SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZUC_A_T98A201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 LEU A 135
GLN A 140
LEU A 345
THR A 163
PHE A 165
 None
 1.18A 1zucA-1iuqA:
undetectable		 1zucA-1iuqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdn PROTEIN
(N-ETHYLMALEIMIDE
SENSITIVE FUSION
PROTEIN (NSF))

(Cricetulus
griseus) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 LEU A  18
ASN A  20
LEU A  64
LEU A 102
PHE A 125
 None
None
SO4  A 501 ( 4.4A)
None
None
 1.43A 1zucA-1qdnA:
undetectable		 1zucA-1qdnA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		5 LEU A 160
LEU A 176
LEU A 134
THR A 143
PHE A 187
 None
 1.35A 1zucA-1t6kA:
undetectable		 1zucA-1t6kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		5 LEU A 274
ASN A 277
LEU A   8
THR A 255
PHE A 248
 None
 1.18A 1zucA-1vblA:
undetectable		 1zucA-1vblA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 701
ASN A 705
GLN A 711
MET A 745
ARG A 752
PHE A 891
 None
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
None
 0.58A 1zucA-2ax9A:
34.8		 1zucA-2ax9A:
54.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III

(Homo sapiens) 		PF05822
(UMPH-1) 		5 LEU A 225
ARG A  17
LEU A 269
TYR A 249
THR A  42
 None
 1.31A 1zucA-2cn1A:
0.6		 1zucA-2cn1A:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  29
ASN A  33
GLN A  39
LEU A  77
ARG A  80
LEU A 111
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
None
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.63A 1zucA-2q3yA:
37.7		 1zucA-2q3yA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  29
ASN A  33
GLN A  39
MET A  73
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.40A 1zucA-2q3yA:
37.7		 1zucA-2q3yA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  29
ASN A  33
LEU A  90
LEU A 111
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
None
None
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.42A 1zucA-2q3yA:
37.7		 1zucA-2q3yA:
63.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		5 LEU A 223
LEU A 205
LEU A 213
TYR A 218
THR A 247
 None
 1.43A 1zucA-3fdjA:
undetectable		 1zucA-3fdjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 MET A  71
LEU A  72
ARG A 106
TYR A  61
PHE A 161
 None
 0.86A 1zucA-3jr3A:
undetectable		 1zucA-3jr3A:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 719
LEU A 784
TYR A 890
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
None
WOW  A   1 (-3.9A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.37A 1zucA-3kbaA:
42.0		 1zucA-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
ASN A 719
GLN A 725
MET A 759
LEU A 763
ARG A 766
TYR A 890
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.53A 1zucA-3kbaA:
42.0		 1zucA-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 715
ASN A 719
LEU A 776
TYR A 890
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
None
WOW  A   1 (-3.9A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.20A 1zucA-3kbaA:
42.0		 1zucA-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 776
LEU A 797
TYR A 890
THR A 894
PHE A 905
 None
WOW  A   1 ( 4.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.33A 1zucA-3kbaA:
42.0		 1zucA-3kbaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A1125
ASN A1129
GLN A1093
LEU A1102
PHE A1076
 None
 1.36A 1zucA-3kuqA:
undetectable		 1zucA-3kuqA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm7 PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE /
2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Yersinia
enterocolitica) 		PF07071
(KDGP_aldolase) 		5 ASN A 114
LEU A  65
LEU A  17
TYR A 218
THR A 190
 None
 1.38A 1zucA-3lm7A:
undetectable		 1zucA-3lm7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0z PUTATIVE ALDOLASE

(Klebsiella
pneumoniae) 		PF07071
(KDGP_aldolase) 		5 ASN A 114
LEU A  65
LEU A  17
TYR A 218
THR A 190
 None
None
None
SO4  A 301 (-4.7A)
None
 1.34A 1zucA-3m0zA:
undetectable		 1zucA-3m0zA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmh METHIONINE-R-SULFOXI
DE REDUCTASE

