SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZVI_A_H4BA901
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 3 | ARG B 91VAL B 96TRP B 143 | None | 0.80A | 1zviA-1bouB:0.0 | 1zviA-1bouB:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1crk | CREATINE KINASE (Gallus gallus) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 125VAL A 222TRP A 223 | PO4 A 401 (-2.7A)NoneNone | 1.00A | 1zviA-1crkA:0.0 | 1zviA-1crkA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fp3 | N-ACYL-D-GLUCOSAMINE2-EPIMERASE (Sus scrofa) |
PF07221(GlcNAc_2-epim) | 3 | ARG A 60VAL A 383TRP A 313 | None | 1.24A | 1zviA-1fp3A:0.0 | 1zviA-1fp3A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | ARG A 310VAL A 304TRP A 308 | None | 0.94A | 1zviA-1itzA:2.4 | 1zviA-1itzA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0n | XANTHAN LYASE (Bacillus sp.GL1) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 3 | ARG A 101VAL A 163TRP A 36 | None | 1.11A | 1zviA-1j0nA:0.0 | 1zviA-1j0nA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5w | GLYCYL-TRNASYNTHETASE ALPHACHAIN (Thermotogamaritima) |
PF02091(tRNA-synt_2e) | 3 | ARG A 163VAL A 129TRP A 130 | None | 1.16A | 1zviA-1j5wA:0.0 | 1zviA-1j5wA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ksi | COPPER AMINE OXIDASE (Pisum sativum) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 3 | ARG A 586VAL A 580TRP A 581 | NAG A 657 ( 4.5A)NoneNone | 1.26A | 1zviA-1ksiA:0.0 | 1zviA-1ksiA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lgy | TRIACYLGLYCEROLLIPASE (Rhizopus niveus) |
PF01764(Lipase_3) | 3 | ARG A 203VAL A 200TRP A 224 | None | 1.10A | 1zviA-1lgyA:0.0 | 1zviA-1lgyA:21.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 3 | ARG A 596VAL A 677TRP A 678 | H4B A 760 (-3.5A)H4B A 760 (-4.6A)H4B A 760 ( 3.6A) | 0.15A | 1zviA-1lzxA:18.8 | 1zviA-1lzxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1or7 | RNA POLYMERASESIGMA-E FACTORSIGMA-E FACTORNEGATIVE REGULATORYPROTEIN (Escherichiacoli) |
PF03872(RseA_N)PF04542(Sigma70_r2)PF08281(Sigma70_r4_2) | 3 | ARG C 40VAL A 27TRP C 33 | None | 1.17A | 1zviA-1or7C:undetectable | 1zviA-1or7C:12.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pk6 | COMPLEMENT C1QSUBCOMPONENT, ACHAIN PRECURSOR (Homo sapiens) |
PF00386(C1q) | 3 | ARG A 163VAL A 195TRP A 194 | None | 1.22A | 1zviA-1pk6A:undetectable | 1zviA-1pk6A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qcx | PECTIN LYASE B (Aspergillusniger) |
PF00544(Pec_lyase_C) | 3 | ARG A 236VAL A 150TRP A 151 | None | 1.19A | 1zviA-1qcxA:undetectable | 1zviA-1qcxA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r8w | GLYCEROL DEHYDRATASE (Clostridiumbutyricum) |
PF01228(Gly_radical)PF02901(PFL-like) | 3 | ARG A 31VAL A 122TRP A 126 | None | 1.16A | 1zviA-1r8wA:1.8 | 1zviA-1r8wA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ru3 | ACETYL-COA SYNTHASE (Carboxydothermushydrogenoformans) |
