SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZZU_A_MTLA870_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		4 ARG A 351
GLN A 393
ASN A 352
TRP A 392
 None
 1.27A 1zzuA-1de6A:
0.0		 1zzuA-1de6A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		4 ASN A 211
GLN A 216
PHE A 214
ASN A 101
 None
 1.29A 1zzuA-1iw8A:
0.0		 1zzuA-1iw8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k61 MATING-TYPE PROTEIN
ALPHA-2

(Saccharomyces
cerevisiae) 		PF00046
(Homeobox) 		4 ARG A 184
PHE A 148
ASN A 154
TRP A 147
 None
 1.21A 1zzuA-1k61A:
2.8		 1zzuA-1k61A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkt TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09008
(Head_binding) 		4 SER A  20
ARG A  21
GLN A  99
ASP A 101
 None
 1.19A 1zzuA-1lktA:
0.0		 1zzuA-1lktA:
11.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		7 ARG A 481
ASN A 498
GLN A 500
PHE A 501
ASN A 569
ASP A 709
TRP A 711
 None
 0.38A 1zzuA-1lzxA:
63.6		 1zzuA-1lzxA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		6 SER A 477
ARG A 481
ASN A 498
GLN A 500
PHE A 501
ASN A 569
 None
 0.70A 1zzuA-1lzxA:
63.6		 1zzuA-1lzxA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 ARG A 250
ASN A 267
ASN A 338
ASP A 478
TRP A 480
 None
 0.57A 1zzuA-1m9qA:
59.3		 1zzuA-1m9qA:
65.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 SER A 246
ARG A 250
ASN A 267
ASN A 338
 None
 0.67A 1zzuA-1m9qA:
59.3		 1zzuA-1m9qA:
65.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.19A 1zzuA-1olpA:
0.0		 1zzuA-1olpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oul STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.03A 1zzuA-1oulA:
0.0		 1zzuA-1oulA:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 SER A 256
ARG A 260
PHE A 280
TRP A 490
 None
 0.79A 1zzuA-1qw5A:
57.8		 1zzuA-1qw5A:
63.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 SER A 256
PHE A 280
ASN A 348
TRP A 490
 None
 0.70A 1zzuA-1qw5A:
57.8		 1zzuA-1qw5A:
63.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twb STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.03A 1zzuA-1twbA:
undetectable		 1zzuA-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.25A 1zzuA-1uwyA:
undetectable		 1zzuA-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 SER A  50
GLN A 180
PHE A 181
ASN A  31
 None
 1.06A 1zzuA-1wraA:
undetectable		 1zzuA-1wraA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.31A 1zzuA-1yvlA:
undetectable		 1zzuA-1yvlA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 SER A 321
GLN A 329
PHE A 326
ASN A 320
 None
 1.24A 1zzuA-1z3vA:
undetectable		 1zzuA-1z3vA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 SER A 124
ARG A 103
PHE A 105
ASN A 125
 None
 1.24A 1zzuA-2aj4A:
undetectable		 1zzuA-2aj4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		4 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.13A 1zzuA-2aqwA:
undetectable		 1zzuA-2aqwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 SER A  25
GLN A 155
PHE A 156
ASN A   6
 None
 1.10A 1zzuA-2bibA:
undetectable		 1zzuA-2bibA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 0.97A 1zzuA-2ckrA:
0.7		 1zzuA-2ckrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.28A 1zzuA-2d1gA:
0.5		 1zzuA-2d1gA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy8 CHROMO DOMAIN
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00385
(Chromo) 		4 ARG A 341
GLN A 334
PHE A 338
ASN A 340
 None
 1.34A 1zzuA-2dy8A:
undetectable		 1zzuA-2dy8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A 261
GLN A 210
PHE A 211
ASP A 258
 None
 1.24A 1zzuA-2e5vA:
undetectable		 1zzuA-2e5vA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		4 ASN A  20
PHE A  21
ASN A  66
ASP A  65
 None
 1.27A 1zzuA-2h4uA:
undetectable		 1zzuA-2h4uA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		4 SER A 117
ARG A 133
ASN A  87
ASP A 119
 None
 1.11A 1zzuA-2h4uA:
undetectable		 1zzuA-2h4uA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iak BULLOUS PEMPHIGOID
ANTIGEN 1, ISOFORM 5

