SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZLQ_A_ACTA1502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1acx ACTINOXANTHIN

(Streptomyces
globisporus) 		PF00960
(Neocarzinostat) 		4 PRO A   2
GLY A  93
ASN A  98
GLY A 100
 None
 1.17A 1zlqA-1acxA:
0.0		 1zlqA-1acxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 PRO A 121
GLY A 198
ASN A 199
GLY A 202
 None
 0.82A 1zlqA-1bwdA:
0.0		 1zlqA-1bwdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjl PROCATHEPSIN L

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 PRO A  83
GLY A  68
ASN A  62
GLY A  61
 None
 1.08A 1zlqA-1cjlA:
undetectable		 1zlqA-1cjlA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 PRO A 376
GLY A 353
ASN A 352
GLY A 349
 None
 1.04A 1zlqA-1d9zA:
0.0		 1zlqA-1d9zA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A  90
GLY A 134
ASN A 135
GLY A 136
 None
 1.11A 1zlqA-1fepA:
0.0		 1zlqA-1fepA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TRP A 801
GLY A 304
ASN A 391
GLY A 682
 None
MGD  A5002 (-3.6A)
None
None
 1.11A 1zlqA-1g8kA:
0.0		 1zlqA-1g8kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ix5 FKBP

(Methanothermococcus
thermolithotrophicus) 		PF00254
(FKBP_C) 		4 PRO A  79
GLY A 140
ASN A  86
GLY A  85
 None
 0.99A 1zlqA-1ix5A:
undetectable		 1zlqA-1ix5A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		4 PRO X  93
GLY X  67
ASN X  77
GLY X  65
 None
 1.17A 1zlqA-1ogoX:
0.6		 1zlqA-1ogoX:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdb CYTOCHROME C NITRITE
REDUCTASE

(Sulfurospirillum
deleyianum) 		PF02335
(Cytochrom_C552) 		4 PRO A 240
GLY A 244
ASN A 243
GLY A 255
 None
 1.16A 1zlqA-1qdbA:
0.0		 1zlqA-1qdbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 PRO 2  71
GLY 2 193
ASN 2 190
GLY 2 118
 None
 1.11A 1zlqA-1qgc2:
undetectable		 1zlqA-1qgc2:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		4 PRO A 443
GLY A 411
ASN A 410
GLY A 451
 None
None
NAD  A1490 (-3.4A)
None
 0.67A 1zlqA-1t90A:
undetectable		 1zlqA-1t90A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		4 PRO A 125
GLY A 228
ASN A 229
GLY A 141
 None
 0.77A 1zlqA-1vi1A:
undetectable		 1zlqA-1vi1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		4 PRO A 340
GLY A 359
ASN A 358
GLY A 354
 None
 0.96A 1zlqA-1z2zA:
undetectable		 1zlqA-1z2zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		4 PRO A 329
GLY A 237
ASN A 281
GLY A 241
 None
 1.14A 1zlqA-2an2A:
undetectable		 1zlqA-2an2A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 PRO A 390
GLY A 239
ASN A 238
GLY A 236
 None
None
CSO  A 249 ( 3.9A)
None
 1.03A 1zlqA-2bwsA:
undetectable		 1zlqA-2bwsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		4 TRP A 303
PRO A 305
GLY A 253
GLY A 255
 None
 1.04A 1zlqA-2c20A:
0.0		 1zlqA-2c20A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 PRO A  64
GLY A   8
ASN A  30
GLY A  10
 NDP  A1302 (-4.0A)
NDP  A1302 (-3.4A)
NDP  A1302 (-3.1A)
NDP  A1302 (-3.3A)
 1.16A 1zlqA-2cvzA:
undetectable		 1zlqA-2cvzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 PRO A 376
GLY A 353
ASN A 352
GLY A 349
 None
 0.96A 1zlqA-2d7dA:
0.6		 1zlqA-2d7dA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 335
PRO A 337
GLY A 571
GLY A 567
 None
 1.00A 1zlqA-2ecfA:
undetectable		 1zlqA-2ecfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		4 PRO A 245
GLY A 263
ASN A  37
GLY A 261
 None
 1.09A 1zlqA-2gljA:
undetectable		 1zlqA-2gljA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 PRO A 358
GLY A 556
ASN A 521
GLY A 524
 None
None
PRX  A 998 ( 4.9A)
None
 1.10A 1zlqA-2p2mA:
undetectable		 1zlqA-2p2mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 PRO A 130
GLY A 282
ASN A 280
GLY A 179
 None
 1.07A 1zlqA-2pxjA:
undetectable		 1zlqA-2pxjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 PRO A 310
GLY A 347
ASN A 346
GLY A 109
 None
 1.02A 1zlqA-2pziA:
undetectable		 1zlqA-2pziA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 PRO A 131
GLY A 283
ASN A 281
GLY A 180
 None
 1.08A 1zlqA-2w2iA:
undetectable		 1zlqA-2w2iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		4 TRP A 331
PRO A 183
GLY A 368
GLY A 363
 None
 1.19A 1zlqA-2x5dA:
undetectable		 1zlqA-2x5dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		4 PRO A 227
GLY A 256
ASN A 255
GLY A 254
 None
 0.81A 1zlqA-2x7xA:
1.3		 1zlqA-2x7xA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x LECTIN-LIKE FOLD
PROTEIN

