SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZZQ_B_ACTB861_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 GLY A   6
GLN A   5
TRP A  38
SER A  11
 None
 1.10A 1zzqB-1amyA:
0.0		 1zzqB-1amyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 GLY A 598
GLN A 599
VAL A 634
SER A 602
 None
 1.26A 1zzqB-1c7tA:
undetectable		 1zzqB-1c7tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 GLY A 466
GLN A  97
VAL A 442
SER A 464
 None
 1.30A 1zzqB-1eyyA:
0.0		 1zzqB-1eyyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 653
GLN A 617
VAL A 698
SER A 651
 None
 1.13A 1zzqB-1fcpA:
0.0		 1zzqB-1fcpA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 251
GLN A 252
VAL A 242
SER A 246
 None
None
None
NAD  A1250 (-3.3A)
 1.35A 1zzqB-1lluA:
undetectable		 1zzqB-1lluA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 GLY A 417
GLN A 420
TRP A 587
VAL A 649
SER A 657
 ACT  A 860 ( 3.9A)
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 3.9A)
 0.64A 1zzqB-1lzxA:
62.7		 1zzqB-1lzxA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 186
GLN A 189
TRP A 356
VAL A 418
SER A 426
 MPD  A 604 (-3.8A)
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 (-3.1A)
 0.24A 1zzqB-1m9qA:
59.2		 1zzqB-1m9qA:
65.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 GLY A 660
GLN A 659
VAL A 372
SER A 385
 None
 1.38A 1zzqB-1pemA:
0.0		 1zzqB-1pemA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.19A 1zzqB-1q8yA:
0.0		 1zzqB-1q8yA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 GLY A 196
GLN A 199
TRP A 366
SER A 436
 HEM  A 900 ( 4.1A)
None
HEM  A 900 ( 3.5A)
None
 0.32A 1zzqB-1qw5A:
58.1		 1zzqB-1qw5A:
63.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.35A 1zzqB-1r6vA:
undetectable		 1zzqB-1r6vA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 GLY A  58
GLN A  59
VAL A 156
SER A 114
 None
 1.30A 1zzqB-2jbmA:
undetectable		 1zzqB-2jbmA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		4 GLY A 127
GLN A 172
VAL A 169
SER A 125
 None
 1.32A 1zzqB-2oseA:
undetectable		 1zzqB-2oseA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		4 GLY A 209
GLN A 211
VAL A 289
SER A 189
 None
 1.14A 1zzqB-2q2rA:
undetectable		 1zzqB-2q2rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.95A 1zzqB-2v9iA:
undetectable		 1zzqB-2v9iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adk ADENYLATE KINASE

(Sus scrofa) 		PF00406
(ADK) 		4 GLY A  22
GLN A  24
VAL A  13
SER A  19
 SO4  A 195 (-3.6A)
None
None
SO4  A 195 (-3.6A)
 1.26A 1zzqB-3adkA:
undetectable		 1zzqB-3adkA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		4 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.20A 1zzqB-3d0qA:
undetectable		 1zzqB-3d0qA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLY A 202
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.20A 1zzqB-3e7gA:
57.4		 1zzqB-3e7gA:
65.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyc PUTATIVE GLYCOSIDE
HYDROLASE

(Parabacteroides
distasonis) 		PF12876
(Cellulase-like) 		4 GLY A 364
TRP A 366
VAL A 369
SER A 399
 None
 1.49A 1zzqB-3gycA:
undetectable		 1zzqB-3gycA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 GLY 1 396
TRP 1 408
VAL 1 407
SER 1 398
 None
None
None
SF4  1 439 ( 4.5A)
 1.01A 1zzqB-3i9v1:
undetectable		 1zzqB-3i9v1:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		4 GLY A 239
GLN A 241
VAL A 174
SER A 243
 None
 1.38A 1zzqB-3l0zA:
undetectable		 1zzqB-3l0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.12A 1zzqB-3ps9A:
undetectable		 1zzqB-3ps9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 408
VAL A 502
 CL  A 691 (-3.5A)
None
None
None
 1.05A 1zzqB-3pvcA:
undetectable		 1zzqB-3pvcA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1x 2-OXO-3-DEOXYGALACTO
NATE KINASE

