SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZQ9_A_SAMA4000_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 HIS A 168
LEU A  83
LEU A  81
ILE A 102
SER A 206
 None
 1.27A 1zq9A-1aqlA:
undetectable		 1zq9A-1aqlA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 ILE A 178
GLY A 174
ASP A 198
VAL A 197
SER A 239
 None
 1.24A 1zq9A-1dciA:
undetectable		 1zq9A-1dciA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7u 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		6 HIS A  40
ILE A  37
GLY A  24
LEU A 236
VAL A  20
ILE A  50
 None
 1.10A 1zq9A-1g7uA:
undetectable		 1zq9A-1g7uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 HIS A 168
LEU A  83
LEU A  81
ILE A 102
SER A 206
 None
 1.27A 1zq9A-1jmyA:
undetectable		 1zq9A-1jmyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko8 GLUCONATE KINASE

(Escherichia
coli) 		PF01202
(SKI) 		5 GLY A  39
LEU A  84
LEU A  37
VAL A  24
ILE A 108
 None
 1.13A 1zq9A-1ko8A:
undetectable		 1zq9A-1ko8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ILE A 326
GLY A 143
LEU A  61
PRO A  75
ILE A  26
 None
 1.26A 1zq9A-1mc8A:
undetectable		 1zq9A-1mc8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		5 HIS A 119
ILE A  92
LEU A 108
VAL A 178
ILE A 187
 None
 1.25A 1zq9A-1pxzA:
undetectable		 1zq9A-1pxzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  70
GLY A  92
VAL A 314
PRO A 160
ILE A 321
 None
 1.20A 1zq9A-1q1nA:
5.7		 1zq9A-1q1nA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		8 GLY A  47
LEU A  67
LEU A  71
ASP A  91
PRO A 115
ILE A 118
MET A 139
SER A 189
 None
 0.73A 1zq9A-1qyrA:
27.0		 1zq9A-1qyrA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		5 ILE A 111
GLY A 122
VAL A  44
PRO A  80
ILE A  77
 None
 1.09A 1zq9A-1rpxA:
undetectable		 1zq9A-1rpxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT

(Homo sapiens) 		PF13472
(Lipase_GDSL_2) 		5 HIS A  28
ILE A  73
GLY A  72
LEU A  69
ILE A  93
 None
 1.27A 1zq9A-1vyhA:
undetectable		 1zq9A-1vyhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Mus musculus) 		PF00400
(WD40) 		5 HIS C 337
GLY C 343
LEU C 386
ASP C 401
VAL C 400
 None
 1.23A 1zq9A-1vyhC:
undetectable		 1zq9A-1vyhC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE

(Methanosarcina
barkeri) 		PF00296
(Bac_luciferase) 		5 HIS A  36
LEU A  46
VAL A  48
PRO A   9
ILE A  16
 F42  A 328 (-3.8A)
None
None
None
None
 1.09A 1zq9A-1z69A:
undetectable		 1zq9A-1z69A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLY A 115
LEU A  91
LEU A 114
ILE A   6
MET A  11
 None
 1.13A 1zq9A-1zejA:
6.1		 1zq9A-1zejA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		11 HIS A  37
ILE A  38
GLY A  66
LEU A  86
LEU A  90
ASP A 113
VAL A 114
PRO A 130
ILE A 133
MET A 154
SER A 204
 SAM  A4000 (-4.9A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.2A)
SAM  A4000 (-3.7A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-3.9A)
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
None
SAM  A4000 (-3.4A)
 0.01A 1zq9A-1zq9A:
44.2		 1zq9A-1zq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		5 ILE A 353
GLY A 345
LEU A 387
VAL A 385
ILE A 551
 None
 1.25A 1zq9A-2bllA:
4.4		 1zq9A-2bllA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Homo sapiens) 		PF05916
(Sld5) 		5 ILE B  26
GLY B  34
LEU B  40
PRO B  19
ILE B  18
 None
 1.20A 1zq9A-2e9xB:
undetectable		 1zq9A-2e9xB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		5 LEU A  39
ASP A  62
VAL A  63
ILE A 112
SER A 141
 NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
NAD  A 257 (-3.4A)
NAD  A 257 ( 4.3A)
NAD  A 257 (-3.1A)
 1.10A 1zq9A-2ewmA:
