SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZP4_C_C2FC997

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		6 ASP A 120
GLN A 183
SER A 215
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.9A)
FAD  A 395 ( 4.4A)
None
None
None
None
 0.32A 1zp4C-1b5tA:
43.8		 1zp4C-1b5tA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		5 ASP A 120
THR A 227
TYR A 275
LEU A 277
ARG A 279
 FAD  A 395 (-3.9A)
None
None
None
None
 1.15A 1zp4C-1b5tA:
43.8		 1zp4C-1b5tA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus) 		PF00503
(G-alpha) 		5 ASP A 318
GLN A 331
PHE A 315
TYR A 255
LEU A 329
 None
 1.28A 1zp4C-1zcaA:
3.2		 1zp4C-1zcaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 GLN A 856
GLN A 863
GLN A 836
PHE A 831
LEU A 854
 None
 1.50A 1zp4C-2po4A:
0.0		 1zp4C-2po4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 ASP A 271
GLN A 242
SER A 251
TYR A 246
LEU A 295
 None
None
MFK  A 401 (-2.6A)
None
MFK  A 401 (-3.8A)
 1.40A 1zp4C-4mfzA:
0.0		 1zp4C-4mfzA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 ASP A 275
GLN A 242
SER A 251
TYR A 246
LEU A 299
 None
None
COA  A 403 (-2.5A)
None
COA  A 403 (-3.9A)
 1.43A 1zp4C-4q38A:
0.0		 1zp4C-4q38A:
21.14