PF03598(CdhC) | 3 | ARG A 312VAL A 152TRP A 154 | None | 1.02A | 1zviA-1ru3A:2.1 | 1zviA-1ru3A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | ARG B 49VAL B 45TRP B 281 | None | 1.03A | 1zviA-1t3qB:undetectable | 1zviA-1t3qB:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u6r | CREATINE KINASE, MCHAIN (Oryctolaguscuniculus) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 129VAL A 226TRP A 227 | ADP A1801 (-3.1A)NoneNone | 0.86A | 1zviA-1u6rA:undetectable | 1zviA-1u6rA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uli | BIPHENYL DIOXYGENASELARGE SUBUNIT (Rhodococcusjostii) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | ARG A 335VAL A 342TRP A 343 | None | 1.18A | 1zviA-1uliA:undetectable | 1zviA-1uliA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrp | CREATINE KINASE, MCHAIN (Tetronarcecalifornica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 130VAL A 227TRP A 228 | ADP A 400 (-3.1A)NoneNone | 1.18A | 1zviA-1vrpA:undetectable | 1zviA-1vrpA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | IRON-SULFUR PROTEINLARGE SUBUNIT OFCUMENE DIOXYGENASE (Pseudomonasfluorescens) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | ARG A 345VAL A 352TRP A 353 | None | 1.17A | 1zviA-1wqlA:undetectable | 1zviA-1wqlA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wx4 | TYROSINASE (Streptomycescastaneoglobisporus) |
PF00264(Tyrosinase) | 3 | ARG A 92VAL A 147TRP A 196 | None | 1.25A | 1zviA-1wx4A:undetectable | 1zviA-1wx4A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdp | POLYPHOSPHATE KINASE (Escherichiacoli) |
PF02503(PP_kinase)PF13089(PP_kinase_N)PF13090(PP_kinase_C) | 3 | ARG A 632VAL A 341TRP A 323 | None | 1.15A | 1zviA-1xdpA:undetectable | 1zviA-1xdpA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkd | ISOCITRATEDEHYDROGENASE (Aeropyrumpernix) |
PF00180(Iso_dh) | 3 | ARG A 139VAL A 302TRP A 219 | None | 1.20A | 1zviA-1xkdA:undetectable | 1zviA-1xkdA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xx5 | NATRIN 1 (Naja atra) |
PF00188(CAP)PF08562(Crisp) | 3 | ARG A 51VAL A 144TRP A 52 | None | 1.22A | 1zviA-1xx5A:undetectable | 1zviA-1xx5A:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzg | GLUCOSE-6-PHOSPHATEISOMERASE (Thermusthermophilus) |
PF00342(PGI) | 3 | ARG A 34VAL A 184TRP A 43 | None | 1.18A | 1zviA-1zzgA:undetectable | 1zviA-1zzgA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfe | RIBONUCLEASE HII (Thermococcuskodakarensis) |
PF01351(RNase_HII) | 3 | ARG A 177VAL A 194TRP A 198 | None | 1.13A | 1zviA-2dfeA:undetectable | 1zviA-2dfeA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eae | ALPHA-FUCOSIDASE (Bifidobacteriumbifidum) |
PF14498(Glyco_hyd_65N_2) | 3 | ARG A 157VAL A 71TRP A 63 | None | 1.12A | 1zviA-2eaeA:undetectable | 1zviA-2eaeA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ess | ACYL-ACPTHIOESTERASE (Bacteroidesthetaiotaomicron) |
PF01643(Acyl-ACP_TE) | 3 | ARG A 110VAL A 84TRP A 83 | None | 1.18A | 1zviA-2essA:undetectable | 1zviA-2essA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixn | SERINE/THREONINE-PROTEIN PHOSPHATASE 2AACTIVATOR 2 (Saccharomycescerevisiae) |
PF03095(PTPA) | 3 | ARG A 251VAL A 190TRP A 191 | None | 0.96A | 1zviA-2ixnA:undetectable | 1zviA-2ixnA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j1q | ARGININE KINASE (Trypanosomacruzi) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 124VAL A 220TRP A 221 | None | 0.84A | 1zviA-2j1qA:undetectable | 1zviA-2j1qA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lgz | DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT STT3 (Saccharomycescerevisiae) |
