SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZZU_A_ACTA860

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 GLY A   6
GLN A   5
TRP A  38
SER A  11
 None
 1.15A 1zzuA-1amyA:
0.0		 1zzuA-1amyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 GLY A 598
GLN A 599
VAL A 634
SER A 602
 None
 1.22A 1zzuA-1c7tA:
0.1		 1zzuA-1c7tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 653
GLN A 617
VAL A 698
SER A 651
 None
 1.10A 1zzuA-1fcpA:
0.0		 1zzuA-1fcpA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 GLY A 127
GLN A 157
VAL A 240
SER A 160
 SF4  A1026 ( 4.2A)
None
None
None
 1.23A 1zzuA-1h7wA:
0.0		 1zzuA-1h7wA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 251
GLN A 252
VAL A 242
SER A 246
 None
None
None
NAD  A1250 (-3.3A)
 1.35A 1zzuA-1lluA:
0.0		 1zzuA-1lluA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 GLN A 420
TRP A 587
VAL A 649
SER A 657
 None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 3.9A)
 0.74A 1zzuA-1lzxA:
63.6		 1zzuA-1lzxA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 GLY A 417
GLN A 420
TRP A 587
VAL A 649
 ACT  A 860 ( 3.9A)
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
 0.16A 1zzuA-1lzxA:
63.6		 1zzuA-1lzxA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 186
GLN A 189
TRP A 356
VAL A 418
SER A 426
 MPD  A 604 (-3.8A)
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 (-3.1A)
 0.23A 1zzuA-1m9qA:
59.3		 1zzuA-1m9qA:
65.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 GLY A 196
GLN A 199
TRP A 366
SER A 436
 HEM  A 900 ( 4.1A)
None
HEM  A 900 ( 3.5A)
None
 0.37A 1zzuA-1qw5A:
57.8		 1zzuA-1qw5A:
63.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.40A 1zzuA-1r6vA:
0.0		 1zzuA-1r6vA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 GLY A  58
GLN A  59
VAL A 156
SER A 114
 None
 1.31A 1zzuA-2jbmA:
undetectable		 1zzuA-2jbmA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		4 GLY A 127
GLN A 172
VAL A 169
SER A 125
 None
 1.35A 1zzuA-2oseA:
undetectable		 1zzuA-2oseA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLY A 518
GLN A 376
VAL A 336
SER A 516
 None
None
None
CL  A 591 (-2.9A)
 1.48A 1zzuA-2pa5A:
undetectable		 1zzuA-2pa5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		4 GLY A  56
GLN A 229
VAL A 177
SER A 214
 None
 1.30A 1zzuA-2pfeA:
undetectable		 1zzuA-2pfeA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 424
GLN A 185
VAL A 121
SER A 428
 None
MN  A 460 (-3.4A)
None
None
 1.35A 1zzuA-2pokA:
undetectable		 1zzuA-2pokA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		4 GLY A 209
GLN A 211
VAL A 289
SER A 189
 None
 1.17A 1zzuA-2q2rA:
undetectable		 1zzuA-2q2rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 GLY A   7
GLN A   6
TRP A  39
SER A  12
 None
 1.15A 1zzuA-2qpsA:
0.3		 1zzuA-2qpsA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.92A 1zzuA-2v9iA:
undetectable		 1zzuA-2v9iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		4 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.24A 1zzuA-3d0qA:
undetectable		 1zzuA-3d0qA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLY A 202
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.24A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 GLY 1 396
TRP 1 408
VAL 1 407
SER 1 398
 None
None
None
SF4  1 439 ( 4.5A)
 0.99A 1zzuA-3i9v1:
undetectable		 1zzuA-3i9v1:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		4 GLY A 509
GLN A 510
TRP A 507
SER A 247
 None
 1.28A 1zzuA-3iukA:
undetectable		 1zzuA-3iukA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 311
GLN A 310
TRP A 309
VAL A 146
 None
 1.35A 1zzuA-3komA:
undetectable		 1zzuA-3komA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 GLY A  91
GLN A  93
VAL A 106
SER A  88
 None
 0.98A 1zzuA-3ndcA:
undetectable		 1zzuA-3ndcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzm DNA POLYMERASE III
SUBUNIT ALPHA

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY A 142
GLN A  46
TRP A  47
VAL A  22
 None
 1.17A 1zzuA-3nzmA:
undetectable		 1zzuA-3nzmA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.13A 1zzuA-3ps9A:
undetectable		 1zzuA-3ps9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 408
VAL A 502
 CL  A 691 (-3.5A)
None
None
None
 1.06A 1zzuA-3pvcA:
undetectable		 1zzuA-3pvcA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1x 2-OXO-3-DEOXYGALACTO
NATE KINASE

