SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZQ9_A_SAMA4000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 HIS A 168
LEU A  83
LEU A  81
ILE A 102
SER A 206
 None
 1.27A 1zq9A-1aqlA:
undetectable		 1zq9A-1aqlA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 ILE A 178
GLY A 174
ASP A 198
VAL A 197
SER A 239
 None
 1.24A 1zq9A-1dciA:
undetectable		 1zq9A-1dciA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7u 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		6 HIS A  40
ILE A  37
GLY A  24
LEU A 236
VAL A  20
ILE A  50
 None
 1.10A 1zq9A-1g7uA:
undetectable		 1zq9A-1g7uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 HIS A 168
LEU A  83
LEU A  81
ILE A 102
SER A 206
 None
 1.27A 1zq9A-1jmyA:
undetectable		 1zq9A-1jmyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko8 GLUCONATE KINASE

(Escherichia
coli) 		PF01202
(SKI) 		5 GLY A  39
LEU A  84
LEU A  37
VAL A  24
ILE A 108
 None
 1.13A 1zq9A-1ko8A:
undetectable		 1zq9A-1ko8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ILE A 326
GLY A 143
LEU A  61
PRO A  75
ILE A  26
 None
 1.26A 1zq9A-1mc8A:
undetectable		 1zq9A-1mc8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		5 HIS A 119
ILE A  92
LEU A 108
VAL A 178
ILE A 187
 None
 1.25A 1zq9A-1pxzA:
undetectable		 1zq9A-1pxzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  70
GLY A  92
VAL A 314
PRO A 160
ILE A 321
 None
 1.20A 1zq9A-1q1nA:
5.7		 1zq9A-1q1nA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		8 GLY A  47
LEU A  67
LEU A  71
ASP A  91
PRO A 115
ILE A 118
MET A 139
SER A 189
 None
 0.73A 1zq9A-1qyrA:
27.0		 1zq9A-1qyrA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		5 ILE A 111
GLY A 122
VAL A  44
PRO A  80
ILE A  77
 None
 1.09A 1zq9A-1rpxA:
undetectable		 1zq9A-1rpxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT

(Homo sapiens) 		PF13472
(Lipase_GDSL_2) 		5 HIS A  28
ILE A  73
GLY A  72
LEU A  69
ILE A  93
 None
 1.27A 1zq9A-1vyhA:
undetectable		 1zq9A-1vyhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Mus musculus) 		PF00400
(WD40) 		5 HIS C 337
GLY C 343
LEU C 386
ASP C 401
VAL C 400
 None
 1.23A 1zq9A-1vyhC:
undetectable		 1zq9A-1vyhC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE

(Methanosarcina
barkeri) 		PF00296
(Bac_luciferase) 		5 HIS A  36
LEU A  46
VAL A  48
PRO A   9
ILE A  16
 F42  A 328 (-3.8A)
None
None
None
None
 1.09A 1zq9A-1z69A:
undetectable		 1zq9A-1z69A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLY A 115
LEU A  91
LEU A 114
ILE A   6
MET A  11
 None
 1.13A 1zq9A-1zejA:
6.1		 1zq9A-1zejA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		11 HIS A  37
ILE A  38
GLY A  66
LEU A  86
LEU A  90
ASP A 113
VAL A 114
PRO A 130
ILE A 133
MET A 154
SER A 204
 SAM  A4000 (-4.9A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.2A)
SAM  A4000 (-3.7A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-3.9A)
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
None
SAM  A4000 (-3.4A)
 0.01A 1zq9A-1zq9A:
44.2		 1zq9A-1zq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		5 ILE A 353
GLY A 345
LEU A 387
VAL A 385
ILE A 551
 None
 1.25A 1zq9A-2bllA:
4.4		 1zq9A-2bllA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Homo sapiens) 		PF05916
(Sld5) 		5 ILE B  26
GLY B  34
LEU B  40
PRO B  19
ILE B  18
 None
 1.20A 1zq9A-2e9xB:
undetectable		 1zq9A-2e9xB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		5 LEU A  39
ASP A  62
VAL A  63
ILE A 112
SER A 141
 NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
NAD  A 257 (-3.4A)
NAD  A 257 ( 4.3A)
NAD  A 257 (-3.1A)
 1.10A 1zq9A-2ewmA:
5.7		 1zq9A-2ewmA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 GLY A 732
LEU A 729
LEU A 735
VAL A 822
SER A 649
 None
 1.14A 1zq9A-2g28A:
undetectable		 1zq9A-2g28A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		5 HIS A  72
ILE A  95
LEU A  43
ASP A  54
VAL A  51
 FE2  A 300 (-3.3A)
None
None
None
None
 1.25A 1zq9A-2gcuA:
undetectable		 1zq9A-2gcuA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		5 GLY A 185
LEU A 215
LEU A 211
VAL A 218
ILE A 175
 None
 1.19A 1zq9A-2h8xA:
undetectable		 1zq9A-2h8xA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		5 HIS A 184
GLY A 144
LEU A 137
ASP A  79
PRO A 140
 None
 0.95A 1zq9A-2qq5A:
5.5		 1zq9A-2qq5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ILE A 180
GLY A 207
LEU A 112
ILE A 125
SER A 151
 None
 1.11A 1zq9A-2v0sA:
undetectable		 1zq9A-2v0sA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjz IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Thermotoga
maritima) 		PF00117
(GATase) 		5 GLY B 174
LEU B 173
VAL B  70
PRO B  49
ILE B   6
 None
 1.27A 1zq9A-2wjzB:
undetectable		 1zq9A-2wjzB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 HIS A 155
ILE A 156
LEU A 169
VAL A 114
ILE A  78
 None
UPG  A1415 (-4.3A)
None
None
None
 1.01A 1zq9A-2xa2A:
4.0		 1zq9A-2xa2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 401
LEU A  61
LEU A  55
PRO A 376
SER A 442
 None
None
None
None
HEM  A 601 (-2.8A)
 1.16A 1zq9A-3c6gA:
undetectable		 1zq9A-3c6gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 HIS A  27
ILE A  28
LEU A  45
ILE A 129
SER A 179
 None
 1.16A 1zq9A-3cc8A:
9.5		 1zq9A-3cc8A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		5 HIS A 282
ILE A 281
LEU A 476
ILE A 314
SER A 289
 None
 1.21A 1zq9A-3fotA:
undetectable		 1zq9A-3fotA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		7 GLY A  40
LEU A  64
ASP A  84
PRO A 103
ILE A 106
MET A 125
SER A 175
 None
 0.91A 1zq9A-3fydA:
27.9		 1zq9A-3fydA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 289
ILE A 287
LEU A 357
ILE A 414
MET A 313
 None
 1.27A 1zq9A-3g4gA:
undetectable		 1zq9A-3g4gA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		7 GLY A  40
LEU A  64
ASP A  84
PRO A 103
ILE A 106
MET A 125
SER A 175
 SAM  A 300 (-3.3A)
SAM  A 300 (-4.8A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.8A)
SAM  A 300 ( 4.4A)
None
None
 0.91A 1zq9A-3gryA:
28.0		 1zq9A-3gryA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 GLY A 152
LEU A 155
ASP A 135
VAL A 136
SER A 184
 None
 1.11A 1zq9A-3lgsA:
undetectable		 1zq9A-3lgsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ILE A 143
GLY A 152
LEU A 155
ASP A 135
VAL A 136
 None
 1.27A 1zq9A-3lgsA:
undetectable		 1zq9A-3lgsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY A 104
LEU A 191
LEU A 189
PRO A 172
ILE A 214
 None
 1.25A 1zq9A-3mm5A:
undetectable		 1zq9A-3mm5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		5 ILE A1330
GLY A1366
LEU A1363
VAL A1398
ILE A1435
 None
 1.25A 1zq9A-3opuA:
undetectable		 1zq9A-3opuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ILE A 230
GLY A 222
LEU A 309
VAL A 114
ILE A 140
 None
 1.10A 1zq9A-3oz6A:
undetectable		 1zq9A-3oz6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 HIS A 385
ILE A 391
GLY A 408
LEU A 412
SER A 349
 None
 1.25A 1zq9A-3p5pA:
undetectable		 1zq9A-3p5pA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 HIS A  83
ILE A  35
GLY A  36
VAL A  53
ILE A  96
 None
None
None
None
EDO  A 265 (-4.4A)
 1.06A 1zq9A-3r9sA:
undetectable		 1zq9A-3r9sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		5 ILE A 161
GLY A 200
LEU A 245
VAL A 263
ILE A 156
 None
 1.27A 1zq9A-3rm5A:
undetectable		 1zq9A-3rm5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 HIS A 348
GLY A 393
LEU A 353
ASP A 361
SER A 232
 None
 1.26A 1zq9A-3s9vA:
undetectable		 1zq9A-3s9vA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 HIS A  48
ILE A  45
LEU A  67
VAL A 183
PRO A  59
 None
 1.03A 1zq9A-3sf6A:
undetectable		 1zq9A-3sf6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLA

(Thermus
thermophilus) 		PF00025
(Arf) 		5 HIS A  75
GLY A  98
LEU A 189
VAL A 192
ILE A  11
 None
 1.20A 1zq9A-3t12A:
undetectable		 1zq9A-3t12A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 ILE A 152
GLY A  76
LEU A 107
LEU A 109
ILE A 129
 None
 1.12A 1zq9A-3t3oA:
2.9		 1zq9A-3t3oA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 454
ILE A 455
LEU A 388
VAL A 437
SER A 205
 OXY  A 511 ( 3.2A)
CU  A 501 (-3.8A)
None
None
None
 1.20A 1zq9A-3t6wA:
undetectable		 1zq9A-3t6wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		5 ILE A  85
GLY A 266
LEU A 267
VAL A  32
SER A 114
 None
 1.21A 1zq9A-3tglA:
undetectable		 1zq9A-3tglA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		7 HIS A  13
GLY A  42
LEU A  66
ASP A  86
ILE A 111
MET A 132
SER A 182
 None
 0.85A 1zq9A-3tqsA:
27.6		 1zq9A-3tqsA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		7 HIS A  13
GLY A  42
LEU A  66
PRO A 108
ILE A 111
MET A 132
SER A 182
 None
 0.60A 1zq9A-3tqsA:
27.6		 1zq9A-3tqsA:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		6 GLY A  48
LEU A  76
ASP A  94
PRO A 119
ILE A 122
SER A 193
 None
 0.66A 1zq9A-3uzuA:
26.1		 1zq9A-3uzuA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		6 LEU A  76
ASP A  94
PRO A 119
ILE A 122
MET A 143
SER A 193
 None
 0.92A 1zq9A-3uzuA:
26.1		 1zq9A-3uzuA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 HIS A 130
ILE A 126
GLY A  30
VAL A   8
ILE A  85
 None
 1.27A 1zq9A-3v98A:
undetectable		 1zq9A-3v98A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 HIS A 368
ILE A 371
VAL A 465
PRO A 248
SER A 573
 None
 1.10A 1zq9A-3vf1A:
undetectable		 1zq9A-3vf1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 ILE A1761
GLY A1762
LEU A1763
PRO A1831
SER A1837
 None
 1.06A 1zq9A-4asiA:
undetectable		 1zq9A-4asiA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 ILE B 391
GLY B 504
VAL B 247
ILE B 114
SER B  74
 None
 1.21A 1zq9A-4cakB:
undetectable		 1zq9A-4cakB:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 GLY A  16
LEU A  39
LEU A  43
ASP A  64
VAL A  65
 NAI  A 301 ( 4.6A)
NAI  A 301 (-3.9A)
None
NAI  A 301 (-3.6A)
NAI  A 301 (-3.5A)
 0.97A 1zq9A-4ituA:
6.0		 1zq9A-4ituA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 ILE A  44
GLY A  68
LEU A  63
VAL A 246
ILE A 276
 None
 1.18A 1zq9A-4ix2A:
undetectable		 1zq9A-4ix2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		5 ILE A  45
GLY A 184
LEU A  81
ASP A  98
VAL A  97
 None
 1.16A 1zq9A-4ixlA:
undetectable		 1zq9A-4ixlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq6 PROTEORHODOPSIN

(uncultured
bacterium) 		PF01036
(Bac_rhodopsin) 		5 ILE A 139
GLY A 137
LEU A 114
VAL A  84
ILE A  88
 None
RET  A 301 (-4.1A)
None
RET  A 301 (-4.3A)
None
 1.21A 1zq9A-4jq6A:
undetectable		 1zq9A-4jq6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 GLY A  52
PRO A 118
ILE A 121
MET A 142
SER A 192
 None
 1.15A 1zq9A-4jxjA:
26.5		 1zq9A-4jxjA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 GLY A 166
LEU A 173
VAL A 137
ILE A 118
SER A 114
 None
 1.14A 1zq9A-4kptA:
undetectable		 1zq9A-4kptA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 ILE A 200
GLY A 230
LEU A 251
ASP A 277
ILE A 300
 SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.5A)
 0.94A 1zq9A-4kriA:
12.9		 1zq9A-4kriA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3u UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF16133
(DUF4844) 		5 HIS A  49
GLY A  59
LEU A  65
ILE A 106
SER A 125
 None
 1.25A 1zq9A-4l3uA:
undetectable		 1zq9A-4l3uA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 GLY A 166
LEU A 444
LEU A 432
ILE A 442
MET A 127
 None
 1.10A 1zq9A-4n0iA:
undetectable		 1zq9A-4n0iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 768
GLY A 822
LEU A 797
LEU A 805
ILE A 793
 None
 1.15A 1zq9A-4ncnA:
undetectable		 1zq9A-4ncnA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis) 		PF13561
(adh_short_C2) 		5 LEU A 247
ASP A 219
VAL A 220
ILE A 186
SER A  93
 None
None
None
NAP  A 300 (-4.2A)
None
 1.18A 1zq9A-4qedA:
6.0		 1zq9A-4qedA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		5 ILE B1334
GLY B1370
LEU B1367
VAL B1402
ILE B1439
 None
 1.22A 1zq9A-4tshB:
undetectable		 1zq9A-4tshB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v35 ALANYL-TRNA-DEPENDEN
T L-ALANYL-
PHOPHATIDYLGLYCEROL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF09924
(DUF2156) 		5 GLY A 784
LEU A 690
LEU A 692
ASP A 688
MET A 675
 None
 1.04A 1zq9A-4v35A:
undetectable		 1zq9A-4v35A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 ILE A 452
GLY A 450
LEU A 604
LEU A 449
ILE A 601
 None
 1.27A 1zq9A-4wd9A:
undetectable		 1zq9A-4wd9A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 HIS A  70
GLY A 264
LEU A 122
VAL A 206
ILE A 147
 None
 1.26A 1zq9A-4x3fA:
undetectable		 1zq9A-4x3fA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		5 ILE A 171
GLY A 155
LEU A 211
ILE A  66
SER A  72
 FZZ  A 602 ( 3.7A)
None
None
None
None
 1.23A 1zq9A-4zaaA:
undetectable		 1zq9A-4zaaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		5 GLY A 237
LEU A 249
LEU A 246
ILE A  23
SER A  46
 None
 1.25A 1zq9A-4zevA:
undetectable		 1zq9A-4zevA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A  30
GLY A  31
LEU A  62
LEU A  51
SER A 152
 C  E   0 ( 3.6A)
None
None
None
G  E   1 ( 4.4A)
 1.17A 1zq9A-5a0tA:
undetectable		 1zq9A-5a0tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		5 HIS A 166
ILE A 183
GLY A 274
VAL A 318
ILE A 298
 None
 1.07A 1zq9A-5afuA:
undetectable		 1zq9A-5afuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		5 GLY A 129
LEU A  67
VAL A  36
PRO A 368
ILE A  33
 None
 1.23A 1zq9A-5bz3A:
undetectable		 1zq9A-5bz3A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Shewanella
halifaxensis) 		PF01791
(DeoC) 		5 ILE A 188
GLY A 196
LEU A  14
PRO A 199
SER A 141
 None
 1.22A 1zq9A-5c6mA:
undetectable		 1zq9A-5c6mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1) 		5 ILE A 231
LEU A 264
LEU A 266
ASP A 323
ILE A  90
 None
 1.19A 1zq9A-5dhgA:
undetectable		 1zq9A-5dhgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ILE A 784
GLY A 815
VAL A 803
PRO A 778
ILE A1045
 None
 1.11A 1zq9A-5epgA:
undetectable		 1zq9A-5epgA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 GLY B 120
ASP B 168
VAL B 169
PRO B 205
SER B 356
 SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 ( 4.9A)
None
 1.07A 1zq9A-5ergB:
13.7		 1zq9A-5ergB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		5 ILE B 410
GLY B 353
LEU B 346
VAL B 431
ILE B 449
 None
 1.25A 1zq9A-5flzB:
undetectable		 1zq9A-5flzB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5t ARGONAUTE