no annotation | 3 | ARG A 248VAL A 68TRP A 72 | None | 1.07A | 1zviA-2lgzA:undetectable | 1zviA-2lgzA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m47 | UNCHARACTERIZEDPROTEIN CGL2373 (Corynebacteriumglutamicum) |
PF10604(Polyketide_cyc2) | 3 | ARG A 133VAL A 84TRP A 91 | None | 1.03A | 1zviA-2m47A:undetectable | 1zviA-2m47A:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oae | DIPEPTIDYL PEPTIDASE4 (Rattusnorvegicus) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 3 | ARG A 182VAL A 165TRP A 166 | None | 1.20A | 1zviA-2oaeA:undetectable | 1zviA-2oaeA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p7v | REGULATOR OF SIGMA D (Escherichiacoli) |
PF04353(Rsd_AlgQ) | 3 | ARG A 137VAL A 25TRP A 22 | None | 0.89A | 1zviA-2p7vA:2.0 | 1zviA-2p7vA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbj | PROSTAGLANDIN ESYNTHASE 2 (Macacafascicularis) |
PF13417(GST_N_3) | 3 | ARG A 322VAL A 315TRP A 314 | None | 1.19A | 1zviA-2pbjA:undetectable | 1zviA-2pbjA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vk2 | ABC TRANSPORTERPERIPLASMIC-BINDINGPROTEIN YTFQ (Escherichiacoli) |
PF13407(Peripla_BP_4) | 3 | ARG A 146VAL A 229TRP A 16 | GZL A1298 (-2.7A)NoneNone | 1.05A | 1zviA-2vk2A:undetectable | 1zviA-2vk2A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vm5 | BACULOVIRAL IAPREPEAT-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00653(BIR) | 3 | ARG A 162VAL A 180TRP A 214 | NoneGOL A1246 ( 4.8A)None | 1.24A | 1zviA-2vm5A:undetectable | 1zviA-2vm5A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wj9 | INTERGENIC-REGIONPROTEIN (Escherichiacoli) |
PF03230(Antirestrict) | 3 | ARG A 126VAL A 53TRP A 56 | None | 1.24A | 1zviA-2wj9A:undetectable | 1zviA-2wj9A:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yhe | SEC-ALKYL SULFATASE (Pseudomonas sp.DSM 6611) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 3 | ARG A 128VAL A 359TRP A 360 | None | 1.21A | 1zviA-2yheA:undetectable | 1zviA-2yheA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzy | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA1012 (Thermusthermophilus) |
no annotation | 3 | ARG A 68VAL A 89TRP A 90 | None | 1.10A | 1zviA-2yzyA:undetectable | 1zviA-2yzyA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1a | 5'-NUCLEOTIDASE (Thermusthermophilus) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 3 | ARG A 351VAL A 424TRP A 427 | None | 1.25A | 1zviA-2z1aA:undetectable | 1zviA-2z1aA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3azc | CYTOCHROME B6-FCOMPLEX IRON-SULFURSUBUNIT (Thermosynechococcuselongatus) |
PF00355(Rieske) | 3 | ARG A 172VAL A 151TRP A 179 | None | 1.26A | 1zviA-3azcA:undetectable | 1zviA-3azcA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dm0 | MALTOSE-BINDINGPERIPLASMIC PROTEINFUSED WITH RACK1 (Arabidopsisthaliana;Escherichiacoli) |
PF00400(WD40)PF01547(SBP_bac_1) | 3 | ARG A1058VAL A1032TRP A1043 | None | 1.16A | 1zviA-3dm0A:undetectable | 1zviA-3dm0A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f4b | ENOYL-ACYL CARRIERPROTEIN REDUCTASE (Plasmodiumberghei) |
PF13561(adh_short_C2) | 3 | ARG A 303VAL A 113TRP A 114 | NoneNoneNAD A 450 (-3.8A) | 1.26A | 1zviA-3f4bA:undetectable | 1zviA-3f4bA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gc6 | ECTO-NAD+GLYCOHYDROLASE (CD38MOLECULE) (Bos taurus) |
