SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZLQ_A_EDTA1513

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		9 TYR A  22
MET A  27
ARG A  97
TRP A 100
ARG A 137
TRP A 398
TYR A 402
HIS A 416
THR A 490
 BHR  A 520 (-4.2A)
BHR  A 520 (-3.7A)
BHR  A 520 ( 2.9A)
BHR  A 520 (-3.5A)
BHR  A 520 (-3.8A)
BHR  A 520 (-3.8A)
BHR  A 520 ( 4.6A)
None
BHR  A 520 (-4.4A)
 0.40A 1zlqA-3mzbA:
61.6		 1zlqA-3mzbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 TYR A  27
MET A  31
TRP A 103
ARG A 140
TYR A 410
 PEG  A 604 ( 4.7A)
PEG  A 604 ( 3.7A)
None
PEG  A 604 (-3.8A)
None
 0.69A 1zlqA-5yh5A:
43.3		 1zlqA-5yh5A:
undetectable