SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZP4_A_C2FA995

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		5 ASP A 120
GLN A 183
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.9A)
FAD  A 395 ( 4.4A)
None
None
None
 0.29A 1zp4A-1b5tA:
42.7		 1zp4A-1b5tA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3o YYCI PROTEIN

(Bacillus
subtilis) 		PF09648
(YycI) 		5 GLN A  85
GLN A 186
GLN A 121
TYR A 184
LEU A 123
 None
 1.34A 1zp4A-2o3oA:
0.0		 1zp4A-2o3oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x56 COAGULASE/FIBRINOLYS
IN

(Yersinia pestis) 		PF01278
(Omptin) 		5 GLN A 182
ASP A  60
GLN A 289
THR A  15
LEU A 193
 None
 1.31A 1zp4A-2x56A:
0.0		 1zp4A-2x56A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE

(Plasmodium
falciparum) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ASP A 134
GLN A 349
PHE A 353
THR A 345
LEU A 310
 None
 1.31A 1zp4A-5jldA:
0.8		 1zp4A-5jldA:
18.77