PF02267(Rib_hydrolayse) | 3 | ARG A 132VAL A 199TRP A 231 | None | 1.04A | 1zviA-3gc6A:undetectable | 1zviA-3gc6A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 3 (Thermusthermophilus) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 3 | ARG 3 455VAL 3 748TRP 3 717 | None | 1.01A | 1zviA-3i9v3:undetectable | 1zviA-3i9v3:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4x | NOL1/NOP2/SUN FAMILYPROTEIN (Enterococcusfaecium) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 3 | ARG A 152VAL A 155TRP A 153 | None | 0.75A | 1zviA-3m4xA:undetectable | 1zviA-3m4xA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mga | ENTEROCHELINESTERASE (Salmonellaenterica) |
PF00756(Esterase)PF11806(DUF3327) | 3 | ARG A 114VAL A 353TRP A 314 | None | 1.05A | 1zviA-3mgaA:undetectable | 1zviA-3mgaA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mga | ENTEROCHELINESTERASE (Salmonellaenterica) |
PF00756(Esterase)PF11806(DUF3327) | 3 | ARG A 118VAL A 353TRP A 314 | GOL A 407 ( 4.6A)NoneNone | 0.75A | 1zviA-3mgaA:undetectable | 1zviA-3mgaA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odo | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 1 (Homo sapiens) |
PF00621(RhoGEF) | 3 | ARG A 514VAL A 470TRP A 507 | None | 1.22A | 1zviA-3odoA:undetectable | 1zviA-3odoA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opw | DNADAMAGE-RESPONSIVETRANSCRIPTIONALREPRESSOR RPH1 (Saccharomycescerevisiae) |
PF02373(JmjC)PF02375(JmjN) | 3 | ARG A 164VAL A 109TRP A 228 | None | 1.26A | 1zviA-3opwA:undetectable | 1zviA-3opwA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5s | CD38 MOLECULE (Bos taurus) |
PF02267(Rib_hydrolayse) | 3 | ARG A 132VAL A 199TRP A 231 | None | 1.14A | 1zviA-3p5sA:undetectable | 1zviA-3p5sA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qa8 | MGC80376 PROTEIN (Xenopus laevis) |
PF00069(Pkinase) | 3 | ARG A 220VAL A 229TRP A 226 | None | 1.06A | 1zviA-3qa8A:undetectable | 1zviA-3qa8A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v65 | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 4 (Rattusnorvegicus) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 3 | ARG B 589VAL B 547TRP B 550 | None | 0.96A | 1zviA-3v65B:undetectable | 1zviA-3v65B:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vac | CFA/I FIMBRIALSUBUNIT E (Escherichiacoli) |
PF07434(CblD) | 3 | ARG A 41VAL A 196TRP A 171 | None | 0.90A | 1zviA-3vacA:undetectable | 1zviA-3vacA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsz | RICIN B LECTIN (Ruminiclostridiumthermocellum) |
PF04616(Glyco_hydro_43)PF14200(RicinB_lectin_2) | 3 | ARG A 158VAL A 126TRP A 128 | None | 1.19A | 1zviA-3vszA:undetectable | 1zviA-3vszA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhl | ARGININE KINASE (Litopenaeusvannamei) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 124VAL A 220TRP A 221 | None | 0.78A | 1zviA-4bhlA:undetectable | 1zviA-4bhlA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cta | CINA-LIKE PROTEIN (Thermusthermophilus) |
PF00994(MoCF_biosynth)PF02464(CinA) | 3 | ARG A 62VAL A 148TRP A 139 | None | 1.10A | 1zviA-4ctaA:undetectable | 1zviA-4ctaA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d0m | RAS-RELATED PROTEINRAB-11A (Homo sapiens) |
