SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZLQ_A_ACTA1507

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		3 GLN A 321
HIS A 317
ARG A 410
 None
 0.95A 1zlqA-1c7gA:
0.0		 1zlqA-1c7gA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci3 PROTEIN (CYTOCHROME
F)

(Phormidium
laminosum) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLN M 159
HIS M  25
ARG M 155
 None
HEM  M 254 (-3.3A)
None
 0.96A 1zlqA-1ci3M:
undetectable		 1zlqA-1ci3M:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		3 GLN A 208
HIS A 175
ARG A 176
 None
 0.75A 1zlqA-1crzA:
0.0		 1zlqA-1crzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctm CYTOCHROME F

(Brassica rapa) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLN A 158
HIS A  25
ARG A 154
 None
HEM  A 253 (-3.1A)
None
 0.77A 1zlqA-1ctmA:
0.0		 1zlqA-1ctmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		3 GLN A 107
HIS A  78
ARG A  79
 None
 0.94A 1zlqA-1e0cA:
0.0		 1zlqA-1e0cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 GLN A 131
HIS A 176
ARG A 180
 None
 0.98A 1zlqA-1e5wA:
0.0		 1zlqA-1e5wA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2
FIBROBLAST GROWTH
FACTOR RECEPTOR 1

(Homo sapiens;
Homo sapiens) 		PF00167
(FGF)
PF07679
(I-set) 		3 GLN C 288
HIS C 286
ARG A  60
 None
 1.01A 1zlqA-1fq9C:
0.0		 1zlqA-1fq9C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 GLN A  16
HIS A  49
ARG A  52
 None
 0.69A 1zlqA-1hbzA:
undetectable		 1zlqA-1hbzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 GLN A  20
HIS A 377
ARG A 378
 None
 0.81A 1zlqA-1js4A:
undetectable		 1zlqA-1js4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 GLN A  20
HIS A 374
ARG A 375
 None
None
CBI  A 777 (-2.5A)
 0.83A 1zlqA-1k72A:
undetectable		 1zlqA-1k72A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 GLN A 493
HIS A 475
ARG A 458
 None
GOL  A1820 (-3.8A)
None
 1.09A 1zlqA-1kb0A:
undetectable		 1zlqA-1kb0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		3 GLN A  19
HIS A 360
ARG A 361
 None
None
SO4  A 450 (-2.9A)
 0.77A 1zlqA-1ks8A:
undetectable		 1zlqA-1ks8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		3 GLN B 344
HIS B  78
ARG B  75
 None
 1.03A 1zlqA-1n94B:
undetectable		 1zlqA-1n94B:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh3 DNA TOPOISOMERASE I

(Homo sapiens) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc) 		3 GLN A 421
HIS A 367
ARG A 364
 None
 0.99A 1zlqA-1nh3A:
undetectable		 1zlqA-1nh3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfy TRANSCRIPTIONAL
REPRESSOR TRAM

(Agrobacterium
tumefaciens) 		PF09228
(Prok-TraM) 		3 GLN A  82
HIS A  40
ARG A  41
 None
 1.02A 1zlqA-1rfyA:
undetectable		 1zlqA-1rfyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		3 GLN A 112
HIS A  71
ARG A  72
 None
 0.98A 1zlqA-1sqhA:
undetectable		 1zlqA-1sqhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLN A 323
HIS A 364
ARG A 586
 None
 1.01A 1zlqA-1tmoA:
undetectable		 1zlqA-1tmoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu2 APOCYTOCHROME F

(Nostoc sp. PCC
7119) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLN B 159
HIS B  26
ARG B 155
 None
HEC  B 255 (-3.3A)
None
 0.72A 1zlqA-1tu2B:
undetectable		 1zlqA-1tu2B:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 GLN A 395
HIS A 471
ARG A 472
 None
 1.04A 1zlqA-1vcnA:
undetectable		 1zlqA-1vcnA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		3 GLN A 446
HIS A  73
ARG A 347
 None
 0.97A 1zlqA-1w18A:
undetectable		 1zlqA-1w18A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1waq GROWTH/DIFFERENTIATI
ON FACTOR 5

