SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZZQ_A_MTLA870_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus)
PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
4 SER A 200
ARG A 157
GLN A 203
PHE A 201
None
1.34A 1zzqA-1c9lA:
0.0
1zzqA-1c9lA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehx SCAFFOLDIN PROTEIN

([Clostridium]
cellulolyticum)
PF03442
(CBM_X2)
4 GLN A   2
PHE A  72
ASN A  28
ASP A   3
None
1.31A 1zzqA-1ehxA:
undetectable
1zzqA-1ehxA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae)
PF01569
(PAP2)
4 ASN A 211
GLN A 216
PHE A 214
ASN A 101
None
1.31A 1zzqA-1iw8A:
0.0
1zzqA-1iw8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 SER A 208
ASN A 241
GLN A 242
ASN A 216
None
None
None
FAD  A 800 (-4.1A)
1.04A 1zzqA-1knrA:
0.0
1zzqA-1knrA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE


(Rattus
norvegicus)
PF02898
(NO_synthase)
8 SER A 477
ARG A 481
ASN A 498
GLN A 500
PHE A 501
ASN A 569
ASP A 709
TRP A 711
None
0.52A 1zzqA-1lzxA:
64.4
1zzqA-1lzxA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE


(Homo sapiens)
PF02898
(NO_synthase)
5 ARG A 250
ASN A 267
ASN A 338
ASP A 478
TRP A 480
None
0.64A 1zzqA-1m9qA:
59.6
1zzqA-1m9qA:
65.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE


(Homo sapiens)
PF02898
(NO_synthase)
4 SER A 246
ARG A 250
ASN A 267
ASN A 338
None
0.73A 1zzqA-1m9qA:
59.6
1zzqA-1m9qA:
65.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli)
PF02264
(LamB)
4 ARG A 109
GLN A  87
ASN A  63
ASP A  61
GLC  A 432 (-3.3A)
None
None
None
1.31A 1zzqA-1mpoA:
0.0
1zzqA-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense)
PF00882
(Zn_dep_PLPC)
PF01477
(PLAT)
4 SER A  96
ARG A  99
ASN A  93
ASP A  92
None
1.15A 1zzqA-1olpA:
undetectable
1zzqA-1olpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)


(Bacillus
circulans)
PF01374
(Glyco_hydro_46)
4 ASN A 224
GLN A 231
ASN A 176
ASP A 172
None
1.36A 1zzqA-1qgiA:
0.0
1zzqA-1qgiA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Mus musculus)
PF02898
(NO_synthase)
5 SER A 256
ARG A 260
PHE A 280
ASN A 348
TRP A 490
None
0.75A 1zzqA-1qw5A:
58.0
1zzqA-1qw5A:
63.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus)
PF00089
(Trypsin)
4 SER A  95
GLN A  95
ASN A  95
ASP A  97
NAG  A  11 (-3.4A)
None
NAG  A  11 (-2.0A)
NAG  A  11 (-4.2A)
1.33A 1zzqA-1sgfA:
undetectable
1zzqA-1sgfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twb STRINGENT STARVATION
PROTEIN B HOMOLOG


(Haemophilus
influenzae)
PF04386
(SspB)
4 ASN A  72
GLN A  63
PHE A  71
ASN A  39
None
1.02A 1zzqA-1twbA:
undetectable
1zzqA-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens)
PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg)
4 SER A 197
ASN A 185
GLN A 249
PHE A 183
None
1.26A 1zzqA-1uwyA:
undetectable
1zzqA-1uwyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)


(Streptococcus
pneumoniae)
PF00753
(Lactamase_B)
4 SER A  50
GLN A 180
PHE A 181
ASN A  31
None
1.07A 1zzqA-1wraA:
undetectable
1zzqA-1wraA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE


(Escherichia
coli)
PF04996
(AstB)
4 ARG A 212
ASN A 134
GLN A 167
ASN A 110
SUG  A1001 (-3.0A)
None
None
SUG  A1001 (-3.2A)
1.30A 1zzqA-1yniA:
undetectable
1zzqA-1yniA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]


