SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZGY_A_BRLA503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 189
GLY A 581
LEU A 577
LEU A 225
LEU A 217
 None
 1.18A 1zgyA-1bf2A:
undetectable		 1zgyA-1bf2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 GLY A 734
LEU A 707
MET A 741
HIS A 542
LEU A 580
 None
 1.17A 1zgyA-1e4oA:
0.0		 1zgyA-1e4oA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		5 GLY A 202
TYR A 158
LEU A 154
LEU A 133
LEU A 115
 None
 1.42A 1zgyA-1eg3A:
undetectable		 1zgyA-1eg3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 GLY A 126
CYH A  79
LEU A 294
LEU A 370
TYR A 371
 None
 1.28A 1zgyA-1h79A:
0.0		 1zgyA-1h79A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 GLY A 249
HIS A 295
TYR A 242
LEU A 243
LEU A 327
 None
 1.47A 1zgyA-1iirA:
undetectable		 1zgyA-1iirA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		5 GLY A   9
SER A  82
TYR A 121
LEU A 126
LEU A  42
 None
 1.42A 1zgyA-1jiuA:
undetectable		 1zgyA-1jiuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nez H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, TLA(C)
ALPHA CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 GLY A 162
SER A 167
TYR A  59
LEU A   5
TYR A   7
 None
 1.38A 1zgyA-1nezA:
0.0		 1zgyA-1nezA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 PHE A  47
LEU A  18
LEU A  54
MET A  57
LEU A  36
 None
 1.26A 1zgyA-1z0xA:
0.0		 1zgyA-1z0xA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		5 PHE A 387
GLY A 389
LEU A 264
LEU A 236
LEU A  41
 None
 1.41A 1zgyA-1zzgA:
0.0		 1zgyA-1zzgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2co5 VIRAL PROTEIN F93

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 GLY A  22
HIS A  85
TYR A  12
LEU A  15
LEU A  30
 None
 1.42A 1zgyA-2co5A:
undetectable		 1zgyA-2co5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		5 GLY A 220
SER A 223
TYR A 290
HIS A 200
LEU A 227
 NDP  A 501 ( 4.2A)
NDP  A 501 (-2.8A)
None
None
None
 1.47A 1zgyA-2gv8A:
undetectable		 1zgyA-2gv8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3s AUTOINHIBITED CRK
PROTEIN

(Gallus gallus) 		PF00018
(SH3_1)
PF07653
(SH3_2) 		5 GLY A 278
LEU A 294
LEU A 231
HIS A 291
LEU A 259
 None
 0.99A 1zgyA-2l3sA:
undetectable		 1zgyA-2l3sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3f DOUBLE-STRANDED
RNA-BINDING PROTEIN
4