5.7		 1zq9A-2ewmA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 GLY A 732
LEU A 729
LEU A 735
VAL A 822
SER A 649
 None
 1.14A 1zq9A-2g28A:
undetectable		 1zq9A-2g28A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		5 HIS A  72
ILE A  95
LEU A  43
ASP A  54
VAL A  51
 FE2  A 300 (-3.3A)
None
None
None
None
 1.25A 1zq9A-2gcuA:
undetectable		 1zq9A-2gcuA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		5 GLY A 185
LEU A 215
LEU A 211
VAL A 218
ILE A 175
 None
 1.19A 1zq9A-2h8xA:
undetectable		 1zq9A-2h8xA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		5 HIS A 184
GLY A 144
LEU A 137
ASP A  79
PRO A 140
 None
 0.95A 1zq9A-2qq5A:
5.5		 1zq9A-2qq5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ILE A 180
GLY A 207
LEU A 112
ILE A 125
SER A 151
 None
 1.11A 1zq9A-2v0sA:
undetectable		 1zq9A-2v0sA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjz IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Thermotoga
maritima) 		PF00117
(GATase) 		5 GLY B 174
LEU B 173
VAL B  70
PRO B  49
ILE B   6
 None
 1.27A 1zq9A-2wjzB:
undetectable		 1zq9A-2wjzB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 HIS A 155
ILE A 156
LEU A 169
VAL A 114
ILE A  78
 None
UPG  A1415 (-4.3A)
None
None
None
 1.01A 1zq9A-2xa2A:
4.0		 1zq9A-2xa2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 401
LEU A  61
LEU A  55
PRO A 376
SER A 442
 None
None
None
None
HEM  A 601 (-2.8A)
 1.16A 1zq9A-3c6gA:
undetectable		 1zq9A-3c6gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 HIS A  27
ILE A  28
LEU A  45
ILE A 129
SER A 179
 None
 1.16A 1zq9A-3cc8A:
9.5		 1zq9A-3cc8A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		5 HIS A 282
ILE A 281
LEU A 476
ILE A 314
SER A 289
 None
 1.21A 1zq9A-3fotA:
undetectable		 1zq9A-3fotA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		7 GLY A  40
LEU A  64
ASP A  84
PRO A 103
ILE A 106
MET A 125
SER A 175
 None
 0.91A 1zq9A-3fydA:
27.9		 1zq9A-3fydA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 289
ILE A 287
LEU A 357
ILE A 414
MET A 313
 None
 1.27A 1zq9A-3g4gA:
undetectable		 1zq9A-3g4gA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		7 GLY A  40
LEU A  64
ASP A  84
PRO A 103
ILE A 106
MET A 125
SER A 175
 SAM  A 300 (-3.3A)
SAM  A 300 (-4.8A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.8A)
SAM  A 300 ( 4.4A)
None
None
 0.91A 1zq9A-3gryA:
28.0		 1zq9A-3gryA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 GLY A 152
LEU A 155
ASP A 135
VAL A 136
SER A 184
 None
 1.11A 1zq9A-3lgsA:
undetectable		 1zq9A-3lgsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ILE A 143
GLY A 152
LEU A 155
ASP A 135
VAL A 136
 None
 1.27A 1zq9A-3lgsA:
undetectable		 1zq9A-3lgsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY A 104
LEU A 191
LEU A 189
PRO A 172
ILE A 214
 None
 1.25A 1zq9A-3mm5A:
undetectable		 1zq9A-3mm5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		5 ILE A1330
GLY A1366
LEU A1363
VAL A1398
ILE A1435
 None
 1.25A 1zq9A-3opuA:
undetectable		 1zq9A-3opuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ILE A 230
GLY A 222
LEU A 309
VAL A 114
ILE A 140
 None
 1.10A 1zq9A-3oz6A:
undetectable		 1zq9A-3oz6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 HIS A 385
ILE A 391
GLY A 408
LEU A 412
SER A 349
 None
 1.25A 1zq9A-3p5pA:
undetectable		 1zq9A-3p5pA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 HIS A  83
ILE A  35
GLY A  36
VAL A  53
ILE A  96
 None
None
None
None
EDO  A 265 (-4.4A)
 1.06A 1zq9A-3r9sA:
undetectable		 1zq9A-3r9sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		5 ILE A 161
GLY A 200
LEU A 245
VAL A 263
ILE A 156
 None
 1.27A 1zq9A-3rm5A:
