SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZWP_A_NIMA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		4 LEU A 206
GLY A  45
TRP A  46
ASP A  48
 None
 0.95A 1zwpA-1b0zA:
0.0		 1zwpA-1b0zA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		4 LEU B 184
GLY B 119
TRP B 191
ASP B 116
 None
 1.12A 1zwpA-1i7qB:
0.0		 1zwpA-1i7qB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LEU A  93
GLY A 246
ASP A 273
LYS A 305
 None
None
PLP  A1494 (-2.7A)
PLP  A1494 (-1.4A)
 1.49A 1zwpA-2jisA:
0.0		 1zwpA-2jisA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 LEU A1144
GLY A1176
TRP A1189
ASP A1193
 None
 1.43A 1zwpA-3k9bA:
0.0		 1zwpA-3k9bA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4f SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 LEU D 666
GLY D 715
TRP D 712
ASP D 720
 LEU  D 666 ( 0.6A)
GLY  D 715 ( 0.0A)
TRP  D 712 ( 0.5A)
ASP  D 720 ( 0.6A)
 1.12A 1zwpA-3l4fD:
0.0		 1zwpA-3l4fD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 349
GLY A 369
TRP A 370
ASP A 375
 None
 1.49A 1zwpA-3mi6A:
0.0		 1zwpA-3mi6A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A 648
GLY A 697
TRP A 694
ASP A 702
 None
 1.23A 1zwpA-3o5nA:
undetectable		 1zwpA-3o5nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 LEU A 659
GLY A 534
ASP A 531
LYS A 655
 None
 1.46A 1zwpA-3ut2A:
0.0		 1zwpA-3ut2A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 567
GLY A 503
TRP A 546
ASP A 505
 None
 1.40A 1zwpA-4jklA:
0.0		 1zwpA-4jklA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldk RNA 2',3'-CYCLIC
PHOSPHODIESTERASE

(Escherichia
coli) 		PF02834
(LigT_PEase) 		4 LEU A 128
GLY A  80
TRP A  82
ASP A  78
 None
 1.50A 1zwpA-5ldkA:
undetectable		 1zwpA-5ldkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 4 LEU A 171
GLY A 174
TRP A 241
ASP A 188
 None
 1.45A 1zwpA-5mktA:
undetectable		 1zwpA-5mktA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 4 LEU A 171
GLY A 174
TRP A 241
ASP A 188
 None
 1.49A 1zwpA-5mlgA:
undetectable		 1zwpA-5mlgA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xft DEHYDROASCORBATE
REDUCTASE

(Chlamydomonas
reinhardtii) 		no annotation 4 LEU A  19
GLY A 210
TRP A 211
LYS A  10
 None
 1.37A 1zwpA-5xftA:
undetectable		 1zwpA-5xftA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 4 LEU A 582
GLY A 518
TRP A 561
ASP A 520
 None
None
E0V  A 701 (-3.9A)
None
 1.39A 1zwpA-6bo6A:
undetectable		 1zwpA-6bo6A:
undetectable