SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZGY_A_BRLA503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 189
GLY A 581
LEU A 577
LEU A 225
LEU A 217
 None
 1.18A 1zgyA-1bf2A:
undetectable		 1zgyA-1bf2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 GLY A 734
LEU A 707
MET A 741
HIS A 542
LEU A 580
 None
 1.17A 1zgyA-1e4oA:
0.0		 1zgyA-1e4oA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		5 GLY A 202
TYR A 158
LEU A 154
LEU A 133
LEU A 115
 None
 1.42A 1zgyA-1eg3A:
undetectable		 1zgyA-1eg3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 GLY A 126
CYH A  79
LEU A 294
LEU A 370
TYR A 371
 None
 1.28A 1zgyA-1h79A:
0.0		 1zgyA-1h79A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 GLY A 249
HIS A 295
TYR A 242
LEU A 243
LEU A 327
 None
 1.47A 1zgyA-1iirA:
undetectable		 1zgyA-1iirA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		5 GLY A   9
SER A  82
TYR A 121
LEU A 126
LEU A  42
 None
 1.42A 1zgyA-1jiuA:
undetectable		 1zgyA-1jiuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nez H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, TLA(C)
ALPHA CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 GLY A 162
SER A 167
TYR A  59
LEU A   5
TYR A   7
 None
 1.38A 1zgyA-1nezA:
0.0		 1zgyA-1nezA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 PHE A  47
LEU A  18
LEU A  54
MET A  57
LEU A  36
 None
 1.26A 1zgyA-1z0xA:
0.0		 1zgyA-1z0xA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		5 PHE A 387
GLY A 389
LEU A 264
LEU A 236
LEU A  41
 None
 1.41A 1zgyA-1zzgA:
0.0		 1zgyA-1zzgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2co5 VIRAL PROTEIN F93

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 GLY A  22
HIS A  85
TYR A  12
LEU A  15
LEU A  30
 None
 1.42A 1zgyA-2co5A:
undetectable		 1zgyA-2co5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		5 GLY A 220
SER A 223
TYR A 290
HIS A 200
LEU A 227
 NDP  A 501 ( 4.2A)
NDP  A 501 (-2.8A)
None
None
None
 1.47A 1zgyA-2gv8A:
undetectable		 1zgyA-2gv8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3s AUTOINHIBITED CRK
PROTEIN

(Gallus gallus) 		PF00018
(SH3_1)
PF07653
(SH3_2) 		5 GLY A 278
LEU A 294
LEU A 231
HIS A 291
LEU A 259
 None
 0.99A 1zgyA-2l3sA:
undetectable		 1zgyA-2l3sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3f DOUBLE-STRANDED
RNA-BINDING PROTEIN
4