(Homo sapiens) 		PF00019
(TGF_beta) 		3 GLN A  69
HIS A  65
ARG A 120
 None
 0.91A 1zlqA-1waqA:
undetectable		 1zlqA-1waqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		3 GLN A 117
HIS A 119
ARG A 196
 None
 1.10A 1zlqA-1ynqA:
undetectable		 1zlqA-1ynqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjd QUORUM-SENSING
ANTIACTIVATOR

(Agrobacterium
tumefaciens) 		PF09228
(Prok-TraM) 		3 GLN A  82
HIS A  40
ARG A  41
 None
 1.06A 1zlqA-2hjdA:
undetectable		 1zlqA-2hjdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLN B 160
HIS B  25
ARG B 156
 None
HEC  B 250 (-3.7A)
None
 0.61A 1zlqA-2jxmB:
undetectable		 1zlqA-2jxmB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lav VACCINIA-RELATED
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLN A  95
HIS A 171
ARG A 203
 None
 1.04A 1zlqA-2lavA:
undetectable		 1zlqA-2lavA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 GLN A  37
HIS A  22
ARG A  19
 None
 1.07A 1zlqA-2q3zA:
0.8		 1zlqA-2q3zA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLN X 175
HIS X  75
ARG X  76
 None
 0.96A 1zlqA-2qvxX:
undetectable		 1zlqA-2qvxX:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzb UNCHARACTERIZED
PROTEIN YFEY

(Escherichia
coli) 		PF06572
(DUF1131) 		3 GLN A 156
HIS A 157
ARG A 190
 None
 0.92A 1zlqA-2qzbA:
undetectable		 1zlqA-2qzbA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbd BH2358 PROTEIN

(Bacillus
halodurans) 		PF11553
(DUF3231) 		3 GLN A 123
HIS A  14
ARG A 126
 None
 0.95A 1zlqA-2rbdA:
undetectable		 1zlqA-2rbdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		3 GLN A 316
HIS A 210
ARG A 290
 None
 1.03A 1zlqA-2wk8A:
undetectable		 1zlqA-2wk8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		3 GLN A 504
HIS A 467
ARG A 468
 None
 0.53A 1zlqA-2wzfA:
undetectable		 1zlqA-2wzfA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		3 GLN A  20
HIS A 377
ARG A 378
 None
 0.80A 1zlqA-2xfgA:
undetectable		 1zlqA-2xfgA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		3 GLN A 347
HIS A  48
ARG A  49
 None
None
NGA  A   2 (-3.0A)
 1.08A 1zlqA-2z8eA:
1.0		 1zlqA-2z8eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 3 GLN C 251
HIS C 182
ARG C 185
 None
 1.07A 1zlqA-3amjC:
undetectable		 1zlqA-3amjC:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		3 GLN A  46
HIS A 134
ARG A 133
 None
 1.04A 1zlqA-3bt5A:
undetectable		 1zlqA-3bt5A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM
PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus;
Mus musculus) 		PF04916
(Phospholip_B)
PF04916
(Phospholip_B) 		3 GLN A 186
HIS A 185
ARG B 287
 None
 0.99A 1zlqA-3fgtA:
undetectable		 1zlqA-3fgtA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		3 GLN A 186
HIS A 185
ARG A 287
 None
 1.08A 1zlqA-3fgwA:
undetectable		 1zlqA-3fgwA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLN A 538
HIS A 534
ARG A 391
 None
 0.74A 1zlqA-3gg4A:
undetectable		 1zlqA-3gg4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjn THYMIDYLATE KINASE