(Methanocaldococcus
jannaschii) 		PF02171
(Piwi) 		5 GLY A 482
LEU A 704
LEU A 710
PRO A 348
ILE A 350
 None
None
None
SO4  A1721 ( 4.5A)
None
 1.27A 1zq9A-5g5tA:
undetectable		 1zq9A-5g5tA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		5 ILE A 730
GLY A 727
LEU A 721
PRO A 169
ILE A 719
 None
None
None
None
C  U 111 ( 4.4A)
 1.26A 1zq9A-5gamA:
undetectable		 1zq9A-5gamA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 HIS A 554
ILE A 557
LEU A 613
VAL A 305
ILE A 313
 None
 1.16A 1zq9A-5gr1A:
undetectable		 1zq9A-5gr1A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 5 HIS A 426
GLY A  68
LEU A  81
PRO A 127
ILE A 143
 None
 1.02A 1zq9A-5i5jA:
undetectable		 1zq9A-5i5jA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 5 HIS A 426
ILE A 489
GLY A  68
PRO A 127
ILE A 143
 None
 0.97A 1zq9A-5i5jA:
undetectable		 1zq9A-5i5jA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 HIS A 328
GLY A 332
LEU A 408
LEU A 406
ILE A 448
 None
 1.18A 1zq9A-5jjtA:
undetectable		 1zq9A-5jjtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		5 HIS A 396
GLY A 132
LEU A 140
LEU A 336
SER A 388
 None
 1.26A 1zq9A-5m8jA:
undetectable		 1zq9A-5m8jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A 153
LEU A 156
ASP A 179
VAL A 178
SER A 349
 None
None
None
None
PLP  A1002 (-2.8A)
 1.14A 1zq9A-5mmsA:
undetectable		 1zq9A-5mmsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN

(Helicobacter
pylori) 		no annotation 5 GLY A 327
LEU A 334
VAL A 350
ILE A 352
SER A 382
 None
 1.19A 1zq9A-5npyA:
undetectable		 1zq9A-5npyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 5 ILE A 244
LEU A 226
ASP A 227
PRO A 254
ILE A 256
 None
None
None
None
EDO  A 601 ( 4.8A)
 1.20A 1zq9A-5nqaA:
undetectable		 1zq9A-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 GLY A  17
LEU A  39
ASP A  63
ILE A 113
SER A 140
 NAD  A 300 (-3.3A)
NAD  A 300 (-4.0A)
NAD  A 300 (-3.5A)
NAD  A 300 ( 4.1A)
NAD  A 300 ( 3.8A)
 1.06A 1zq9A-5t5qA:
6.1		 1zq9A-5t5qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 ILE A1404
LEU A1414
LEU A1430
ILE A1398
SER A1373
 None
 1.02A 1zq9A-5uakA:
undetectable		 1zq9A-5uakA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 5 HIS A 145
ILE A 147
LEU A 241
VAL A 224
ILE A  18
 None
 1.23A 1zq9A-5x8hA:
6.4		 1zq9A-5x8hA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 5 LEU A 276
ASP A 275
VAL A 274
MET A  16
SER A  13
 None
 1.11A 1zq9A-5xoeA:
undetectable		 1zq9A-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 HIS A 231
ILE A 236
GLY A 255
LEU A 267
ILE A 259
 None
 1.24A 1zq9A-5z5dA:
undetectable		 1zq9A-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 5 GLY A 298
LEU A 282
LEU A 284
ASP A 278
VAL A 271
 None
 1.21A 1zq9A-5znnA:
undetectable		 1zq9A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bng 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Acinetobacter
baumannii) 		no annotation 5 ILE A  41
GLY A  28
LEU A 238
VAL A  24
ILE A  54
 None
 1.19A 1zq9A-6bngA:
undetectable		 1zq9A-6bngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 ILE H  20
GLY F  75
LEU H  12
LEU F  79
ILE H 121
 None
 1.16A 1zq9A-6cfwH:
undetectable		 1zq9A-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 LEU A 656
VAL A 637
ILE A 641
MET A 466
SER A 413
 EDO  A 803 (-3.8A)
None
None
None
None
 1.14A 1zq9A-6cgmA:
2.6		 1zq9A-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE H 637
GLY H 638
LEU H 656
VAL H 617
ILE H 576
 None
 1.05A 1zq9A-6chsH:
2.2		 1zq9A-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft


