SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZGY_A_BRLA503_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		4 ILE B 214
ILE B 136
MET B 193
LEU B 288
 None
 0.91A 1zgyA-1bouB:
undetectable		 1zgyA-1bouB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 ILE A 104
ILE A 118
ILE A 127
MET A  43
 None
 0.78A 1zgyA-1ckmA:
undetectable		 1zgyA-1ckmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 ILE C 537
ILE C 290
ILE C 551
LEU C 260
 None
 0.85A 1zgyA-1d7wC:
0.0		 1zgyA-1d7wC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 ILE A 183
ILE A  95
ILE A 263
LEU A 177
 None
 0.83A 1zgyA-1dciA:
undetectable		 1zgyA-1dciA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ILE A 344
ILE A 221
MET A 331
LEU A 352
 None
 0.94A 1zgyA-1g8xA:
0.0		 1zgyA-1g8xA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		4 ILE A  73
ILE A 154
MET A 254
LEU A 162
 None
 0.90A 1zgyA-1ia7A:
0.0		 1zgyA-1ia7A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		4 ILE P 115
ILE P  94
ILE P 163
MET P 165
 None
 0.87A 1zgyA-1ikoP:
undetectable		 1zgyA-1ikoP:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 ILE A  14
ILE A 199
ILE A  42
MET A 142
LEU A  89
 None
 1.40A 1zgyA-1kugA:
undetectable		 1zgyA-1kugA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu2 DISABLED HOMOLOG 1

(Mus musculus) 		PF00640
(PID) 		4 ILE A 116
ILE A  85
ILE A  89
LEU A  68
 None
 0.94A 1zgyA-1nu2A:
0.0		 1zgyA-1nu2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A  51
ILE A 113
MET A  90
LEU A 328
 None
 0.90A 1zgyA-1ortA:
0.0		 1zgyA-1ortA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 383
ILE A 397
ILE A 540
LEU A 407
 None
 0.79A 1zgyA-1poxA:
0.1		 1zgyA-1poxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 ILE A  74
ILE A 196
ILE A 205
MET A 260
 None
 0.83A 1zgyA-1qguA:
0.0		 1zgyA-1qguA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		4 ILE A 246
ILE A 143
ILE A  22
LEU A 206
 None
HH2  A 282 (-4.1A)
None
None
 0.94A 1zgyA-1twwA:
undetectable		 1zgyA-1twwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A  45
ILE A 370
MET A 372
LEU A  50
 None
 0.91A 1zgyA-1uokA:
undetectable		 1zgyA-1uokA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 ILE A 121
ILE A 156
ILE A 256
LEU A 135
 None
 0.84A 1zgyA-1v5wA:
undetectable		 1zgyA-1v5wA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 ILE A  12
ILE A 197
ILE A  40
MET A 140
LEU A  87
 None
 1.26A 1zgyA-1wniA:
undetectable		 1zgyA-1wniA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		4 ILE A 200
ILE A  48
ILE A 171
MET A 165
 None
 0.90A 1zgyA-2a5vA:
undetectable		 1zgyA-2a5vA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		4 ILE A  83
ILE A 190
ILE A   9
LEU A 105
 GOL  A 825 (-4.8A)
None
None
None
 0.94A 1zgyA-2a7mA:
undetectable		 1zgyA-2a7mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ILE A  83
ILE A  15
ILE A   6
LEU A 123
 None
 0.83A 1zgyA-2ahrA:
undetectable		 1zgyA-2ahrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		4 ILE A 336
ILE A 377
ILE A 369
LEU A 294
 None
 0.88A 1zgyA-2bg5A:
undetectable		 1zgyA-2bg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		4 ILE A 428
ILE A 481
ILE A 432
LEU A 520
 None
 0.89A 1zgyA-2bg5A:
undetectable		 1zgyA-2bg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ILE A  99
ILE A  95
MET A 143
LEU A 126
 None
 0.79A 1zgyA-2djzA:
undetectable		 1zgyA-2djzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 145
ILE A 214
ILE A 227
MET A 113
 None
 0.82A 1zgyA-2eklA:
undetectable		 1zgyA-2eklA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 ILE A  13
ILE A 250
ILE A 108
LEU A  46
 None
 0.86A 1zgyA-2gk3A:
undetectable		 1zgyA-2gk3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ILE A 429
ILE A 482
ILE A 433
LEU A 521
 None
 0.90A 1zgyA-2hroA:
undetectable		 1zgyA-2hroA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 ILE A 204
ILE A   8
ILE A  34
LEU A 233
 None
 0.88A 1zgyA-2nuxA:
undetectable		 1zgyA-2nuxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 688
ILE A 703
MET A 764
LEU A 574
 None
 0.74A 1zgyA-2oajA:
undetectable		 1zgyA-2oajA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ILE A  99
ILE A 154
ILE A 174
LEU A  71
 None
 0.80A 1zgyA-2odlA:
undetectable		 1zgyA-2odlA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ILE A 149
ILE A  92
ILE A  99
LEU A 136
 None
 0.94A 1zgyA-2odlA:
undetectable		 1zgyA-2odlA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A   8
ILE A  80
MET A 228
LEU A  60
 None
 0.79A 1zgyA-2ohhA:
undetectable		 1zgyA-2ohhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgg 16S RRNA-PROCESSING
PROTEIN RIMM