(Arabidopsis
thaliana) 		PF00035
(dsrm) 		5 GLY A  44
CYH A  43
TYR A  12
LEU A  71
HIS A  16
 None
 1.41A 1zgyA-2n3fA:
undetectable		 1zgyA-2n3fA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 PHE A 286
GLY A 296
CYH A 295
LEU A 316
LEU A 289
 None
 1.43A 1zgyA-2nqnA:
undetectable		 1zgyA-2nqnA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 456
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.6A)
 1.45A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.69A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 273
CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.93A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		5 LEU A 471
LEU A 436
MET A 440
LEU A 328
TYR A 327
 None
 1.36A 1zgyA-2qz4A:
undetectable		 1zgyA-2qz4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 SER A 264
TYR A  44
LEU A  59
HIS A  43
TYR A 169
 None
FE  A1347 (-4.1A)
None
FE  A1347 (-3.3A)
FE  A1347 (-4.3A)
 1.25A 1zgyA-2vp1A:
undetectable		 1zgyA-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 PHE A 112
GLY A 115
LEU A 147
LEU A 128
LEU A 177
 None
 1.42A 1zgyA-2wxzA:
undetectable		 1zgyA-2wxzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PHE A 165
HIS A  24
LEU A  64
LEU A  51
LEU A 191
 ACT  A1463 (-3.7A)
None
None
None
None
 1.22A 1zgyA-2y0eA:
undetectable		 1zgyA-2y0eA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		5 GLY C 191
CYH C 190
LEU C 141
LEU C 385
TYR C 450
 None
 1.23A 1zgyA-3al0C:
undetectable		 1zgyA-3al0C:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 PHE A 282
GLY A 284
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
LEU A 353
MET A 364
HIS A 449
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.39A 1zgyA-3b0qA:
40.1		 1zgyA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
GLY A 284
LEU A 356
HIS A 449
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 ( 4.5A)
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 1.44A 1zgyA-3b0qA:
40.1		 1zgyA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  50
CYH A  49
HIS A 132
LEU A 244
LEU A 174
 None
 1.34A 1zgyA-3bn1A:
undetectable		 1zgyA-3bn1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		5 GLY A 393
HIS A 157
LEU A 428
LEU A 235
MET A 210
 None
 1.35A 1zgyA-3bzmA:
undetectable		 1zgyA-3bzmA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 CYH A 285
HIS A 323
LEU A 330
LEU A 353
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.72A 1zgyA-3d5fA:
36.3		 1zgyA-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
HIS A 323
LEU A 356
LEU A 469
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 1.32A 1zgyA-3d5fA:
36.3		 1zgyA-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 GLY C 427
CYH C 422
LEU C 458
LEU C 441
MET C 408
 None
 1.45A 1zgyA-3degC:
undetectable		 1zgyA-3degC:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		5 GLY A 232
SER A  48
HIS A  52
TYR A 248
LEU A 256
 FAD  A 500 ( 4.6A)
FAD  A 500 ( 2.9A)
TLA  A 999 ( 3.7A)
TLA  A 999 (-4.7A)
None
 1.25A 1zgyA-3dmeA:
undetectable		 1zgyA-3dmeA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 0.97A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLY D 284
CYH D 285
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 1.06A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLY D 284
CYH D 285
TYR D 473
LEU D 469
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
None
None
None
 1.49A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 GLY D 284
SER D 289
LEU D 330
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.69A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 282
GLY D 284
CYH D 285
LEU D 330
MET D 364
 None
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
 1.10A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 PHE D 282
GLY D 284
SER D 289
LEU D 330
LEU D 353
MET D 364
LEU D 469
TYR D 473
 None
PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
 0.78A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 TYR D 327
LEU D 330
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 None
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.88A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Bos taurus) 		PF06052
(3-HAO) 		5 GLY A  51
SER A 209
LEU A  32
LEU A 137
LEU A  84
 None
None
None
CSO  A 134 ( 4.6A)
None
 1.15A 1zgyA-3fe5A:
undetectable		 1zgyA-3fe5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
BETA

(Camelus
dromedarius) 		PF00042
(Globin) 		5 PHE B  71
GLY B  72
LEU B   3
LEU B  81
LEU B 114
 HEM  B 147 (-4.2A)
None
None
None
None
 1.36A 1zgyA-3gdjB:
undetectable		 1zgyA-3gdjB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 GLY W 926
LEU W 931
LEU W 981
HIS W1027
LEU W 828
 None
 1.10A 1zgyA-3iylW:
undetectable		 1zgyA-3iylW:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 128
CYH A 127
LEU A 155
MET A 110
LEU A  88
 None
 1.18A 1zgyA-3kzwA:
undetectable		 1zgyA-3kzwA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 GLY A 219
HIS A 144
TYR A 147
LEU A 215
HIS A 179
 None
None
UNL  A 300 ( 4.2A)
UNL  A 300 ( 4.5A)
UNL  A 300 ( 4.1A)
 1.30A 1zgyA-3qc0A:
undetectable		 1zgyA-3qc0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		5 GLY A  70
SER A  68
LEU A 163
HIS A  32
LEU A  13
 NA  A 276 (-3.4A)
None
None
None
None
 1.46A 1zgyA-3qm1A:
undetectable		 1zgyA-3qm1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 PHE A  55
GLY A   4
LEU A  60
LEU A  74
LEU A 288
 None
 1.02A 1zgyA-3r5xA:
undetectable		 1zgyA-3r5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 PHE A 112
GLY A 383
HIS A 117
LEU A 402
LEU A 125
 None
 1.35A 1zgyA-3rv6A:
undetectable		 1zgyA-3rv6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip APOPTOSIS 1
INHIBITOR