(Arabidopsis
thaliana) 		PF00035
(dsrm) 		5 GLY A  44
CYH A  43
TYR A  12
LEU A  71
HIS A  16
 None
 1.41A 1zgyA-2n3fA:
undetectable		 1zgyA-2n3fA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 PHE A 286
GLY A 296
CYH A 295
LEU A 316
LEU A 289
 None
 1.43A 1zgyA-2nqnA:
undetectable		 1zgyA-2nqnA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 456
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.6A)
 1.45A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.69A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 273
CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.93A 1zgyA-2p54A:
37.6		 1zgyA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		5 LEU A 471
LEU A 436
MET A 440
LEU A 328
TYR A 327
 None
 1.36A 1zgyA-2qz4A:
undetectable		 1zgyA-2qz4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 SER A 264
TYR A  44
LEU A  59
HIS A  43
TYR A 169
 None
FE  A1347 (-4.1A)
None
FE  A1347 (-3.3A)
FE  A1347 (-4.3A)
 1.25A 1zgyA-2vp1A:
undetectable		 1zgyA-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 PHE A 112
GLY A 115
LEU A 147
LEU A 128
LEU A 177
 None
 1.42A 1zgyA-2wxzA:
undetectable		 1zgyA-2wxzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PHE A 165
HIS A  24
LEU A  64
LEU A  51
LEU A 191
 ACT  A1463 (-3.7A)
None
None
None
None
 1.22A 1zgyA-2y0eA:
undetectable		 1zgyA-2y0eA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		5 GLY C 191
CYH C 190
LEU C 141
LEU C 385
TYR C 450
 None
 1.23A 1zgyA-3al0C:
undetectable		 1zgyA-3al0C:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 PHE A 282
GLY A 284
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
LEU A 353
MET A 364
HIS A 449
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.39A 1zgyA-3b0qA:
40.1		 1zgyA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
GLY A 284
LEU A 356
HIS A 449
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 ( 4.5A)
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 1.44A 1zgyA-3b0qA:
40.1		 1zgyA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  50
CYH A  49
HIS A 132
LEU A 244
LEU A 174
 None
 1.34A 1zgyA-3bn1A:
undetectable		 1zgyA-3bn1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		5 GLY A 393
HIS A 157
LEU A 428
LEU A 235
MET A 210
 None
 1.35A 1zgyA-3bzmA:
undetectable		 1zgyA-3bzmA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 CYH A 285
HIS A 323
LEU A 330
LEU A 353
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.72A 1zgyA-3d5fA:
36.3		 1zgyA-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
HIS A 323
LEU A 356
LEU A 469
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 1.32A 1zgyA-3d5fA:
36.3		 1zgyA-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 GLY C 427
CYH C 422
LEU C 458
LEU C 441
MET C 408
 None
 1.45A 1zgyA-3degC:
undetectable		 1zgyA-3degC:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		5 GLY A 232
SER A  48
HIS A  52
TYR A 248
LEU A 256
 FAD  A 500 ( 4.6A)
FAD  A 500 ( 2.9A)
TLA  A 999 ( 3.7A)
TLA  A 999 (-4.7A)
None
 1.25A 1zgyA-3dmeA:
undetectable		 1zgyA-3dmeA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 0.97A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLY D 284
CYH D 285
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 1.06A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLY D 284
CYH D 285
TYR D 473
LEU D 469
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
None
None
None
 1.49A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 GLY D 284
SER D 289
LEU D 330
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.69A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 282
GLY D 284
CYH D 285
LEU D 330
MET D 364
 None
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
 1.10A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 PHE D 282
GLY D 284
SER D 289
LEU D 330
LEU D 353
MET D 364
LEU D 469
TYR D 473
 None
PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
 0.78A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 TYR D 327
LEU D 330
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 None
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.88A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Bos taurus) 		PF06052
(3-HAO) 		5 GLY A  51
SER A 209
LEU A  32
LEU A 137
LEU A  84
 None
None
None
CSO  A 134 ( 4.6A)
None
 1.15A 1zgyA-3fe5A:
undetectable		 1zgyA-3fe5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
BETA

(Camelus
dromedarius) 		PF00042
(Globin) 		5 PHE B  71
GLY B  72
LEU B   3
LEU B  81
LEU B 114
 HEM  B 147 (-4.2A)
None
None
None
None
 1.36A 1zgyA-3gdjB:
undetectable		 1zgyA-3gdjB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 GLY W 926
LEU W 931
LEU W 981
HIS W1027
LEU W 828
 None
 1.10A 1zgyA-3iylW:
undetectable		 1zgyA-3iylW:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 128
CYH A 127
LEU A 155
MET A 110
LEU A  88
 None
 1.18A 1zgyA-3kzwA:
undetectable		 1zgyA-3kzwA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 GLY A 219
HIS A 144
TYR A 147
LEU A 215
HIS A 179
 None
None
UNL  A 300 ( 4.2A)
UNL  A 300 ( 4.5A)
UNL  A 300 ( 4.1A)
 1.30A 1zgyA-3qc0A:
undetectable		 1zgyA-3qc0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		5 GLY A  70
SER A  68
LEU A 163
HIS A  32
LEU A  13
 NA  A 276 (-3.4A)
None
None
None
None
 1.46A 1zgyA-3qm1A:
undetectable		 1zgyA-3qm1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 PHE A  55
GLY A   4
LEU A  60
LEU A  74
LEU A 288
 None
 1.02A 1zgyA-3r5xA:
undetectable		 1zgyA-3r5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 PHE A 112
GLY A 383
HIS A 117
LEU A 402
LEU A 125
 None
 1.35A 1zgyA-3rv6A:
undetectable		 1zgyA-3rv6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip APOPTOSIS 1
INHIBITOR