(Mus musculus) 		PF00435
(Spectrin) 		4 ARG A 128
ASN A 124
PHE A 125
ASN A 131
 None
 1.34A 1zzuA-2iakA:
undetectable		 1zzuA-2iakA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxy MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin) 		4 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.10A 1zzuA-2jxyA:
undetectable		 1zzuA-2jxyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcy 30S RIBOSOMAL
PROTEIN S8E

(Methanothermobacter
thermautotrophicus) 		PF01201
(Ribosomal_S8e) 		4 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 0.99A 1zzuA-2kcyA:
undetectable		 1zzuA-2kcyA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfs UNCHARACTERIZED
PROTEIN, OSMOLARITY
SENSOR PROTEIN ENVZ
CHIMERA

(Shigella
flexneri;
Archaeoglobus
fulgidus) 		PF00512
(HisKA)
PF00672
(HAMP) 		4 SER A 288
PHE A 291
ASN A 289
ASP A 292
 None
 1.35A 1zzuA-2lfsA:
undetectable		 1zzuA-2lfsA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN
H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U BETA
CHAIN

(Mus musculus;
Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set)
PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 SER A 144
ARG B 134
GLN A  88
ASP A 110
 None
 1.11A 1zzuA-2p24A:
undetectable		 1zzuA-2p24A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjv UNCHARACTERIZED
IOLB-LIKE PROTEIN

(Salmonella
enterica) 		PF04962
(KduI) 		4 ARG A 190
ASN A 217
GLN A 195
PHE A 191
 SO4  A 277 (-3.2A)
SO4  A 277 (-3.5A)
None
None
 1.05A 1zzuA-2qjvA:
undetectable		 1zzuA-2qjvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9

(Homo sapiens) 		PF06821
(Ser_hydrolase) 		4 SER A  97
GLN A 167
PHE A 166
ASP A 138
 None
 1.34A 1zzuA-2qs9A:
undetectable		 1zzuA-2qs9A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA

(Mycobacterium
tuberculosis) 		PF16708
(LppA) 		4 GLN A  99
PHE A  92
ASN A 186
ASP A 102
 None
GOL  A1209 (-4.5A)
None
None
 1.17A 1zzuA-2v7sA:
undetectable		 1zzuA-2v7sA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 SER A 225
ARG A 216
GLN A 229
ASN A 242
 None
 1.20A 1zzuA-2vgiA:
1.2		 1zzuA-2vgiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vra ROUNDABOUT 1

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 ARG A 117
ASN A  70
GLN A 120
ASP A 126
 None
None
SO4  A1253 ( 3.8A)
None
 1.35A 1zzuA-2vraA:
undetectable		 1zzuA-2vraA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		4 SER A 475
ASN A 446
GLN A 444
ASN A 476
 NAG  A 676 (-4.5A)
NAG  A 646 (-2.5A)
None
NAG  A 676 (-2.5A)
 1.25A 1zzuA-2xrcA:
undetectable		 1zzuA-2xrcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dal PR DOMAIN ZINC
FINGER PROTEIN 1

(Homo sapiens) 		PF00856
(SET) 		4 ARG A  75
PHE A  76
ASN A  26
ASP A  27
 None
 1.31A 1zzuA-3dalA:
undetectable		 1zzuA-3dalA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.03A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 0.92A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 SER A 242
ASN A 208
ASN A 370
TRP A 194
 HEM  A 901 (-3.2A)
None
None
HEM  A 901 (-3.3A)
 1.33A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5o THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		4 SER A 117
ARG A 133
ASN A  87
ASP A 119
 None
 1.11A 1zzuA-3f5oA:
undetectable		 1zzuA-3f5oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 SER B 744
ARG B 747
ASN B 741
ASP B 907
 None
 1.23A 1zzuA-3hkzB:
undetectable		 1zzuA-3hkzB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 SER A 344
ARG A 378
PHE A 225
ASP A 222
 None
None
None
EDO  A 514 ( 3.9A)
 1.35A 1zzuA-3icfA:
undetectable		 1zzuA-3icfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.14A 1zzuA-3ihvA:
undetectable		 1zzuA-3ihvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 ASN A 281
GLN A 274
ASN A  53
ASP A  51
 None
 1.21A 1zzuA-3ij6A:
undetectable		 1zzuA-3ij6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 SER A 109
ARG A 112
ASN A 289
PHE A 294
TRP A 239
 None
 1.32A 1zzuA-3ix1A:
undetectable		 1zzuA-3ix1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		4 ARG A 305
GLN A 192
PHE A 302
ASN A 304
 None
 1.34A 1zzuA-3khzA:
undetectable		 1zzuA-3khzA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 SER A 390
ASN A 381
GLN A 385
PHE A 273
 None
 1.16A 1zzuA-3kieA:
undetectable		 1zzuA-3kieA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 345
ARG A 318
GLN A 428
ASN A 344
 None
 1.17A 1zzuA-3mosA:
undetectable		 1zzuA-3mosA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 0.97A 1zzuA-3nvlA:
undetectable		 1zzuA-3nvlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		4 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.96A 1zzuA-3otxA:
undetectable		 1zzuA-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1