(Drosophila
melanogaster) 		PF00653
(BIR) 		5 PHE E  82
GLY E  84
CYH E  80
LEU E  64
LEU E  41
 None
None
ZN  E   1 (-2.3A)
None
None
 1.20A 1zgyA-3sipE:
undetectable		 1zgyA-3sipE:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		5 PHE A  64
SER A 305
TYR A  89
LEU A  91
LEU A 113
 MD0  A 993 (-3.7A)
None
None
None
None
 1.28A 1zgyA-3t7vA:
undetectable		 1zgyA-3t7vA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 GLY A 165
HIS A 239
LEU A 204
MET A 222
LEU A 183
 None
 1.26A 1zgyA-3vupA:
undetectable		 1zgyA-3vupA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		5 PHE A1892
GLY A1894
CYH A1895
LEU A1908
LEU A1949
 None
 1.38A 1zgyA-4c0eA:
undetectable		 1zgyA-4c0eA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmg VP1

(Human
polyomavirus 5) 		PF00718
(Polyoma_coat) 		5 GLY A 169
SER A 285
LEU A  57
LEU A 108
LEU A 220
 None
 1.23A 1zgyA-4fmgA:
undetectable		 1zgyA-4fmgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 GLY A 295
SER A 382
HIS A 386
LEU A 337
LEU A 351
 None
 1.42A 1zgyA-4im7A:
undetectable		 1zgyA-4im7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		5 CYH A 117
SER A 106
HIS A 109
LEU A  63
LEU A 114
 None
 1.44A 1zgyA-4irtA:
undetectable		 1zgyA-4irtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY A 217
SER A 156
LEU A 200
HIS A 184
TYR A 319
 None
 1.29A 1zgyA-4k9dA:
undetectable		 1zgyA-4k9dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		5 PHE A 131
GLY A 174
LEU A 152
LEU A 124
TYR A 123
 None
 1.27A 1zgyA-4madA:
undetectable		 1zgyA-4madA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 GLY B 176
SER B 150
HIS B 109
LEU B 240
LEU B 147
 None
 1.33A 1zgyA-4nfuB:
undetectable		 1zgyA-4nfuB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 PHE A  70
GLY A  71
HIS A  39
LEU A  49
LEU A  31
 None
 1.33A 1zgyA-4po0A:
undetectable		 1zgyA-4po0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		5 PHE A 109
GLY A 200
TYR A 170
LEU A 107
LEU A 136
 None
 1.20A 1zgyA-4r72A:
undetectable		 1zgyA-4r72A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 GLY A 162
HIS A 389
LEU A 337
LEU A 106
TYR A 109
 None
 1.37A 1zgyA-4txaA:
undetectable		 1zgyA-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		5 PHE A  53
HIS A  38
TYR A  78
LEU A  74
LEU A  99
 None
 1.46A 1zgyA-4u2nA:
undetectable		 1zgyA-4u2nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 GLY A1178
CYH A1179
LEU A1537
MET A1625
TYR A1248
 None
 1.49A 1zgyA-4u48A:
undetectable		 1zgyA-4u48A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 GLY A 464
TYR A 421
LEU A 418
LEU A 534
MET A 532
 None
None
None
GOL  A 707 (-4.2A)
None
 1.30A 1zgyA-4z0vA:
undetectable		 1zgyA-4z0vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 GLY A1186
CYH A1187
LEU A1546
MET A1634
TYR A1256
 None
 1.47A 1zgyA-4ziuA:
undetectable		 1zgyA-4ziuA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		5 CYH A 285
TYR A 172
LEU A 174
LEU A 253
HIS A 217
 GOL  A 401 ( 4.5A)
None
None
None
None
 1.09A 1zgyA-4ztbA:
undetectable		 1zgyA-4ztbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy8 PROTEIN LST4