(Drosophila
melanogaster) 		PF00653
(BIR) 		5 PHE E  82
GLY E  84
CYH E  80
LEU E  64
LEU E  41
 None
None
ZN  E   1 (-2.3A)
None
None
 1.20A 1zgyA-3sipE:
undetectable		 1zgyA-3sipE:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		5 PHE A  64
SER A 305
TYR A  89
LEU A  91
LEU A 113
 MD0  A 993 (-3.7A)
None
None
None
None
 1.28A 1zgyA-3t7vA:
undetectable		 1zgyA-3t7vA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 GLY A 165
HIS A 239
LEU A 204
MET A 222
LEU A 183
 None
 1.26A 1zgyA-3vupA:
undetectable		 1zgyA-3vupA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		5 PHE A1892
GLY A1894
CYH A1895
LEU A1908
LEU A1949
 None
 1.38A 1zgyA-4c0eA:
undetectable		 1zgyA-4c0eA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmg VP1

(Human
polyomavirus 5) 		PF00718
(Polyoma_coat) 		5 GLY A 169
SER A 285
LEU A  57
LEU A 108
LEU A 220
 None
 1.23A 1zgyA-4fmgA:
undetectable		 1zgyA-4fmgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 GLY A 295
SER A 382
HIS A 386
LEU A 337
LEU A 351
 None
 1.42A 1zgyA-4im7A:
undetectable		 1zgyA-4im7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		5 CYH A 117
SER A 106
HIS A 109
LEU A  63
LEU A 114
 None
 1.44A 1zgyA-4irtA:
undetectable		 1zgyA-4irtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY A 217
SER A 156
LEU A 200
HIS A 184
TYR A 319
 None
 1.29A 1zgyA-4k9dA:
undetectable		 1zgyA-4k9dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		5 PHE A 131
GLY A 174
LEU A 152
LEU A 124
TYR A 123
 None
 1.27A 1zgyA-4madA:
undetectable		 1zgyA-4madA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 GLY B 176
SER B 150
HIS B 109
LEU B 240
LEU B 147
 None
 1.33A 1zgyA-4nfuB:
undetectable		 1zgyA-4nfuB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 PHE A  70
GLY A  71
HIS A  39
LEU A  49
LEU A  31
 None
 1.33A 1zgyA-4po0A:
undetectable		 1zgyA-4po0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		5 PHE A 109
GLY A 200
TYR A 170
LEU A 107
LEU A 136
 None
 1.20A 1zgyA-4r72A:
undetectable		 1zgyA-4r72A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 GLY A 162
HIS A 389
LEU A 337
LEU A 106
TYR A 109
 None
 1.37A 1zgyA-4txaA:
undetectable		 1zgyA-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		5 PHE A  53
HIS A  38
TYR A  78
LEU A  74
LEU A  99
 None
 1.46A 1zgyA-4u2nA:
undetectable		 1zgyA-4u2nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 GLY A1178
CYH A1179
LEU A1537
MET A1625
TYR A1248
 None
 1.49A 1zgyA-4u48A:
undetectable		 1zgyA-4u48A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 GLY A 464
TYR A 421
LEU A 418
LEU A 534
MET A 532
 None
None
None
GOL  A 707 (-4.2A)
None
 1.30A 1zgyA-4z0vA:
undetectable		 1zgyA-4z0vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 GLY A1186
CYH A1187
LEU A1546
MET A1634
TYR A1256
 None
 1.47A 1zgyA-4ziuA:
undetectable		 1zgyA-4ziuA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		5 CYH A 285
TYR A 172
LEU A 174
LEU A 253
HIS A 217
 GOL  A 401 ( 4.5A)
None
None
None
None
 1.09A 1zgyA-4ztbA:
undetectable		 1zgyA-4ztbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy8 PROTEIN LST4

(Kluyveromyces
lactis) 		no annotation 5 PHE C  11
CYH C 100
LEU C 121
LEU C 167
LEU C  32
 None
 1.13A 1zgyA-4zy8C:
undetectable		 1zgyA-4zy8C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.) 		PF06778
(Chlor_dismutase) 		5 GLY A  22
TYR A  64
LEU A  76
LEU A  91
LEU A  15
 None
 1.49A 1zgyA-5a12A:
undetectable		 1zgyA-5a12A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 GLY A 106
SER A 130
TYR A  99
LEU A  44
LEU A  52
 CL  A 302 (-3.7A)
None
None
None
None
 1.14A 1zgyA-5bp7A:
undetectable		 1zgyA-5bp7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP0
VP1

