SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZZ1_A_SHHA2452
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 9 | HIS A 131HIS A 132PHE A 141ASP A 168HIS A 170PHE A 198ASP A 258GLY A 295TYR A 297 | TSN A 502 (-4.0A)TSN A 502 (-3.9A)TSN A 502 (-3.7A) ZN A 501 ( 2.3A) ZN A 501 ( 3.1A)TSN A 502 ( 3.9A) ZN A 501 ( 2.5A) ZN A 501 ( 4.1A)TSN A 502 (-4.3A) | 0.49A | 1zz1A-1c3rA:41.7 | 1zz1A-1c3rA:27.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcw | CERULOPLASMIN (Homo sapiens) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | HIS A 978HIS A 103HIS A 101GLY A 981TYR A 107 | CU A1052 ( 3.2A) CU A1051 (-3.3A) CU A1052 (-3.2A) O A1058 ( 4.9A)None | 1.20A | 1zz1A-1kcwA:undetectable | 1zz1A-1kcwA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 5 | LEU A 103HIS A 12HIS A 211ASP A 292ASP A 293 | PRH A 401 (-4.4A) ZN A 501 ( 3.3A) ZN A 501 ( 3.4A)PRH A 401 ( 2.5A)PRH A 401 (-3.5A) | 1.21A | 1zz1A-1krmA:undetectable | 1zz1A-1krmA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p1m | HYPOTHETICAL PROTEINTM0936 (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | LEU A 81HIS A 55HIS A 200ASP A 279GLY A 280 | None NI A9001 (-3.3A) NI A9001 (-3.4A) NI A9001 (-2.6A)None | 1.21A | 1zz1A-1p1mA:undetectable | 1zz1A-1p1mA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9e | METHYL PARATHIONHYDROLASE (Pseudomonas sp.WBC-3) |
PF00753(Lactamase_B) | 5 | LEU A 110ILE A 143HIS A 147ASP A 255GLY A 254 | NoneNone ZN A 402 (-3.5A) ZN A 401 ( 2.2A)None | 0.97A | 1zz1A-1p9eA:undetectable | 1zz1A-1p9eA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwy | PEPTIDOGLYCANHYDROLASE (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 5 | HIS A 291HIS A 260ASP A 214HIS A 293TYR A 204 | NoneNone ZN A 400 (-2.2A) ZN A 400 (-3.1A)None | 1.23A | 1zz1A-1qwyA:undetectable | 1zz1A-1qwyA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsv | AMINOMETHYLTRANSFERASE (Homo sapiens) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | LEU A 152ILE A 219HIS A 14PHE A 13GLY A 229 | LEU A 152 ( 0.6A)ILE A 219 ( 0.7A)HIS A 14 ( 1.0A)PHE A 13 ( 1.3A)GLY A 229 ( 0.0A) | 0.99A | 1zz1A-1wsvA:undetectable | 1zz1A-1wsvA:22.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zz3 | HISTONEDEACETYLASE-LIKEAMIDOHYDROLASE (Alcaligenaceaebacterium FB188) |
PF00850(Hist_deacetyl) | 5 | HIS A 142HIS A 182ASP A 268GLY A 311TYR A 312 | 3YP A1452 (-3.3A) ZN A1451 (-3.3A) ZN A1451 ( 2.5A)None3YP A1452 (-4.6A) | 1.24A | 1zz1A-1zz3A:71.3 | 1zz1A-1zz3A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zz3 | HISTONEDEACETYLASE-LIKEAMIDOHYDROLASE (Alcaligenaceaebacterium FB188) |
PF00850(Hist_deacetyl) | 5 | HIS A 143HIS A 182ASP A 268GLY A 310TYR A 312 | 3YP A1452 (-3.4A) ZN A1451 (-3.3A) ZN A1451 ( 2.5A)3YP A1452 ( 3.7A)3YP A1452 (-4.6A) | 1.05A | 1zz1A-1zz3A:71.3 | 1zz1A-1zz3A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zz3 | HISTONEDEACETYLASE-LIKEAMIDOHYDROLASE (Alcaligenaceaebacterium FB188) |
PF00850(Hist_deacetyl) | 6 | LEU A 21HIS A 182PHE A 208ASP A 268GLY A 311TYR A 312 | None ZN A1451 (-3.3A)3YP A1452 (-3.6A) ZN A1451 ( 2.5A)None3YP A1452 (-4.6A) | 1.16A | 1zz1A-1zz3A:71.3 | 1zz1A-1zz3A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zz3 | HISTONEDEACETYLASE-LIKEAMIDOHYDROLASE (Alcaligenaceaebacterium FB188) |
PF00850(Hist_deacetyl) | 11 | LEU A 21ILE A 100HIS A 142HIS A 143PHE A 152ASP A 180HIS A 182PHE A 208ASP A 268GLY A 310TYR A 312 | NoneNone3YP A1452 (-3.3A)3YP A1452 (-3.4A)3YP A1452 (-3.8A) ZN A1451 (-1.9A) ZN A1451 (-3.3A)3YP A1452 (-3.6A) ZN A1451 ( 2.5A)3YP A1452 ( 3.7A)3YP A1452 (-4.6A) | 0.52A | 1zz1A-1zz3A:71.3 | 1zz1A-1zz3A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bxy | MALTOOLIGOSYLTREHALOSE TREHALOHYDROLASE (Deinococcusradiodurans) |