(Agaricus
bisporus) 		no annotation 4 TRP E 106
GLY E 100
ASN E 101
GLY E 102
 None
 0.94A 1zlqA-2y9xE:
undetectable		 1zlqA-2y9xE:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 TRP A  44
PRO A  42
GLY A  86
GLY A  89
 None
 0.97A 1zlqA-2z4gA:
undetectable		 1zlqA-2z4gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		4 PRO A  72
GLY A  10
ASN A  35
GLY A  12
 NAD  A1001 (-3.8A)
NAD  A1001 ( 3.8A)
NAD  A1001 (-3.1A)
NAD  A1001 (-3.4A)
 1.16A 1zlqA-3b1fA:
undetectable		 1zlqA-3b1fA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE

(Lactobacillus
delbrueckii) 		PF00155
(Aminotran_1_2) 		4 PRO A 171
GLY A 357
ASN A 358
GLY A 359
 None
 0.99A 1zlqA-3dzzA:
undetectable		 1zlqA-3dzzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 PRO A 221
GLY A 288
ASN A 290
GLY A 240
 None
 1.09A 1zlqA-3fedA:
undetectable		 1zlqA-3fedA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 PRO D  58
GLY D  48
ASN D 134
GLY D 133
 None
FES  D 908 (-3.8A)
None
None
 1.10A 1zlqA-3hrdD:
undetectable		 1zlqA-3hrdD:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 PRO D  58
GLY D 107
ASN D 134
GLY D  48
 None
None
None
FES  D 908 (-3.8A)
 1.17A 1zlqA-3hrdD:
undetectable		 1zlqA-3hrdD:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP3
PROTEIN VP2

(Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 PRO B  54
GLY C 171
ASN C 172
GLY C 169
 None
 1.19A 1zlqA-3j2jB:
undetectable		 1zlqA-3j2jB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris) 		PF00378
(ECH_1) 		4 PRO A  71
GLY A  60
ASN A  64
GLY A 122
 None
 1.05A 1zlqA-3m6mA:
undetectable		 1zlqA-3m6mA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 PRO A  11
GLY A 127
ASN A 129
GLY A 132
 None
 0.98A 1zlqA-3mgbA:
undetectable		 1zlqA-3mgbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 PRO A  11
GLY A 136
ASN A 129
GLY A 132
 None
 1.15A 1zlqA-3mgbA:
undetectable		 1zlqA-3mgbA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 TRP A  10
PRO A  11
GLY A 219
ASN A 220
GLY A 222
 DTD  A 522 (-4.0A)
DTD  A 522 (-4.2A)
DTD  A 522 (-3.4A)
DTD  A 522 (-3.0A)
DTD  A 522 (-3.7A)
 0.31A 1zlqA-3mzbA:
61.6		 1zlqA-3mzbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PRO A  15
GLY A 294
ASN A 295
GLY A 163
 FAD  A 501 (-4.0A)
FAD  A 501 (-3.5A)
FAD  A 501 (-3.3A)
FAD  A 501 (-3.0A)
 1.10A 1zlqA-3nixA:
undetectable		 1zlqA-3nixA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE

(Staphylococcus
aureus) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		4 PRO A  96
GLY A 199
ASN A 200
GLY A 297
 None
 0.75A 1zlqA-3orqA:
undetectable		 1zlqA-3orqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb5 TRANSLIN-ASSOCIATED
PROTEIN X

(Homo sapiens) 		PF01997
(Translin) 		4 PRO K 214
GLY K 207
ASN K 208
GLY K 209
 None
 0.94A 1zlqA-3qb5K:
undetectable		 1zlqA-3qb5K:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqm MLR3007 PROTEIN

(Mesorhizobium
loti) 		PF01063
(Aminotran_4) 		4 TRP A  98
GLY A 208
ASN A 209
GLY A 213
 None
None
IOD  A 234 (-4.1A)
IOD  A 225 ( 3.9A)
 1.17A 1zlqA-3qqmA:
undetectable		 1zlqA-3qqmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rez PLATELET
GLYCOPROTEIN IB BETA
CHAIN, PLATELET
GLYCOPROTEIN IX

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT) 		4 PRO A   4
GLY A  18
ASN A  37
GLY A  15
 None
NAG  A 127 ( 4.0A)
None
None
 0.98A 1zlqA-3rezA:
undetectable		 1zlqA-3rezA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN

(Homo sapiens) 		PF01463
(LRRCT) 		4 PRO A   4
GLY A  18
ASN A  40
GLY A  15
 None
NAG  A 130 (-4.0A)
None
None
 1.00A 1zlqA-3rfeA:
undetectable		 1zlqA-3rfeA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 PRO L 339
GLY L 524
ASN L  92
GLY L 522
 None
 1.17A 1zlqA-3rgwL:
undetectable		 1zlqA-3rgwL:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 PRO A 117
GLY A  44
ASN A  46
GLY A  48
 None
 0.82A 1zlqA-3sutA:
undetectable		 1zlqA-3sutA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 165
GLY A 279
ASN A 278
GLY A 259
 None
C8E  A 471 (-4.1A)
None
None
 1.00A 1zlqA-3sybA:
undetectable		 1zlqA-3sybA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		4 PRO A 377
GLY A 348
ASN A 346
GLY A 314
 None
 1.15A 1zlqA-3v7iA:
undetectable		 1zlqA-3v7iA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 PRO A 239
GLY A 183
ASN A 184
GLY A 231
 None
 1.15A 1zlqA-3vlyA:
undetectable		 1zlqA-3vlyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 PRO A 225
GLY A 230
ASN A 234
GLY A 236
 None
 1.08A 1zlqA-3vocA:
undetectable		 1zlqA-3vocA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 PRO A 198
GLY A  82
ASN A  81
GLY A  80
 None
 0.91A 1zlqA-3vomA:
undetectable		 1zlqA-3vomA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 PRO A 387
GLY A 150
ASN A 151
GLY A 147
 None
 1.07A 1zlqA-4autA:
undetectable		 1zlqA-4autA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 PRO B 329
GLY A 105
ASN B 335
GLY A 103
 None
 1.08A 1zlqA-4az3B:
undetectable		 1zlqA-4az3B:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PRO A 192
GLY A  33
ASN A  32
GLY A  28
 None
None
None
MG  A1304 ( 4.7A)
 0.89A 1zlqA-4bkmA:
undetectable		 1zlqA-4bkmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 PRO A  80
GLY A  60
ASN A  72
GLY A  71
 None
 1.02A 1zlqA-4cvcA:
undetectable		 1zlqA-4cvcA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 TRP A 440
PRO A 441
GLY A 557
GLY A 529
 PQQ  A1608 (-4.1A)
None
None
None
 1.04A 1zlqA-4cvcA:
undetectable		 1zlqA-4cvcA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 PRO A 442
GLY A 410
ASN A 409
GLY A 450
 None
 0.83A 1zlqA-4e4gA:
undetectable		 1zlqA-4e4gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PRO A  91
GLY A 115
ASN A 347
GLY A 388
 None
None
None
COA  A2598 ( 4.4A)
 0.99A 1zlqA-4eudA:
0.7		 1zlqA-4eudA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fms PROBABLE PORIN