PF00071(Ras) | 3 | ARG B 82VAL B 15TRP B 65 | None | 1.16A | 1zviA-4d0mB:undetectable | 1zviA-4d0mB:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3c | INHIBITOR OF NUCLEARFACTOR KAPPA-BKINASE SUBUNIT BETA (Homo sapiens) |
PF00069(Pkinase) | 3 | ARG A 118VAL A 433TRP A 434 | None | 1.14A | 1zviA-4e3cA:undetectable | 1zviA-4e3cA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | ARG A1019VAL A 781TRP A 796 | None | 1.26A | 1zviA-4f4cA:3.0 | 1zviA-4f4cA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jm2 | GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 3 | ARG E 350VAL E 360TRP E 395 | None | 1.07A | 1zviA-4jm2E:undetectable | 1zviA-4jm2E:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh0 | RAP GUANINENUCLEOTIDE EXCHANGEFACTOR 4 (Mus musculus) |
PF00027(cNMP_binding)PF00617(RasGEF)PF00618(RasGEF_N) | 3 | ARG E 801VAL E 974TRP E 808 | None | 1.24A | 1zviA-4mh0E:undetectable | 1zviA-4mh0E:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0r | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesvulgatus) |
PF13204(DUF4038)PF16586(DUF5060) | 3 | ARG A 165VAL A 269TRP A 270 | None | 1.17A | 1zviA-4n0rA:undetectable | 1zviA-4n0rA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfk | ABC TRANSPORTERPERIPLASMICPEPTIDE-BINDINGPROTEIN (Pseudoalteromonassp. SM9913) |
no annotation | 3 | ARG H 301VAL H 429TRP H 377 | None | 1.21A | 1zviA-4qfkH:undetectable | 1zviA-4qfkH:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf7 | ARGININE KINASE (Anthopleurajaponica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 128VAL A 224TRP A 225 | ARG A 806 (-4.3A)NoneNone | 0.89A | 1zviA-4rf7A:2.2 | 1zviA-4rf7A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf7 | ARGININE KINASE (Anthopleurajaponica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 480VAL A 576TRP A 577 | None | 0.84A | 1zviA-4rf7A:2.2 | 1zviA-4rf7A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u3a | ENDOGLUCANASE H (Ruminiclostridiumthermocellum) |
PF00150(Cellulase) | 3 | ARG A 124VAL A 317TRP A 347 | None | 1.03A | 1zviA-4u3aA:undetectable | 1zviA-4u3aA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubd | MONOCLONAL ANTIBODYH CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | ARG C 112VAL C 37TRP C 47 | None | 1.24A | 1zviA-4ubdC:undetectable | 1zviA-4ubdC:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ug4 | CHOLINE SULFATASE (Sinorhizobiummeliloti) |
PF00884(Sulfatase)PF12411(Choline_sulf_C) | 3 | ARG A 69VAL A 357TRP A 360 | None | 1.19A | 1zviA-4ug4A:undetectable | 1zviA-4ug4A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uul | L-LACTATEDEHYDROGENASE (Trichomonasvaginalis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | ARG A 310VAL A 191TRP A 183 | None | 1.11A | 1zviA-4uulA:undetectable | 1zviA-4uulA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v1l | CARBOHYDRATE BINDINGMODULE (Ruminococcusflavefaciens) |
