SIMILAR PATTERNS OF AMINO ACIDS FOR 209D_C_DVAC2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		3 THR A 192
PRO A 194
THR A 217
 None
 0.79A 209dC-1cj2A:
undetectable		 209dC-1cj2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 THR A 109
PRO A 107
THR A 111
 None
 0.71A 209dC-1cptA:
undetectable		 209dC-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 THR A  59
PRO A  57
THR A  61
 None
 0.62A 209dC-1ethA:
undetectable		 209dC-1ethA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		3 THR A 162
PRO A 151
THR A 149
 None
 0.76A 209dC-1gq7A:
undetectable		 209dC-1gq7A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		3 THR A 115
PRO A 109
THR A 113
 None
 0.80A 209dC-1gz4A:
undetectable		 209dC-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		3 THR A  56
PRO A  54
THR A  58
 None
 0.70A 209dC-1h0pA:
undetectable		 209dC-1h0pA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  64
PRO H  60
THR H  62
 None
 0.80A 209dC-1h3pH:
undetectable		 209dC-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 THR A 166
PRO A 201
THR A 199
 None
 0.77A 209dC-1he3A:
undetectable		 209dC-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 THR A 189
PRO A 187
THR A 191
 None
 0.79A 209dC-1hxjA:
undetectable		 209dC-1hxjA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k94 GRANCALCIN

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		3 THR A 159
PRO A 157
THR A 161
 None
 0.80A 209dC-1k94A:
undetectable		 209dC-1k94A:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 THR C 504
PRO C 502
THR C 506
 None
 0.62A 209dC-1o7dC:
undetectable		 209dC-1o7dC:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 307
PRO A 305
THR A 309
 None
 0.64A 209dC-1pjbA:
undetectable		 209dC-1pjbA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		3 THR A 501
PRO A 499
THR A 503
 GOL  A 906 (-2.8A)
SO4  A 709 (-3.8A)
None
 0.79A 209dC-1qsaA:
undetectable		 209dC-1qsaA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twu HYPOTHETICAL PROTEIN
YYCE

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		3 THR A  71
PRO A  73
THR A  19
 None
 0.77A 209dC-1twuA:
undetectable		 209dC-1twuA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 212
PRO A 210
THR A 214
 None
DCS  A 401 (-4.9A)
None
 0.78A 209dC-1vftA:
undetectable		 209dC-1vftA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 THR A 256
PRO A 254
THR A 258
 None
 0.81A 209dC-1yb4A:
undetectable		 209dC-1yb4A:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 3 THR A 252
PRO A 100
THR A  98
 None
 0.81A 209dC-2cl2A:
undetectable		 209dC-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		3 THR A 204
PRO A 202
THR A 206
 None
 0.75A 209dC-2d4eA:
undetectable		 209dC-2d4eA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 306
PRO A 304
THR A 308
 None
 0.71A 209dC-2eezA:
undetectable		 209dC-2eezA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw5 DHC, DIHEME
CYTOCHROME C

(Rhodobacter
sphaeroides) 		PF09626
(DHC) 		3 THR A  20
PRO A  18
THR A  22
 None
 0.75A 209dC-2fw5A:
undetectable		 209dC-2fw5A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwt DHC, DIHEME
CYTOCHROME C

(Rhodobacter
sphaeroides) 		PF09626
(DHC) 		3 THR A  20
PRO A  18
THR A  22
 None
 0.67A 209dC-2fwtA:
undetectable		 209dC-2fwtA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz0 V-SNARE COMPONENT OF
THE VACUOLAR SNARE
COMPLEX INVOLVED IN
VESICLE FUSION
INHIBITS
ATP-DEPENDENT CA(2+)
TRANSPORT ACTIVITY
OF PMC1P IN THE
VACUOLAR MEMBRANE
NYV1P

(Saccharomyces
cerevisiae) 		PF09426
(Nyv1_N) 		3 THR A  90
PRO A  88
THR A  83
 None
 0.77A 209dC-2fz0A:
undetectable		 209dC-2fz0A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8d UNCHARACTERIZED
CONSERVED PROTEIN OF
COG5646