PF00128(Alpha-amylase)PF02922(CBM_48)PF11941(DUF3459) | 5 | LEU A 299ILE A 296HIS A 203ASP A 116HIS A 268 | None | 1.24A | 1zz1A-2bxyA:undetectable | 1zz1A-2bxyA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fdr | CONSERVEDHYPOTHETICAL PROTEIN (Agrobacteriumfabrum) |
PF13419(HAD_2) | 5 | LEU A 200ILE A 173HIS A 191GLY A 43TYR A 193 | None | 1.24A | 1zz1A-2fdrA:undetectable | 1zz1A-2fdrA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igw | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE3 (Caenorhabditiselegans) |
PF00160(Pro_isomerase) | 5 | LEU A 39HIS A 61PHE A 74PHE A 119GLY A 81 | None | 1.22A | 1zz1A-2igwA:undetectable | 1zz1A-2igwA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6i | HD DOMAIN PROTEIN (Enterococcusfaecalis) |
PF01966(HD) | 5 | LEU A 370HIS A 114HIS A 129ASP A 111ASP A 183 | NoneNoneNone ZN A 501 (-2.6A) ZN A 501 (-2.4A) | 1.23A | 1zz1A-2o6iA:undetectable | 1zz1A-2o6iA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogg | TREHALOSE OPERONTRANSCRIPTIONALREPRESSOR (Bacillussubtilis) |
PF07702(UTRA) | 5 | LEU A 115ILE A 123HIS A 148ASP A 212PHE A 216 | NoneGOL A 304 (-4.5A)NoneNoneNone | 1.25A | 1zz1A-2oggA:undetectable | 1zz1A-2oggA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjp | CYTOCHROME C1 (Rhodobactersphaeroides) |
PF02167(Cytochrom_C1) | 5 | LEU B 50PHE B 89ASP B 99GLY B 41TYR B 32 | None | 1.25A | 1zz1A-2qjpB:undetectable | 1zz1A-2qjpB:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vif | SUPPRESSOR OFCYTOKINE SIGNALLING6 (Homo sapiens) |
PF00017(SH2) | 5 | LEU A 420ILE A 433HIS A 451PHE A 442ASP A 464 | None | 1.14A | 1zz1A-2vifA:undetectable | 1zz1A-2vifA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yiu | CYTOCHROME C1, HEMEPROTEIN (Paracoccusdenitrificans) |
PF02167(Cytochrom_C1) | 5 | LEU B 96PHE B 135ASP B 146GLY B 87TYR B 78 | None | 1.25A | 1zz1A-2yiuB:undetectable | 1zz1A-2yiuB:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3auz | DNA DOUBLE-STRANDBREAK REPAIR PROTEINMRE11 (Methanocaldococcusjannaschii) |
PF00149(Metallophos) | 5 | ILE A 191HIS A 10HIS A 188ASP A 49GLY A 48 | None MN A 401 (-3.4A) MN A 401 (-3.5A) MN A 402 ( 2.9A)None | 1.24A | 1zz1A-3auzA:undetectable | 1zz1A-3auzA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bga | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 5 | LEU A 966ILE A 959HIS A 627HIS A 919GLY A 554 | None | 1.12A | 1zz1A-3bgaA:undetectable | 1zz1A-3bgaA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bus | METHYLTRANSFERASE (Lechevalieriaaerocolonigenes) |
PF08241(Methyltransf_11) | 5 | LEU A 224HIS A 141HIS A 140PHE A 184GLY A 25 | NoneSAH A 274 (-4.0A)NoneNoneNone | 1.17A | 1zz1A-3busA:3.0 | 1zz1A-3busA:24.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c10 | HISTONE DEACETYLASE7A (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 669HIS A 670ASP A 707ASP A 801GLY A 799 | TSN A 301 (-3.9A)TSN A 301 (-3.8A) ZN A 101 (-2.1A) ZN A 101 ( 2.5A)None | 1.14A | 1zz1A-3c10A:47.9 | 1zz1A-3c10A:33.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c10 | HISTONE DEACETYLASE7A (Homo sapiens) |
PF00850(Hist_deacetyl) | 8 | HIS A 669HIS A 670PHE A 679ASP A 707HIS A 709PHE A 738ASP A 801GLY A 841 | TSN A 301 (-3.9A)TSN A 301 (-3.8A)TSN A 301 (-3.9A) ZN A 101 (-2.1A) ZN A 101 (-3.1A)TSN A 301 ( 4.0A) ZN A 101 ( 2.5A)TSN A 301 ( 3.9A) | 0.48A | 1zz1A-3c10A:47.9 | 1zz1A-3c10A:33.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c10 | HISTONE DEACETYLASE7A (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | PHE A 679HIS A 709PHE A 738ASP A 801GLY A 842 | TSN A 301 (-3.9A) ZN A 101 (-3.1A)TSN A 301 ( 4.0A) ZN A 101 ( 2.5A)None | 1.17A | 1zz1A-3c10A:47.9 | 1zz1A-3c10A:33.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hx6 | TYPE 4 FIMBRIALBIOGENESIS PROTEINPILY1 (Pseudomonasaeruginosa) |