(Acinetobacter
calcoaceticus) 		PF01782
(RimM)
PF05239
(PRC) 		4 ILE A 174
ILE A 150
ILE A 157
MET A 141
 None
 0.80A 1zgyA-2qggA:
undetectable		 1zgyA-2qggA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		4 ILE A 210
ILE A 180
ILE A 142
LEU A 170
 None
GTP  A 300 (-3.8A)
GTP  A 300 (-4.1A)
None
 0.89A 1zgyA-2qv6A:
undetectable		 1zgyA-2qv6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb4 ATP-DEPENDENT RNA
HELICASE DDX25

(Homo sapiens) 		PF00271
(Helicase_C) 		4 ILE A 448
ILE A 409
ILE A 467
LEU A 354
 None
 0.93A 1zgyA-2rb4A:
undetectable		 1zgyA-2rb4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 ILE A 158
ILE A  70
ILE A 238
LEU A 152
 None
 0.86A 1zgyA-2vreA:
undetectable		 1zgyA-2vreA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 ILE B 422
ILE B 365
ILE B 393
MET B 315
 None
 0.93A 1zgyA-2xdqB:
undetectable		 1zgyA-2xdqB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ILE B 153
ILE B  16
ILE B 169
MET B 172
LEU B 144
 None
 1.40A 1zgyA-3ayxB:
undetectable		 1zgyA-3ayxB:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 281
ILE A 326
ILE A 341
MET A 348
LEU A 453
 MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.9A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-4.2A)
 0.37A 1zgyA-3b0qA:
40.1		 1zgyA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 ILE D 281
ILE D 326
ILE D 341
MET D 348
 PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
 0.35A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggy INCREASED SODIUM
TOLERANCE PROTEIN 1

(Saccharomyces
cerevisiae) 		PF03398
(Ist1) 		4 ILE A 116
ILE A 136
ILE A 145
LEU A  12
 None
 0.92A 1zgyA-3ggyA:
undetectable		 1zgyA-3ggyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 217
ILE A 332
MET A 189
LEU A 267
 None
 0.87A 1zgyA-3igoA:
1.0		 1zgyA-3igoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		4 ILE A  64
ILE A   7
ILE A  84
LEU A 148
 None
 0.88A 1zgyA-3in1A:
undetectable		 1zgyA-3in1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		4 ILE A 119
ILE A 100
ILE A  93
LEU A  85
 None
None
ELA  A 301 (-4.1A)
None
 0.84A 1zgyA-3lupA:
undetectable		 1zgyA-3lupA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 ILE A 185
ILE A 168
MET A  67
LEU A 198
 None
 0.91A 1zgyA-3myxA:
undetectable		 1zgyA-3myxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzy RNA POLYMERASE
SIGMA-H FACTOR

(Fusobacterium
nucleatum) 		PF04542
(Sigma70_r2) 		4 ILE A 162
ILE A 196
ILE A 188
LEU A 135
 None
 0.81A 1zgyA-3mzyA:
undetectable		 1zgyA-3mzyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 ILE A1162
ILE A1045
ILE A1074
MET A1071
 None
 0.87A 1zgyA-3pvlA:
undetectable		 1zgyA-3pvlA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 ILE A 198
ILE A 212
MET A 104
LEU A 231
 None
 0.94A 1zgyA-3t5tA:
undetectable		 1zgyA-3t5tA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u12 USP37 PROTEIN

(Homo sapiens) 		PF16674
(UCH_N) 		4 ILE A  29
ILE A  12
ILE A   6
MET A  95
 None
None
UNX  A1019 ( 4.3A)
None
 0.90A 1zgyA-3u12A:
undetectable		 1zgyA-3u12A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		4 ILE A 186
ILE A 286
ILE A 191
MET A 201
 None
 0.76A 1zgyA-3w25A:
undetectable		 1zgyA-3w25A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		4 ILE A 193
ILE A 217
ILE A 257
LEU A 175
 None
 0.78A 1zgyA-3wqoA:
undetectable		 1zgyA-3wqoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 584
ILE A1258
ILE A1052
MET A1063
 None
 0.78A 1zgyA-3zyvA:
undetectable		 1zgyA-3zyvA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A  44
ILE A 357
MET A 359
LEU A  49
 None
 0.86A 1zgyA-4aieA:
undetectable		 1zgyA-4aieA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as3 PHOSPHORYLCHOLINE
PHOSPHATASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 320
ILE A 294
MET A 291
LEU A 151
 None
 0.84A 1zgyA-4as3A:
undetectable		 1zgyA-4as3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ILE B2286
ILE B2096
ILE B2182
LEU B2161
 None
 0.94A 1zgyA-4bedB:
undetectable		 1zgyA-4bedB:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE

(Clostridioides
difficile) 		PF00155
(Aminotran_1_2) 		4 ILE A 198
ILE A 155
ILE A 114
LEU A 183
 None
 0.83A 1zgyA-4dq6A:
undetectable		 1zgyA-4dq6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A 308
ILE A 148
ILE A 126
MET A 215
 None
 0.83A 1zgyA-4e6eA:
undetectable		 1zgyA-4e6eA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egw MAGNESIUM TRANSPORT
PROTEIN CORA

(Methanocaldococcus
jannaschii) 		PF01544
(CorA) 		4 ILE A 104
ILE A 132
ILE A  48
LEU A 140
 None
 0.82A 1zgyA-4egwA:
undetectable		 1zgyA-4egwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		4 ILE B  39
ILE B 124
ILE B  55
LEU B 161
 None
 0.87A 1zgyA-4ejsB:
undetectable		 1zgyA-4ejsB:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		no annotation 4 ILE S  12
ILE S 160
ILE S 109
LEU S  48
 None
 0.91A 1zgyA-4gd3S:
undetectable		 1zgyA-4gd3S:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 ILE A 121
ILE A 156
ILE A 256
LEU A 135
 None
 0.87A 1zgyA-4hyyA:
undetectable		 1zgyA-4hyyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A  83
ILE A 418
MET A 420
LEU A  88
 None
 0.81A 1zgyA-4lxfA:
undetectable		 1zgyA-4lxfA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 540
ILE A 504
ILE A 494
LEU A 556
 None
 0.91A 1zgyA-4m7eA:
undetectable		 1zgyA-4m7eA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ILE A 221
ILE A 246
ILE A 209
LEU A 278
 None
 0.92A 1zgyA-4nsxA:
undetectable		 1zgyA-4nsxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pia AUTOLYSIN E

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase) 		4 ILE A  89
ILE A 190
ILE A 129
MET A 238
 None
 0.90A 1zgyA-4piaA:
undetectable		 1zgyA-4piaA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 ILE A 418
ILE A 266
ILE A 448
LEU A 234
 None
 0.86A 1zgyA-4r12A:
undetectable		 1zgyA-4r12A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfa LMO0740 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ILE A  90
ILE A 174
ILE A  67
LEU A  29
 None
 0.92A 1zgyA-4rfaA:
undetectable		 1zgyA-4rfaA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		4 ILE A 227
ILE A 329
ILE A 321
LEU A 201
 None
 0.78A 1zgyA-4tvmA:
undetectable		 1zgyA-4tvmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfv VIOF

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N) 		4 ILE A  72
ILE A 155
ILE A 121
LEU A  47
 None
 0.94A 1zgyA-4yfvA:
undetectable		 1zgyA-4yfvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 187
ILE A 222
ILE A 173
LEU A 256
 None
 0.93A 1zgyA-4z61A:
undetectable		 1zgyA-4z61A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 538
ILE A 573
ILE A 489
LEU A 607
 None
 0.84A 1zgyA-4z61A:
undetectable		 1zgyA-4z61A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE A 528
ILE A 563
ILE A 479
LEU A 597
 None
 0.78A 1zgyA-4z64A:
undetectable		 1zgyA-4z64A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		4 ILE A 166
ILE A 275
ILE A 241
LEU A 148
 None
 0.84A 1zgyA-4zdlA:
undetectable		 1zgyA-4zdlA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 267
ILE A 278
MET A 220
LEU A 304
 None
 0.94A 1zgyA-4zyjA:
undetectable		 1zgyA-4zyjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE S  12
ILE S 160
ILE S 109
LEU S  48
 None
 0.90A 1zgyA-5a4mS:
undetectable		 1zgyA-5a4mS:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ILE A 701
ILE A 634
ILE A 681
LEU A 381
 None
 0.94A 1zgyA-5aw4A:
undetectable		 1zgyA-5aw4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b23 UNCHARACTERIZED
PROTEIN SORTASE B