(Thermotoga
maritima) 		PF02223
(Thymidylate_kin) 		3 GLN A  16
HIS A 182
ARG A 183
 None
 1.08A 1zlqA-3hjnA:
undetectable		 1zlqA-3hjnA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		3 GLN A 184
HIS A 107
ARG A  62
 None
 0.86A 1zlqA-3isaA:
0.0		 1zlqA-3isaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy0 FAB 14, HEAVY DOMAIN
FAB 14, LIGHT DOMAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 GLN L  89
HIS L  91
ARG H  99
 None
 0.74A 1zlqA-3iy0L:
undetectable		 1zlqA-3iy0L:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		3 GLN D 363
HIS D 365
ARG D 358
 None
 1.08A 1zlqA-3j9eD:
undetectable		 1zlqA-3j9eD:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 GLN A 344
HIS A 370
ARG A 367
 None
 0.96A 1zlqA-3k0sA:
undetectable		 1zlqA-3k0sA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 GLN A 385
HIS A 395
ARG A 396
 ACT  A 508 (-2.9A)
ACT  A 508 (-3.9A)
None
 0.53A 1zlqA-3mzbA:
61.6		 1zlqA-3mzbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 GLN A 245
HIS A 246
ARG A 158
 None
 1.09A 1zlqA-3n7zA:
undetectable		 1zlqA-3n7zA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		3 GLN A 270
HIS A 266
ARG A 145
 None
 0.93A 1zlqA-3nibA:
undetectable		 1zlqA-3nibA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 GLN A 390
HIS A 466
ARG A 465
 None
 1.03A 1zlqA-3nvaA:
undetectable		 1zlqA-3nvaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		3 GLN A 169
HIS A 155
ARG A 152
 PHE  A 980 (-3.5A)
None
None
 0.99A 1zlqA-3pcoA:
undetectable		 1zlqA-3pcoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN

(Escherichia
virus P1) 		PF16786
(RecA_dep_nuc) 		3 GLN A 126
HIS A 123
ARG A  85
 None
 0.81A 1zlqA-3plwA:
undetectable		 1zlqA-3plwA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzd MYOSIN-X

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF00788
(RA) 		3 GLN A1594
HIS A1597
ARG A1682
 None
 0.90A 1zlqA-3pzdA:
undetectable		 1zlqA-3pzdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		3 GLN A  82
HIS A  84
ARG A 101
 None
 0.91A 1zlqA-3q3qA:
undetectable		 1zlqA-3q3qA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		3 GLN A 122
HIS A 117
ARG A  87
 None
None
SO4  A 453 (-4.1A)
 1.09A 1zlqA-3rv6A:
undetectable		 1zlqA-3rv6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 GLN A 102
HIS A 462
ARG A 463
 None
None
9MR  A 603 (-2.7A)
 0.75A 1zlqA-3rx8A:
undetectable		 1zlqA-3rx8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 GLN A   8
HIS A 157
ARG A 181
 None
 1.01A 1zlqA-3tr7A:
undetectable		 1zlqA-3tr7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		3 GLN A 248
HIS A 252
ARG A 253
 None
 0.99A 1zlqA-3zbyA:
undetectable		 1zlqA-3zbyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLN A 142
HIS A 146
ARG A 186
 None
 0.89A 1zlqA-3zo9A:
undetectable		 1zlqA-3zo9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		3 GLN A 342
HIS A 354
ARG A 273
 None
 0.92A 1zlqA-4b67A:
undetectable		 1zlqA-4b67A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		3 GLN A  42
HIS A 397
ARG A 398
 None
None
CBK  A 503 (-2.5A)
 0.85A 1zlqA-4doeA:
undetectable		 1zlqA-4doeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en2 PROTEIN NEF