PF05567(Neisseria_PilC) | 5 | ILE A 820HIS A 797ASP A 855ASP A 851GLY A 856 | NoneNone CA A 1 (-2.8A) CA A 1 (-3.4A)None | 1.08A | 1zz1A-3hx6A:undetectable | 1zz1A-3hx6A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6y | ESTERASE APC40077 (Oleispiraantarctica) |
PF00756(Esterase) | 5 | LEU A 247HIS A 273HIS A 269PHE A 272GLY A 146 | None | 1.18A | 1zz1A-3i6yA:undetectable | 1zz1A-3i6yA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls2 | S-FORMYLGLUTATHIONEHYDROLASE (Pseudoalteromonashaloplanktis) |
PF00756(Esterase) | 5 | LEU A 248HIS A 274HIS A 270PHE A 273GLY A 145 | None | 1.15A | 1zz1A-3ls2A:undetectable | 1zz1A-3ls2A:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3max | HISTONE DEACETYLASE2 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 145HIS A 146ASP A 181ASP A 269GLY A 267 | LLX A 400 (-4.0A)LLX A 400 (-3.8A) ZN A 379 (-2.3A) ZN A 379 ( 2.5A)None | 1.16A | 1zz1A-3maxA:44.5 | 1zz1A-3maxA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3max | HISTONE DEACETYLASE2 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 145HIS A 146ASP A 181PHE A 210GLY A 305 | LLX A 400 (-4.0A)LLX A 400 (-3.8A) ZN A 379 (-2.3A)LLX A 400 (-3.6A)LLX A 400 (-3.5A) | 0.92A | 1zz1A-3maxA:44.5 | 1zz1A-3maxA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3max | HISTONE DEACETYLASE2 (Homo sapiens) |
PF00850(Hist_deacetyl) | 9 | HIS A 145HIS A 146PHE A 155ASP A 181HIS A 183PHE A 210ASP A 269GLY A 306TYR A 308 | LLX A 400 (-4.0A)LLX A 400 (-3.8A)LLX A 400 (-4.1A) ZN A 379 (-2.3A) ZN A 379 (-3.2A)LLX A 400 (-3.6A) ZN A 379 ( 2.5A)LLX A 400 (-3.7A)LLX A 400 (-4.4A) | 0.57A | 1zz1A-3maxA:44.5 | 1zz1A-3maxA:25.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3men | ACETYLPOLYAMINEAMINOHYDROLASE (Burkholderiapseudomallei) |
PF00850(Hist_deacetyl) | 8 | HIS A 156HIS A 157PHE A 166ASP A 192HIS A 194ASP A 281GLY A 318TYR A 320 | SO4 A 401 (-3.6A)SO4 A 401 (-3.4A)None ZN A 400 (-2.3A) ZN A 400 (-3.3A) ZN A 400 ( 2.6A)SO4 A 401 ( 3.7A)SO4 A 401 (-4.5A) | 0.45A | 1zz1A-3menA:40.8 | 1zz1A-3menA:33.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3men | ACETYLPOLYAMINEAMINOHYDROLASE (Burkholderiapseudomallei) |
PF00850(Hist_deacetyl) | 5 | HIS A 157HIS A 194ASP A 281GLY A 318TYR A 320 | SO4 A 401 (-3.4A) ZN A 400 (-3.3A) ZN A 400 ( 2.6A)SO4 A 401 ( 3.7A)SO4 A 401 (-4.5A) | 1.17A | 1zz1A-3menA:40.8 | 1zz1A-3menA:33.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 5 | LEU A 140HIS A 18ASP A 278GLY A 21TYR A 63 | NoneADE A 328 ( 3.0A)ADE A 328 (-2.8A)NoneADE A 328 (-4.0A) | 1.21A | 1zz1A-3paoA:undetectable | 1zz1A-3paoA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdx | TYROSINEAMINOTRANSFERASE (Mus musculus) |
PF00155(Aminotran_1_2) | 5 | LEU A 363ILE A 378HIS A 441PHE A 383PHE A 437 | None | 1.18A | 1zz1A-3pdxA:3.3 | 1zz1A-3pdxA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pin | PEPTIDE METHIONINESULFOXIDE REDUCTASE (Saccharomycescerevisiae) |
PF01625(PMSR) | 5 | LEU B 120ILE B 19HIS B 179HIS B 100GLY B 24 | None | 1.18A | 1zz1A-3pinB:undetectable | 1zz1A-3pinB:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnz | PHOSPHOTRIESTERASEFAMILY PROTEIN (Listeriamonocytogenes) |
PF02126(PTE) | 5 | LEU A 288ILE A 63HIS A 215HIS A 22GLY A 239 | NoneNone ZN A 334 ( 3.4A) ZN A 333 ( 3.3A)None | 1.09A | 1zz1A-3pnzA:undetectable | 1zz1A-3pnzA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9c | ACETYLPOLYAMINEAMIDOHYDROLASE (Mycoplanaramosa) |