(Enterovirus A) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		5 GLY B 238
TYR B 148
LEU B 229
LEU B 244
TYR A 222
 None
 1.34A 1zgyA-5c8cB:
undetectable		 1zgyA-5c8cB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8h ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Homo sapiens) 		PF04084
(ORC2) 		5 PHE A 492
GLY A 490
LEU A 511
LEU A 536
LEU A 570
 None
 1.09A 1zgyA-5c8hA:
undetectable		 1zgyA-5c8hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		5 PHE A  15
GLY A  14
LEU A 121
MET A 354
TYR A 442
 None
 1.12A 1zgyA-5gnxA:
undetectable		 1zgyA-5gnxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 HIS A 267
TYR A 265
LEU A 312
LEU A 180
TYR A 217
 None
 1.47A 1zgyA-5hy7A:
undetectable		 1zgyA-5hy7A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 GLY A 600
HIS A 224
TYR A 679
LEU A 678
LEU A 210
 None
 1.26A 1zgyA-5idoA:
undetectable		 1zgyA-5idoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 HIS A  82
LEU A  38
LEU A 204
LEU A 116
TYR A 114
 None
 1.37A 1zgyA-5l2pA:
undetectable		 1zgyA-5l2pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 HIS A 116
TYR A 128
LEU A 239
LEU A 150
TYR A 148
 None
 1.49A 1zgyA-5mifA:
undetectable		 1zgyA-5mifA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		5 SER A 168
LEU A  89
LEU A  70
MET A  67
HIS A 107
 None
 1.40A 1zgyA-5nlaA:
undetectable		 1zgyA-5nlaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 5 PHE A 232
GLY A 236
SER A 255
HIS A 219
TYR A 206
 None
 1.47A 1zgyA-5ojrA:
undetectable		 1zgyA-5ojrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 GLY A 313
LEU A 338
HIS A 450
LEU A 486
TYR A 482
 None
 1.49A 1zgyA-5t81A:
undetectable		 1zgyA-5t81A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  48
CYH A  47
HIS A 130
LEU A 241
LEU A 172
 EDO  A 403 ( 4.5A)
None
None
None
None
 1.44A 1zgyA-5u24A:
undetectable		 1zgyA-5u24A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		5 TYR A 297
LEU A 253
LEU A 308
LEU A 559
TYR A 560
 None
 1.42A 1zgyA-5wx1A:
undetectable		 1zgyA-5wx1A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 158
SER A 307
LEU A 333
HIS A 348
LEU A 362
 None
 1.34A 1zgyA-5x5hA:
undetectable		 1zgyA-5x5hA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 GLY A 255
CYH A 254
LEU A 187
MET A 225
LEU A 276
 None
 1.15A 1zgyA-5xgsA:
undetectable		 1zgyA-5xgsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9s VV2_1132

(Vibrio
vulnificus) 		no annotation 5 SER A 231
LEU A 256
HIS A 250
LEU A 207
TYR A 153
 None
None
None
BR  A 402 (-3.8A)
None
 1.46A 1zgyA-5y9sA:
undetectable		 1zgyA-5y9sA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.49A 1zgyA-5yo8A:
undetectable		 1zgyA-5yo8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 PHE A 158
GLY A 150
HIS A 111
LEU A  75
TYR A 110
 None
 1.30A 1zgyA-6bs7A:
undetectable		 1zgyA-6bs7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 PHE A 158
HIS A 111
LEU A 198
LEU A 165
TYR A 110
 None
 1.45A 1zgyA-6bs7A:
undetectable		 1zgyA-6bs7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 5 TYR W1052
LEU W1017
LEU W1127
MET W1055
LEU W1139
 None
 1.46A 1zgyA-6ftxW:
undetectable		 1zgyA-6ftxW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		4 ILE B 214
ILE B 136
MET B 193
LEU B 288
 None
 0.91A 1zgyA-1bouB:
undetectable		 1zgyA-1bouB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 ILE A 104
ILE A 118
ILE A 127
MET A  43
 None
 0.78A 1zgyA-1ckmA:
undetectable		 1zgyA-1ckmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 ILE C 537
ILE C 290
ILE C 551
LEU C 260
 None
 0.85A 1zgyA-1d7wC:
0.0		 1zgyA-1d7wC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 ILE A 183
ILE A  95
ILE A 263
LEU A 177
 None
 0.83A 1zgyA-1dciA:
undetectable		 1zgyA-1dciA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ILE A 344
ILE A 221
MET A 331
LEU A 352
 None
 0.94A 1zgyA-1g8xA:
0.0		 1zgyA-1g8xA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		4 ILE A  73
ILE A 154
MET A 254
LEU A 162
 None
 0.90A 1zgyA-1ia7A:
0.0		 1zgyA-1ia7A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		4 ILE P 115
ILE P  94
ILE P 163
MET P 165
 None
 0.87A 1zgyA-1ikoP:
undetectable		 1zgyA-1ikoP:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 ILE A  14
ILE A 199
ILE A  42
MET A 142
LEU A  89
 None
 1.40A 1zgyA-1kugA:
undetectable		 1zgyA-1kugA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu2 DISABLED HOMOLOG 1