(Klebsiella
pneumoniae) 		PF05035
(DGOK) 		4 GLY A  65
TRP A  10
VAL A  35
SER A  69
 None
 1.32A 1zzuA-3r1xA:
2.2		 1zzuA-3r1xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		4 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.48A 1zzuA-3tfwA:
undetectable		 1zzuA-3tfwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		4 GLY A 916
GLN A 501
VAL A1037
SER A 504
 None
 1.35A 1zzuA-3u6nA:
1.1		 1zzuA-3u6nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 GLY A  31
GLN A  30
TRP A  63
SER A  36
 None
 1.15A 1zzuA-3wn6A:
0.6		 1zzuA-3wn6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 GLY B 379
GLN A 185
VAL B 384
SER A 181
 None
 1.47A 1zzuA-4az3B:
undetectable		 1zzuA-4az3B:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 GLY A  77
GLN A  75
VAL A 111
SER A  72
 None
 1.44A 1zzuA-4c1oA:
undetectable		 1zzuA-4c1oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN

(Plasmodium
berghei;
synthetic
construct) 		PF00022
(Actin) 		4 GLY A  24
GLN A   7
VAL A  10
SER A 349
 None
 1.34A 1zzuA-4cbwA:
undetectable		 1zzuA-4cbwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 GLY A  43
GLN A  44
VAL A 115
SER A  96
 None
 1.48A 1zzuA-4ccwA:
undetectable		 1zzuA-4ccwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLN A 461
TRP A 156
VAL A 106
SER A 466
 None
 1.49A 1zzuA-4e4gA:
undetectable		 1zzuA-4e4gA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		4 GLY A 284
GLN A 285
VAL A 294
SER A 257
 None
 1.33A 1zzuA-4e69A:
undetectable		 1zzuA-4e69A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		4 GLY A2066
GLN A2065
VAL A2285
SER A2068
 None
 1.45A 1zzuA-4f6cA:
undetectable		 1zzuA-4f6cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 4 GLY B2066
GLN B2065
VAL B2285
SER B2068
 None
 1.42A 1zzuA-4f6lB:
undetectable		 1zzuA-4f6lB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		4 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.36A 1zzuA-4fblA:
undetectable		 1zzuA-4fblA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		4 GLY A 297
GLN A 296
TRP A 291
SER A 102
 None
 1.32A 1zzuA-4iviA:
undetectable		 1zzuA-4iviA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 4 GLY D 425
GLN D 426
TRP D 300
SER D 428
 None
 1.41A 1zzuA-4jf7D:
undetectable		 1zzuA-4jf7D:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		4 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.22A 1zzuA-4k22A:
undetectable		 1zzuA-4k22A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 GLY A 313
TRP A 221
VAL A 203
SER A 262
 None
 1.24A 1zzuA-4mo9A:
undetectable		 1zzuA-4mo9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)

(Agrobacterium
fabrum) 		PF04069
(OpuAC) 		4 GLY A 204
GLN A 258
VAL A 199
SER A 209
 None
 1.16A 1zzuA-4ne4A:
undetectable		 1zzuA-4ne4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		4 GLY C 234
GLN C 239
VAL C 258
SER C 242
 None
 1.29A 1zzuA-5b04C:
undetectable		 1zzuA-5b04C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g ENDOLYSIN,CLAUDIN-4

(Homo sapiens;
Escherichia
virus T4) 		PF00822
(PMP22_Claudin)
PF00959
(Phage_lysozyme) 		4 GLY A1257
TRP A1181
VAL A1178
SER A1261
 None
 1.48A 1zzuA-5b2gA:
undetectable		 1zzuA-5b2gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		4 GLY A 704
GLN A 703
VAL A 659
SER A 629
 None
 1.46A 1zzuA-5bptA:
undetectable		 1zzuA-5bptA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		4 GLY A 296
TRP A 300
VAL A 303
SER A 333
 None
 1.29A 1zzuA-5mrwA:
undetectable		 1zzuA-5mrwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 4 GLY A 465
GLN A  95
TRP A 468
SER A 461
 None
 1.20A 1zzuA-5wi9A:
0.3		 1zzuA-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Cryptococcus
neoformans) 		PF06090
(Ins_P5_2-kin) 		4 GLY A  40
GLN A  41
VAL A 140
SER A  37
 None
 1.37A 1zzuA-5xu6A:
undetectable		 1zzuA-5xu6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxs PROTEIN RIBT

(Bacillus
subtilis) 		no annotation 4 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.25A 1zzuA-5xxsA:
undetectable		 1zzuA-5xxsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 GLY A 651
GLN A 650
VAL A 364
SER A 379
 None
 1.22A 1zzuA-6cgmA:
undetectable		 1zzuA-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 GLY B 309
GLN B 362
VAL B 573
SER B 291
 None
 0.98A 1zzuA-6f0kB:
undetectable		 1zzuA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 4 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.46A 1zzuA-6gupA:
undetectable		 1zzuA-6gupA:
undetectable