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		3 GLN B 125
HIS B 102
ARG B 106
 None
 0.99A 1zlqA-4en2B:
undetectable		 1zlqA-4en2B:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		3 GLN A 324
HIS A 323
ARG A 335
 None
 0.97A 1zlqA-4eswA:
0.0		 1zlqA-4eswA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		3 GLN A 531
HIS A 183
ARG A 182
 None
 0.96A 1zlqA-4fj6A:
undetectable		 1zlqA-4fj6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 GLN A 247
HIS A 629
ARG A 628
 None
 0.88A 1zlqA-4g9iA:
undetectable		 1zlqA-4g9iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Acidimicrobium
ferrooxidans) 		PF09481
(CRISPR_Cse1) 		3 GLN A 411
HIS A 408
ARG A 524
 None
 1.00A 1zlqA-4h3tA:
undetectable		 1zlqA-4h3tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h44 APOCYTOCHROME F

(Nostoc sp. PCC
7120) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLN C 159
HIS C  26
ARG C 155
 None
HEM  C 301 (-3.5A)
None
 0.79A 1zlqA-4h44C:
undetectable		 1zlqA-4h44C:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5

(Saccharomyces
cerevisiae) 		PF09084
(NMT1) 		3 GLN A 324
HIS A 323
ARG A 335
 None
 1.03A 1zlqA-4h65A:
0.6		 1zlqA-4h65A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0o PROTEIN ELYS

(Mus musculus) 		PF16687
(ELYS-bb) 		3 GLN A 179
HIS A 210
ARG A 209
 None
 1.01A 1zlqA-4i0oA:
0.5		 1zlqA-4i0oA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7z APOCYTOCHROME F

(Mastigocladus
laminosus) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLN C 159
HIS C  26
ARG C 155
 None
HEM  C 301 (-3.4A)
None
 0.78A 1zlqA-4i7zC:
undetectable		 1zlqA-4i7zC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		3 GLN A 153
HIS A 157
ARG A 259
 HEM  A 701 ( 3.1A)
IMD  A 705 (-3.8A)
None
 1.09A 1zlqA-4kvlA:
undetectable		 1zlqA-4kvlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		3 GLN B 415
HIS B 129
ARG B 126
 None
 1.05A 1zlqA-4mbgB:
undetectable		 1zlqA-4mbgB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1d NODAL/BMP2 CHIMERA
PROTEIN

(Homo sapiens) 		PF00019
(TGF_beta) 		3 GLN A  64
HIS A  60
ARG A 115
 None
 1.01A 1zlqA-4n1dA:
undetectable		 1zlqA-4n1dA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		3 GLN A 317
HIS A 314
ARG A 284
 None
 0.77A 1zlqA-4ofwA:
undetectable		 1zlqA-4ofwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogq APOCYTOCHROME F

(Nostoc sp. PCC
7120) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLN C 159
HIS C  26
ARG C 155
 None
HEM  C 301 (-3.7A)
None
 0.94A 1zlqA-4ogqC:
undetectable		 1zlqA-4ogqC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 GLN A 156
HIS A 152
ARG A 149
 None
 0.83A 1zlqA-4qvgA:
undetectable		 1zlqA-4qvgA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		3 GLN A 905
HIS A 823
ARG A 825
 None
 0.98A 1zlqA-4rgwA:
undetectable		 1zlqA-4rgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 GLN A 409
HIS A 319
ARG A 322
 None
 1.09A 1zlqA-4wlhA:
undetectable		 1zlqA-4wlhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycg BONE MORPHOGENETIC
PROTEIN 9 PRODOMAIN

(Homo sapiens) 		PF00019
(TGF_beta) 		3 GLN C 355
HIS C 351
ARG C 407
 None
 0.90A 1zlqA-4ycgC:
undetectable		 1zlqA-4ycgC:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 GLN A 397
HIS A 476
ARG A 477
 ONL  A 601 (-3.0A)
ONL  A 601 (-4.9A)
None
 0.70A 1zlqA-4zdkA:
undetectable		 1zlqA-4zdkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		3 GLN A  26
HIS A 362
ARG A 363
 None
 0.79A 1zlqA-4zg8A:
undetectable		 1zlqA-4zg8A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		3 GLN K 797
HIS K 793
ARG K 817
 None
 1.07A 1zlqA-5anbK:
undetectable		 1zlqA-5anbK:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b82 TLL0287 PROTEIN