PF00850(Hist_deacetyl) | 7 | HIS A 158ASP A 195HIS A 197PHE A 225ASP A 284GLY A 321TYR A 323 | Q9C A 401 (-4.2A) ZN A 343 (-2.3A) ZN A 343 (-3.4A)Q9C A 401 (-3.8A) ZN A 343 (-2.7A)Q9C A 401 (-3.6A)None | 0.39A | 1zz1A-3q9cA:41.9 | 1zz1A-3q9cA:29.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9c | ACETYLPOLYAMINEAMIDOHYDROLASE (Mycoplanaramosa) |
PF00850(Hist_deacetyl) | 5 | HIS A 158HIS A 197ASP A 284GLY A 322TYR A 323 | Q9C A 401 (-4.2A) ZN A 343 (-3.4A) ZN A 343 (-2.7A)NoneNone | 1.25A | 1zz1A-3q9cA:41.9 | 1zz1A-3q9cA:29.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 5 | LEU A 143HIS A 21ASP A 281GLY A 24TYR A 66 | NoneADE A 345 ( 3.2A)ADE A 345 (-2.8A)NoneADE A 345 (-4.0A) | 1.25A | 1zz1A-3rysA:undetectable | 1zz1A-3rysA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5k | FALCILYSIN (Plasmodiumfalciparum) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 5 | LEU A 252ILE A 445ASP A 356GLY A 586TYR A 354 | None | 0.97A | 1zz1A-3s5kA:undetectable | 1zz1A-3s5kA:12.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3o | METAL DEPENDENTHYDROLASE (Thermusthermophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 5 | LEU A 395ILE A 12HIS A 80ASP A 172GLY A 171 | NoneNone ZN A 600 (-3.6A) ZN A 600 (-2.4A)None | 1.21A | 1zz1A-3t3oA:undetectable | 1zz1A-3t3oA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a69 | HISTONE DEACETYLASE3, (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 134HIS A 135PHE A 144ASP A 170GLY A 295 | ACT A 501 (-4.0A)ACT A 501 (-3.7A)None ZN A 500 (-2.2A)None | 1.12A | 1zz1A-4a69A:43.9 | 1zz1A-4a69A:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a69 | HISTONE DEACETYLASE3, (Homo sapiens) |
PF00850(Hist_deacetyl) | 9 | HIS A 134HIS A 135PHE A 144ASP A 170HIS A 172PHE A 200ASP A 259GLY A 296TYR A 298 | ACT A 501 (-4.0A)ACT A 501 (-3.7A)None ZN A 500 (-2.2A) ZN A 500 (-3.1A)None ZN A 500 ( 2.4A)ACT A 501 (-3.0A)ACT A 501 (-4.7A) | 0.57A | 1zz1A-4a69A:43.9 | 1zz1A-4a69A:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a69 | HISTONE DEACETYLASE3, (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 134HIS A 172ASP A 259GLY A 296TYR A 298 | ACT A 501 (-4.0A) ZN A 500 (-3.1A) ZN A 500 ( 2.4A)ACT A 501 (-3.0A)ACT A 501 (-4.7A) | 1.04A | 1zz1A-4a69A:43.9 | 1zz1A-4a69A:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a69 | HISTONE DEACETYLASE3, (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | LEU A 29HIS A 134ASP A 170ASP A 259GLY A 257 | NoneACT A 501 (-4.0A) ZN A 500 (-2.2A) ZN A 500 ( 2.4A)None | 1.25A | 1zz1A-4a69A:43.9 | 1zz1A-4a69A:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b0s | DEAMIDASE-DEPUPYLASEDOP (Acidothermuscellulolyticus) |
PF03136(Pup_ligase) | 5 | LEU A 370ILE A 369HIS A 394ASP A 246GLY A 185 | None | 1.25A | 1zz1A-4b0sA:undetectable | 1zz1A-4b0sA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bkx | HISTONE DEACETYLASE1 (Homo sapiens) |
PF00850(Hist_deacetyl) | 9 | HIS B 140HIS B 141PHE B 150ASP B 176HIS B 178PHE B 205ASP B 264GLY B 301TYR B 303 | ACT B 601 (-3.7A)ACT B 601 (-3.8A)None ZN B 600 (-2.2A) ZN B 600 (-3.3A)None ZN B 600 ( 2.5A)ACT B 601 (-3.4A)ACT B 601 ( 4.7A) | 0.58A | 1zz1A-4bkxB:43.4 | 1zz1A-4bkxB:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bof | ARGININE DEIMINASE (Streptococcuspyogenes) |