(Pseudomonas
aeruginosa) 		no annotation 4 TRP B 116
PRO B 118
GLY B 137
GLY B 157
 None
 1.08A 1zlqA-4fmsB:
undetectable		 1zlqA-4fmsB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 PRO A 387
GLY A 150
ASN A 151
GLY A 147
 None
 1.12A 1zlqA-4g3tA:
undetectable		 1zlqA-4g3tA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 4 PRO A 275
GLY A  38
ASN A  40
GLY A   7
 None
 1.13A 1zlqA-4gk9A:
undetectable		 1zlqA-4gk9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 PRO A 134
GLY A 286
ASN A 284
GLY A 183
 None
 1.05A 1zlqA-4hooA:
undetectable		 1zlqA-4hooA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 PRO A 196
GLY A 117
ASN A 116
GLY A 151
 None
 1.18A 1zlqA-4j4mA:
undetectable		 1zlqA-4j4mA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PRO A  32
GLY A  47
ASN A  67
GLY A  45
 None
NAG  A 601 (-4.2A)
None
None
 0.97A 1zlqA-4kt1A:
undetectable		 1zlqA-4kt1A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 PRO A 380
GLY A 143
ASN A 144
GLY A 140
 None
 1.10A 1zlqA-4kw5A:
undetectable		 1zlqA-4kw5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ

(Ruegeria
lacuscaerulensis) 		PF16867
(DMSP_lyase) 		4 TRP A  26
PRO A  27
GLY A 109
GLY A  97
 None
 1.01A 1zlqA-4la2A:
undetectable		 1zlqA-4la2A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 TRP A 870
PRO A 871
ASN A 702
GLY A 676
 CME  A 974 ( 4.7A)
None
None
None
 0.98A 1zlqA-4lglA:
undetectable		 1zlqA-4lglA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 PRO A 131
GLY A 283
ASN A 281
GLY A 180
 None
 1.12A 1zlqA-4lxlA:
undetectable		 1zlqA-4lxlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 PRO A 329
GLY A 105
ASN A 335
GLY A 103
 PRO  A 329 ( 1.1A)
GLY  A 105 ( 0.0A)
ASN  A 335 ( 0.6A)
GLY  A 103 ( 0.0A)
 1.16A 1zlqA-4mwtA:
undetectable		 1zlqA-4mwtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 TRP A 437
PRO A 433
GLY A 755
GLY A 753
 None
 1.13A 1zlqA-4nh0A:
0.3		 1zlqA-4nh0A:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 TRP A   8
PRO A   9
GLY A 217
GLY A 220
 None
None
GOL  A 605 (-3.4A)
None
 0.87A 1zlqA-4oerA:
37.9		 1zlqA-4oerA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 PRO A 389
GLY A 237
ASN A 236
GLY A 234
 None
 1.06A 1zlqA-4pv4A:
undetectable		 1zlqA-4pv4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PRO A  32
GLY A  47
ASN A  67
GLY A  45
 None
 0.94A 1zlqA-4qxeA:
undetectable		 1zlqA-4qxeA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PRO A  32
GLY A  47
ASN A  67
GLY A  45
 None
 0.96A 1zlqA-4qxfA:
undetectable		 1zlqA-4qxfA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 PRO A  99
GLY A 307
ASN A 309
GLY A 311
 None
 0.81A 1zlqA-4r1dA:
undetectable		 1zlqA-4r1dA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		4 PRO A 152
GLY A 192
ASN A 208
GLY A 210
 None
 1.18A 1zlqA-4rg1A:
undetectable		 1zlqA-4rg1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		4 TRP A 167
PRO A 286
GLY A 219
GLY A 209
 None
 1.00A 1zlqA-4rjzA:
undetectable		 1zlqA-4rjzA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 PRO A 132
GLY A 284
ASN A 282
GLY A 181
 None
 1.13A 1zlqA-4xdoA:
undetectable		 1zlqA-4xdoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 PRO A 322
GLY A  92
ASN A  91
GLY A  87
 None
 0.81A 1zlqA-4xzcA:
undetectable		 1zlqA-4xzcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		4 PRO A 443
GLY A 411
ASN A 410
GLY A 451
 None
None
NAD  A 501 (-3.2A)
None
 0.75A 1zlqA-4zz7A:
undetectable		 1zlqA-4zz7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		4 TRP B 299
PRO B 296
GLY C 243
GLY B 346
 None
 1.18A 1zlqA-5a8rB:
undetectable		 1zlqA-5a8rB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab4 SCP2-THIOLASE LIKE
PROTEIN