(Lactobacillus
casei) 		PF08818
(DUF1801) 		3 THR A  70
PRO A  68
THR A  72
 None
 0.80A 209dC-2i8dA:
undetectable		 209dC-2i8dA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		3 THR A 185
PRO A 154
THR A 187
 PLP  A 400 (-3.6A)
None
None
 0.80A 209dC-2isqA:
undetectable		 209dC-2isqA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF08327
(AHSA1) 		3 THR A  66
PRO A  68
THR A  71
 None
 0.67A 209dC-2ldkA:
undetectable		 209dC-2ldkA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqj MG2+ TRANSPORT
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 THR A 192
PRO A 185
THR A 183
 None
 0.79A 209dC-2lqjA:
undetectable		 209dC-2lqjA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 THR A 546
PRO A 544
THR A 548
 None
 0.76A 209dC-2nq5A:
undetectable		 209dC-2nq5A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 THR A 184
PRO A 186
THR A 188
 None
 0.75A 209dC-2okxA:
undetectable		 209dC-2okxA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00483
(NTP_transferase) 		3 THR A  30
PRO A  34
THR A  32
 None
 0.82A 209dC-2pa4A:
undetectable		 209dC-2pa4A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 3 THR A 674
PRO A 672
THR A 676
 None
 0.72A 209dC-2po4A:
undetectable		 209dC-2po4A:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		3 THR A  16
PRO A  14
THR A  18
 None
 0.77A 209dC-2qv6A:
undetectable		 209dC-2qv6A:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		3 THR A 115
PRO A  41
THR A 117
 None
 0.82A 209dC-2qzwA:
undetectable		 209dC-2qzwA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		3 THR A 699
PRO A 697
THR A 701
 None
 0.82A 209dC-2r6fA:
undetectable		 209dC-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgv PSIV CAPSID
N-TERMINAL DOMAIN

(Microcebus
murinus) 		PF00607
(Gag_p24) 		3 THR A  36
PRO A  34
THR A  38
 None
 0.69A 209dC-2xgvA:
undetectable		 209dC-2xgvA:
8.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xgy RELIK CAPSID
N-TERMINAL DOMAIN

(Oryctolagus
cuniculus) 		PF00607
(Gag_p24) 		3 THR A  36
PRO A  34
THR A  38
 None
 0.76A 209dC-2xgyA:
undetectable		 209dC-2xgyA:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.82A 209dC-2z5xA:
undetectable		 209dC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adk ADENYLATE KINASE

(Sus scrofa) 		PF00406
(ADK) 		3 THR A 124
PRO A 122
THR A 126
 None
 0.78A 209dC-3adkA:
undetectable		 209dC-3adkA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		3 THR A 178
PRO A 176
THR A 180
 CL  A 275 (-3.2A)
None
None
 0.65A 209dC-3b8bA:
undetectable		 209dC-3b8bA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 3 THR A 378
PRO A 376
THR A 380
 None
 0.72A 209dC-3c2qA:
undetectable		 209dC-3c2qA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		3 THR A 236
PRO A 240
THR A 238
 None
 0.66A 209dC-3cskA:
undetectable		 209dC-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		3 THR A 252
PRO A 250
THR A 254
 None
 0.78A 209dC-3cswA:
undetectable		 209dC-3cswA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dde TENA/THI-4 PROTEIN,
DOMAIN OF UNKNOWN
FUNCTION WITH A HEME
OXYGENASE-LIKE FOLD

(Shewanella
denitrificans) 		PF14518
(Haem_oxygenas_2) 		3 THR A 113
PRO A 111
THR A 115
 None
 0.78A 209dC-3ddeA:
undetectable		 209dC-3ddeA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
mutans) 		PF00156
(Pribosyltran) 		3 THR A  48
PRO A  46
THR A  50
 None
 0.69A 209dC-3dezA:
undetectable		 209dC-3dezA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 THR A 136
PRO A 134
THR A 138
 None
 0.62A 209dC-3djlA:
undetectable		 209dC-3djlA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 THR A 201
PRO A 203
THR A 314
 None
 0.70A 209dC-3g05A:
undetectable		 209dC-3g05A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 THR A 265
PRO A 263
THR A 267
 None
IMD  A 503 (-4.3A)
None
 0.79A 209dC-3l07A:
undetectable		 209dC-3l07A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		3 THR A 111
PRO A 133
THR A 131
 None
 0.82A 209dC-3luyA:
undetectable		 209dC-3luyA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 THR A 129
PRO A 125
THR A 127
 None
 0.72A 209dC-3nz4A:
undetectable		 209dC-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		3 THR A 103
PRO A 101
THR A 105
 None
 0.76A 209dC-3paoA:
undetectable		 209dC-3paoA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		3 THR A 110
PRO A 108
THR A 112
 None
 0.78A 209dC-3pcoA:
undetectable		 209dC-3pcoA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pct CLASS C ACID
PHOSPHATASE

