 113
LEU A 165
LEU A  97
 None
 1.25A 2a15A-4o1sA:
undetectable		 2a15A-4o1sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Vibrio cholerae) 		PF00926
(DHBP_synthase) 		5 VAL A 138
ILE A 119
LEU A  69
LEU A  81
LEU A  71
 None
 1.24A 2a15A-4p8eA:
undetectable		 2a15A-4p8eA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 SER A 260
VAL A 150
ILE A 204
LEU A 199
LEU A 178
 None
 1.15A 2a15A-4q3rA:
undetectable		 2a15A-4q3rA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrp DD31 TCR ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 VAL D  94
LEU D  19
LEU D  53
LEU D  89
TYR D  45
 None
 1.30A 2a15A-4qrpD:
undetectable		 2a15A-4qrpD:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 VAL A 375
ILE A 401
LEU A 395
LEU A 358
LEU A 393
 None
 1.26A 2a15A-4rt6A:
undetectable		 2a15A-4rt6A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 VAL A 312
ILE A 322
LEU A 345
LEU A 334
LEU A 335
 None
 1.19A 2a15A-4rvhA:
undetectable		 2a15A-4rvhA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 VAL A 179
ILE A 151
LEU A 191
LEU A 172
LEU A 222
 None
 1.28A 2a15A-4w87A:
undetectable		 2a15A-4w87A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 VAL A 178
ILE A 214
LEU A 175
LEU A 139
LEU A 170
 None
 1.05A 2a15A-4x8fA:
undetectable		 2a15A-4x8fA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1

(Thermus
aquaticus) 		PF04563
(RNA_pol_Rpb2_1) 		5 VAL A 355
ILE A  54
LEU A  66
LEU A 367
LEU A 100
 None
 1.20A 2a15A-4xaxA:
1.1		 2a15A-4xaxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 VAL A 154
LEU A 151
LEU A 106
LEU A 127
MET A 120
 None
 1.09A 2a15A-4xgoA:
undetectable		 2a15A-4xgoA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		5 VAL A  95
ILE A 123
LEU A  97
LEU A 162
LEU A 131
 None
 1.29A 2a15A-4ymgA:
undetectable		 2a15A-4ymgA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 VAL A 257
TRP A 414
LEU A 298
LEU A 387
LEU A 302
 None
 1.02A 2a15A-4yweA:
undetectable		 2a15A-4yweA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		5 VAL A 381
ILE A 423
LEU A 425
LEU A 284
LEU A 283
 VAL  A 381 ( 0.6A)
ILE  A 423 ( 0.7A)
LEU  A 425 ( 0.6A)
LEU  A 284 ( 0.6A)
LEU  A 283 ( 0.6A)
 1.18A 2a15A-4zkeA:
undetectable		 2a15A-4zkeA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 SER A 164
VAL A 162
LEU A 105
LEU A 185
LEU A 141
 None
 1.29A 2a15A-5cm9A:
undetectable		 2a15A-5cm9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqw PUTATIVE MAJOR COAT
PROTEIN

(Acidianus
tailed spindle
virus) 		no annotation 5 VAL A  15
ILE A  18
LEU A  19
LEU A 111
LEU A 108
 None
 1.22A 2a15A-5eqwA:
undetectable		 2a15A-5eqwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmu TRAF3-INTERACTING
PROTEIN 1

(Mus musculus) 		PF10243
(MIP-T3) 		5 VAL A  42
ILE A  17
LEU A  13
LEU A 107
LEU A 108
 None
 1.30A 2a15A-5fmuA:
undetectable		 2a15A-5fmuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 TRP C 199
ILE C  81
LEU C 254
LEU C 224
LEU C 253
 None
 1.25A 2a15A-5g5gC:
undetectable		 2a15A-5g5gC:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h69 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF06470
(SMC_hinge) 		5 VAL A 607
ILE A 617
LEU A 621
LEU A 673
LEU A 542
 None
 1.23A 2a15A-5h69A:
undetectable		 2a15A-5h69A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14

(Staphylococcus
aureus;
synthetic
construct) 		PF02216
(B) 		5 VAL A 143
ILE A 156
LEU A 140
LEU A 100
LEU A 120
 None
 1.27A 2a15A-5h7cA:
undetectable		 2a15A-5h7cA:
13.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ier OHP9

(synthetic
construct) 		PF02136
(NTF2) 		5 TRP A  24
ILE A  64
LEU A  69
LEU A  89
TYR A 109
 3QZ  A 201 ( 4.5A)
3QZ  A 201 ( 4.4A)
3QZ  A 201 (-4.0A)
3QZ  A 201 ( 4.5A)
None
 0.91A 2a15A-5ierA:
25.3		 2a15A-5ierA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 5 VAL A  70
ILE A 105
LEU A 108
LEU A  62
LEU A  64
 None
 1.14A 2a15A-5ig9A:
undetectable		 2a15A-5ig9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 SER A 312
VAL A 317
LEU A 342
LEU A 397
LEU A 417
 None
 1.17A 2a15A-5kkgA:
undetectable		 2a15A-5kkgA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oak BAZOOKA, ISOFORM
C,LD29223P

(Drosophila
melanogaster) 		no annotation 5 VAL A  86
ILE A  11
LEU A  84
LEU A  75
LEU A  79
 None
 1.22A 2a15A-5oakA:
undetectable		 2a15A-5oakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l VIRAL PROTEIN 3

(Rhinovirus B) 		PF00073
(Rhv) 		5 VAL B 101
TRP B 107
ILE B  87
LEU B  97
LEU B  44
 None
 1.12A 2a15A-5w3lB:
undetectable		 2a15A-5w3lB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 VAL A 440
ILE A 387
LEU A 451
LEU A  43
LEU A  46
 None
 1.19A 2a15A-5ykbA:
undetectable		 2a15A-5ykbA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z3r STEROID
DELTA-ISOMERASE

(Mycolicibacterium
neoaurum) 		no annotation 8 SER A  20
TRP A  32
ASP A  44
ILE A  72
LEU A  77
LEU A  97
LEU A  99
TYR A 117
 None
 0.89A 2a15A-5z3rA:
24.7		 2a15A-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z3r STEROID
DELTA-ISOMERASE

(Mycolicibacterium
neoaurum) 		no annotation 6 TRP A  21
VAL A  24
TRP A  32
ILE A  72
LEU A  77
LEU A  97
 None
 1.37A 2a15A-5z3rA:
24.7		 2a15A-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z3r STEROID
DELTA-ISOMERASE

(Mycolicibacterium
neoaurum) 		no annotation 8 VAL A  24
TRP A  32
ASP A  44
ILE A  72
LEU A  77
LEU A  97
LEU A  99
TYR A 117
 None
 0.89A 2a15A-5z3rA:
24.7		 2a15A-5z3rA:
undetectable