(Mus musculus) 		PF00640
(PID) 		4 ILE A 116
ILE A  85
ILE A  89
LEU A  68
 None
 0.94A 1zgyA-1nu2A:
0.0		 1zgyA-1nu2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A  51
ILE A 113
MET A  90
LEU A 328
 None
 0.90A 1zgyA-1ortA:
0.0		 1zgyA-1ortA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 383
ILE A 397
ILE A 540
LEU A 407
 None
 0.79A 1zgyA-1poxA:
0.1		 1zgyA-1poxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 ILE A  74
ILE A 196
ILE A 205
MET A 260
 None
 0.83A 1zgyA-1qguA:
0.0		 1zgyA-1qguA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		4 ILE A 246
ILE A 143
ILE A  22
LEU A 206
 None
HH2  A 282 (-4.1A)
None
None
 0.94A 1zgyA-1twwA:
undetectable		 1zgyA-1twwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A  45
ILE A 370
MET A 372
LEU A  50
 None
 0.91A 1zgyA-1uokA:
undetectable		 1zgyA-1uokA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 ILE A 121
ILE A 156
ILE A 256
LEU A 135
 None
 0.84A 1zgyA-1v5wA:
undetectable		 1zgyA-1v5wA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 ILE A  12
ILE A 197
ILE A  40
MET A 140
LEU A  87
 None
 1.26A 1zgyA-1wniA:
undetectable		 1zgyA-1wniA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		4 ILE A 200
ILE A  48
ILE A 171
MET A 165
 None
 0.90A 1zgyA-2a5vA:
undetectable		 1zgyA-2a5vA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		4 ILE A  83
ILE A 190
ILE A   9
LEU A 105
 GOL  A 825 (-4.8A)
None
None
None
 0.94A 1zgyA-2a7mA:
undetectable		 1zgyA-2a7mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ILE A  83
ILE A  15
ILE A   6
LEU A 123
 None
 0.83A 1zgyA-2ahrA:
undetectable		 1zgyA-2ahrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		4 ILE A 336
ILE A 377
ILE A 369
LEU A 294
 None
 0.88A 1zgyA-2bg5A:
undetectable		 1zgyA-2bg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		4 ILE A 428
ILE A 481
ILE A 432
LEU A 520
 None
 0.89A 1zgyA-2bg5A:
undetectable		 1zgyA-2bg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ILE A  99
ILE A  95
MET A 143
LEU A 126
 None
 0.79A 1zgyA-2djzA:
undetectable		 1zgyA-2djzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 145
ILE A 214
ILE A 227
MET A 113
 None
 0.82A 1zgyA-2eklA:
undetectable		 1zgyA-2eklA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 ILE A  13
ILE A 250
ILE A 108
LEU A  46
 None
 0.86A 1zgyA-2gk3A:
undetectable		 1zgyA-2gk3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ILE A 429
ILE A 482
ILE A 433
LEU A 521
 None
 0.90A 1zgyA-2hroA:
undetectable		 1zgyA-2hroA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 ILE A 204
ILE A   8
ILE A  34
LEU A 233
 None
 0.88A 1zgyA-2nuxA:
undetectable		 1zgyA-2nuxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 688
ILE A 703
MET A 764
LEU A 574
 None
 0.74A 1zgyA-2oajA:
undetectable		 1zgyA-2oajA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ILE A  99
ILE A 154
ILE A 174
LEU A  71
 None
 0.80A 1zgyA-2odlA:
undetectable		 1zgyA-2odlA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ILE A 149
ILE A  92
ILE A  99
LEU A 136
 None
 0.94A 1zgyA-2odlA:
undetectable		 1zgyA-2odlA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A   8
ILE A  80
MET A 228
LEU A  60
 None
 0.79A 1zgyA-2ohhA:
undetectable		 1zgyA-2ohhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgg 16S RRNA-PROCESSING
PROTEIN RIMM