undetectable		 1zq9A-3rm5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 HIS A 348
GLY A 393
LEU A 353
ASP A 361
SER A 232
 None
 1.26A 1zq9A-3s9vA:
undetectable		 1zq9A-3s9vA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 HIS A  48
ILE A  45
LEU A  67
VAL A 183
PRO A  59
 None
 1.03A 1zq9A-3sf6A:
undetectable		 1zq9A-3sf6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLA

(Thermus
thermophilus) 		PF00025
(Arf) 		5 HIS A  75
GLY A  98
LEU A 189
VAL A 192
ILE A  11
 None
 1.20A 1zq9A-3t12A:
undetectable		 1zq9A-3t12A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 ILE A 152
GLY A  76
LEU A 107
LEU A 109
ILE A 129
 None
 1.12A 1zq9A-3t3oA:
2.9		 1zq9A-3t3oA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 454
ILE A 455
LEU A 388
VAL A 437
SER A 205
 OXY  A 511 ( 3.2A)
CU  A 501 (-3.8A)
None
None
None
 1.20A 1zq9A-3t6wA:
undetectable		 1zq9A-3t6wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		5 ILE A  85
GLY A 266
LEU A 267
VAL A  32
SER A 114
 None
 1.21A 1zq9A-3tglA:
undetectable		 1zq9A-3tglA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		7 HIS A  13
GLY A  42
LEU A  66
ASP A  86
ILE A 111
MET A 132
SER A 182
 None
 0.85A 1zq9A-3tqsA:
27.6		 1zq9A-3tqsA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		7 HIS A  13
GLY A  42
LEU A  66
PRO A 108
ILE A 111
MET A 132
SER A 182
 None
 0.60A 1zq9A-3tqsA:
27.6		 1zq9A-3tqsA:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		6 GLY A  48
LEU A  76
ASP A  94
PRO A 119
ILE A 122
SER A 193
 None
 0.66A 1zq9A-3uzuA:
26.1		 1zq9A-3uzuA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		6 LEU A  76
ASP A  94
PRO A 119
ILE A 122
MET A 143
SER A 193
 None
 0.92A 1zq9A-3uzuA:
26.1		 1zq9A-3uzuA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 HIS A 130
ILE A 126
GLY A  30
VAL A   8
ILE A  85
 None
 1.27A 1zq9A-3v98A:
undetectable		 1zq9A-3v98A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 HIS A 368
ILE A 371
VAL A 465
PRO A 248
SER A 573
 None
 1.10A 1zq9A-3vf1A:
undetectable		 1zq9A-3vf1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 ILE A1761
GLY A1762
LEU A1763
PRO A1831
SER A1837
 None
 1.06A 1zq9A-4asiA:
undetectable		 1zq9A-4asiA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 ILE B 391
GLY B 504
VAL B 247
ILE B 114
SER B  74
 None
 1.21A 1zq9A-4cakB:
undetectable		 1zq9A-4cakB:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 GLY A  16
LEU A  39
LEU A  43
ASP A  64
VAL A  65
 NAI  A 301 ( 4.6A)
NAI  A 301 (-3.9A)
None
NAI  A 301 (-3.6A)
NAI  A 301 (-3.5A)
 0.97A 1zq9A-4ituA:
6.0		 1zq9A-4ituA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 ILE A  44
GLY A  68
LEU A  63
VAL A 246
ILE A 276
 None
 1.18A 1zq9A-4ix2A:
undetectable		 1zq9A-4ix2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		5 ILE A  45
GLY A 184
LEU A  81
ASP A  98
VAL A  97
 None
 1.16A 1zq9A-4ixlA:
undetectable		 1zq9A-4ixlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq6 PROTEORHODOPSIN

(uncultured
bacterium) 		PF01036
(Bac_rhodopsin) 		5 ILE A 139
GLY A 137
LEU A 114
VAL A  84
ILE A  88
 None
RET  A 301 (-4.1A)
None
RET  A 301 (-4.3A)
None
 1.21A 1zq9A-4jq6A:
undetectable		 1zq9A-4jq6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 GLY A  52
PRO A 118
ILE A 121
MET A 142
SER A 192
 None
 1.15A 1zq9A-4jxjA:
26.5		 1zq9A-4jxjA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 GLY A 166
LEU A 173
VAL A 137
ILE A 118
SER A 114
 None
 1.14A 1zq9A-4kptA:
undetectable		 1zq9A-4kptA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 ILE A 200
GLY A 230
LEU A 251
ASP A 277
ILE A 300
 SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.5A)
 0.94A 1zq9A-4kriA:
