SIMILAR PATTERNS OF AMINO ACIDS FOR 209D_C_DVAC8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 THR A 111
THR A 109
PRO A 107
 None
 0.64A 209dC-1cptA:
undetectable		 209dC-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0b SWI6 PROTEIN

(Schizosaccharomyces
pombe) 		PF01393
(Chromo_shadow) 		3 THR A 304
THR A 306
PRO A 302
 None
 0.86A 209dC-1e0bA:
undetectable		 209dC-1e0bA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 THR A   7
THR A   5
PRO A   8
 None
 0.87A 209dC-1eg1A:
undetectable		 209dC-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 THR B 766
THR B 768
PRO B 765
 None
 0.85A 209dC-1ffvB:
undetectable		 209dC-1ffvB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2a HYDROGENASE

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 THR S 128
THR S  80
PRO S  79
 None
 0.84A 209dC-1h2aS:
undetectable		 209dC-1h2aS:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  62
THR H  64
PRO H  60
 None
 0.74A 209dC-1h3pH:
undetectable		 209dC-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 THR A 199
THR A 166
PRO A 201
 None
 0.81A 209dC-1he3A:
undetectable		 209dC-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 THR A 199
THR A   7
PRO A   6
 None
 0.79A 209dC-1i1qA:
undetectable		 209dC-1i1qA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		3 THR A  70
THR A  84
PRO A  72
 None
 0.85A 209dC-1j3eA:
undetectable		 209dC-1j3eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 THR A  99
THR A  97
PRO A  95
 None
 0.72A 209dC-1jioA:
undetectable		 209dC-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 THR A 474
THR A 472
PRO A 471
 None
 0.87A 209dC-1lamA:
undetectable		 209dC-1lamA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		3 THR A 135
THR A 149
PRO A 137
 None
 0.82A 209dC-1lrrA:
undetectable		 209dC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		3 THR A  61
THR A  63
PRO A  60
 None
 0.85A 209dC-1nwaA:
undetectable		 209dC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 THR A 163
THR A 133
PRO A 165
 None
GDP  A1318 ( 4.9A)
None
 0.88A 209dC-1ofuA:
undetectable		 209dC-1ofuA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		3 THR A 243
THR A 245
PRO A 241
 None
 0.83A 209dC-1qyiA:
undetectable		 209dC-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		3 THR A1035
THR A1032
PRO A1034
 None
 0.70A 209dC-1ux6A:
undetectable		 209dC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A  37
THR A  36
PRO A  37
 None
 0.83A 209dC-1zlrA:
undetectable		 209dC-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zn6 PHAGE-RELATED
CONSERVED
HYPOTHETICAL PROTEIN

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		3 THR A 199
THR A 201
PRO A 197
 None
 0.87A 209dC-1zn6A:
undetectable		 209dC-1zn6A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 THR C 241
THR C  37
PRO C  36
 None
 0.88A 209dC-1zrtC:
undetectable		 209dC-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 THR A  25
THR A  23
PRO A  22
 None
 0.85A 209dC-2ad1A:
undetectable		 209dC-2ad1A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bht CYSTEINE SYNTHASE B

(Escherichia
coli) 		PF00291
(PALP) 		3 THR A 180
THR A 178
PRO A 147
 None
PLP  A 320 (-4.1A)
None
 0.88A 209dC-2bhtA:
undetectable		 209dC-2bhtA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1d SOXA

(Paracoccus
denitrificans) 		no annotation 3 THR A 243
THR A 233
PRO A 232
 None
HEC  A1292 ( 4.5A)
None
 0.86A 209dC-2c1dA:
undetectable		 209dC-2c1dA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 3 THR A  98
THR A 252
PRO A 100
 None
 0.67A 209dC-2cl2A:
undetectable		 209dC-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz0 V-SNARE COMPONENT OF
THE VACUOLAR SNARE
COMPLEX INVOLVED IN
VESICLE FUSION
INHIBITS
ATP-DEPENDENT CA(2+)
TRANSPORT ACTIVITY
OF PMC1P IN THE
VACUOLAR MEMBRANE
NYV1P