(Thermosynechococcus
elongatus) 		PF11845
(DUF3365) 		3 GLN A  88
HIS A  98
ARG A  94
 HEC  A 501 (-3.5A)
HEC  A 501 (-3.7A)
HEC  A 501 (-4.6A)
 0.90A 1zlqA-5b82A:
undetectable		 1zlqA-5b82A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 GLN A 332
HIS A 319
ARG A 314
 None
 0.85A 1zlqA-5cweA:
undetectable		 1zlqA-5cweA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		3 GLN A 107
HIS A 142
ARG A 103
 None
 0.77A 1zlqA-5d8gA:
undetectable		 1zlqA-5d8gA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 GLN A 573
HIS A 296
ARG A 299
 None
 1.03A 1zlqA-5e02A:
0.0		 1zlqA-5e02A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 GLN A 643
HIS A 344
ARG A 632
 None
 1.03A 1zlqA-5e9aA:
undetectable		 1zlqA-5e9aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 3 GLN C 435
HIS C 415
ARG C 413
 None
 0.92A 1zlqA-5elpC:
undetectable		 1zlqA-5elpC:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd5 FERRIC UPTAKE
REGULATION PROTEIN

(Rhizobium
leguminosarum) 		PF01475
(FUR) 		3 GLN A 114
HIS A 128
ARG A 129
 None
 1.04A 1zlqA-5fd5A:
undetectable		 1zlqA-5fd5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		3 GLN G 905
HIS G 823
ARG G 825
 None
 0.98A 1zlqA-5furG:
undetectable		 1zlqA-5furG:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 GLN A  47
HIS A 389
ARG A 390
 None
 0.82A 1zlqA-5gy0A:
undetectable		 1zlqA-5gy0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		3 GLN A 619
HIS A 615
ARG A 612
 None
 1.07A 1zlqA-5h11A:
undetectable		 1zlqA-5h11A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		3 GLN A 238
HIS A 203
ARG A 162
 None
 0.93A 1zlqA-5hvmA:
0.0		 1zlqA-5hvmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 GLN A 209
HIS A 132
ARG A 131
 None
 1.03A 1zlqA-5jmdA:
undetectable		 1zlqA-5jmdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		3 GLN A 318
HIS A  76
ARG A  81
 None
 1.01A 1zlqA-5ny5A:
undetectable		 1zlqA-5ny5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 3 GLN A  74
HIS A 124
ARG A 118
 None
 1.06A 1zlqA-5nzgA:
undetectable		 1zlqA-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		3 GLN A 318
HIS A  76
ARG A  81
 None
 1.01A 1zlqA-5o3mA:
undetectable		 1zlqA-5o3mA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oms CYTOCHROME P450

(Amycolatopsis
sp. ATCC 39116) 		no annotation 3 GLN A 267
HIS A 340
ARG A 280
 None
 1.09A 1zlqA-5omsA:
undetectable		 1zlqA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 3 GLN A 213
HIS A  96
ARG A  89
 None
 1.06A 1zlqA-5opfA:
undetectable		 1zlqA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0F02343P
KLLA0C15939P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF05859
(Mis12)
PF08641
(Mis14) 		3 GLN N 123
HIS A 108
ARG N 118
 None
 0.88A 1zlqA-5t58N:
undetectable		 1zlqA-5t58N:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		3 GLN A 190
HIS A 193
ARG A 194
 None
 1.10A 1zlqA-5vlhA:
0.1		 1zlqA-5vlhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 3 GLN A 310
HIS A 309
ARG A 346
 CU4  A 601 (-3.6A)
None
None
 1.09A 1zlqA-6b5iA:
undetectable		 1zlqA-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 GLN A 668
HIS A 679
ARG A 682
 None
 1.09A 1zlqA-6ez8A:
undetectable		 1zlqA-6ez8A:
undetectable