SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZLQ_B_EDTB1511

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 TYR A  74
ARG A  71
TYR A 236
THR A 188
 GLU  A 701 (-4.6A)
None
GLU  A 701 (-3.4A)
GLU  A 701 (-3.1A)
 1.45A 1zlqB-1ewkA:
0.8		 1zlqB-1ewkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 TYR A 263
ARG A 243
ARG A 299
THR A  77
 DHE  A 602 (-4.4A)
DHE  A 602 (-3.9A)
None
None
 1.44A 1zlqB-1gq1A:
undetectable		 1zlqB-1gq1A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iub FUCOSE-SPECIFIC
LECTIN

(Aleuria
aurantia) 		PF07938
(Fungal_lectin) 		4 TYR A 241
TRP A 245
TYR A 181
THR A 171
 None
 1.47A 1zlqB-1iubA:
undetectable		 1zlqB-1iubA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 TYR A 250
TRP A 259
TYR A 286
THR A 288
 None
 1.24A 1zlqB-1j0hA:
0.3		 1zlqB-1j0hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A 292
ARG A 569
TYR A 606
THR A 237
 None
 1.49A 1zlqB-1ji6A:
0.0		 1zlqB-1ji6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xq1 PEROXISOMAL CATALASE

(Ogataea angusta) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 TYR A 213
TRP A 219
TYR A 221
THR A 209
 None
 1.33A 1zlqB-2xq1A:
undetectable		 1zlqB-2xq1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 ARG A 386
ARG A 394
TYR A  38
THR A  40
 None
None
None
PO4  A1569 (-4.7A)
 1.49A 1zlqB-2xymA:
0.0		 1zlqB-2xymA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 TYR A 651
TRP A 550
TRP A 647
TYR A 230
 None
 1.48A 1zlqB-3d3lA:
0.0		 1zlqB-3d3lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 TYR A  64
ARG A  61
TYR A 223
THR A 175
 GLU  A 506 (-4.6A)
None
GLU  A 506 (-3.4A)
GLU  A 506 (-3.0A)
 1.46A 1zlqB-3lmkA:
1.3		 1zlqB-3lmkA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		8 TYR A  22
MET A  27
ARG A  97
TRP A 100
ARG A 137
TRP A 398
TYR A 402
THR A 490
 BHR  A 520 (-4.2A)
BHR  A 520 (-3.7A)
BHR  A 520 ( 2.9A)
BHR  A 520 (-3.5A)
BHR  A 520 (-3.8A)
BHR  A 520 (-3.8A)
BHR  A 520 ( 4.6A)
BHR  A 520 (-4.4A)
 0.30A 1zlqB-3mzbA:
59.7		 1zlqB-3mzbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 4 TYR A 299
TRP A 364
ARG A 361
TYR A 292
 None
 1.35A 1zlqB-3pf7A:
undetectable		 1zlqB-3pf7A:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 TYR A  20
MET A  25
TRP A  98
ARG A 135
 GOL  A 608 ( 4.5A)
GOL  A 601 (-3.5A)
GOL  A 608 (-3.8A)
None
 0.58A 1zlqB-4oerA:
48.6		 1zlqB-4oerA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 TYR A  20
TRP A  98
ARG A 135
TYR A 400
 GOL  A 608 ( 4.5A)
GOL  A 608 (-3.8A)
None
None
 0.78A 1zlqB-4oerA:
48.6		 1zlqB-4oerA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		4 MET A 136
ARG A 202
TYR A 110
THR A 128
 None
 1.28A 1zlqB-4qn9A:
undetectable		 1zlqB-4qn9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kta FDHC

(Acinetobacter
nosocomialis) 		PF13302
(Acetyltransf_3) 		4 TRP A  50
ARG A  28
TYR A  65
THR A  79
 DMS  A 204 (-3.4A)
SO4  A 202 (-3.1A)
DMS  A 204 (-4.5A)
None
 1.19A 1zlqB-5ktaA:
undetectable		 1zlqB-5ktaA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ARG A 918
ARG A 896
TYR A1168
THR A1100
 None
 1.41A 1zlqB-5ngyA:
undetectable		 1zlqB-5ngyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 4 MET A  88
ARG A  83
TRP A 100
THR A 186
 None
 1.43A 1zlqB-5v8cA:
undetectable		 1zlqB-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US3
RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
US14

(Toxoplasma
gondii;
Toxoplasma
gondii;
Toxoplasma
gondii) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2)
PF03501
(S10_plectin)
PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 MET d  36
ARG D  78
TRP K  69
ARG d  20
 None
 1.44A 1zlqB-5xxud:
undetectable		 1zlqB-5xxud:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 TYR A  27
MET A  31
TRP A 103
ARG A 140
TYR A 410
 PEG  A 604 ( 4.7A)
PEG  A 604 ( 3.7A)
None
PEG  A 604 (-3.8A)
None
 0.69A 1zlqB-5yh5A:
30.4		 1zlqB-5yh5A:
undetectable