(Pasteurella
multocida) 		PF03767
(Acid_phosphat_B) 		3 THR A  89
PRO A  87
THR A  91
 None
 0.80A 209dC-3pctA:
undetectable		 209dC-3pctA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		3 THR A 270
PRO A 266
THR A 268
 None
 0.68A 209dC-3q1yA:
undetectable		 209dC-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s06 MOTILITY PROTEIN B

(Helicobacter
pylori) 		PF00691
(OmpA) 		3 THR A  96
PRO A  94
THR A  98
 None
 0.80A 209dC-3s06A:
undetectable		 209dC-3s06A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		3 THR B 346
PRO B 342
THR B 344
 None
 0.65A 209dC-3sc2B:
undetectable		 209dC-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 THR A  83
PRO A  81
THR A  85
 CL  A 404 ( 4.9A)
CL  A 404 (-3.9A)
None
 0.76A 209dC-3thuA:
undetectable		 209dC-3thuA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		3 THR A 716
PRO A 714
THR A 718
 None
 0.65A 209dC-3zqjA:
undetectable		 209dC-3zqjA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 THR A 421
PRO A 419
THR A 423
 None
 0.72A 209dC-4av6A:
undetectable		 209dC-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 THR A 265
PRO A 263
THR A 267
 None
EDO  A1286 (-4.3A)
None
 0.70A 209dC-4b4uA:
undetectable		 209dC-4b4uA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz1 KYNURENINE
FORMAMIDASE

(Bacillus
anthracis) 		PF04199
(Cyclase) 		3 THR A  53
PRO A 201
THR A  51
 None
 0.78A 209dC-4cz1A:
undetectable		 209dC-4cz1A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A

(Escherichia
coli) 		PF03749
(SfsA) 		3 THR A  66
PRO A  64
THR A  55
 None
 0.81A 209dC-4dapA:
undetectable		 209dC-4dapA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyv SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF00106
(adh_short) 		3 THR A 178
PRO A 176
THR A 180
 CL  A 301 ( 4.0A)
None
None
 0.80A 209dC-4dyvA:
undetectable		 209dC-4dyvA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 248
PRO A 252
THR A 250
 None
 0.77A 209dC-4dzaA:
undetectable		 209dC-4dzaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex5 LYSINE--TRNA LIGASE

(Burkholderia
thailandensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 THR A 179
PRO A 177
THR A 181
 None
 0.79A 209dC-4ex5A:
undetectable		 209dC-4ex5A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		3 THR A 150
PRO A 148
THR A 152
 None
 0.68A 209dC-4fdaA:
undetectable		 209dC-4fdaA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		3 THR A 142
PRO A 140
THR A 144
 None
 0.80A 209dC-4gvlA:
undetectable		 209dC-4gvlA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		3 THR A 142
PRO A 140
THR A 144
 None
 0.78A 209dC-4gx0A:
undetectable		 209dC-4gx0A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		3 THR A  70
PRO A  68
THR A  72
 None
 0.74A 209dC-4i6nA:
undetectable		 209dC-4i6nA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		PF08210
(APOBEC_N) 		3 THR A -19
PRO A -21
THR A -17
 None
 0.72A 209dC-4j4jA:
undetectable		 209dC-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 THR A  84
PRO A  82
THR A  86
 CL  A 503 ( 4.8A)
CL  A 503 (-3.9A)
None
 0.74A 209dC-4kwsA:
undetectable		 209dC-4kwsA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 3 THR B 260
PRO B 229
THR B 262
 PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
None
 0.77A 209dC-4l27B:
undetectable		 209dC-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		3 THR A 611
PRO A 609
THR A 613
 HEC  A 810 (-3.9A)
None
HEC  A 808 (-4.6A)
 0.72A 209dC-4lm8A:
undetectable		 209dC-4lm8A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 308
PRO A 306
THR A 310
 None
 0.62A 209dC-4lmpA:
undetectable		 209dC-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4r EPHRIN TYPE-A
RECEPTOR 4