(Klebsiella
pneumoniae) 		PF05035
(DGOK) 		4 GLY A  65
TRP A  10
VAL A  35
SER A  69
 None
 1.28A 1zzqB-3r1xA:
undetectable		 1zzqB-3r1xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		4 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.46A 1zzqB-3tfwA:
undetectable		 1zzqB-3tfwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		4 GLY A 916
GLN A 501
VAL A1037
SER A 504
 None
 1.37A 1zzqB-3u6nA:
undetectable		 1zzqB-3u6nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 GLY B 379
GLN A 185
VAL B 384
SER A 181
 None
 1.43A 1zzqB-4az3B:
undetectable		 1zzqB-4az3B:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 GLY A 397
GLN A 216
VAL A 378
SER A 214
 None
None
7AH  A1000 (-4.8A)
None
 1.30A 1zzqB-4cgnA:
undetectable		 1zzqB-4cgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		4 GLY A 284
GLN A 285
VAL A 294
SER A 257
 None
 1.29A 1zzqB-4e69A:
undetectable		 1zzqB-4e69A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		4 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.39A 1zzqB-4fblA:
undetectable		 1zzqB-4fblA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcy THIAMINASE-I

(Naegleria
gruberi) 		no annotation 4 GLY A 252
GLN A 166
VAL A 332
SER A 119
 None
 1.34A 1zzqB-4hcyA:
undetectable		 1zzqB-4hcyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 4 GLY D 425
GLN D 426
TRP D 300
SER D 428
 None
 1.41A 1zzqB-4jf7D:
undetectable		 1zzqB-4jf7D:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		4 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.20A 1zzqB-4k22A:
undetectable		 1zzqB-4k22A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 GLY A 313
TRP A 221
VAL A 203
SER A 262
 None
 1.31A 1zzqB-4mo9A:
undetectable		 1zzqB-4mo9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.41A 1zzqB-4mwtA:
undetectable		 1zzqB-4mwtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)

(Agrobacterium
fabrum) 		PF04069
(OpuAC) 		4 GLY A 204
GLN A 258
VAL A 199
SER A 209
 None
 1.11A 1zzqB-4ne4A:
undetectable		 1zzqB-4ne4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)

(Agrobacterium
fabrum) 		PF04069
(OpuAC) 		4 GLY A 205
GLN A 258
VAL A 199
SER A 209
 None
 1.39A 1zzqB-4ne4A:
undetectable		 1zzqB-4ne4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp HEAVY CHAIN OF
ANTIBODY VRC08

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  95
GLN H 101
VAL H   2
SER H  97
 None
None
PCA  H   1 ( 3.3A)
None
 1.49A 1zzqB-4xmpH:
undetectable		 1zzqB-4xmpH:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 GLY K  95
GLN K 126
VAL K 130
SER K 100
 None
 1.41A 1zzqB-5anbK:
undetectable		 1zzqB-5anbK:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		4 GLY C 234
GLN C 239
VAL C 258
SER C 242
 None
 1.33A 1zzqB-5b04C:
undetectable		 1zzqB-5b04C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g ENDOLYSIN,CLAUDIN-4

(Homo sapiens;
Escherichia
virus T4) 		PF00822
(PMP22_Claudin)
PF00959
(Phage_lysozyme) 		4 GLY A1257
TRP A1181
VAL A1178
SER A1261
 None
 1.49A 1zzqB-5b2gA:
undetectable		 1zzqB-5b2gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		4 GLY A 704
GLN A 703
VAL A 659
SER A 629
 None
 1.49A 1zzqB-5bptA:
undetectable		 1zzqB-5bptA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 GLN A 668
TRP A 198
VAL A 196
SER A 335
 None
 1.44A 1zzqB-5mfaA:
undetectable		 1zzqB-5mfaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		4 GLY A 296
TRP A 300
VAL A 303
SER A 333
 None
 1.26A 1zzqB-5mrwA:
undetectable		 1zzqB-5mrwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A  60
GLN A  62
TRP A  58
VAL A 189
 None
 1.34A 1zzqB-5u1oA:
undetectable		 1zzqB-5u1oA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 GLY A 465
GLN A  95
TRP A 468
SER A 461
 None
 1.20A 1zzqB-5vanA:
undetectable		 1zzqB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 4 GLY A 465
GLN A  95
TRP A 468
SER A 461
 None
 1.21A 1zzqB-5wi9A:
undetectable		 1zzqB-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xru ADENYLATE KINASE

(Notothenia
coriiceps) 		no annotation 4 GLY A  22
GLN A  24
VAL A  13
SER A  19
 AP5  A 201 (-3.5A)
None
None
AP5  A 201 (-3.5A)
 1.25A 1zzqB-5xruA:
undetectable		 1zzqB-5xruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 GLY A 423
GLN A 422
VAL A 402
SER A 367
 None
 1.34A 1zzqB-5yl7A:
undetectable		 1zzqB-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 GLY A 651
GLN A 650
VAL A 364
SER A 379
 None
 1.22A 1zzqB-6cgmA:
undetectable		 1zzqB-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 GLY B 309
GLN B 362
VAL B 573
SER B 291
 None
 0.98A 1zzqB-6f0kB:
undetectable		 1zzqB-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 4 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.48A 1zzqB-6gupA:
undetectable		 1zzqB-6gupA:
undetectable