(Kluyveromyces
lactis) 		no annotation 5 PHE C  11
CYH C 100
LEU C 121
LEU C 167
LEU C  32
 None
 1.13A 1zgyA-4zy8C:
undetectable		 1zgyA-4zy8C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.) 		PF06778
(Chlor_dismutase) 		5 GLY A  22
TYR A  64
LEU A  76
LEU A  91
LEU A  15
 None
 1.49A 1zgyA-5a12A:
undetectable		 1zgyA-5a12A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 GLY A 106
SER A 130
TYR A  99
LEU A  44
LEU A  52
 CL  A 302 (-3.7A)
None
None
None
None
 1.14A 1zgyA-5bp7A:
undetectable		 1zgyA-5bp7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP0
VP1

(Enterovirus A) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		5 GLY B 238
TYR B 148
LEU B 229
LEU B 244
TYR A 222
 None
 1.34A 1zgyA-5c8cB:
undetectable		 1zgyA-5c8cB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8h ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Homo sapiens) 		PF04084
(ORC2) 		5 PHE A 492
GLY A 490
LEU A 511
LEU A 536
LEU A 570
 None
 1.09A 1zgyA-5c8hA:
undetectable		 1zgyA-5c8hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		5 PHE A  15
GLY A  14
LEU A 121
MET A 354
TYR A 442
 None
 1.12A 1zgyA-5gnxA:
undetectable		 1zgyA-5gnxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 HIS A 267
TYR A 265
LEU A 312
LEU A 180
TYR A 217
 None
 1.47A 1zgyA-5hy7A:
undetectable		 1zgyA-5hy7A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 GLY A 600
HIS A 224
TYR A 679
LEU A 678
LEU A 210
 None
 1.26A 1zgyA-5idoA:
undetectable		 1zgyA-5idoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 HIS A  82
LEU A  38
LEU A 204
LEU A 116
TYR A 114
 None
 1.37A 1zgyA-5l2pA:
undetectable		 1zgyA-5l2pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 HIS A 116
TYR A 128
LEU A 239
LEU A 150
TYR A 148
 None
 1.49A 1zgyA-5mifA:
undetectable		 1zgyA-5mifA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		5 SER A 168
LEU A  89
LEU A  70
MET A  67
HIS A 107
 None
 1.40A 1zgyA-5nlaA:
undetectable		 1zgyA-5nlaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 5 PHE A 232
GLY A 236
SER A 255
HIS A 219
TYR A 206
 None
 1.47A 1zgyA-5ojrA:
undetectable		 1zgyA-5ojrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 GLY A 313
LEU A 338
HIS A 450
LEU A 486
TYR A 482
 None
 1.49A 1zgyA-5t81A:
undetectable		 1zgyA-5t81A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  48
CYH A  47
HIS A 130
LEU A 241
LEU A 172
 EDO  A 403 ( 4.5A)
None
None
None
None
 1.44A 1zgyA-5u24A:
undetectable		 1zgyA-5u24A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		5 TYR A 297
LEU A 253
LEU A 308
LEU A 559
TYR A 560
 None
 1.42A 1zgyA-5wx1A:
undetectable		 1zgyA-5wx1A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 158
SER A 307
LEU A 333
HIS A 348
LEU A 362
 None
 1.34A 1zgyA-5x5hA:
undetectable		 1zgyA-5x5hA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 GLY A 255
CYH A 254
LEU A 187
MET A 225
LEU A 276
 None
 1.15A 1zgyA-5xgsA:
undetectable		 1zgyA-5xgsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9s VV2_1132

(Vibrio
vulnificus) 		no annotation 5 SER A 231
LEU A 256
HIS A 250
LEU A 207
TYR A 153
 None
None
None
BR  A 402 (-3.8A)
None
 1.46A 1zgyA-5y9sA:
undetectable		 1zgyA-5y9sA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.49A 1zgyA-5yo8A:
undetectable		 1zgyA-5yo8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 PHE A 158
GLY A 150
HIS A 111
LEU A  75
TYR A 110
 None
 1.30A 1zgyA-6bs7A:
undetectable		 1zgyA-6bs7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 PHE A 158
HIS A 111
LEU A 198
LEU A 165
TYR A 110
 None
 1.45A 1zgyA-6bs7A:
undetectable		 1zgyA-6bs7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 5 TYR W1052
LEU W1017
LEU W1127
MET W1055
LEU W1139
 None
 1.46A 1zgyA-6ftxW:
undetectable		 1zgyA-6ftxW:
undetectable