12.9		 1zq9A-4kriA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3u UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF16133
(DUF4844) 		5 HIS A  49
GLY A  59
LEU A  65
ILE A 106
SER A 125
 None
 1.25A 1zq9A-4l3uA:
undetectable		 1zq9A-4l3uA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 GLY A 166
LEU A 444
LEU A 432
ILE A 442
MET A 127
 None
 1.10A 1zq9A-4n0iA:
undetectable		 1zq9A-4n0iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 768
GLY A 822
LEU A 797
LEU A 805
ILE A 793
 None
 1.15A 1zq9A-4ncnA:
undetectable		 1zq9A-4ncnA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis) 		PF13561
(adh_short_C2) 		5 LEU A 247
ASP A 219
VAL A 220
ILE A 186
SER A  93
 None
None
None
NAP  A 300 (-4.2A)
None
 1.18A 1zq9A-4qedA:
6.0		 1zq9A-4qedA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		5 ILE B1334
GLY B1370
LEU B1367
VAL B1402
ILE B1439
 None
 1.22A 1zq9A-4tshB:
undetectable		 1zq9A-4tshB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v35 ALANYL-TRNA-DEPENDEN
T L-ALANYL-
PHOPHATIDYLGLYCEROL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF09924
(DUF2156) 		5 GLY A 784
LEU A 690
LEU A 692
ASP A 688
MET A 675
 None
 1.04A 1zq9A-4v35A:
undetectable		 1zq9A-4v35A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 ILE A 452
GLY A 450
LEU A 604
LEU A 449
ILE A 601
 None
 1.27A 1zq9A-4wd9A:
undetectable		 1zq9A-4wd9A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 HIS A  70
GLY A 264
LEU A 122
VAL A 206
ILE A 147
 None
 1.26A 1zq9A-4x3fA:
undetectable		 1zq9A-4x3fA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		5 ILE A 171
GLY A 155
LEU A 211
ILE A  66
SER A  72
 FZZ  A 602 ( 3.7A)
None
None
None
None
 1.23A 1zq9A-4zaaA:
undetectable		 1zq9A-4zaaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		5 GLY A 237
LEU A 249
LEU A 246
ILE A  23
SER A  46
 None
 1.25A 1zq9A-4zevA:
undetectable		 1zq9A-4zevA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A  30
GLY A  31
LEU A  62
LEU A  51
SER A 152
 C  E   0 ( 3.6A)
None
None
None
G  E   1 ( 4.4A)
 1.17A 1zq9A-5a0tA:
undetectable		 1zq9A-5a0tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		5 HIS A 166
ILE A 183
GLY A 274
VAL A 318
ILE A 298
 None
 1.07A 1zq9A-5afuA:
undetectable		 1zq9A-5afuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		5 GLY A 129
LEU A  67
VAL A  36
PRO A 368
ILE A  33
 None
 1.23A 1zq9A-5bz3A:
undetectable		 1zq9A-5bz3A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Shewanella
halifaxensis) 		PF01791
(DeoC) 		5 ILE A 188
GLY A 196
LEU A  14
PRO A 199
SER A 141
 None
 1.22A 1zq9A-5c6mA:
undetectable		 1zq9A-5c6mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1) 		5 ILE A 231
LEU A 264
LEU A 266
ASP A 323
ILE A  90
 None
 1.19A 1zq9A-5dhgA:
undetectable		 1zq9A-5dhgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ILE A 784
GLY A 815
VAL A 803
PRO A 778
ILE A1045
 None
 1.11A 1zq9A-5epgA:
undetectable		 1zq9A-5epgA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 GLY B 120
ASP B 168
VAL B 169
PRO B 205
SER B 356
 SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 ( 4.9A)
None
 1.07A 1zq9A-5ergB:
13.7		 1zq9A-5ergB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		5 ILE B 410
GLY B 353
LEU B 346
VAL B 431
ILE B 449
 None
 1.25A 1zq9A-5flzB:
undetectable		 1zq9A-5flzB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5t ARGONAUTE

(Methanocaldococcus
jannaschii) 		PF02171
(Piwi) 		5 GLY A 482
LEU A 704
LEU A 710
PRO A 348
ILE A 350
 None
None
None
SO4  A1721 ( 4.5A)
None
 1.27A 1zq9A-5g5tA:
undetectable		 1zq9A-5g5tA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		5 ILE A 730