PF02274(Amidinotransf) | 5 | LEU A 71ILE A 195PHE A 168ASP A 166GLY A 221 | PGE A 422 (-3.7A)NonePGE A 422 (-3.9A)NoneNone | 1.25A | 1zz1A-4bofA:undetectable | 1zz1A-4bofA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 5 | HIS A 141HIS A 142ASP A 186ASP A 285GLY A 283 | B3N A 700 (-3.9A)B3N A 700 (-3.7A) ZN A 500 (-2.3A) ZN A 500 ( 2.5A)None | 1.13A | 1zz1A-4bz7A:40.5 | 1zz1A-4bz7A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 9 | HIS A 141HIS A 142PHE A 151ASP A 186HIS A 188PHE A 216ASP A 285GLY A 339TYR A 341 | B3N A 700 (-3.9A)B3N A 700 (-3.7A)B3N A 700 (-4.2A) ZN A 500 (-2.3A) ZN A 500 (-3.1A)B3N A 700 ( 3.7A) ZN A 500 ( 2.5A)B3N A 700 ( 4.1A)B3N A 700 (-4.4A) | 0.58A | 1zz1A-4bz7A:40.5 | 1zz1A-4bz7A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 5 | HIS A 141HIS A 188ASP A 285GLY A 339TYR A 341 | B3N A 700 (-3.9A) ZN A 500 (-3.1A) ZN A 500 ( 2.5A)B3N A 700 ( 4.1A)B3N A 700 (-4.4A) | 1.11A | 1zz1A-4bz7A:40.5 | 1zz1A-4bz7A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 5 | HIS A 142PHE A 151HIS A 188ASP A 285TYR A 341 | B3N A 700 (-3.7A)B3N A 700 (-4.2A) ZN A 500 (-3.1A) ZN A 500 ( 2.5A)B3N A 700 (-4.4A) | 1.07A | 1zz1A-4bz7A:40.5 | 1zz1A-4bz7A:22.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4cby | HISTONE DEACETYLASE4 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 802HIS A 803ASP A 840ASP A 934GLY A 932 | KEE A2033 (-3.8A)KEE A2033 (-4.0A) ZN A2034 (-2.0A) ZN A2034 ( 2.4A)None | 1.20A | 1zz1A-4cbyA:47.0 | 1zz1A-4cbyA:32.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4cby | HISTONE DEACETYLASE4 (Homo sapiens) |
PF00850(Hist_deacetyl) | 7 | HIS A 802HIS A 803ASP A 840HIS A 842PHE A 871ASP A 934GLY A 974 | KEE A2033 (-3.8A)KEE A2033 (-4.0A) ZN A2034 (-2.0A) ZN A2034 (-3.2A)KEE A2033 (-3.8A) ZN A2034 ( 2.4A)KEE A2033 (-3.6A) | 0.48A | 1zz1A-4cbyA:47.0 | 1zz1A-4cbyA:32.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4cby | HISTONE DEACETYLASE4 (Homo sapiens) |
PF00850(Hist_deacetyl) | 7 | HIS A 802HIS A 803PHE A 812HIS A 842PHE A 871ASP A 934GLY A 974 | KEE A2033 (-3.8A)KEE A2033 (-4.0A)KEE A2033 (-4.2A) ZN A2034 (-3.2A)KEE A2033 (-3.8A) ZN A2034 ( 2.4A)KEE A2033 (-3.6A) | 0.73A | 1zz1A-4cbyA:47.0 | 1zz1A-4cbyA:32.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gtn | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Acinetobactersp. ADP1) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | LEU A 199ILE A 225HIS A 241ASP A 106GLY A 105 | None | 1.14A | 1zz1A-4gtnA:undetectable | 1zz1A-4gtnA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kam | O-ACETYLHOMOSERINESULFHYDRYLASE METC (Mycobacteriummarinum) |
PF01053(Cys_Met_Meta_PP) | 5 | LEU A 318HIS A 376PHE A 367HIS A 374ASP A 428 | None | 1.11A | 1zz1A-4kamA:undetectable | 1zz1A-4kamA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4keq | 4-PYRIDOXOLACTONASE (Mesorhizobiumjaponicum) |
PF00753(Lactamase_B) | 5 | LEU A 62HIS A 96HIS A 98PHE A 99ASP A 207 | None ZN A 302 (-3.4A) ZN A 302 ( 3.2A)5PN A 303 (-4.4A) ZN A 301 ( 2.1A) | 1.21A | 1zz1A-4keqA:undetectable | 1zz1A-4keqA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y0i | 4-AMINOBUTYRATEAMINOTRANSFERASE,MITOCHONDRIAL (Sus scrofa) |
PF00202(Aminotran_3) | 5 | LEU A 284ILE A 262HIS A 190PHE A 185GLY A 187 | None | 1.25A | 1zz1A-4y0iA:4.2 | 1zz1A-4y0iA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysl | BETA-LACTAMASEDOMAIN PROTEIN (Pseudomonasputida) |
PF00753(Lactamase_B) | 5 | ILE A 100HIS A 149ASP A 170HIS A 76GLY A 169 | None FE A 301 ( 3.5A) FE A 301 ( 3.1A)NoneNone | 1.17A | 1zz1A-4yslA:undetectable | 1zz1A-4yslA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cw2 | PUTATIVE EPOXIDEHYDROLASE EPHA (Mycolicibacteriumthermoresistibile) |
no annotation | 5 | LEU C 167ILE C 201HIS C 297ASP C 103TYR C 238 | NoneNoneBSU C 401 (-3.8A)BSU C 401 (-2.8A)BSU C 401 (-4.4A) | 1.20A | 1zz1A-5cw2C:undetectable | 1zz1A-5cw2C:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dn6 | ATP SYNTHASE SUBUNITALPHA (Paracoccusdenitrificans) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | LEU A 12ILE A 16ASP A 45GLY A 43TYR A 42 | None | 1.21A | 1zz1A-5dn6A:undetectable | 1zz1A-5dn6A:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dny | DNA DOUBLE-STRANDBREAK REPAIR PROTEINMRE11 (Methanocaldococcusjannaschii) |