(Neisseria
meningitidis) 		PF13185
(GAF_2) 		5 LEU A  43
LEU A 147
LEU A  19
THR A  39
PHE A  54
 None
 1.46A 1zucA-3mmhA:
undetectable		 1zucA-3mmhA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		5 LEU A 122
GLN A 219
LEU A  79
LEU A  96
THR A 231
 None
 1.40A 1zucA-3qitA:
undetectable		 1zucA-3qitA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		5 LEU A 106
LEU A 149
LEU A 179
THR A 117
PHE A 215
 None
 1.28A 1zucA-3rksA:
undetectable		 1zucA-3rksA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 ASN A  33
GLN A  39
LEU A  77
ARG A  80
LEU A 111
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.73A 1zucA-3ry9A:
36.7		 1zucA-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 LEU A  29
ASN A  33
GLN A  39
MET A  73
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.50A 1zucA-3ry9A:
36.7		 1zucA-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  29
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.12A 1zucA-3ry9A:
36.7		 1zucA-3ry9A:
62.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcr PUTATIVE KDPG
(2-KETO-3-DEOXY-6-PH
OSPHOGLUCONATE)
ALDOLASE

(Oleispira
antarctica) 		PF01081
(Aldolase) 		5 LEU A 149
ASN A 180
GLN A 134
LEU A 115
TYR A 175
 None
 1.46A 1zucA-3vcrA:
undetectable		 1zucA-3vcrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 LEU A  60
GLN A  66
LEU A  19
LEU A  35
THR A  56
 None
 1.38A 1zucA-4bqnA:
undetectable		 1zucA-4bqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 LEU A 335
GLN A 125
LEU A 321
THR A 318
PHE A 359
 None
PLP  A 500 ( 4.3A)
None
None
None
 1.13A 1zucA-4k6nA:
undetectable		 1zucA-4k6nA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldp NDP-FOROSAMYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		5 LEU A 151
GLN A 337
LEU A 363
TYR A 221
THR A 205
 None
 1.47A 1zucA-4ldpA:
undetectable		 1zucA-4ldpA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLN A 570
LEU A 608
ARG A 611
TYR A 735
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.8A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.58A 1zucA-4p6wA:
36.2		 1zucA-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 564
LEU A 621
TYR A 735
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-4.8A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.98A 1zucA-4p6wA:
36.2		 1zucA-4p6wA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 766
ASN A 770
GLN A 776
LEU A 814
ARG A 817
LEU A 848
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.72A 1zucA-4udbA:
36.0		 1zucA-4udbA:
54.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
ASN A 770
LEU A 827
LEU A 848
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 4.4A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.28A 1zucA-4udbA:
36.0		 1zucA-4udbA:
54.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		5 LEU A 133
ARG A 107
LEU A 164
THR A 212
PHE A 206
 NA  A1337 ( 4.7A)
None
None
None
None
 1.20A 1zucA-4us5A:
undetectable		 1zucA-4us5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8k CAS1 PROTEIN

(Vibrio phage
ICP1) 		PF01867
(Cas_Cas1) 		5 GLN A   9
LEU A 282
ARG A  11
LEU A 220
TYR A 100
 None
 1.49A 1zucA-4w8kA:
undetectable		 1zucA-4w8kA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 ASN A  70
LEU A  87
LEU A 214
TYR A 218
THR A 475
 None
None
None
None
FAD  A1801 (-3.2A)
 1.47A 1zucA-5laeA:
undetectable		 1zucA-5laeA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 766
ASN A 770
GLN A 776
LEU A 814
ARG A 817
LEU A 848
THR A 945
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.76A 1zucA-5mwpA:
36.5		 1zucA-5mwpA:
46.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLN A  39
LEU A  77
ARG A  80
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.48A 1zucA-5ufsA:
37.6		 1zucA-5ufsA:
57.36