SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZUC_B_T98B202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 527
LEU A 512
LEU A 429
THR A 480
PHE A 482
 None
 1.11A 1zucB-1f3lA:
undetectable		 1zucB-1f3lA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A  29
LEU A  59
ARG A 279
LEU A  76
THR A  24
 LEU  A  29 ( 0.6A)
LEU  A  59 ( 0.6A)
ARG  A 279 ( 0.6A)
LEU  A  76 ( 0.6A)
THR  A  24 ( 0.8A)
 1.28A 1zucB-1gc7A:
undetectable		 1zucB-1gc7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 197
LEU A 200
LEU A 150
LEU A 209
THR A 225
 None
 1.09A 1zucB-1gdhA:
undetectable		 1zucB-1gdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 LEU A 135
GLN A 140
LEU A 345
THR A 163
PHE A 165
 None
 1.20A 1zucB-1iuqA:
undetectable		 1zucB-1iuqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		5 LEU A  86
LEU A 185
LEU A 183
THR A 169
PHE A  78
 None
 1.17A 1zucB-1j3bA:
undetectable		 1zucB-1j3bA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 LEU A 591
ASN A 592
LEU A 594
GLN A 598
LEU A 619
 None
 0.89A 1zucB-1kblA:
undetectable		 1zucB-1kblA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 223
LEU A 226
LEU A 177
LEU A 235
THR A 251
 None
 1.01A 1zucB-1mx3A:
undetectable		 1zucB-1mx3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 223
LEU A 226
LEU A 201
LEU A 235
THR A 251
 None
 1.14A 1zucB-1mx3A:
undetectable		 1zucB-1mx3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D  36
LEU D  60
LEU D  82
LEU D  25
THR D  33
 None
 1.24A 1zucB-1u0nD:
undetectable		 1zucB-1u0nD:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8c MOAD RELATED PROTEIN

(Thermus
thermophilus) 		PF02597
(ThiS)
PF09189
(DUF1952) 		5 LEU A   5
LEU A  80
LEU A  49
ARG A  63
THR A  13
 None
 1.00A 1zucB-1v8cA:
undetectable		 1zucB-1v8cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		5 LEU A 274
ASN A 277
LEU A   8
THR A 255
PHE A 248
 None
 1.19A 1zucB-1vblA:
undetectable		 1zucB-1vblA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
MET A 362
ARG A 372
LEU A 401
 None
 0.80A 1zucB-1xb7A:
25.3		 1zucB-1xb7A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5l TRP REPRESSOR
BINDING PROTEIN WRBA

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		5 LEU A 133
LEU A 130
MET A  84
LEU A   9
THR A  95
 None
 0.96A 1zucB-2a5lA:
undetectable		 1zucB-2a5lA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 745
ARG A 752
PHE A 891
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
None
 0.63A 1zucB-2ax9A:
34.7		 1zucB-2ax9A:
54.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 701
LEU A 704
ASN A 705
MET A 742
PHE A 891
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.0A)
None
 1.26A 1zucB-2ax9A:
34.7		 1zucB-2ax9A:
54.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 108
LEU A 136
LEU A 137
LEU A 161
LEU A 119
 None
 1.16A 1zucB-2bexA:
undetectable		 1zucB-2bexA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF00515
(TPR_1)
PF13432
(TPR_16) 		5 LEU A 494
LEU A 497
LEU A 500
GLN A 419
LEU A 467
 None
 1.23A 1zucB-2c0lA:
undetectable		 1zucB-2c0lA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 265
LEU A 268
LEU A 271
MET A 306
ARG A 316
LEU A 345
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
OHT  A 500 (-4.3A)
 0.77A 1zucB-2gpvA:
25.6		 1zucB-2gpvA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2m COMM
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF17221
(COMMD1_N) 		5 LEU A  16
ASN A  17
LEU A  19
ARG A  49
LEU A  72
 None
 1.22A 1zucB-2h2mA:
undetectable		 1zucB-2h2mA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Mus musculus) 		PF14580
(LRR_9) 		5 LEU A  66
LEU A  90
ASN A  89
LEU A 109
LEU A  60
 None
 1.26A 1zucB-2jqdA:
undetectable		 1zucB-2jqdA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 LEU A  82
LEU A  85
LEU A  88
MET A 163
LEU A 193
 None
 1.17A 1zucB-2nx4A:
undetectable		 1zucB-2nx4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 341
LEU A 336
LEU A 324
LEU A 430
PHE A 498
 None
 1.28A 1zucB-2og8A:
undetectable		 1zucB-2og8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 LEU A 184
LEU A 187
GLN A 191
LEU A 168
ARG A 160
 None
 1.14A 1zucB-2olaA:
undetectable		 1zucB-2olaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 229
LEU A 232
LEU A 183
LEU A 241
THR A 257
 None
 1.14A 1zucB-2omeA:
undetectable		 1zucB-2omeA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
LEU A  77
ARG A  80
LEU A 111
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
None
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.63A 1zucB-2q3yA:
37.3		 1zucB-2q3yA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.47A 1zucB-2q3yA:
37.3		 1zucB-2q3yA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  29
LEU A  32
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
None
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.23A 1zucB-2q3yA:
37.3		 1zucB-2q3yA:
63.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		5 LEU A 403
LEU A 399
MET A 301
LEU A 289
PHE A 266
 None
 1.21A 1zucB-2ve3A:
2.3		 1zucB-2ve3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 LEU A 527
ASN A 528
LEU A 526
LEU A 578
LEU A 466
 None
 1.29A 1zucB-2wghA:
undetectable		 1zucB-2wghA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whn PILUS ASSEMBLY
PROTEIN PILC