(Clostridium
perfringens) 		PF04203
(Sortase) 		4 ILE A 175
ILE A 190
ILE A 147
LEU A 204
 None
 0.88A 1zgyA-5b23A:
undetectable		 1zgyA-5b23A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		4 ILE A 108
ILE A  33
ILE A 110
LEU A  96
 None
None
SAH  A 303 ( 4.0A)
None
 0.95A 1zgyA-5bp9A:
undetectable		 1zgyA-5bp9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		4 ILE A 107
ILE A 193
ILE A 181
LEU A  96
 None
 0.77A 1zgyA-5czyA:
undetectable		 1zgyA-5czyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 ILE A 707
ILE A 753
ILE A 760
LEU A 646
 None
 0.89A 1zgyA-5czzA:
undetectable		 1zgyA-5czzA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		4 ILE A 139
ILE A  37
ILE A 203
LEU A  22
 None
 0.93A 1zgyA-5dwdA:
undetectable		 1zgyA-5dwdA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 ILE A 359
ILE A 371
ILE A 376
LEU A 306
 MLI  A 633 (-3.9A)
None
None
None
 0.89A 1zgyA-5ecuA:
undetectable		 1zgyA-5ecuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		5 ILE A  34
ILE A 237
ILE A 161
MET A 165
LEU A 114
 None
 1.32A 1zgyA-5egnA:
undetectable		 1zgyA-5egnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejh NAD KINASE 1

(Listeria
monocytogenes) 		PF01513
(NAD_kinase) 		4 ILE A  67
ILE A  62
ILE A   5
MET A  20
 None
 0.78A 1zgyA-5ejhA:
undetectable		 1zgyA-5ejhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 ILE A 112
ILE A 339
ILE A 331
MET A  31
 None
 0.92A 1zgyA-5gheA:
undetectable		 1zgyA-5gheA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE B 206
ILE B 241
ILE B 193
LEU B 275
 None
 0.94A 1zgyA-5gqrB:
undetectable		 1zgyA-5gqrB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 ILE A  62
ILE A 397
MET A 399
LEU A  67
 None
 0.86A 1zgyA-5h2tA:
undetectable		 1zgyA-5h2tA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		4 ILE B 411
ILE B 446
ILE B 398
LEU B 480
 None
 0.89A 1zgyA-5hz1B:
undetectable		 1zgyA-5hz1B:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 101
ILE A 138
MET A  90
LEU A 134
 None
 0.83A 1zgyA-5j5pA:
undetectable		 1zgyA-5j5pA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 ILE B  21
ILE B  53
ILE B 363
LEU B 529
 None
 0.87A 1zgyA-5k1cB:
undetectable		 1zgyA-5k1cB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 ILE A 173
ILE A 269
ILE A 291
LEU A 242
 None
 0.94A 1zgyA-5k8dA:
undetectable		 1zgyA-5k8dA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 ILE A 112
ILE A 339
ILE A 331
MET A  31
 None
 0.93A 1zgyA-5kucA:
2.1		 1zgyA-5kucA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		4 ILE A 952
ILE A 966
ILE A 962
LEU A 643
 None
 0.85A 1zgyA-5lrbA:
undetectable		 1zgyA-5lrbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 934
ILE A 218
ILE A 791
LEU A 914
 None
 0.94A 1zgyA-5n0cA:
undetectable		 1zgyA-5n0cA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ILE A 327
ILE A 214
ILE A 116
LEU A 258
 None
 0.93A 1zgyA-5nnyA:
undetectable		 1zgyA-5nnyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		4 ILE A 196
ILE A  79
ILE A 181
LEU A 242
 None
 0.94A 1zgyA-5vprA:
undetectable		 1zgyA-5vprA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 ILE M 288
ILE M 379
ILE M 268
LEU M 342
 None
 0.90A 1zgyA-5wc8M:
undetectable		 1zgyA-5wc8M:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wls POLLEN RECEPTOR-LIKE
KINASE 3

(Arabidopsis
thaliana) 		no annotation 4 ILE A  96
ILE A 130
ILE A  82
LEU A 165
 None
 0.85A 1zgyA-5wlsA:
undetectable		 1zgyA-5wlsA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 ILE A  95
ILE A 280
ILE A 422
LEU A 170
 None
 0.93A 1zgyA-5wvbA:
undetectable		 1zgyA-5wvbA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9w POLLEN RECEPTOR-LIKE
KINASE 6

(Arabidopsis
thaliana) 		no annotation 4 ILE B 101
ILE B 135
ILE B  87
LEU B 170
 None
 0.80A 1zgyA-5y9wB:
undetectable		 1zgyA-5y9wB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 4 ILE A 194
ILE A 296
ILE A 199
MET A 210
 None
 0.81A 1zgyA-6fheA:
undetectable		 1zgyA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 ILE D 297
ILE D 305
ILE D 108
LEU D 350
 None
 0.94A 1zgyA-6fmlD:
undetectable		 1zgyA-6fmlD:
15.25