no annotation | 3 | ARG A 515VAL A 549TRP A 607 | GOL A1626 ( 4.8A)NoneNone | 1.04A | 1zviA-4v1lA:undetectable | 1zviA-4v1lA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woe | TAUROCYAMINE KINASE (Schistosomamansoni) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 121VAL A 217TRP A 218 | ADP A 801 (-3.1A)NoneNone | 1.01A | 1zviA-4woeA:undetectable | 1zviA-4woeA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woe | TAUROCYAMINE KINASE (Schistosomamansoni) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | ARG A 484VAL A 580TRP A 581 | ADP A 802 (-3.0A)NoneNone | 1.07A | 1zviA-4woeA:undetectable | 1zviA-4woeA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwh | ALPHA-N-ACETYLGLUCOSAMINIDASE (Homo sapiens) |
PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 3 | ARG A 149VAL A 101TRP A 156 | None | 1.22A | 1zviA-4xwhA:undetectable | 1zviA-4xwhA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yam | BETA-ETHERASE (Sphingobium sp.SYK-6) |
PF13417(GST_N_3) | 3 | ARG A 26VAL A 74TRP A 73 | None | 0.96A | 1zviA-4yamA:undetectable | 1zviA-4yamA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynv | ACL4 (Chaetomiumthermophilum) |
PF13432(TPR_16) | 3 | ARG A 298VAL A 290TRP A 291 | None | 0.84A | 1zviA-4ynvA:3.3 | 1zviA-4ynvA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z48 | UNCHARACTERIZEDPROTEIN (Desulfovibriopiger) |
PF17131(LolA_like) | 3 | ARG A 127VAL A 103TRP A 104 | None | 1.05A | 1zviA-4z48A:undetectable | 1zviA-4z48A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEMOLYBDOPTERIN-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | ARG A 38VAL A 34TRP A 241 | None | 0.90A | 1zviA-4zohA:undetectable | 1zviA-4zohA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 3 | ARG A 14VAL A 71TRP A 85 | None | 1.02A | 1zviA-4zxiA:undetectable | 1zviA-4zxiA:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7d | INSCUTEABLEPINS (Drosophilamelanogaster) |
PF13176(TPR_7)PF13424(TPR_12)no annotation | 3 | ARG B 339VAL L 310TRP L 313 | None | 0.99A | 1zviA-5a7dB:undetectable | 1zviA-5a7dB:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aew | BIPHENYL DIOXYGENASESUBUNIT ALPHA (Paraburkholderiaxenovorans) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | ARG A 345VAL A 352TRP A 353 | None | 1.20A | 1zviA-5aewA:undetectable | 1zviA-5aewA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b4x | LOW DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 8,APOLIPOPROTEIN ERECEPTOR, ISOFORMCRA_EREELIN (Homo sapiens;Mus musculus) |
PF00057(Ldl_recept_a)PF00058(Ldl_recept_b)PF07645(EGF_CA)PF07974(EGF_2)PF14670(FXa_inhibition) | 3 | ARG A2364VAL B 62TRP B 63 | None | 1.21A | 1zviA-5b4xA:undetectable | 1zviA-5b4xA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5w | GLYCINE--TRNA LIGASEALPHA SUBUNIT (Aquifexaeolicus) |
PF02091(tRNA-synt_2e) | 3 | ARG A 163VAL A 129TRP A 130 | G5A A 300 (-4.0A)NoneNone | 1.25A | 1zviA-5f5wA:undetectable | 1zviA-5f5wA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fav | CHOLINETRIMETHYLAMINE-LYASE (Desulfovibrioalaskensis) |
PF01228(Gly_radical)PF02901(PFL-like) | 3 | ARG A 80VAL A 172TRP A 176 | None | 1.15A | 1zviA-5favA:2.2 | 1zviA-5favA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjn | L-AMINO ACIDDEAMINASE (Cosenzaeamyxofaciens) |