(;
) 		no annotation
no annotation 		5 ILE B  75
GLY B 101
LEU B 263
ASP A 326
SER B 321
 None
None
NAD  A 502 (-3.7A)
NAD  A 502 (-3.6A)
None
 1.26A 1zq9A-6dftB:
2.4		 1zq9A-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 HIS A  22
ILE A  20
LEU A 108
ASP A  33
VAL A  32
 None
 1.19A 1zq9A-6fuyA:
undetectable		 1zq9A-6fuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 GLY A 162
GLU A 155
ASN A 163
 FAD  A 600 (-3.2A)
FAD  A 600 (-2.7A)
FAD  A 600 (-3.6A)
 0.67A 1zq9A-1d4eA:
0.4		 1zq9A-1d4eA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		3 GLY A 158
GLU A 162
ASN A 155
 None
 0.54A 1zq9A-1fehA:
undetectable		 1zq9A-1fehA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 GLY A 179
GLU A 208
ASN A 122
 None
 0.62A 1zq9A-1oi7A:
5.2		 1zq9A-1oi7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		3 GLY A  45
GLU A  66
ASN A 113
 None
 0.52A 1zq9A-1qyrA:
27.0		 1zq9A-1qyrA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		3 GLY A 121
GLU A   9
ASN A  78
 None
 0.65A 1zq9A-1rcyA:
undetectable		 1zq9A-1rcyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		3 GLY A  57
GLU A  79
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.6A)
 0.69A 1zq9A-1wy7A:
15.3		 1zq9A-1wy7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens;
Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
PF00364
(Biotin_lipoyl) 		3 GLY B 177
GLU B 168
ASN A 373
 None
 0.68A 1zq9A-1y8pB:
undetectable		 1zq9A-1y8pB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6u NP95-LIKE RING
FINGER PROTEIN
ISOFORM B

(Homo sapiens) 		PF00097
(zf-C3HC4) 		3 GLY A 720
GLU A 688
ASN A 722
 None
 0.70A 1zq9A-1z6uA:
undetectable		 1zq9A-1z6uA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		3 GLY A  64
GLU A  85
ASN A 128
 SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-2.7A)
 0.01A 1zq9A-1zq9A:
44.2		 1zq9A-1zq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		3 GLY A 137
GLU A 106
ASN A 139
 None
 0.70A 1zq9A-2aafA:
undetectable		 1zq9A-2aafA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeh FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M) 		3 GLY A 132
GLU A 277
ASN A 135
 None
 0.72A 1zq9A-2aehA:
undetectable		 1zq9A-2aehA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B

(Methanocaldococcus
jannaschii) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		3 GLY A 292
GLU A 288
ASN A  33
 None
 0.72A 1zq9A-2apoA:
undetectable		 1zq9A-2apoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0g WINDBEUTEL PROTEIN

(Drosophila
melanogaster) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		3 GLY A1148
GLU A1186
ASN A1237
 None
 0.53A 1zq9A-2c0gA:
undetectable		 1zq9A-2c0gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 GLY A 258
GLU A 254
ASN A 261
 None
 0.67A 1zq9A-2epjA:
undetectable		 1zq9A-2epjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 GLY X  25
GLU X  26
ASN X  23
 None
 0.70A 1zq9A-2epkX:
undetectable		 1zq9A-2epkX:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 GLY X 342
GLU X 380
ASN X 440
 None
 0.68A 1zq9A-2epkX:
undetectable		 1zq9A-2epkX:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ful EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		3 GLY A 326
GLU A 329
ASN A 323
 None
 0.66A 1zq9A-2fulA:
undetectable		 1zq9A-2fulA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrj TALIN-1

(Gallus gallus) 		PF00373
(FERM_M) 		3 GLY A  60
GLU A 103
ASN A  63
 None
 0.73A 1zq9A-2hrjA:
undetectable		 1zq9A-2hrjA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 GLY A  63
GLU A  67
ASN A  61
 None
 0.73A 1zq9A-2iw1A:
4.4		 1zq9A-2iw1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 GLY A 132
GLU A 277
ASN A 135
 None
 0.41A 1zq9A-2j0jA:
undetectable		 1zq9A-2j0jA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnk HYALURONONGLUCOSAMIN
IDASE

(Clostridium
perfringens) 		PF00404
(Dockerin_1)
PF07554
(FIVAR) 		3 GLY A  13
GLU A  40
ASN A  11
 None
 0.73A 1zq9A-2jnkA:
undetectable		 1zq9A-2jnkA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la6 RNA-BINDING PROTEIN
FUS