(Saccharomyces
cerevisiae) 		PF09426
(Nyv1_N) 		3 THR A  83
THR A  90
PRO A  88
 None
 0.80A 209dC-2fz0A:
undetectable		 209dC-2fz0A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		3 THR A 187
THR A 185
PRO A 154
 None
PLP  A 400 (-3.6A)
None
 0.84A 209dC-2isqA:
undetectable		 209dC-2isqA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		3 THR A  64
THR A  66
PRO A  63
 None
 0.85A 209dC-2v7zA:
undetectable		 209dC-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 THR A  71
THR A  42
PRO A  41
 None
 0.87A 209dC-2wqwA:
undetectable		 209dC-2wqwA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		3 THR A 470
THR A 468
PRO A 467
 None
 0.87A 209dC-2xutA:
undetectable		 209dC-2xutA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 THR A 845
THR A 961
PRO A 960
 None
 0.88A 209dC-2xvgA:
undetectable		 209dC-2xvgA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.75A 209dC-2z5xA:
undetectable		 209dC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		3 THR A 182
THR A 180
PRO A  38
 None
None
FAD  A 500 (-4.3A)
 0.85A 209dC-3djdA:
undetectable		 209dC-3djdA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		3 THR A 216
THR A 214
PRO A 212
 None
 0.80A 209dC-3drkA:
undetectable		 209dC-3drkA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		3 THR A 702
THR A 704
PRO A 700
 None
 0.77A 209dC-3fg6A:
undetectable		 209dC-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmt PROTEIN SEQA

(Escherichia
coli) 		PF03925
(SeqA)
PF17206
(SeqA_N) 		3 THR A 135
THR A 149
PRO A 137
 None
 0.81A 209dC-3fmtA:
undetectable		 209dC-3fmtA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		3 THR A  50
THR A  84
PRO A  48
 THR  A  50 ( 0.8A)
THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
 0.81A 209dC-3gleA:
undetectable		 209dC-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		3 THR A 147
THR A 166
PRO A 165
 None
 0.76A 209dC-3h1qA:
undetectable		 209dC-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 THR A 636
THR A 638
PRO A 635
 None
 0.73A 209dC-3ikmA:
undetectable		 209dC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens) 		PF00787
(PX) 		3 THR A 133
THR A 135
PRO A 132
 None
 0.88A 209dC-3iq2A:
undetectable		 209dC-3iq2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		3 THR A  64
THR A  17
PRO A  16
 None
 0.88A 209dC-3isrA:
undetectable		 209dC-3isrA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 US2