(Acinetobacter
calcoaceticus) 		PF01782
(RimM)
PF05239
(PRC) 		4 ILE A 174
ILE A 150
ILE A 157
MET A 141
 None
 0.80A 1zgyA-2qggA:
undetectable		 1zgyA-2qggA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		4 ILE A 210
ILE A 180
ILE A 142
LEU A 170
 None
GTP  A 300 (-3.8A)
GTP  A 300 (-4.1A)
None
 0.89A 1zgyA-2qv6A:
undetectable		 1zgyA-2qv6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb4 ATP-DEPENDENT RNA
HELICASE DDX25

(Homo sapiens) 		PF00271
(Helicase_C) 		4 ILE A 448
ILE A 409
ILE A 467
LEU A 354
 None
 0.93A 1zgyA-2rb4A:
undetectable		 1zgyA-2rb4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 ILE A 158
ILE A  70
ILE A 238
LEU A 152
 None
 0.86A 1zgyA-2vreA:
undetectable		 1zgyA-2vreA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 ILE B 422
ILE B 365
ILE B 393
MET B 315
 None
 0.93A 1zgyA-2xdqB:
undetectable		 1zgyA-2xdqB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ILE B 153
ILE B  16
ILE B 169
MET B 172
LEU B 144
 None
 1.40A 1zgyA-3ayxB:
undetectable		 1zgyA-3ayxB:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 281
ILE A 326
ILE A 341
MET A 348
LEU A 453
 MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.9A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-4.2A)
 0.37A 1zgyA-3b0qA:
40.1		 1zgyA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 ILE D 281
ILE D 326
ILE D 341
MET D 348
 PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
 0.35A 1zgyA-3dzuD:
37.2		 1zgyA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggy INCREASED SODIUM
TOLERANCE PROTEIN 1

(Saccharomyces
cerevisiae) 		PF03398
(Ist1) 		4 ILE A 116
ILE A 136
ILE A 145
LEU A  12
 None
 0.92A 1zgyA-3ggyA:
undetectable		 1zgyA-3ggyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 217
ILE A 332
MET A 189
LEU A 267
 None
 0.87A 1zgyA-3igoA:
1.0		 1zgyA-3igoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		4 ILE A  64
ILE A   7
ILE A  84
LEU A 148
 None
 0.88A 1zgyA-3in1A:
undetectable		 1zgyA-3in1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		4 ILE A 119
ILE A 100
ILE A  93
LEU A  85
 None
None
ELA  A 301 (-4.1A)
None
 0.84A 1zgyA-3lupA:
undetectable		 1zgyA-3lupA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 ILE A 185
ILE A 168
MET A  67
LEU A 198
 None
 0.91A 1zgyA-3myxA:
undetectable		 1zgyA-3myxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzy RNA POLYMERASE
SIGMA-H FACTOR

(Fusobacterium
nucleatum) 		PF04542
(Sigma70_r2) 		4 ILE A 162
ILE A 196
ILE A 188
LEU A 135
 None
 0.81A 1zgyA-3mzyA:
undetectable		 1zgyA-3mzyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 ILE A1162
ILE A1045
ILE A1074
MET A1071
 None
 0.87A 1zgyA-3pvlA:
undetectable		 1zgyA-3pvlA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 ILE A 198
ILE A 212
MET A 104
LEU A 231
 None
 0.94A 1zgyA-3t5tA:
undetectable		 1zgyA-3t5tA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u12 USP37 PROTEIN

(Homo sapiens) 		PF16674
(UCH_N) 		4 ILE A  29
ILE A  12
ILE A   6
MET A  95
 None
None
UNX  A1019 ( 4.3A)
None
 0.90A 1zgyA-3u12A:
undetectable		 1zgyA-3u12A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		4 ILE A 186
ILE A 286
ILE A 191
MET A 201
 None
 0.76A 1zgyA-3w25A:
undetectable		 1zgyA-3w25A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		4 ILE A 193
ILE A 217
ILE A 257
LEU A 175
 None
 0.78A 1zgyA-3wqoA:
undetectable		 1zgyA-3wqoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 584
ILE A1258
ILE A1052
MET A1063
 None
 0.78A 1zgyA-3zyvA:
undetectable		 1zgyA-3zyvA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A  44
ILE A 357
MET A 359
LEU A  49
 None
 0.86A 1zgyA-4aieA:
undetectable		 1zgyA-4aieA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as3 PHOSPHORYLCHOLINE
PHOSPHATASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 320
ILE A 294
MET A 291
LEU A 151
 None
 0.84A 1zgyA-4as3A:
undetectable		 1zgyA-4as3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ILE B2286
ILE B2096
ILE B2182
LEU B2161
 None
 0.94A 1zgyA-4bedB:
undetectable		 1zgyA-4bedB:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE

(Clostridioides
difficile) 		PF00155
(Aminotran_1_2) 		4 ILE A 198
ILE A 155
ILE A 114
LEU A 183
 None
 0.83A 1zgyA-4dq6A:
undetectable		 1zgyA-4dq6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A 308
ILE A 148
ILE A 126
MET A 215
 None
 0.83A 1zgyA-4e6eA:
undetectable		 1zgyA-4e6eA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egw MAGNESIUM TRANSPORT
PROTEIN CORA

(Methanocaldococcus
jannaschii) 		PF01544
(CorA) 		4 ILE A 104
ILE A 132
ILE A  48
LEU A 140
 None
 0.82A 1zgyA-4egwA:
undetectable		 1zgyA-4egwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		4 ILE B  39
ILE B 124
ILE B  55
LEU B 161
 None
 0.87A 1zgyA-4ejsB:
undetectable		 1zgyA-4ejsB:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		no annotation 4 ILE S  12
ILE S 160
ILE S 109
LEU S  48
 None
 0.91A 1zgyA-4gd3S:
undetectable		 1zgyA-4gd3S:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 ILE A 121
ILE A 156
ILE A 256
LEU A 135
 None
 0.87A 1zgyA-4hyyA:
undetectable		 1zgyA-4hyyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A  83
ILE A 418
MET A 420
LEU A  88
 None
 0.81A 1zgyA-4lxfA:
undetectable		 1zgyA-4lxfA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 540
ILE A 504
ILE A 494
LEU A 556
 None
 0.91A 1zgyA-4m7eA:
undetectable		 1zgyA-4m7eA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ILE A 221
ILE A 246
ILE A 209
LEU A 278
 None
 0.92A 1zgyA-4nsxA:
undetectable		 1zgyA-4nsxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pia AUTOLYSIN E

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase) 		4 ILE A  89
ILE A 190
ILE A 129
MET A 238
 None
 0.90A 1zgyA-4piaA:
undetectable		 1zgyA-4piaA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 ILE A 418
ILE A 266
ILE A 448
LEU A 234
 None
 0.86A 1zgyA-4r12A:
undetectable		 1zgyA-4r12A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfa LMO0740 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ILE A  90
ILE A 174
ILE A  67
LEU A  29
 None
 0.92A 1zgyA-4rfaA:
undetectable		 1zgyA-4rfaA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		4 ILE A 227
ILE A 329
ILE A 321
LEU A 201
 None
 0.78A 1zgyA-4tvmA:
undetectable		 1zgyA-4tvmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfv VIOF

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N) 		4 ILE A  72
ILE A 155
ILE A 121
LEU A  47
 None
 0.94A 1zgyA-4yfvA:
undetectable		 1zgyA-4yfvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 187
ILE A 222
ILE A 173
LEU A 256
 None
 0.93A 1zgyA-4z61A:
undetectable		 1zgyA-4z61A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 538
ILE A 573
ILE A 489
LEU A 607
 None
 0.84A 1zgyA-4z61A:
undetectable		 1zgyA-4z61A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE A 528
ILE A 563
ILE A 479
LEU A 597
 None
 0.78A 1zgyA-4z64A:
undetectable		 1zgyA-4z64A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		4 ILE A 166
ILE A 275
ILE A 241
LEU A 148
 None
 0.84A 1zgyA-4zdlA:
undetectable		 1zgyA-4zdlA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 267
ILE A 278
MET A 220
LEU A 304
 None
 0.94A 1zgyA-4zyjA:
undetectable		 1zgyA-4zyjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE S  12
ILE S 160
ILE S 109
LEU S  48
 None
 0.90A 1zgyA-5a4mS:
undetectable		 1zgyA-5a4mS:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ILE A 701
ILE A 634
ILE A 681
LEU A 381
 None
 0.94A 1zgyA-5aw4A:
undetectable		 1zgyA-5aw4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b23 UNCHARACTERIZED
PROTEIN SORTASE B