(Anaerobiospirillum
succiniciproducens)
PF01293
(PEPCK_ATP)
4 SER A 379
ASN A 514
GLN A 512
PHE A 511
None
1.28A 1zzqA-1ytmA:
undetectable
1zzqA-1ytmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA


(Homo sapiens)
PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int)
4 GLN A  95
PHE A  94
ASN A  89
ASP A  92
None
1.25A 1zzqA-1yvlA:
undetectable
1zzqA-1yvlA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE


(Plasmodium
yoelii)
PF00215
(OMPdecase)
4 SER A 202
ASN A 207
PHE A 203
ASN A 199
None
1.15A 1zzqA-2aqwA:
undetectable
1zzqA-2aqwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens)
PF13088
(BNR_2)
4 ARG A 517
ASN A 514
GLN A 493
ASN A 562
None
None
SIA  A1692 (-3.0A)
None
1.17A 1zzqA-2bf6A:
undetectable
1zzqA-2bf6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN


(Streptococcus
pneumoniae)
PF00753
(Lactamase_B)
PF01473
(CW_binding_1)
4 SER A  25
GLN A 155
PHE A 156
ASN A   6
None
1.11A 1zzqA-2bibA:
undetectable
1zzqA-2bibA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis)
PF04185
(Phosphoesterase)
4 SER A 281
ASN A 275
GLN A 347
ASP A 283
None
None
ETX  A1006 (-3.5A)
None
1.30A 1zzqA-2d1gA:
undetectable
1zzqA-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN


(Thermus
thermophilus)
PF00496
(SBP_bac_5)
4 ARG A 550
GLN A 279
PHE A 277
ASN A 552
None
1.23A 1zzqA-2d5wA:
undetectable
1zzqA-2d5wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv0 LYSOZYME C

(Pelodiscus
sinensis)
PF00062
(Lys)
4 SER A  62
GLN A  51
ASN A  61
ASP A  50
None
1.15A 1zzqA-2gv0A:
undetectable
1zzqA-2gv0A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxy MACROPHAGE
METALLOELASTASE


(Homo sapiens)
PF00045
(Hemopexin)
4 SER A 464
PHE A 300
ASN A 465
TRP A 307
None
1.12A 1zzqA-2jxyA:
undetectable
1zzqA-2jxyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcy 30S RIBOSOMAL
PROTEIN S8E


(Methanothermobacter
thermautotrophicus)
PF01201
(Ribosomal_S8e)
4 SER A  75
ARG A  76
ASN A  84
ASP A  80
None
1.19A 1zzqA-2kcyA:
undetectable
1zzqA-2kcyA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzb AUTOPHAGY-RELATED
PROTEIN 19


(Saccharomyces
cerevisiae)
PF12744
(ATG19_autophagy)
4 SER A 261
ARG A 359
PHE A 346
ASN A 280
None
1.36A 1zzqA-2kzbA:
undetectable
1zzqA-2kzbA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica)
PF02264
(LamB)
4 ARG A 109
GLN A  87
ASN A  63
ASP A  61
GLC  A 429 ( 3.0A)
None
None
None
1.25A 1zzqA-2mprA:
undetectable
1zzqA-2mprA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjv UNCHARACTERIZED
IOLB-LIKE PROTEIN


(Salmonella
enterica)
PF04962
(KduI)
4 ARG A 190
ASN A 217
GLN A 195
PHE A 191
SO4  A 277 (-3.2A)
SO4  A 277 (-3.5A)
None
None
0.97A 1zzqA-2qjvA:
undetectable
1zzqA-2qjvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE


(Tetrahymena
thermophila)
PF12009
(Telomerase_RBD)
4 ASN A 317
GLN A 282
PHE A 318
ASN A 322
None
1.33A 1zzqA-2r4gA:
undetectable
1zzqA-2r4gA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I