(Kluyveromyces
lactis) 		PF00318
(Ribosomal_S2) 		3 THR A 147
THR A 124
PRO A 126
 None
 0.87A 209dC-3j81A:
undetectable		 209dC-3j81A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		3 THR D 205
THR D 239
PRO D 204
 None
 0.77A 209dC-3k70D:
undetectable		 209dC-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.88A 209dC-3k9dA:
undetectable		 209dC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		3 THR A  20
THR A  22
PRO A  85
 None
 0.87A 209dC-3kh5A:
undetectable		 209dC-3kh5A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Nostoc
punctiforme) 		PF00903
(Glyoxalase) 		3 THR A  54
THR A  56
PRO A  52
 None
 0.79A 209dC-3kolA:
undetectable		 209dC-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		3 THR A  46
THR A  48
PRO A 195
 None
 0.85A 209dC-3krvA:
undetectable		 209dC-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR A 137
THR A 139
PRO A 136
 None
 0.87A 209dC-3lxmA:
undetectable		 209dC-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 THR A  53
THR A  51
PRO A  50
 None
 0.83A 209dC-3m9vA:
undetectable		 209dC-3m9vA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		3 THR A 377
THR A 375
PRO A 374
 None
 0.85A 209dC-3nvqA:
undetectable		 209dC-3nvqA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 THR A 127
THR A 129
PRO A 125
 None
 0.70A 209dC-3nz4A:
undetectable		 209dC-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		3 THR A 410
THR A 367
PRO A 366
 None
 0.73A 209dC-3p40A:
undetectable		 209dC-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 3 THR A 297
THR A 275
PRO A 299
 None
 0.76A 209dC-3picA:
undetectable		 209dC-3picA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		3 THR A 268
THR A 270
PRO A 266
 None
 0.72A 209dC-3q1yA:
undetectable		 209dC-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		3 THR A 477
THR A 140
PRO A 479
 None
 0.88A 209dC-3rh9A:
undetectable		 209dC-3rh9A:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		3 THR B 344
THR B 346
PRO B 342
 None
 0.72A 209dC-3sc2B:
undetectable		 209dC-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 THR A  15
THR A  13
PRO A  12
 None
 0.87A 209dC-3t79A:
undetectable		 209dC-3t79A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00132
(Hexapep) 		3 THR A   9
THR A  25
PRO A   4
 None
 0.88A 209dC-3vnpA:
undetectable		 209dC-3vnpA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 3 THR A  96
THR A 248
PRO A  98
 None
 0.74A 209dC-3wdyA:
undetectable		 209dC-3wdyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 THR A 421
THR A 423
PRO A 420
 None
 0.85A 209dC-4av6A:
undetectable		 209dC-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 3 THR A 295
THR A 297
PRO A 299
 None
 0.84A 209dC-4btpA:
undetectable		 209dC-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 THR A 650
THR A 647
PRO A 649
 None
 0.71A 209dC-4byfA:
undetectable		 209dC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		3 THR A 174
THR A 176
PRO A 173
 None
 0.85A 209dC-4eogA:
undetectable		 209dC-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 3 THR A 232
THR A 210
PRO A 234
 None
 0.78A 209dC-4g4iA:
undetectable		 209dC-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago
maydis;
Ustilago maydis) 		PF08661
(Rep_fac-A_3)
PF01336
(tRNA_anti-codon) 		3 THR B 102
THR A   5
PRO A   4
 None
 0.82A 209dC-4gnxB:
undetectable		 209dC-4gnxB:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 THR A 413
THR A 422
PRO A 421
 EDO  A 806 ( 4.2A)
None
EDO  A 806 ( 4.8A)
 0.83A 209dC-4hvtA:
undetectable		 209dC-4hvtA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4j ACP-POLYENE
THIOESTERASE

(Streptomyces
globisporus) 		PF13279
(4HBT_2) 		3 THR A 126
THR A 128
PRO A 124
 None
 0.84A 209dC-4i4jA:
undetectable		 209dC-4i4jA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 3 THR B 262
THR B 260
PRO B 229
 None
PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
 0.85A 209dC-4l27B:
undetectable		 209dC-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN

(Calotropis
procera) 		PF00314
(Thaumatin) 		3 THR A 187
THR A 189
PRO A 186
 None
 0.87A 209dC-4l2jA:
undetectable		 209dC-4l2jA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 THR A  35
THR A  61
PRO A  58
 None
 0.85A 209dC-4ldzA:
undetectable		 209dC-4ldzA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 310
THR A 308
PRO A 306
 None
 0.71A 209dC-4lmpA:
undetectable		 209dC-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqd DNA-ENTRY NUCLEASE
INHIBITOR

(Bacillus
subtilis) 		PF11033
(ComJ) 		3 THR A 112
THR A 124
PRO A 114
 None
 0.73A 209dC-4mqdA:
undetectable		 209dC-4mqdA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		3 THR A 200
THR A 202
PRO A 198
 None
 0.73A 209dC-4n8gA:
undetectable		 209dC-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		3 THR A 178
THR A 208
PRO A 176
 KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
 0.79A 209dC-4ov4A:
undetectable		 209dC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		3 THR A 257
THR A 259
PRO A 255
 None
 0.76A 209dC-4ovjA:
undetectable		 209dC-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		3 THR B  94
THR B  95
PRO B  93
 None
 0.77A 209dC-4uu9B:
undetectable		 209dC-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 THR A 303
THR A 305
PRO A 302
 None
 0.87A 209dC-4wzbA:
undetectable		 209dC-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)