(Clostridium
perfringens) 		PF04203
(Sortase) 		4 ILE A 175
ILE A 190
ILE A 147
LEU A 204
 None
 0.88A 1zgyA-5b23A:
undetectable		 1zgyA-5b23A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		4 ILE A 108
ILE A  33
ILE A 110
LEU A  96
 None
None
SAH  A 303 ( 4.0A)
None
 0.95A 1zgyA-5bp9A:
undetectable		 1zgyA-5bp9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		4 ILE A 107
ILE A 193
ILE A 181
LEU A  96
 None
 0.77A 1zgyA-5czyA:
undetectable		 1zgyA-5czyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 ILE A 707
ILE A 753
ILE A 760
LEU A 646
 None
 0.89A 1zgyA-5czzA:
undetectable		 1zgyA-5czzA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		4 ILE A 139
ILE A  37
ILE A 203
LEU A  22
 None
 0.93A 1zgyA-5dwdA:
undetectable		 1zgyA-5dwdA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 ILE A 359
ILE A 371
ILE A 376
LEU A 306
 MLI  A 633 (-3.9A)
None
None
None
 0.89A 1zgyA-5ecuA:
undetectable		 1zgyA-5ecuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		5 ILE A  34
ILE A 237
ILE A 161
MET A 165
LEU A 114
 None
 1.32A 1zgyA-5egnA:
undetectable		 1zgyA-5egnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejh NAD KINASE 1

(Listeria
monocytogenes) 		PF01513
(NAD_kinase) 		4 ILE A  67
ILE A  62
ILE A   5
MET A  20
 None
 0.78A 1zgyA-5ejhA:
undetectable		 1zgyA-5ejhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 ILE A 112
ILE A 339
ILE A 331
MET A  31
 None
 0.92A 1zgyA-5gheA:
undetectable		 1zgyA-5gheA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE B 206
ILE B 241
ILE B 193
LEU B 275
 None
 0.94A 1zgyA-5gqrB:
undetectable		 1zgyA-5gqrB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 ILE A  62
ILE A 397
MET A 399
LEU A  67
 None
 0.86A 1zgyA-5h2tA:
undetectable		 1zgyA-5h2tA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		4 ILE B 411
ILE B 446
ILE B 398
LEU B 480
 None
 0.89A 1zgyA-5hz1B:
undetectable		 1zgyA-5hz1B:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 101
ILE A 138
MET A  90
LEU A 134
 None
 0.83A 1zgyA-5j5pA:
undetectable		 1zgyA-5j5pA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 ILE B  21
ILE B  53
ILE B 363
LEU B 529
 None
 0.87A 1zgyA-5k1cB:
undetectable		 1zgyA-5k1cB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 ILE A 173
ILE A 269
ILE A 291
LEU A 242
 None
 0.94A 1zgyA-5k8dA:
undetectable		 1zgyA-5k8dA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 ILE A 112
ILE A 339
ILE A 331
MET A  31
 None
 0.93A 1zgyA-5kucA:
2.1		 1zgyA-5kucA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		4 ILE A 952
ILE A 966
ILE A 962
LEU A 643
 None
 0.85A 1zgyA-5lrbA:
undetectable		 1zgyA-5lrbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 934
ILE A 218
ILE A 791
LEU A 914
 None
 0.94A 1zgyA-5n0cA:
undetectable		 1zgyA-5n0cA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ILE A 327
ILE A 214
ILE A 116
LEU A 258
 None
 0.93A 1zgyA-5nnyA:
undetectable		 1zgyA-5nnyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		4 ILE A 196
ILE A  79
ILE A 181
LEU A 242
 None
 0.94A 1zgyA-5vprA:
undetectable		 1zgyA-5vprA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 ILE M 288
ILE M 379
ILE M 268
LEU M 342
 None
 0.90A 1zgyA-5wc8M:
undetectable		 1zgyA-5wc8M:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wls POLLEN RECEPTOR-LIKE
KINASE 3

(Arabidopsis
thaliana) 		no annotation 4 ILE A  96
ILE A 130
ILE A  82
LEU A 165
 None
 0.85A 1zgyA-5wlsA:
undetectable		 1zgyA-5wlsA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 ILE A  95
ILE A 280
ILE A 422
LEU A 170
 None
 0.93A 1zgyA-5wvbA:
undetectable		 1zgyA-5wvbA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9w POLLEN RECEPTOR-LIKE
KINASE 6

(Arabidopsis
thaliana) 		no annotation 4 ILE B 101
ILE B 135
ILE B  87
LEU B 170
 None
 0.80A 1zgyA-5y9wB:
undetectable		 1zgyA-5y9wB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 4 ILE A 194
ILE A 296
ILE A 199
MET A 210
 None
 0.81A 1zgyA-6fheA:
undetectable		 1zgyA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 ILE D 297
ILE D 305
ILE D 108
LEU D 350
 None
 0.94A 1zgyA-6fmlD:
undetectable		 1zgyA-6fmlD:
15.25