(Homo sapiens)
PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR)
4 SER A 475
ASN A 446
GLN A 444
ASN A 476
NAG  A 676 (-4.5A)
NAG  A 646 (-2.5A)
None
NAG  A 676 (-2.5A)
1.30A 1zzqA-2xrcA:
undetectable
1zzqA-2xrcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster)
PF00225
(Kinesin)
4 SER A 311
ARG A  20
PHE A  19
ASN A 316
None
1.15A 1zzqA-2y5wA:
undetectable
1zzqA-2y5wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA


(Clostridium
perfringens)
PF03496
(ADPrib_exo_Tox)
4 SER A  50
GLN A 181
PHE A 136
ASN A  51
None
1.08A 1zzqA-3buzA:
undetectable
1zzqA-3buzA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dal PR DOMAIN ZINC
FINGER PROTEIN 1


(Homo sapiens)
PF00856
(SET)
4 ARG A  75
PHE A  76
ASN A  26
ASP A  27
None
1.05A 1zzqA-3dalA:
undetectable
1zzqA-3dalA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Homo sapiens)
PF02898
(NO_synthase)
4 ARG A 266
ASN A 283
PHE A 286
TRP A 496
AT2  A 906 (-3.6A)
None
None
None
1.10A 1zzqA-3e7gA:
57.2
1zzqA-3e7gA:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Homo sapiens)
PF02898
(NO_synthase)
4 ASN A 283
PHE A 286
ASN A 354
TRP A 496
None
0.97A 1zzqA-3e7gA:
57.2
1zzqA-3e7gA:
65.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE


(Brucella
abortus)
PF00171
(Aldedh)
4 ARG A 427
GLN A 299
ASN A 421
ASP A 268
None
1.23A 1zzqA-3ek1A:
undetectable
1zzqA-3ek1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae)
PF11713
(Peptidase_C80)
4 ARG A3530
GLN A3582
PHE A3579
ASP A3537
None
1.27A 1zzqA-3fzyA:
undetectable
1zzqA-3fzyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
4 ASN A 384
GLN A 382
ASN A 523
TRP A 515
None
1.12A 1zzqA-3ihvA:
undetectable
1zzqA-3ihvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Lactobacillus
acidophilus)
PF04909
(Amidohydro_2)
4 ASN A 281
GLN A 274
ASN A  53
ASP A  51
None
1.29A 1zzqA-3ij6A:
undetectable
1zzqA-3ij6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN


(Bacillus
halodurans)
PF09084
(NMT1)
5 SER A 109
ARG A 112
ASN A 289
PHE A 294
TRP A 239
None
1.37A 1zzqA-3ix1A:
undetectable
1zzqA-3ix1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 SER A 390
ASN A 381
GLN A 385
PHE A 273
None
1.18A 1zzqA-3kieA:
undetectable
1zzqA-3kieA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN


(Rattus
norvegicus;
Rattus
norvegicus)
PF00225
(Kinesin)
PF00225
(Kinesin)
4 SER B 305
ARG A  16
PHE A  15
ASN B 310
None
1.35A 1zzqA-3kinB:
undetectable
1zzqA-3kinB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 SER A 345
ARG A 318
GLN A 428
ASN A 344
None
1.14A 1zzqA-3mosA:
undetectable
1zzqA-3mosA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Trypanosoma
brucei)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 SER A  74
ASN A 419
GLN A 355
ASP A 319
CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
1.08A 1zzqA-3nvlA:
undetectable
1zzqA-3nvlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
4 SER A 167
ASN A  13
ASN A 195
ASP A 299
None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
0.95A 1zzqA-3otxA:
undetectable
1zzqA-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1


(Homo sapiens)
PF03031
(NIF)
4 SER A 208
ASN A 187
ASN A 207
ASP A  96
None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
1.00A 1zzqA-3pglA:
undetectable
1zzqA-3pglA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 SER A 393
ASN A 384
GLN A 388
PHE A 276
None
1.23A 1zzqA-3ra2A:
undetectable
1zzqA-3ra2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t24 PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 SER A 123
ARG A 124
GLN A 128
ASP A 285
SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
1.23A 1zzqA-3t24A:
undetectable
1zzqA-3t24A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB


(Bacillus
anthracis)
PF04183
(IucA_IucC)
PF06276
(FhuF)
4 ASN A 175
GLN A 171
PHE A 170
ASN A 303
None
1.11A 1zzqA-3to3A:
undetectable
1zzqA-3to3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE


(Candida
albicans)
PF04446
(Thg1)
PF14413
(Thg1C)
4 ARG A 143
GLN A 150
PHE A 146
ASN A 144
None
1.36A 1zzqA-3wbzA:
undetectable
1zzqA-3wbzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN


(Chaetomium
thermophilum)
no annotation 4 SER B 538
ARG B 540
GLN B 484
ASN B 523
None
1.19A 1zzqA-4d0kB:
undetectable
1zzqA-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
4 ARG B1375
ASN B1444
GLN B1446
ASN B1449
None
1.29A 1zzqA-4f92B:
undetectable
1zzqA-4f92B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdz UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
PF14059
(DUF4251)
4 SER A 181
ASN A  73
ASN A 161
ASP A 160
None
1.33A 1zzqA-4gdzA:
undetectable
1zzqA-4gdzA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
4 SER A 257
ARG A 179
GLN A 115
ASN A 258
None
1.19A 1zzqA-4ineA:
undetectable
1zzqA-4ineA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Caulobacter
vibrioides)
PF13407
(Peripla_BP_4)
4 ASN A 231
GLN A 278
ASN A  45
ASP A 125
INS  A 401 (-3.9A)
INS  A 401 (-3.1A)
None
INS  A 401 (-2.8A)
1.22A 1zzqA-4irxA:
undetectable
1zzqA-4irxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS


(Staphylococcus
aureus)
no annotation 4 ASN A 275
GLN A 482
ASN A 347
ASP A 330
None
None
None
GOL  A 602 (-3.3A)
1.36A 1zzqA-4m01A:
undetectable
1zzqA-4m01A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
4 ARG B 597
GLN B 693
PHE B 692
ASP B 687
None
1.29A 1zzqA-4oavB:
undetectable
1zzqA-4oavB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oi3 NICKEL RESPONSIVE
PROTEIN


(Streptomyces
coelicolor)
PF14026
(DUF4242)
4 SER A  53
GLN A  62
PHE A   4
ASP A   6
None
1.19A 1zzqA-4oi3A:
undetectable
1zzqA-4oi3A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD


(Escherichia
coli)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 ARG A 141
ASN A 142
ASN A 134
ASP A 135
None
1.34A 1zzqA-4pl0A:
undetectable
1zzqA-4pl0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus)
PF03664
(Glyco_hydro_62)
4 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
None
1.23A 1zzqA-4pviA:
undetectable
1zzqA-4pviA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N


(Thermococcus
kodakarensis;
Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF01194
(RNA_pol_N)
4 SER B 746
ARG B 749
PHE N   8
ASN B 743
None
1.24A 1zzqA-4qiwB:
undetectable
1zzqA-4qiwB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27


(Chaetomium
thermophilum)
PF00160
(Pro_isomerase)
4 SER A  77
ASN A 107
PHE A 108
TRP A  91
None
1.29A 1zzqA-4r3fA:
undetectable
1zzqA-4r3fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus)
PF00740
(Parvo_coat)
4 SER A 392
ASN A 383
GLN A 387
PHE A 275
None
1.18A 1zzqA-4rsoA:
undetectable
1zzqA-4rsoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)


([Eubacterium]
rectale)
PF13416
(SBP_bac_8)
4 GLN A 394
PHE A 189
ASN A 191
ASP A 190
EDO  A 504 (-3.3A)
None
ACR  A 501 (-3.3A)
EDO  A 504 ( 4.2A)
1.27A 1zzqA-4uacA:
undetectable
1zzqA-4uacA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN


(Bordetella
bronchiseptica)
PF03480
(DctP)
4 GLN A 264
PHE A 267
ASN A 149
TRP A 256
None
1.26A 1zzqA-4yzzA:
undetectable
1zzqA-4yzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4


(Saccharomyces
cerevisiae)
PF01793
(Glyco_transf_15)
4 PHE A 241
ASN A 172
ASP A 173
TRP A 204
None
1.30A 1zzqA-5a08A:
undetectable
1zzqA-5a08A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK


(Cupriavidus
necator)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 GLN A 263
PHE A 223
ASN A 182
ASP A 214
None
1.33A 1zzqA-5aa5A:
undetectable
1zzqA-5aa5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
4 SER A 116
ASN A 174
PHE A  89
ASP A 122
None
1.13A 1zzqA-5aexA:
undetectable
1zzqA-5aexA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE


(Caenorhabditis
elegans)
PF07910
(Peptidase_C78)
4 ASN A  72
GLN A  74
PHE A  75
ASN A 288
None
1.14A 1zzqA-5ejjA:
undetectable
1zzqA-5ejjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus)
PF02668
(TauD)
4 ARG A 203
GLN A 115
ASP A 152
TRP A 311
None
None
MG  A 401 (-3.5A)
None
1.08A 1zzqA-5eqnA:
undetectable
1zzqA-5eqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica)
no annotation 4 ARG A 331
ASN A 327
GLN A 323
PHE A 326
None
1.27A 1zzqA-5hafA:
undetectable
1zzqA-5hafA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL


(Drosophila
melanogaster;
Rattus
norvegicus)
PF00225
(Kinesin)
4 SER K 319
ARG K  32
PHE K  31
ASN K 324
None
1.17A 1zzqA-5hnzK:
undetectable
1zzqA-5hnzK:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A


(Homo sapiens;
Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
4 GLN A 583
PHE A 594
ASN A 488
ASP A 604
None
1.35A 1zzqA-5i4eA:
undetectable
1zzqA-5i4eA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
4 SER A 119
ARG A 254
ASN A 252
ASP A 226
None
1.03A 1zzqA-5imwA:
undetectable
1zzqA-5imwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
4 SER A 133
PHE A 121
ASN A 126
ASP A 124
None
1.30A 1zzqA-5imyA:
undetectable
1zzqA-5imyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN


(Klebsiella
pneumoniae)
PF04453
(OstA_C)
4 SER A 386
GLN A 356
PHE A 376
ASN A 418
None
1.18A 1zzqA-5iv8A:
undetectable
1zzqA-5iv8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans)
PF03055
(RPE65)
4 ARG A 356
GLN A 417
PHE A 354
ASN A 122
None
1.06A 1zzqA-5j55A:
undetectable
1zzqA-5j55A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron)
PF13402
(Peptidase_M60)
PF17291
(M60-like_N)
4 SER A 617
GLN A 627
ASN A 613
ASP A 641
EDO  A 903 ( 4.3A)
None
EDO  A 903 (-4.1A)
None
1.34A 1zzqA-5kd5A:
undetectable
1zzqA-5kd5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 SER A 208
ASN A 241
GLN A 242
PHE A 243
None
1.26A 1zzqA-5kxjA:
undetectable
1zzqA-5kxjA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS


(Listeria
monocytogenes)
PF12354
(Internalin_N)
PF13855
(LRR_8)
4 GLN A 346
PHE A 347
ASN A 303
ASP A 349
None
1.32A 1zzqA-5kzsA:
undetectable
1zzqA-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lii MAJOR CAPSID PROTEIN

(Staphylococcus
phage 812)
no annotation 4 ASN P 247
GLN P 237
ASN P 242
ASP P 241
None
1.24A 1zzqA-5liiP:
undetectable
1zzqA-5liiP:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens)
PF00225
(Kinesin)
4 SER A 303
ARG A  16
PHE A  15
ASN A 308
None
1.20A 1zzqA-5lt1A:
undetectable
1zzqA-5lt1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3