(Homo sapiens) 		PF03031
(NIF) 		4 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 0.99A 1zzuA-3pglA:
undetectable		 1zzuA-3pglA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbt RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		4 ASN A 126
GLN A 130
ASN A 121
ASP A  89
 None
None
GNP  A 200 (-3.5A)
None
 1.13A 1zzuA-3qbtA:
undetectable		 1zzuA-3qbtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 SER A 393
ASN A 384
GLN A 388
PHE A 276
 None
 1.22A 1zzuA-3ra2A:
undetectable		 1zzuA-3ra2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 SER A 391
ASN A 382
GLN A 386
PHE A 274
 None
 1.19A 1zzuA-3shmA:
undetectable		 1zzuA-3shmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t24 PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.25A 1zzuA-3t24A:
undetectable		 1zzuA-3t24A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ASN A 175
GLN A 171
PHE A 170
ASN A 303
 None
 1.12A 1zzuA-3to3A:
undetectable		 1zzuA-3to3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		4 ARG A 490
ASN A 534
GLN A 528
ASP A 530
 None
 1.35A 1zzuA-3u7vA:
undetectable		 1zzuA-3u7vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 SER A 392
ASN A 383
GLN A 387
PHE A 275
 None
 1.16A 1zzuA-3ux1A:
undetectable		 1zzuA-3ux1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 SER A 307
ASN A 627
ASN A 306
ASP A 303
 None
 1.34A 1zzuA-4am6A:
undetectable		 1zzuA-4am6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 SER A  21
ASN A  47
PHE A  46
ASN A 273
 None
 1.35A 1zzuA-4e8dA:
undetectable		 1zzuA-4e8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ARG B1375
ASN B1444
GLN B1446
ASN B1449
 None
 1.18A 1zzuA-4f92B:
undetectable		 1zzuA-4f92B:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ASN B 912
GLN B 980
PHE B 979
ASP B 973
 None
 1.12A 1zzuA-4f92B:
undetectable		 1zzuA-4f92B:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		4 ASN A 190
GLN A 194
PHE A 192
TRP A 209
 None
 1.32A 1zzuA-4gl3A:
undetectable		 1zzuA-4gl3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.21A 1zzuA-4ineA:
undetectable		 1zzuA-4ineA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oi3 NICKEL RESPONSIVE
PROTEIN

(Streptomyces
coelicolor) 		PF14026
(DUF4242) 		4 SER A  53
GLN A  62
PHE A   4
ASP A   6
 None
 1.15A 1zzuA-4oi3A:
undetectable		 1zzuA-4oi3A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.19A 1zzuA-4pviA:
undetectable		 1zzuA-4pviA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 SER A 212
ARG A 215
GLN A 180
PHE A 181
 None
 1.05A 1zzuA-4q38A:
undetectable		 1zzuA-4q38A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 ASN A 292
PHE A 548
ASN A 610
ASP A 547
 CD  A 909 (-4.6A)
None
None
None
 1.19A 1zzuA-4qi4A:
undetectable		 1zzuA-4qi4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 ASN A 292
PHE A 548
ASN A 610
ASP A 547
 None
 1.08A 1zzuA-4qi6A:
undetectable		 1zzuA-4qi6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF01194
(RNA_pol_N) 		4 SER B 746
ARG B 749
PHE N   8
ASP B 911
 None
 1.13A 1zzuA-4qiwB:
undetectable		 1zzuA-4qiwB:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		4 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.30A 1zzuA-4r3fA:
undetectable		 1zzuA-4r3fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 SER A 392
ASN A 383
GLN A 387
PHE A 275
 None
 1.17A 1zzuA-4rsoA:
undetectable		 1zzuA-4rsoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)