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		3 THR A 453
PRO A 536
THR A 534
 None
 0.80A 209dC-4m4rA:
undetectable		 209dC-4m4rA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n80 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 THR A 175
PRO A 173
THR A 177
 None
 0.76A 209dC-4n80A:
undetectable		 209dC-4n80A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		3 THR A 202
PRO A 198
THR A 200
 None
 0.73A 209dC-4n8gA:
undetectable		 209dC-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		3 THR C  31
PRO C  29
THR C  33
 None
 0.69A 209dC-4p74C:
undetectable		 209dC-4p74C:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		3 THR A 117
PRO A 115
THR A 133
 None
 0.78A 209dC-4q2hA:
undetectable		 209dC-4q2hA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		3 THR A 258
PRO A 256
THR A 260
 None
 0.69A 209dC-4q3lA:
undetectable		 209dC-4q3lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE

(Pseudomonas
putida) 		PF00296
(Bac_luciferase) 		3 THR A 326
PRO A 324
THR A 328
 None
 0.70A 209dC-4uwmA:
undetectable		 209dC-4uwmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		3 THR A  42
PRO A  40
THR A  44
 None
 0.65A 209dC-4xmrA:
undetectable		 209dC-4xmrA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		3 THR A 843
PRO A 849
THR A 769
 None
 0.74A 209dC-4zgvA:
undetectable		 209dC-4zgvA:
1.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 THR 1  70
PRO 1 188
THR 1  68
 None
 0.69A 209dC-5ac91:
undetectable		 209dC-5ac91:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox) 		3 THR A 647
PRO A 645
THR A 649
 None
 0.74A 209dC-5apaA:
undetectable		 209dC-5apaA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 THR A 145
PRO A 143
THR A 147
 MRD  A 601 (-3.7A)
None
None
 0.64A 209dC-5ez3A:
undetectable		 209dC-5ez3A:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 225
PRO A 223
THR A 227
 None
 0.71A 209dC-5facA:
undetectable		 209dC-5facA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		3 THR A 206
PRO A 204
THR A 208
 None
 0.81A 209dC-5fjnA:
undetectable		 209dC-5fjnA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		3 THR A 517
PRO A 515
THR A 519
 None
 0.81A 209dC-5fn4A:
undetectable		 209dC-5fn4A:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		3 THR A 100
PRO A  98
THR A 102
 None
 0.74A 209dC-5fubA:
undetectable		 209dC-5fubA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		3 THR A  64
PRO A  62
THR A  66
 None
 0.55A 209dC-5hasA:
undetectable		 209dC-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB

(Bacillus
subtilis) 		PF01638
(HxlR) 		3 THR A  39
PRO A  43
THR A  41
 None
 0.78A 209dC-5hs8A:
undetectable		 209dC-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		3 THR A 647
PRO A 645
THR A 649
 None
 0.76A 209dC-5jz8A:
undetectable		 209dC-5jz8A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus) 		PF03026
(CM1) 		3 THR A  21
PRO A  19
THR A  23
 None
 0.69A 209dC-5m1mA:
undetectable		 209dC-5m1mA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 THR A  85
PRO A  83
THR A  87
 None
 0.66A 209dC-5mchA:
undetectable		 209dC-5mchA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo sapiens) 		no annotation 3 THR A 197
PRO A 195
THR A 199
 None
 0.68A 209dC-5sxgA:
undetectable		 209dC-5sxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR B 131
PRO B 127
THR B 129
 None
 0.66A 209dC-5tteB:
undetectable		 209dC-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubc PROTEIN TOC75-3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 THR A 231
PRO A 233
THR A 236
 None
 0.78A 209dC-5ubcA:
undetectable		 209dC-5ubcA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 3 THR A 189
PRO A 187
THR A 191
 None
 0.77A 209dC-5zmyA:
undetectable		 209dC-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ama PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
venezuelae) 		no annotation 3 THR A  27
PRO A  25
THR A  29
 None
 0.77A 209dC-6amaA:
undetectable		 209dC-6amaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE

(Helicobacter
pylori) 		no annotation 3 THR A  15
PRO A  13
THR A  17
 F5D  A 301 (-4.0A)
None
None
 0.72A 209dC-6ck0A:
undetectable		 209dC-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 THR A1042
PRO A1040
THR A1044
 None
 0.74A 209dC-6emkA:
undetectable		 209dC-6emkA:
undetectable