(Schizosaccharomyces
pombe)
no annotation 4 SER A 188
ARG A 160
PHE A 192
ASN A 187
None
1.34A 1zzqA-5oqrA:
undetectable
1zzqA-5oqrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979


(Staphylococcus
aureus)
PF01832
(Glucosaminidase)
PF05257
(CHAP)
4 ASN A 283
PHE A 282
ASN A 383
ASP A 290
None
1.18A 1zzqA-5t1qA:
undetectable
1zzqA-5t1qA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron)
no annotation 4 SER D 343
ASN D 309
GLN D 307
ASN D 366
None
1.02A 1zzqA-5t4yD:
undetectable
1zzqA-5t4yD:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)


(Neisseria
meningitidis;
Neisseria
meningitidis)
PF13395
(HNH_4)
no annotation
4 ASN A  88
PHE A  87
ASN A  13
ASP B  44
SO4  A 203 (-3.9A)
None
None
None
1.12A 1zzqA-5vgbA:
undetectable
1zzqA-5vgbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN


(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
4 SER A 224
GLN A  15
PHE A 225
ASN A 227
None
None
GTP  A 502 (-3.8A)
None
1.05A 1zzqA-5w3fA:
undetectable
1zzqA-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION


(Mycobacterium
tuberculosis)
no annotation 4 ASN A 132
GLN A 139
PHE A 130
TRP A  84
1PE  A 402 (-3.7A)
None
1PE  A 402 (-3.5A)
None
1.35A 1zzqA-5w95A:
undetectable
1zzqA-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Campylobacter
jejuni)
no annotation 4 SER A 922
ASN A 926
ASN A 910
ASP A 891
None
1.29A 1zzqA-5x2gA:
undetectable
1zzqA-5x2gA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb6 UNCHARACTERIZED
PROTEIN YCJY


(Escherichia
coli)
no annotation 4 SER A 146
ARG A 149
ASN A 143
ASP A 261
None
1.00A 1zzqA-5xb6A:
undetectable
1zzqA-5xb6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00514
(Arm)
no annotation
4 SER A 280
ARG A 242
GLN B 308
ASN B 304
None
0.86A 1zzqA-5xjgA:
undetectable
1zzqA-5xjgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE


(Streptococcus
pneumoniae)
no annotation 4 ARG M 240
ASN M  56
GLN M  54
ASN M 242
None
1.14A 1zzqA-5xu1M:
undetectable
1zzqA-5xu1M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Staphylococcus
aureus)
no annotation 4 ASN A 450
GLN A 130
ASN A 310
ASP A 308
None
1.15A 1zzqA-5yh5A:
undetectable
1zzqA-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-)
no annotation 4 SER A 569
ASN A 148
GLN A 166
ASP A  61
None
1.31A 1zzqA-6bo6A:
undetectable
1zzqA-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE


(Chaetomium
thermophilum)
no annotation 4 SER A   2
GLN A 192
PHE A 191
ASP A 218
None
1.29A 1zzqA-6dg4A:
undetectable
1zzqA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 4 SER A 310
ASN A 329
GLN A 376
PHE A 387
None
1.33A 1zzqA-6eojA:
undetectable
1zzqA-6eojA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2


(Influenza B
virus)
no annotation 4 GLN A 325
PHE A 327
ASN A 517
ASP A 518
BYB  A 601 (-3.3A)
BYB  A 601 ( 4.4A)
None
None
1.33A 1zzqA-6euxA:
undetectable
1zzqA-6euxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT


(Influenza A
virus)
no annotation 4 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.31A 1zzqA-6evjB:
undetectable
1zzqA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT


(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus)
no annotation
no annotation
no annotation
4 ARG C 142
PHE B 939
ASN E  37
ASP E  41
None
None
HEC  A 301 (-2.9A)
None
1.16A 1zzqA-6f0kC:
undetectable
1zzqA-6f0kC:
undetectable