PF00149(Metallophos) | 5 | ILE A 191HIS A 10HIS A 188ASP A 49GLY A 48 | None MG A 401 (-3.5A) MG A 401 (-3.4A) MG A 402 ( 2.7A)None | 1.25A | 1zz1A-5dnyA:undetectable | 1zz1A-5dnyA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edu | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HISTONE DEACETYLASE6 CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 5 | HIS B 610HIS B 611ASP B 649ASP B 742GLY B 740 | TSN B2501 (-3.8A)TSN B2501 (-3.9A) ZN B2502 (-2.2A) ZN B2502 ( 2.7A)None | 1.17A | 1zz1A-5eduB:49.0 | 1zz1A-5eduB:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edu | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HISTONE DEACETYLASE6 CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 9 | HIS B 610HIS B 611PHE B 620ASP B 649HIS B 651PHE B 680ASP B 742GLY B 780TYR B 782 | TSN B2501 (-3.8A)TSN B2501 (-3.9A)TSN B2501 (-3.7A) ZN B2502 (-2.2A) ZN B2502 (-3.2A)TSN B2501 (-3.7A) ZN B2502 ( 2.7A)TSN B2501 ( 4.0A)TSN B2501 (-4.2A) | 0.47A | 1zz1A-5eduB:49.0 | 1zz1A-5eduB:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edu | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HISTONE DEACETYLASE6 CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 5 | HIS B 610HIS B 651ASP B 742GLY B 781TYR B 782 | TSN B2501 (-3.8A) ZN B2502 (-3.2A) ZN B2502 ( 2.7A)NoneTSN B2501 (-4.2A) | 1.26A | 1zz1A-5eduB:49.0 | 1zz1A-5eduB:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edu | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HISTONE DEACETYLASE6 CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 9 | ILE B 569HIS B 611PHE B 620ASP B 649HIS B 651PHE B 680ASP B 742GLY B 780TYR B 782 | NoneTSN B2501 (-3.9A)TSN B2501 (-3.7A) ZN B2502 (-2.2A) ZN B2502 (-3.2A)TSN B2501 (-3.7A) ZN B2502 ( 2.7A)TSN B2501 ( 4.0A)TSN B2501 (-4.2A) | 1.33A | 1zz1A-5eduB:49.0 | 1zz1A-5eduB:21.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | HIS A 192HIS A 193ASP A 230ASP A 323GLY A 321 | TSN A2002 (-3.9A)TSN A2002 (-3.9A) ZN A2001 (-2.3A) ZN A2001 ( 2.7A)None | 1.14A | 1zz1A-5eefA:49.6 | 1zz1A-5eefA:32.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 8 | HIS A 192HIS A 193PHE A 202ASP A 230HIS A 232ASP A 323GLY A 361TYR A 363 | TSN A2002 (-3.9A)TSN A2002 (-3.9A)TSN A2002 (-3.9A) ZN A2001 (-2.3A) ZN A2001 (-3.1A) ZN A2001 ( 2.7A)TSN A2002 ( 3.8A)TSN A2002 (-4.3A) | 0.44A | 1zz1A-5eefA:49.6 | 1zz1A-5eefA:32.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | HIS A 193HIS A 232ASP A 323GLY A 361TYR A 363 | TSN A2002 (-3.9A) ZN A2001 (-3.1A) ZN A2001 ( 2.7A)TSN A2002 ( 3.8A)TSN A2002 (-4.3A) | 1.01A | 1zz1A-5eefA:49.6 | 1zz1A-5eefA:32.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5efn | HDAC6 PROTEIN (Danio rerio) |
no annotation | 5 | HIS B 573HIS B 614ASP B 705GLY B 744TYR B 745 | None ZN B 801 ( 3.2A) ZN B 801 (-2.6A)NoneNone | 1.24A | 1zz1A-5efnB:50.0 | 1zz1A-5efnB:33.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5efn | HDAC6 PROTEIN (Danio rerio) |
no annotation | 8 | HIS B 573PHE B 583ASP B 612HIS B 614PHE B 643ASP B 705GLY B 743TYR B 745 | NoneNone ZN B 801 ( 2.1A) ZN B 801 ( 3.2A)None ZN B 801 (-2.6A) ZN B 801 ( 4.1A)None | 0.44A | 1zz1A-5efnB:50.0 | 1zz1A-5efnB:33.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5efn | HDAC6 PROTEIN (Danio rerio) |