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLY A  20
GLU A  65
ASN A  91
 None
 0.48A 1zq9A-2la6A:
undetectable		 1zq9A-2la6A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF08295
(Sin3_corepress) 		3 GLY B 659
GLU B 663
ASN B 656
 None
 0.61A 1zq9A-2n2hB:
undetectable		 1zq9A-2n2hB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		3 GLY A 342
GLU A 182
ASN A 345
 None
 0.71A 1zq9A-2o2cA:
1.9		 1zq9A-2o2cA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Pectobacterium
atrosepticum) 		PF06508
(QueC) 		3 GLY A 191
GLU A  42
ASN A 190
 None
 0.60A 1zq9A-2pg3A:
3.0		 1zq9A-2pg3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pif UPF0317 PROTEIN
PSPTO_5379

(Pseudomonas
syringae group
genomosp. 3) 		PF07286
(DUF1445) 		3 GLY A 203
GLU A 201
ASN A 208
 None
 0.66A 1zq9A-2pifA:
undetectable		 1zq9A-2pifA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		3 GLY A 458
GLU A 462
ASN A 457
 None
None
HEM  A 600 (-4.2A)
 0.70A 1zq9A-2rchA:
undetectable		 1zq9A-2rchA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 GLY A 298
GLU A 194
ASN A 347
 None
 0.73A 1zq9A-2vr2A:
undetectable		 1zq9A-2vr2A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 GLY A 247
GLU A 251
ASN A 245
 None
 0.71A 1zq9A-2y3sA:
undetectable		 1zq9A-2y3sA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		3 GLY A 173
GLU A 154
ASN A 175
 None
 0.66A 1zq9A-2zuyA:
undetectable		 1zq9A-2zuyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		3 GLY A 271
GLU A 243
ASN A  14
 None
 0.65A 1zq9A-3a5vA:
undetectable		 1zq9A-3a5vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		3 GLY A 200
GLU A 291
ASN A 197
 None
 0.69A 1zq9A-3c3vA:
undetectable		 1zq9A-3c3vA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		3 GLY A 413
GLU A 417
ASN A 412
 None
None
HEM  A 600 (-4.4A)
 0.68A 1zq9A-3danA:
undetectable		 1zq9A-3danA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		3 GLY A  54
GLU A  75
ASN A 117
 None
 0.65A 1zq9A-3futA:
24.8		 1zq9A-3futA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		3 GLY A  38
GLU A  59
ASN A 101
 None
 0.64A 1zq9A-3fydA:
27.9		 1zq9A-3fydA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7z PROTEIN CCDA

(Escherichia
coli) 		PF07362
(CcdA) 		3 GLY C  51
GLU C  54
ASN C  48
 None
 0.61A 1zq9A-3g7zC:
undetectable		 1zq9A-3g7zC:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjb CYTC3

(Streptomyces
sp.) 		PF05721
(PhyH) 		3 GLY A 280
GLU A 276
ASN A  64
 None
 0.70A 1zq9A-3gjbA:
undetectable		 1zq9A-3gjbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		3 GLY A 257
GLU A 261
ASN A 255
 None
 0.68A 1zq9A-3go7A:
3.8		 1zq9A-3go7A:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		3 GLY A  38
GLU A  59
ASN A 101
 SAM  A 300 (-3.3A)
SAM  A 300 (-2.8A)
SAM  A 300 (-3.6A)
 0.73A 1zq9A-3gryA:
27.1		 1zq9A-3gryA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h05 UNCHARACTERIZED
PROTEIN VPA0413

(Vibrio
parahaemolyticus) 		PF01467
(CTP_transf_like) 		3 GLY A 106
GLU A 133
ASN A 109
 None
 0.67A 1zq9A-3h05A:
undetectable		 1zq9A-3h05A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 GLY C 252
GLU C 272
ASN C 249
 UNL  C3106 ( 4.8A)
None
None
 0.56A 1zq9A-3h1lC:
undetectable		 1zq9A-3h1lC:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdu PUTATIVE
THIOESTERASE

(Syntrophus
aciditrophicus) 		PF03061
(4HBT) 		3 GLY A  30
GLU A  46
ASN A  26
 None
 0.67A 1zq9A-3hduA:
undetectable		 1zq9A-3hduA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjn THYMIDYLATE KINASE

(Thermotoga
maritima) 		PF02223
(Thymidylate_kin) 		3 GLY A 105
GLU A 107
ASN A 103
 None
 0.66A 1zq9A-3hjnA:
undetectable		 1zq9A-3hjnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		3 GLY C 166
GLU C 168
ASN C 164
 None
 0.63A 1zq9A-3j7aC:
undetectable		 1zq9A-3j7aC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		3 GLY A  86
GLU A  89
ASN A 196
 None
 0.68A 1zq9A-3kzxA:
undetectable		 1zq9A-3kzxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		3 GLY B 507
GLU B 509
ASN B 503
 None
 0.73A 1zq9A-3l4gB:
undetectable		 1zq9A-3l4gB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lri PROTEIN
(INSULIN-LIKE GROWTH
FACTOR I)