GLY A 727
LEU A 721
PRO A 169
ILE A 719
 None
None
None
None
C  U 111 ( 4.4A)
 1.26A 1zq9A-5gamA:
undetectable		 1zq9A-5gamA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 HIS A 554
ILE A 557
LEU A 613
VAL A 305
ILE A 313
 None
 1.16A 1zq9A-5gr1A:
undetectable		 1zq9A-5gr1A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 5 HIS A 426
GLY A  68
LEU A  81
PRO A 127
ILE A 143
 None
 1.02A 1zq9A-5i5jA:
undetectable		 1zq9A-5i5jA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 5 HIS A 426
ILE A 489
GLY A  68
PRO A 127
ILE A 143
 None
 0.97A 1zq9A-5i5jA:
undetectable		 1zq9A-5i5jA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 HIS A 328
GLY A 332
LEU A 408
LEU A 406
ILE A 448
 None
 1.18A 1zq9A-5jjtA:
undetectable		 1zq9A-5jjtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		5 HIS A 396
GLY A 132
LEU A 140
LEU A 336
SER A 388
 None
 1.26A 1zq9A-5m8jA:
undetectable		 1zq9A-5m8jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A 153
LEU A 156
ASP A 179
VAL A 178
SER A 349
 None
None
None
None
PLP  A1002 (-2.8A)
 1.14A 1zq9A-5mmsA:
undetectable		 1zq9A-5mmsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN

(Helicobacter
pylori) 		no annotation 5 GLY A 327
LEU A 334
VAL A 350
ILE A 352
SER A 382
 None
 1.19A 1zq9A-5npyA:
undetectable		 1zq9A-5npyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 5 ILE A 244
LEU A 226
ASP A 227
PRO A 254
ILE A 256
 None
None
None
None
EDO  A 601 ( 4.8A)
 1.20A 1zq9A-5nqaA:
undetectable		 1zq9A-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 GLY A  17
LEU A  39
ASP A  63
ILE A 113
SER A 140
 NAD  A 300 (-3.3A)
NAD  A 300 (-4.0A)
NAD  A 300 (-3.5A)
NAD  A 300 ( 4.1A)
NAD  A 300 ( 3.8A)
 1.06A 1zq9A-5t5qA:
6.1		 1zq9A-5t5qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 ILE A1404
LEU A1414
LEU A1430
ILE A1398
SER A1373
 None
 1.02A 1zq9A-5uakA:
undetectable		 1zq9A-5uakA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 5 HIS A 145
ILE A 147
LEU A 241
VAL A 224
ILE A  18
 None
 1.23A 1zq9A-5x8hA:
6.4		 1zq9A-5x8hA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 5 LEU A 276
ASP A 275
VAL A 274
MET A  16
SER A  13
 None
 1.11A 1zq9A-5xoeA:
undetectable		 1zq9A-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 HIS A 231
ILE A 236
GLY A 255
LEU A 267
ILE A 259
 None
 1.24A 1zq9A-5z5dA:
undetectable		 1zq9A-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 5 GLY A 298
LEU A 282
LEU A 284
ASP A 278
VAL A 271
 None
 1.21A 1zq9A-5znnA:
undetectable		 1zq9A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bng 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Acinetobacter
baumannii) 		no annotation 5 ILE A  41
GLY A  28
LEU A 238
VAL A  24
ILE A  54
 None
 1.19A 1zq9A-6bngA:
undetectable		 1zq9A-6bngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 ILE H  20
GLY F  75
LEU H  12
LEU F  79
ILE H 121
 None
 1.16A 1zq9A-6cfwH:
undetectable		 1zq9A-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 LEU A 656
VAL A 637
ILE A 641
MET A 466
SER A 413
 EDO  A 803 (-3.8A)
None
None
None
None
 1.14A 1zq9A-6cgmA:
2.6		 1zq9A-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE H 637
GLY H 638
LEU H 656
VAL H 617
ILE H 576
 None
 1.05A 1zq9A-6chsH:
2.2		 1zq9A-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft


(;
) 		no annotation
no annotation 		5 ILE B  75
GLY B 101
LEU B 263
ASP A 326
SER B 321
 None
None
NAD  A 502 (-3.7A)
NAD  A 502 (-3.6A)
None
 1.26A 1zq9A-6dftB:
2.4		 1zq9A-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 HIS A  22
ILE A  20
LEU A 108
ASP A  33
VAL A  32
 None
 1.19A 1zq9A-6fuyA:
undetectable		 1zq9A-6fuyA:
undetectable