(Chaetomium) 		PF13472
(Lipase_GDSL_2) 		3 THR A 288
THR A 285
PRO A 287
 None
 0.63A 209dC-4xvhA:
undetectable		 209dC-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		3 THR A 769
THR A 843
PRO A 849
 None
 0.87A 209dC-4zgvA:
undetectable		 209dC-4zgvA:
1.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 THR 1  68
THR 1  70
PRO 1 188
 None
 0.78A 209dC-5ac91:
undetectable		 209dC-5ac91:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2

(Saccharomyces
cerevisiae) 		PF16843
(Get5_bdg) 		3 THR D  21
THR D  23
PRO D  25
 None
 0.85A 209dC-5bw8D:
undetectable		 209dC-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		3 THR A 114
THR A 116
PRO A 113
 None
 0.79A 209dC-5bwyA:
undetectable		 209dC-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT

(Azospira oryzae) 		PF13247
(Fer4_11) 		3 THR B 252
THR B 141
PRO B 254
 SF4  B 403 ( 4.9A)
None
None
 0.81A 209dC-5e7oB:
undetectable		 209dC-5e7oB:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 THR A 393
THR A 390
PRO A 392
 None
 0.73A 209dC-5eodA:
undetectable		 209dC-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		3 THR A  28
THR A 151
PRO A 153
 None
 0.82A 209dC-5h5jA:
undetectable		 209dC-5h5jA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		3 THR A  66
THR A  64
PRO A  62
 None
 0.65A 209dC-5hasA:
undetectable		 209dC-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB

(Bacillus
subtilis) 		PF01638
(HxlR) 		3 THR A  41
THR A  39
PRO A  43
 None
 0.79A 209dC-5hs8A:
undetectable		 209dC-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 THR A 129
THR A 131
PRO A 147
 None
 0.88A 209dC-5i68A:
undetectable		 209dC-5i68A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		3 THR A 144
THR A 146
PRO A 143
 ACT  A1005 (-3.3A)
None
ACT  A1005 (-3.9A)
 0.86A 209dC-5j78A:
undetectable		 209dC-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		3 THR L  22
THR L  24
PRO L  21
 None
 0.88A 209dC-5lj3L:
undetectable		 209dC-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus) 		PF03026
(CM1) 		3 THR A  23
THR A  21
PRO A  19
 None
 0.85A 209dC-5m1mA:
undetectable		 209dC-5m1mA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 3 THR A  75
THR A  77
PRO A 255
 None
 0.83A 209dC-5nmpA:
undetectable		 209dC-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4

(Homo sapiens) 		no annotation 3 THR D 386
THR D 388
PRO D 385
 None
 0.83A 209dC-5of4D:
undetectable		 209dC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR B 129
THR B 131
PRO B 127
 None
 0.72A 209dC-5tteB:
undetectable		 209dC-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR A 129
THR A 131
PRO A 127
 None
 0.85A 209dC-5udhA:
undetectable		 209dC-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 3 THR A   7
THR A   5
PRO A   8
 THR  A   7 ( 0.8A)
THR  A   5 ( 0.8A)
PRO  A   8 ( 1.1A)
 0.87A 209dC-5w0aA:
undetectable		 209dC-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		3 THR A 505
THR A 502
PRO A 504
 None
 0.80A 209dC-5w1uA:
undetectable		 209dC-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		3 THR A 347
THR A 345
PRO A 343
 None
 0.83A 209dC-5x5hA:
undetectable		 209dC-5x5hA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		3 THR A 212
THR A 210
PRO A 209
 None
 0.82A 209dC-5xfaA:
undetectable		 209dC-5xfaA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR

(Escherichia
coli) 		no annotation 3 THR A  14
THR A  12
PRO A  11
 None
 0.87A 209dC-6ayiA:
undetectable		 209dC-6ayiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 3 THR A 821
THR A 973
PRO A 956
 None
 0.82A 209dC-6bhvA:
undetectable		 209dC-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 THR A1086
THR A1051
PRO A1050
 None
 0.88A 209dC-6eojA:
undetectable		 209dC-6eojA:
1.20