(Homo sapiens) 		PF00049
(Insulin) 		3 GLY A  55
GLU A  59
ASN A  39
 None
 0.67A 1zq9A-3lriA:
undetectable		 1zq9A-3lriA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Aquifex
aeolicus) 		PF04551
(GcpE) 		3 GLY A 105
GLU A 137
ASN A 103
 None
 0.57A 1zq9A-3noyA:
undetectable		 1zq9A-3noyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		3 GLY A 111
GLU A 115
ASN A 132
 None
None
PLP  A 701 (-3.9A)
 0.66A 1zq9A-3nzpA:
undetectable		 1zq9A-3nzpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 GLY A 768
GLU A 827
ASN A 726
 FDP  A   1 (-3.7A)
FDP  A   1 (-2.8A)
FDP  A   1 (-3.7A)
 0.61A 1zq9A-3o8oA:
undetectable		 1zq9A-3o8oA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		3 GLY A  27
GLU A 224
ASN A  52
 None
 0.73A 1zq9A-3rrlA:
undetectable		 1zq9A-3rrlA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 GLY A 433
GLU A 468
ASN A 432
 None
 0.67A 1zq9A-3s9vA:
undetectable		 1zq9A-3s9vA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		3 GLY A  40
GLU A  61
ASN A 106
 None
 0.25A 1zq9A-3tqsA:
27.4		 1zq9A-3tqsA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLY A 655
GLU A 678
ASN A 654
 None
 0.73A 1zq9A-3u9sA:
undetectable		 1zq9A-3u9sA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 GLY A 162
GLU A  65
ASN A  31
 None
 0.53A 1zq9A-3ujgA:
undetectable		 1zq9A-3ujgA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		3 GLY A  46
GLU A  71
ASN A 117
 None
 0.16A 1zq9A-3uzuA:
25.7		 1zq9A-3uzuA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		3 GLY A  47
GLU A 114
ASN A 292
 None
 0.71A 1zq9A-4ccdA:
undetectable		 1zq9A-4ccdA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli) 		PF00285
(Citrate_synt) 		3 GLY A 195
GLU A 216
ASN A 199
 None
 0.73A 1zq9A-4g6bA:
undetectable		 1zq9A-4g6bA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Vibrio cholerae) 		PF00117
(GATase) 		3 GLY A 133
GLU A 132
ASN A 138
 None
 0.69A 1zq9A-4gudA:
undetectable		 1zq9A-4gudA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdo KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M) 		3 GLY A 439
GLU A 420
ASN A 441
 None
 0.62A 1zq9A-4hdoA:
undetectable		 1zq9A-4hdoA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		3 GLY A  50
GLU A  72
ASN A 116
 None
 0.57A 1zq9A-4jxjA:
26.0		 1zq9A-4jxjA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE

(Streptococcus
pyogenes) 		PF07461
(NADase_NGA) 		3 GLY A 382
GLU A 219
ASN A 387
 None
 0.70A 1zq9A-4kt6A:
undetectable		 1zq9A-4kt6A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lws UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata) 		PF06013
(WXG100) 		3 GLY B  10
GLU B  14
ASN B   8
 None
 0.64A 1zq9A-4lwsB:
undetectable		 1zq9A-4lwsB:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET) 		3 GLY A 709
GLU A 549
ASN A 708
 None
 0.66A 1zq9A-4mi5A:
undetectable		 1zq9A-4mi5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 3 GLY B  38
GLU B  31
ASN B  39
 FDA  B 402 (-3.2A)
FDA  B 402 (-2.7A)
FDA  B 402 (-4.2A)
 0.65A 1zq9A-4mo2B:
undetectable		 1zq9A-4mo2B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		3 GLY A 354
GLU A 173
ASN A 356
 None
 0.71A 1zq9A-4nwzA:
undetectable		 1zq9A-4nwzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orl UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF16022
(DUF4783) 		3 GLY A 103
GLU A 130
ASN A 102
 None
 0.72A 1zq9A-4orlA:
undetectable		 1zq9A-4orlA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 GLY A 531
GLU A 532
ASN A 297
 None
 0.70A 1zq9A-4ox2A:
undetectable		 1zq9A-4ox2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		3 GLY A 189
GLU A 210
ASN A 164
 None
 0.48A 1zq9A-4pufA:
undetectable		 1zq9A-4pufA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1t GLUTAMATE 5-KINASE

(Burkholderia
thailandensis) 		PF00696
(AA_kinase)
PF01472
(PUA) 		3 GLY A  26
GLU A  59
ASN A  22
 None
 0.56A 1zq9A-4q1tA:
4.2		 1zq9A-4q1tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 GLY A 734
GLU A 738
ASN A 732
 None
 0.69A 1zq9A-4qiwA:
undetectable		 1zq9A-4qiwA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		3 GLY A 300
GLU A 246
ASN A 298
 ANP  A 401 (-3.2A)
ANP  A 401 ( 4.9A)
ANP  A 401 (-3.7A)
 0.68A 1zq9A-4r3aA:
undetectable		 1zq9A-4r3aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 GLY A 326
GLU A 328
ASN A 353
 None
 0.64A 1zq9A-4r5dA:
undetectable		 1zq9A-4r5dA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 3 GLY B  45
GLU B  38
ASN B  46
 FAD  B 401 (-3.0A)
FAD  B 401 (-2.6A)
FAD  B 401 ( 4.0A)
 0.61A 1zq9A-4rphB:
undetectable		 1zq9A-4rphB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 GLY A 358
GLU A 324
ASN A 411
 None
 0.71A 1zq9A-4wkyA:
undetectable		 1zq9A-4wkyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0n HELIANTHAMIDE