(Trypanosoma
brucei) 		no annotation 4 PRO A 360
GLY A 392
ASN A 393
GLY A 394
 None
 1.12A 1zlqA-5ab4A:
undetectable		 1zlqA-5ab4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxm CYTOCHROME B6/F
COMPLEX IRON-SULFUR
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF00355
(Rieske) 		4 PRO A  75
GLY A  57
ASN A  53
GLY A  52
 None
 1.13A 1zlqA-5cxmA:
undetectable		 1zlqA-5cxmA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT

(Azospira oryzae) 		PF13247
(Fer4_11) 		4 PRO B 281
GLY B 123
ASN B 128
GLY B 121
 None
 1.14A 1zlqA-5e7oB:
undetectable		 1zlqA-5e7oB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 PRO A  70
GLY A  50
ASN A 147
GLY A 146
 None
FES  A3002 (-3.4A)
None
None
 1.11A 1zlqA-5epgA:
undetectable		 1zlqA-5epgA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 PRO A 206
GLY A 242
ASN A 241
GLY A 228
 None
 1.07A 1zlqA-5fqdA:
undetectable		 1zlqA-5fqdA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 469
GLY A 499
ASN A 500
GLY A 501
 None
 1.07A 1zlqA-5fr8A:
undetectable		 1zlqA-5fr8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii) 		PF08541
(ACP_syn_III_C) 		4 PRO A 156
GLY A 336
ASN A 337
GLY A 339
 None
 1.06A 1zlqA-5gk2A:
undetectable		 1zlqA-5gk2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 PRO A 180
GLY A 184
ASN A 185
GLY A 160
 None
None
NAG  A 706 (-1.9A)
None
 1.18A 1zlqA-5ixqA:
undetectable		 1zlqA-5ixqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN

(Mamastrovirus
1;
Mus musculus) 		PF12226
(Astro_capsid_p)
PF07686
(V-set) 		4 TRP C  52
GLY C 101
ASN C 102
GLY A 460
 None
 0.67A 1zlqA-5kovC:
undetectable		 1zlqA-5kovC:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		4 PRO A 187
GLY A 246
ASN A 305
GLY A 250
 None
None
None
EDO  A 605 (-3.5A)
 1.09A 1zlqA-5m77A:
undetectable		 1zlqA-5m77A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 4 PRO A 487
GLY A 419
ASN A 418
GLY A 417
 None
 1.01A 1zlqA-5mqpA:
undetectable		 1zlqA-5mqpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 PRO A  92
GLY A 136
ASN A 137
GLY A 138
 None
 1.16A 1zlqA-5mzsA:
undetectable		 1zlqA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10) 		no annotation 4 PRO A 289
GLY A 252
ASN A 251
GLY A 250
 None
 1.05A 1zlqA-5uytA:
undetectable		 1zlqA-5uytA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF13561
(adh_short_C2) 		4 PRO A  92
GLY A 155
ASN A 154
GLY A 151
 TCE  A 302 ( 4.7A)
None
None
None
 0.98A 1zlqA-5va8A:
0.3		 1zlqA-5va8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A 426
GLY A 417
ASN A 416
GLY A 412
 None
 1.09A 1zlqA-5vrbA:
undetectable		 1zlqA-5vrbA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ)
PF03739
(YjgP_YjgQ) 		4 PRO F 222
GLY G 170
ASN G 160
GLY G 139
 None
 1.16A 1zlqA-5x5yF:
undetectable		 1zlqA-5x5yF:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S13,
PUTATIVE

(Trichomonas
vaginalis) 		PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N) 		4 TRP N  25
PRO N  23
GLY N  59
GLY N  61
 None
None
None
U  2 779 ( 3.1A)
 0.99A 1zlqA-5xyiN:
undetectable		 1zlqA-5xyiN:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 TRP A 337
PRO A 339
GLY A 574
GLY A 570
 None
 0.89A 1zlqA-5yp3A:
undetectable		 1zlqA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 PRO B  74
GLY B 474
ASN B 312
GLY B  81
 None
 1.15A 1zlqA-6evjB:
undetectable		 1zlqA-6evjB:
undetectable