([Eubacterium]
rectale) 		PF13416
(SBP_bac_8) 		4 GLN A 394
PHE A 189
ASN A 191
ASP A 190
 EDO  A 504 (-3.3A)
None
ACR  A 501 (-3.3A)
EDO  A 504 ( 4.2A)
 1.20A 1zzuA-4uacA:
undetectable		 1zzuA-4uacA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.18A 1zzuA-4yzzA:
undetectable		 1zzuA-4yzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.20A 1zzuA-5a08A:
undetectable		 1zzuA-5a08A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 GLN A 202
PHE A  67
ASN A  38
ASP A  76
 None
 1.19A 1zzuA-5bnzA:
undetectable		 1zzuA-5bnzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c00 MDBA PROTEIN

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		4 GLN A 163
PHE A  89
ASN A 122
ASP A  88
 None
 1.31A 1zzuA-5c00A:
undetectable		 1zzuA-5c00A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ARG B 898
GLN B 909
ASN B 893
ASP B 910
 None
 1.28A 1zzuA-5dlqB:
undetectable		 1zzuA-5dlqB:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb2 YFIR

(Pseudomonas
aeruginosa) 		PF13689
(DUF4154) 		4 SER A 168
ARG A 171
PHE A 127
ASN A 165
 None
 1.14A 1zzuA-5eb2A:
undetectable		 1zzuA-5eb2A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 ASN A  72
GLN A  74
PHE A  75
ASN A 288
 None
 1.12A 1zzuA-5ejjA:
undetectable		 1zzuA-5ejjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus) 		PF02668
(TauD) 		4 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 0.89A 1zzuA-5eqnA:
1.2		 1zzuA-5eqnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		4 ARG A 277
ASN A  63
GLN A  66
ASP A  54
 None
 1.33A 1zzuA-5g0aA:
undetectable		 1zzuA-5g0aA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.31A 1zzuA-5i4eA:
undetectable		 1zzuA-5i4eA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 SER A 119
ARG A 254
ASN A 252
ASP A 226
 None
 1.06A 1zzuA-5imwA:
undetectable		 1zzuA-5imwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 GLN A 130
PHE A 198
ASN A 195
ASP A 132
 None
 1.32A 1zzuA-5jm0A:
undetectable		 1zzuA-5jm0A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 SER A 319
ARG A 144
ASN A 320
ASP A  37
 None
 1.31A 1zzuA-5kc9A:
undetectable		 1zzuA-5kc9A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lii MAJOR CAPSID PROTEIN

(Staphylococcus
phage 812) 		no annotation 4 ASN P 247
GLN P 237
ASN P 242
ASP P 241
 None
 1.22A 1zzuA-5liiP:
undetectable		 1zzuA-5liiP:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A 401
ASN A 229
GLN A 231
ASP A 396
 None
 1.13A 1zzuA-5nccA:
undetectable		 1zzuA-5nccA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 SER A 114
ARG A 117
GLN A 209
PHE A 227
 None
 1.26A 1zzuA-5nn7A:
undetectable		 1zzuA-5nn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		4 ASN A 283
PHE A 282
ASN A 383
ASP A 290
 None
 1.11A 1zzuA-5t1qA:
undetectable		 1zzuA-5t1qA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 SER B 118
GLN B 111
PHE B 115
ASP B 114
 None
 1.30A 1zzuA-5tpwB:
undetectable		 1zzuA-5tpwB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)

(Neisseria
meningitidis;
Neisseria
meningitidis) 		PF13395
(HNH_4)
no annotation 		4 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.13A 1zzuA-5vgbA:
undetectable		 1zzuA-5vgbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.09A 1zzuA-5w3fA:
0.4		 1zzuA-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 SER C 503
ASN C 238
GLN C 236
PHE C 237
 None
 1.15A 1zzuA-5wqlC:
undetectable		 1zzuA-5wqlC:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00514
(Arm)
no annotation 		4 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.91A 1zzuA-5xjgA:
undetectable		 1zzuA-5xjgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE

(Streptococcus
pneumoniae) 		no annotation 4 ARG M 240
ASN M  56
GLN M  54
ASN M 242
 None
 1.10A 1zzuA-5xu1M:
undetectable		 1zzuA-5xu1M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.14A 1zzuA-5yh5A:
undetectable		 1zzuA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 4 SER A   2
GLN A 192
PHE A 191
ASP A 218
 None
 1.28A 1zzuA-6dg4A:
undetectable		 1zzuA-6dg4A:
undetectable