(Thermus
thermophilus) 		PF00482
(T2SSF) 		5 LEU A  78
LEU A 148
LEU A 151
LEU A  67
LEU A  91
 None
 1.22A 1zucB-2whnA:
undetectable		 1zucB-2whnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		5 LEU A 140
LEU A 137
LEU A 217
ARG A 211
THR A 145
 None
 1.10A 1zucB-3a2kA:
undetectable		 1zucB-3a2kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 LEU A 985
LEU A 876
LEU A 784
GLN A 814
LEU A1018
 None
 1.07A 1zucB-3bgaA:
undetectable		 1zucB-3bgaA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		5 LEU A 168
LEU A 171
LEU A 174
LEU A 183
LEU A 219
 None
 1.26A 1zucB-3g23A:
undetectable		 1zucB-3g23A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		5 LEU A 533
LEU A 504
LEU A 480
LEU A 493
LEU A 517
 None
 1.16A 1zucB-3j0aA:
undetectable		 1zucB-3j0aA:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
LEU A 763
ARG A 766
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.34A 1zucB-3kbaA:
40.5		 1zucB-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 715
LEU A 718
ASN A 719
LEU A 776
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
None
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.32A 1zucB-3kbaA:
40.5		 1zucB-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLN A 725
MET A 756
MET A 759
LEU A 763
ARG A 766
THR A 894
PHE A 905
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.58A 1zucB-3kbaA:
40.5		 1zucB-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 756
LEU A 763
ARG A 766
LEU A 797
THR A 894
PHE A 905
 WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.67A 1zucB-3kbaA:
40.5		 1zucB-3kbaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		5 LEU A 155
LEU A 152
GLN A 148
LEU A 179
LEU A 174
 None
 1.25A 1zucB-3lfvA:
undetectable		 1zucB-3lfvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 LEU A 412
LEU A 409
LEU A 214
LEU A 449
PHE A 393
 None
 1.18A 1zucB-3m1cA:
undetectable		 1zucB-3m1cA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		6 LEU A 847
LEU A 850
LEU A 853
LEU A 826
LEU A 841
THR A 886
 None
 1.44A 1zucB-3nowA:
undetectable		 1zucB-3nowA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 LEU A 853
LEU A 850
LEU A 847
LEU A 841
LEU A 826
 None
 1.18A 1zucB-3nowA:
undetectable		 1zucB-3nowA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
LEU A 111
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.70A 1zucB-3ry9A:
36.5		 1zucB-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.56A 1zucB-3ry9A:
36.5		 1zucB-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 LEU A  29
LEU A  32
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.20A 1zucB-3ry9A:
36.5		 1zucB-3ry9A:
62.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti2 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 LEU A  54
LEU A  57
LEU A  60
LEU A  34
LEU A  41
 None
 1.25A 1zucB-3ti2A:
undetectable		 1zucB-3ti2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE

(Clostridium
tetani) 		PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 0.91A 1zucB-3wgoA:
undetectable		 1zucB-3wgoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE

(Clostridium
tetani) 		PF16654
(DAPDH_C) 		5 LEU A 130
ASN A 131
LEU A 133
LEU A 313
PHE A 269
 None
 1.15A 1zucB-3wgoA:
undetectable		 1zucB-3wgoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 305
LEU A 308
ASN A 309
LEU A 311
LEU A  28
 None
 0.99A 1zucB-3wnvA:
undetectable		 1zucB-3wnvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 LEU A 185
ASN A 186
LEU A 188
GLN A 192
PHE A 249
 None
 0.92A 1zucB-3wxbA:
undetectable		 1zucB-3wxbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 LEU A 406
LEU A 403
ASN A 402
LEU A 400
THR A 343
 None
 1.12A 1zucB-3x0vA:
undetectable		 1zucB-3x0vA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA

(Salmonella
enterica) 		PF03193
(RsgA_GTPase) 		5 LEU V 243
LEU V 232
ASN V 233
LEU V 231
LEU V 213
 None
 1.11A 1zucB-4a2iV:
undetectable		 1zucB-4a2iV:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czd PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Desulfovibrio
desulfuricans) 		no annotation 5 LEU B  48
LEU B  45
LEU B  42
MET B  36
LEU B  30
 None
 1.27A 1zucB-4czdB:
undetectable		 1zucB-4czdB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 324
LEU A 327
LEU A 330
GLN A 337
ARG A 341
 None
 1.14A 1zucB-4fdhA:
undetectable		 1zucB-4fdhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 LEU A  65
LEU A  68
LEU A  71
LEU A  85
LEU A 117
 None
 1.01A 1zucB-4fgsA:
undetectable		 1zucB-4fgsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 LEU A 466
LEU A  57
ASN A  58
MET A  64
LEU A 141
 None
None
ACT  A 514 (-3.4A)
None
None
 1.11A 1zucB-4g2cA:
undetectable		 1zucB-4g2cA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02759
(RUN) 		5 LEU A 185
LEU A 128
ASN A 129
LEU A 127
LEU A 175
 None
 1.21A 1zucB-4giwA:
undetectable		 1zucB-4giwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 LEU A 328
LEU A 329
LEU A 289
LEU A 282
THR A 347
 None
 1.08A 1zucB-4itaA:
undetectable		 1zucB-4itaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 448
LEU A 445
LEU A 478
LEU A 466
LEU A 431
 None
 1.25A 1zucB-4k17A:
undetectable		 1zucB-4k17A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 LEU A 335
GLN A 125
LEU A 321
THR A 318
PHE A 359
 None
PLP  A 500 ( 4.3A)
None
None
None
 1.20A 1zucB-4k6nA:
undetectable		 1zucB-4k6nA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 5 LEU A1488
LEU A1484
LEU A1480
LEU A1513
THR A1491
 None
 1.24A 1zucB-4kf8A:
undetectable		 1zucB-4kf8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpk ENOYL-COA
HYDRATASE/ISOMERASE