no annotation | 7 | ILE B 532HIS B 573ASP B 612HIS B 614ASP B 705GLY B 743TYR B 745 | NoneNone ZN B 801 ( 2.1A) ZN B 801 ( 3.2A) ZN B 801 (-2.6A) ZN B 801 ( 4.1A)None | 1.06A | 1zz1A-5efnB:50.0 | 1zz1A-5efnB:33.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | HIS A 573HIS A 574ASP A 612ASP A 705GLY A 703 | E1Z A1801 (-3.9A)E1Z A1801 (-3.8A) ZN A1804 (-2.1A) ZN A1804 ( 2.5A)None | 1.16A | 1zz1A-5g0hA:50.2 | 1zz1A-5g0hA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 9 | HIS A 573HIS A 574PHE A 583ASP A 612HIS A 614PHE A 643ASP A 705GLY A 743TYR A 745 | E1Z A1801 (-3.9A)E1Z A1801 (-3.8A)E1Z A1801 (-3.9A) ZN A1804 (-2.1A) ZN A1804 (-3.2A)E1Z A1801 (-3.6A) ZN A1804 ( 2.5A) ZN A1804 ( 4.2A)E1Z A1801 (-4.4A) | 0.42A | 1zz1A-5g0hA:50.2 | 1zz1A-5g0hA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | HIS A 573HIS A 614ASP A 705GLY A 744TYR A 745 | E1Z A1801 (-3.9A) ZN A1804 (-3.2A) ZN A1804 ( 2.5A)NoneE1Z A1801 (-4.4A) | 1.25A | 1zz1A-5g0hA:50.2 | 1zz1A-5g0hA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | HIS A 574HIS A 614ASP A 705GLY A 743TYR A 745 | E1Z A1801 (-3.8A) ZN A1804 (-3.2A) ZN A1804 ( 2.5A) ZN A1804 ( 4.2A)E1Z A1801 (-4.4A) | 1.07A | 1zz1A-5g0hA:50.2 | 1zz1A-5g0hA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 8 | ILE A 532HIS A 573HIS A 574ASP A 612HIS A 614ASP A 705GLY A 743TYR A 745 | NoneE1Z A1801 (-3.9A)E1Z A1801 (-3.8A) ZN A1804 (-2.1A) ZN A1804 (-3.2A) ZN A1804 ( 2.5A) ZN A1804 ( 4.2A)E1Z A1801 (-4.4A) | 1.14A | 1zz1A-5g0hA:50.2 | 1zz1A-5g0hA:20.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5g10 | HDAH (Pseudomonasaeruginosa) |
PF00850(Hist_deacetyl) | 7 | HIS A 143HIS A 144ASP A 181HIS A 183PHE A 209ASP A 269GLY A 267 | 6DK A1375 (-4.1A)6DK A1375 (-3.9A) ZN A1372 (-2.0A) ZN A1372 (-3.2A)6DK A1375 ( 4.0A) ZN A1372 ( 2.5A)None | 1.23A | 1zz1A-5g10A:56.8 | 1zz1A-5g10A:45.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5g10 | HDAH (Pseudomonasaeruginosa) |
PF00850(Hist_deacetyl) | 9 | HIS A 143HIS A 144PHE A 153ASP A 181HIS A 183PHE A 209ASP A 269GLY A 311TYR A 313 | 6DK A1375 (-4.1A)6DK A1375 (-3.9A)6DK A1375 ( 4.0A) ZN A1372 (-2.0A) ZN A1372 (-3.2A)6DK A1375 ( 4.0A) ZN A1372 ( 2.5A)6DK A1375 (-3.3A)6DK A1375 (-4.4A) | 0.27A | 1zz1A-5g10A:56.8 | 1zz1A-5g10A:45.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5g10 | HDAH (Pseudomonasaeruginosa) |
PF00850(Hist_deacetyl) | 6 | LEU A 23ASP A 181HIS A 183ASP A 269GLY A 311TYR A 313 | None ZN A1372 (-2.0A) ZN A1372 (-3.2A) ZN A1372 ( 2.5A)6DK A1375 (-3.3A)6DK A1375 (-4.4A) | 1.19A | 1zz1A-5g10A:56.8 | 1zz1A-5g10A:45.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5g10 | HDAH (Pseudomonasaeruginosa) |
PF00850(Hist_deacetyl) | 5 | LEU A 23HIS A 144HIS A 183ASP A 269TYR A 313 | None6DK A1375 (-3.9A) ZN A1372 (-3.2A) ZN A1372 ( 2.5A)6DK A1375 (-4.4A) | 1.09A | 1zz1A-5g10A:56.8 | 1zz1A-5g10A:45.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxd | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Dinoroseobactershibae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | LEU A 505ILE A 566PHE A 143ASP A 281GLY A 283 | NoneNoneNoneCOA A 703 ( 4.4A)None | 1.25A | 1zz1A-5gxdA:2.5 | 1zz1A-5gxdA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hif | RECONSTRUCTEDLACTONASE ANCESTOR,ANC1-MPH (syntheticconstruct) |
PF00753(Lactamase_B) | 5 | LEU A 77ILE A 110HIS A 114ASP A 221GLY A 220 | NoneNone ZN A 402 (-3.4A) ZN A 401 ( 2.4A)None | 0.96A | 1zz1A-5hifA:undetectable | 1zz1A-5hifA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ine | PRE-GLYCOPROTEINPOLYPROTEIN GPCOMPLEX (Lymphocyticchoriomeningitismammarenavirus) |
PF00798(Arena_glycoprot) | 5 | LEU A 110ILE A 101HIS A 360PHE A 199GLY A 201 | None | 1.22A | 1zz1A-5ineA:undetectable | 1zz1A-5ineA:20.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ji5 | BUPHA.10154.A.B1 (Paraburkholderiaphymatum) |
PF00850(Hist_deacetyl) | 5 | HIS A 125HIS A 126ASP A 163ASP A 244GLY A 242 | NoneEDO A 403 (-4.2A) ZN A 401 ( 2.2A) ZN A 401 (-2.5A)None | 1.25A | 1zz1A-5ji5A:46.7 | 1zz1A-5ji5A:33.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ji5 | BUPHA.10154.A.B1 (Paraburkholderiaphymatum) |