PF01266(DAO) | 3 | ARG A 316VAL A 438TRP A 439 | BE2 A1476 (-4.0A)BE2 A1476 ( 4.3A)BE2 A1476 ( 3.7A) | 0.93A | 1zviA-5fjnA:undetectable | 1zviA-5fjnA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fkc | BETA-FRUCTOFURANOSIDASE (Xanthophyllomycesdendrorhous) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | ARG A 520VAL A 543TRP A 532 | None | 0.89A | 1zviA-5fkcA:undetectable | 1zviA-5fkcA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h2g | DIAMINOPIMELATEEPIMERASE (Corynebacteriumglutamicum) |
PF01678(DAP_epimerase) | 3 | ARG A 209VAL A 195TRP A 211 | None | 1.19A | 1zviA-5h2gA:undetectable | 1zviA-5h2gA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hkj | COMPLEMENT C1QSUBCOMPONENT SUBUNITA,COMPLEMENT C1QSUBCOMPONENT SUBUNITC,COMPLEMENT C1QSUBCOMPONENT SUBUNITB (Homo sapiens) |
PF00386(C1q) | 3 | ARG A 76VAL A 108TRP A 107 | None | 1.22A | 1zviA-5hkjA:undetectable | 1zviA-5hkjA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqn | SPHINGOMYELINPHOSPHODIESTERASE (Mus musculus) |
PF00149(Metallophos) | 3 | ARG A 494VAL A 476TRP A 551 | None | 1.24A | 1zviA-5hqnA:undetectable | 1zviA-5hqnA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jem | INTERFERONREGULATORY FACTOR 3 (Homo sapiens) |
PF10401(IRF-3) | 3 | ARG A 236VAL A 243TRP A 241 | None | 1.18A | 1zviA-5jemA:undetectable | 1zviA-5jemA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jyl | SCFV TSP7 (Mus musculus) |
PF07686(V-set) | 3 | ARG B 99VAL B 37TRP B 47 | None | 1.03A | 1zviA-5jylB:undetectable | 1zviA-5jylB:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 3 | ARG A 839VAL A 874TRP A 852 | None | 1.27A | 1zviA-5n4lA:undetectable | 1zviA-5n4lA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ocp | - (-) |
no annotation | 3 | ARG A 143VAL A 225TRP A 14 | AHR A 407 ( 2.6A)NoneAHR A 407 ( 4.8A) | 0.87A | 1zviA-5ocpA:undetectable | 1zviA-5ocpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oj3 | - (-) |
no annotation | 3 | ARG A 397VAL A 377TRP A 378 | None | 1.20A | 1zviA-5oj3A:undetectable | 1zviA-5oj3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0g | PROTEASOME SUBUNITBETA TYPE-5 (Homo sapiens) |
PF00227(Proteasome) | 3 | ARG R 186VAL R 179TRP R 184 | None | 1.23A | 1zviA-5t0gR:undetectable | 1zviA-5t0gR:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v4b | F-BOX/WDREPEAT-CONTAININGPROTEIN 7 (Homo sapiens) |
PF00400(WD40)PF12937(F-box-like) | 3 | ARG B2674VAL B2424TRP B2425 | SO4 B2803 (-4.9A)NoneNone | 1.23A | 1zviA-5v4bB:undetectable | 1zviA-5v4bB:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vms | POTASSIUMVOLTAGE-GATEDCHANNEL SUBFAMILYKQT MEMBER 1 (Xenopus laevis) |
PF00520(Ion_trans)PF03520(KCNQ_channel) | 3 | ARG A 182VAL A 177TRP A 178 | None | 1.27A | 1zviA-5vmsA:2.2 | 1zviA-5vmsA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrv | PROTEIN REGULATED BYACID PH (Agrobacteriumfabrum) |
PF09924(DUF2156) | 3 | ARG A 611VAL A 603TRP A 604 | None | 1.07A | 1zviA-5vrvA:undetectable | 1zviA-5vrvA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xev | XAA-PRODIPEPTIDASE,PEPTIDASE-RELATED PROTEIN (Deinococcusradiodurans) |
no annotation | 3 | ARG A 277VAL A 253TRP A 255 | None | 1.17A | 1zviA-5xevA:2.0 | 1zviA-5xevA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | GUANINENUCLEOTIDE-BINDINGPROTEIN BETASUBUNIT, PUTATIVE (Trichomonasvaginalis) |
no annotation | 3 | ARG g 75VAL g 49TRP g 60 | None | 1.20A | 1zviA-5xyig:undetectable | 1zviA-5xyig:20.14 |