(Shewanella
pealeana) 		PF00378
(ECH_1) 		5 LEU A  67
LEU A 130
LEU A 101
LEU A  53
THR A 115
 None
 1.21A 1zucB-4kpkA:
undetectable		 1zucB-4kpkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 280
LEU A 283
LEU A 286
MET A 321
ARG A 331
PHE A 462
 None
 0.58A 1zucB-4n1yA:
27.5		 1zucB-4n1yA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 323
GLN A 386
LEU A 261
LEU A 286
 None
 1.28A 1zucB-4n1yA:
27.5		 1zucB-4n1yA:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 564
LEU A 566
GLN A 570
MET A 601
LEU A 608
ARG A 611
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.62A 1zucB-4p6wA:
35.9		 1zucB-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 563
ASN A 564
LEU A 566
GLN A 570
LEU A 608
ARG A 611
THR A 739
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.78A 1zucB-4p6wA:
35.9		 1zucB-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 566
GLN A 570
MET A 604
LEU A 608
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
 0.92A 1zucB-4p6wA:
35.9		 1zucB-4p6wA:
54.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A 188
LEU A 189
ASN A 185
LEU A 336
GLN A 242
 CL  A 401 ( 4.9A)
CL  A 401 ( 4.4A)
CL  A 401 ( 4.2A)
None
None
 1.29A 1zucB-4u1aA:
undetectable		 1zucB-4u1aA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
ASN A 770
LEU A 772
GLN A 776
MET A 807
LEU A 814
ARG A 817
LEU A 848
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.64A 1zucB-4udbA:
35.0		 1zucB-4udbA:
54.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
ASN A 770
LEU A 827
LEU A 848
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 4.4A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.30A 1zucB-4udbA:
35.0		 1zucB-4udbA:
54.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
LEU A 814
ARG A 817
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.57A 1zucB-4udbA:
35.0		 1zucB-4udbA:
54.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
LEU A 769
ASN A 770
LEU A 827
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.17A 1zucB-4udbA:
35.0		 1zucB-4udbA:
54.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		5 LEU A 133
ARG A 107
LEU A 164
THR A 212
PHE A 206
 NA  A1337 ( 4.7A)
None
None
None
None
 1.22A 1zucB-4us5A:
undetectable		 1zucB-4us5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 LEU A 387
LEU A 390
LEU A 393
LEU A 441
LEU A 435
 None
 1.14A 1zucB-4uvkA:
undetectable		 1zucB-4uvkA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 119
LEU A 118
LEU A  79
LEU A  71
LEU A 110
 None
 1.17A 1zucB-5avmA:
undetectable		 1zucB-5avmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.10A 1zucB-5bswA:
undetectable		 1zucB-5bswA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans) 		PF08652
(RAI1) 		5 LEU A 350
LEU A 122
MET A 106
LEU A   5
THR A 338
 None
 1.19A 1zucB-5bthA:
undetectable		 1zucB-5bthA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.02A 1zucB-5gz1A:
undetectable		 1zucB-5gz1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		5 LEU A 130
ASN A 131
LEU A 133
LEU A 313
PHE A 269
 None
 1.21A 1zucB-5gz1A:
undetectable		 1zucB-5gz1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 589
LEU A 559
LEU A 535
LEU A 521
LEU A 577
 None
 1.23A 1zucB-5hdhA:
undetectable		 1zucB-5hdhA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00180
(Iso_dh) 		5 ASN A 144
LEU A 309
MET A 344
LEU A 345
LEU A 111
 None
 1.29A 1zucB-5j32A:
undetectable		 1zucB-5j32A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		5 LEU A 184
LEU A 187
LEU A 190
MET A 197
LEU A 134
 None
 1.05A 1zucB-5lq4A:
undetectable		 1zucB-5lq4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m30 TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.21A 1zucB-5m30A:
undetectable		 1zucB-5m30A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwn TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.19A 1zucB-5mwnA:
undetectable		 1zucB-5mwnA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
LEU A 848
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.71A 1zucB-5mwpA:
36.4		 1zucB-5mwpA:
46.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 10 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
LEU A 814
ARG A 817
THR A 945
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.44A 1zucB-5mwpA:
36.4		 1zucB-5mwpA:
46.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 766
LEU A 769
ASN A 770
LEU A 827
THR A 945
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.29A 1zucB-5mwpA:
36.4		 1zucB-5mwpA:
46.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU B 304
LEU B 301
LEU B 298
LEU B 185
LEU B 163
 None
 1.04A 1zucB-5op0B:
undetectable		 1zucB-5op0B:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
LEU A 301
MET A 336
LEU A 343
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.7A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 0.41A 1zucB-5toaA:
25.5		 1zucB-5toaA:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
LEU A 562
GLN A 566
MET A 597
LEU A 604
ARG A 607
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
 0.86A 1zucB-5uc1A:
24.6		 1zucB-5uc1A:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
LEU A 604
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
 0.67A 1zucB-5uc1A:
24.6		 1zucB-5uc1A:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 562
GLN A 566
MET A 597
MET A 600
LEU A 604
ARG A 607
 486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
 0.81A 1zucB-5uc1A:
24.6		 1zucB-5uc1A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufk EFFECTOR PROTEIN
SIDK

(Legionella
pneumophila) 		no annotation 5 LEU A  91
LEU A  88
LEU A  42
LEU A 107
THR A 169
 None
 1.27A 1zucB-5ufkA:
undetectable		 1zucB-5ufkA:
26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 218
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.68A 1zucB-5ufsA:
37.0		 1zucB-5ufsA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
ASN A  33
LEU A  90
THR A 208
PHE A 218
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.28A 1zucB-5ufsA:
37.0		 1zucB-5ufsA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
MET A  73
LEU A  77
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
 0.96A 1zucB-5ufsA:
37.0		 1zucB-5ufsA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  66
LEU A 151
LEU A 152
LEU A 251
THR A  93
 None
 1.23A 1zucB-5ujzA:
undetectable		 1zucB-5ujzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 LEU J 468
LEU J 469
LEU J 428
LEU J 501
THR J 491
 None
 1.26A 1zucB-5vzjJ:
undetectable		 1zucB-5vzjJ:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		5 LEU A 460
LEU A 463
LEU A 466
LEU A 405
LEU A 449
 None
 1.26A 1zucB-5wrrA:
undetectable		 1zucB-5wrrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 5 LEU A 381
ASN A 378
LEU A 461
LEU A 529
LEU A 443
 None
 1.25A 1zucB-6au1A:
undetectable		 1zucB-6au1A:
15.26