PF00850(Hist_deacetyl) | 8 | HIS A 125HIS A 126PHE A 135ASP A 163HIS A 165ASP A 244GLY A 286TYR A 288 | NoneEDO A 403 (-4.2A)EDO A 403 ( 3.8A) ZN A 401 ( 2.2A) ZN A 401 (-3.1A) ZN A 401 (-2.5A) ZN A 401 ( 4.2A)None | 0.42A | 1zz1A-5ji5A:46.7 | 1zz1A-5ji5A:33.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ji5 | BUPHA.10154.A.B1 (Paraburkholderiaphymatum) |
PF00850(Hist_deacetyl) | 5 | HIS A 125HIS A 165ASP A 244GLY A 286TYR A 288 | None ZN A 401 (-3.1A) ZN A 401 (-2.5A) ZN A 401 ( 4.2A)None | 1.19A | 1zz1A-5ji5A:46.7 | 1zz1A-5ji5A:33.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jx3 | URACIL-DNAGLYCOSYLASE (Vaccinia virus) |
no annotation | 5 | LEU A 110ILE A 89ASP A 192GLY A 179TYR A 156 | None | 1.21A | 1zz1A-5jx3A:undetectable | 1zz1A-5jx3A:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9h | 0940_GH29 (unidentified) |
PF00754(F5_F8_type_C)PF01120(Alpha_L_fucos) | 5 | LEU A 146PHE A 161ASP A 213GLY A 212TYR A 192 | NoneNone NA A 629 ( 4.9A) NA A 629 (-4.5A)None | 1.07A | 1zz1A-5k9hA:undetectable | 1zz1A-5k9hA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mtz | RIBONUCLEASE Z (Saccharomycescerevisiae) |
PF13691(Lactamase_B_4) | 5 | ILE A 536HIS A 540ASP A 699GLY A 698TYR A 696 | None ZN A 901 (-3.4A) ZN A 902 (-2.3A)NoneNone | 1.17A | 1zz1A-5mtzA:undetectable | 1zz1A-5mtzA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td7 | ZGC:55652 (Danio rerio) |
PF00850(Hist_deacetyl) | 6 | HIS A 136HIS A 137ASP A 174HIS A 176ASP A 267GLY A 265 | FKS A 711 (-4.0A)FKS A 711 (-3.5A) ZN A 701 (-1.9A) ZN A 701 (-3.3A) ZN A 701 ( 2.6A)None | 1.17A | 1zz1A-5td7A:49.4 | 1zz1A-5td7A:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td7 | ZGC:55652 (Danio rerio) |
PF00850(Hist_deacetyl) | 7 | HIS A 136HIS A 137PHE A 146ASP A 174HIS A 176ASP A 267GLY A 305 | FKS A 711 (-4.0A)FKS A 711 (-3.5A)FKS A 711 (-3.9A) ZN A 701 (-1.9A) ZN A 701 (-3.3A) ZN A 701 ( 2.6A)FKS A 711 (-3.2A) | 0.34A | 1zz1A-5td7A:49.4 | 1zz1A-5td7A:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8s | CELL DIVISIONCONTROL PROTEIN 45 (Saccharomycescerevisiae) |
PF02724(CDC45) | 5 | ILE E 629PHE E 625ASP E 124HIS E 126GLY E 85 | None | 0.93A | 1zz1A-5u8sE:undetectable | 1zz1A-5u8sE:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uem | 354NC37 FAB HEAVYCHAIN354NC37 FAB LIGHTCHAIN (Homo sapiens) |
no annotation | 5 | LEU L 28ILE L 2HIS H 35ASP H 95GLY H 100 | None | 1.10A | 1zz1A-5uemL:undetectable | 1zz1A-5uemL:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vi6 | HISTONE DEACETYLASE8 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 142HIS A 143PHE A 152ASP A 178GLY A 303 | NoneEDO A 410 (-4.4A)EDO A 407 (-4.2A) ZN A 401 ( 2.3A)None | 1.03A | 1zz1A-5vi6A:42.2 | 1zz1A-5vi6A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vi6 | HISTONE DEACETYLASE8 (Homo sapiens) |
PF00850(Hist_deacetyl) | 9 | HIS A 142HIS A 143PHE A 152ASP A 178HIS A 180PHE A 208ASP A 267GLY A 304TYR A 306 | NoneEDO A 410 (-4.4A)EDO A 407 (-4.2A) ZN A 401 ( 2.3A) ZN A 401 ( 3.1A)EDO A 410 ( 3.7A) ZN A 401 (-2.4A) ZN A 401 ( 4.2A)EDO A 407 ( 3.3A) | 0.55A | 1zz1A-5vi6A:42.2 | 1zz1A-5vi6A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vi6 | HISTONE DEACETYLASE8 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 142HIS A 180ASP A 267GLY A 304TYR A 306 | None ZN A 401 ( 3.1A) ZN A 401 (-2.4A) ZN A 401 ( 4.2A)EDO A 407 ( 3.3A) | 1.06A | 1zz1A-5vi6A:42.2 | 1zz1A-5vi6A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cud | SHORT TRANSIENTRECEPTOR POTENTIALCHANNEL 3 (Homo sapiens) |
no annotation | 5 | LEU A 275PHE A 308HIS A 311ASP A 263GLY A 260 | None | 1.05A | 1zz1A-6cudA:undetectable | 1zz1A-6cudA:11.99 |