(Stichodactyla
helianthus) 		no annotation 3 GLY B1003
GLU B1001
ASN B1004
 None
 0.61A 1zq9A-4x0nB:
undetectable		 1zq9A-4x0nB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		3 GLY A  41
GLU A  34
ASN A  42
 FDA  A 403 (-3.2A)
FDA  A 403 (-2.7A)
FDA  A 403 (-4.0A)
 0.66A 1zq9A-4xgkA:
undetectable		 1zq9A-4xgkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		3 GLY A 101
GLU A 100
ASN A 103
 VTB  A1339 ( 4.3A)
VTB  A1339 (-2.9A)
None
 0.68A 1zq9A-5a5lA:
undetectable		 1zq9A-5a5lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 GLY D 341
GLU D 379
ASN D 439
 None
 0.63A 1zq9A-5a6bD:
undetectable		 1zq9A-5a6bD:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		3 GLY A 398
GLU A 507
ASN A 369
 None
 0.64A 1zq9A-5by3A:
undetectable		 1zq9A-5by3A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 GLY A 336
GLU A 302
ASN A 389
 None
 0.71A 1zq9A-5e6kA:
undetectable		 1zq9A-5e6kA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 3 GLY A  86
GLU A  91
ASN A  85
 None
 0.54A 1zq9A-5efvA:
undetectable		 1zq9A-5efvA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elz TYPE II PANTOTHENATE
KINASE

(Staphylococcus
aureus) 		PF03630
(Fumble) 		3 GLY A  51
GLU A  70
ASN A  53
 None
3V9  A 303 (-3.2A)
None
 0.49A 1zq9A-5elzA:
undetectable		 1zq9A-5elzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 GLY A 336
GLU A 302
ASN A 389
 None
 0.67A 1zq9A-5enyA:
undetectable		 1zq9A-5enyA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epz ANGIOGENIN

(Homo sapiens) 		PF00074
(RnaseA) 		3 GLY A 110
GLU A  58
ASN A 109
 None
 0.66A 1zq9A-5epzA:
undetectable		 1zq9A-5epzA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		3 GLY A  54
GLU A  47
ASN A  55
 FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
FAD  A 501 (-3.8A)
 0.70A 1zq9A-5eqdA:
undetectable		 1zq9A-5eqdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7r LMO0178 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 GLY E 159
GLU E 175
ASN E 155
 None
 0.57A 1zq9A-5f7rE:
undetectable		 1zq9A-5f7rE:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy2 FLAGELLIN

(Bacillus
subtilis) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		3 GLY C 207
GLU C  77
ASN C 211
 None
 0.63A 1zq9A-5gy2C:
undetectable		 1zq9A-5gy2C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9k LIPOCALIN AI-4

(Rhodnius
prolixus) 		PF03973
(Triabin) 		3 GLY A  60
GLU A  46
ASN A  62
 None
 0.50A 1zq9A-5h9kA:
undetectable		 1zq9A-5h9kA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5j DESMOCOLLIN-2,DESMOG
LEIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		3 GLY A 193
GLU A 196
ASN A 142
 None
 0.73A 1zq9A-5j5jA:
undetectable		 1zq9A-5j5jA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		3 GLY N 723
GLU N 718
ASN N 231
 None
 0.63A 1zq9A-5mpdN:
undetectable		 1zq9A-5mpdN:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 3 GLY A 196
GLU A 144
ASN A 198
 None
 0.73A 1zq9A-5oj3A:
undetectable		 1zq9A-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oms CYTOCHROME P450

(Amycolatopsis
sp. ATCC 39116) 		no annotation 3 GLY A 185
GLU A 188
ASN A 182
 None
 0.68A 1zq9A-5omsA:
undetectable		 1zq9A-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 3 GLY A 140
GLU A 141
ASN A 326
 GLY  A 140 ( 0.0A)
GLU  A 141 ( 0.6A)
ASN  A 326 ( 0.6A)
 0.72A 1zq9A-5w0aA:
undetectable		 1zq9A-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 3 GLY A 471
GLU A 473
ASN A 589
 None
 0.58A 1zq9A-5w1aA:
undetectable		 1zq9A-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 GLY A 205
GLU A  42
ASN A 203
 None
 0.62A 1zq9A-5xa1A:
undetectable		 1zq9A-5xa1A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC

(Sulfolobus
islandicus) 		no annotation 3 GLY A 151
GLU A 134
ASN A 155
 None
 0.54A 1zq9A-5ywwA:
3.2		 1zq9A-5ywwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 3 GLY A 609
GLU A 607
ASN A 610
 None
 0.71A 1zq9A-6fn1A:
undetectable		 1zq9A-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 3 GLY A 336
GLU A 323
ASN A 418
 None
 0.69A 1zq9A-6fosA:
undetectable		 1zq9A-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 3 GLY A 729
GLU A 786
ASN A 733
 None
 0.69A 1zq9A-6gh2A:
undetectable		 1zq9A-6gh2A:
undetectable