SIMILAR PATTERNS OF AMINO ACIDS FOR 1ZEA_A_DHIA6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a6t IGG1 FAB1-IA FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP B  47
ARG B  95
PHE B 100
 None
 1.35A 1zeaH-1a6tB:
26.3
1zeaL-1a6tB:
16.7		 1zeaH-1a6tB:
67.74
1zeaL-1a6tB:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b04 PROTEIN (DNA LIGASE)

(Geobacillus
stearothermophilus) 		PF01653
(DNA_ligase_aden) 		3 TRP A 268
ARG A 272
PHE A 310
 None
 1.22A 1zeaH-1b04A:
undetectable
1zeaL-1b04A:
undetectable		 1zeaH-1b04A:
20.00
1zeaL-1b04A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		3 TRP A 367
ARG A 370
PHE A 426
 None
 1.42A 1zeaH-1fkmA:
undetectable
1zeaL-1fkmA:
undetectable		 1zeaH-1fkmA:
20.49
1zeaL-1fkmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		3 TRP 1 169
ARG 1 382
PHE 1 343
 None
 1.39A 1zeaH-1gff1:
0.3
1zeaL-1gff1:
0.2		 1zeaH-1gff1:
20.88
1zeaL-1gff1:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 TRP A 309
ARG A 281
PHE A 319
 None
 1.44A 1zeaH-1kczA:
undetectable
1zeaL-1kczA:
undetectable		 1zeaH-1kczA:
19.33
1zeaL-1kczA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		3 TRP A 380
ARG A 338
PHE A 388
 None
 1.27A 1zeaH-1lmlA:
undetectable
1zeaL-1lmlA:
undetectable		 1zeaH-1lmlA:
20.18
1zeaL-1lmlA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG

(Staphylococcus
aureus) 		PF02898
(NO_synthase) 		3 TRP A  68
ARG A  65
PHE A 299
 None
 0.97A 1zeaH-1mjtA:
undetectable
1zeaL-1mjtA:
undetectable		 1zeaH-1mjtA:
21.94
1zeaL-1mjtA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qgc PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP A  47
ARG A  99
PHE A 107
 None
 1.11A 1zeaH-1qgcA:
23.7
1zeaL-1qgcA:
14.6		 1zeaH-1qgcA:
66.82
1zeaL-1qgcA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		3 TRP A 294
ARG A 103
PHE A  99
 None
 1.36A 1zeaH-1ru3A:
0.0
1zeaL-1ru3A:
undetectable		 1zeaH-1ru3A:
14.21
1zeaL-1ru3A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 3 TRP A 234
ARG A 130
PHE A 108
 None
 1.47A 1zeaH-1ufoA:
undetectable
1zeaL-1ufoA:
undetectable		 1zeaH-1ufoA:
20.37
1zeaL-1ufoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upi DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Mycobacterium
tuberculosis) 		PF00908
(dTDP_sugar_isom) 		3 TRP A  29
ARG A 108
PHE A  27
 None
 1.43A 1zeaH-1upiA:
undetectable
1zeaL-1upiA:
undetectable		 1zeaH-1upiA:
20.32
1zeaL-1upiA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zea MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP H  47
ARG H  95
PHE H 100
 None
 1.30A 1zeaH-1zeaH:
33.2
1zeaL-1zeaH:
16.3		 1zeaH-1zeaH:
100.00
1zeaL-1zeaH:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		3 TRP A  68
ARG A  65
PHE A 308
 None
 1.05A 1zeaH-2an2A:
undetectable
1zeaL-2an2A:
undetectable		 1zeaH-2an2A:
19.50
1zeaL-2an2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 TRP A 399
ARG A  46
PHE A  49
 None
 1.30A 1zeaH-2cfzA:
undetectable
1zeaL-2cfzA:
undetectable		 1zeaH-2cfzA:
15.31
1zeaL-2cfzA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 TRP A 165
ARG A 202
PHE A 191
 None
 1.48A 1zeaH-2cxeA:
undetectable
1zeaL-2cxeA:
undetectable		 1zeaH-2cxeA:
19.26
1zeaL-2cxeA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flq NITRIC OXIDE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF02898
(NO_synthase) 		3 TRP A  82
ARG A  79
PHE A 317
 None
 0.97A 1zeaH-2flqA:
undetectable
1zeaL-2flqA:
undetectable		 1zeaH-2flqA:
20.79
1zeaL-2flqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		3 TRP A 139
ARG A 166
PHE A 162
 None
 1.48A 1zeaH-2ibdA:
undetectable
1zeaL-2ibdA:
undetectable		 1zeaH-2ibdA:
19.28
1zeaL-2ibdA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifx HYPOTHETICAL PROTEIN

(Cupriavidus
necator) 		PF09448
(MmlI) 		3 TRP A  87
ARG A  84
PHE A  88
 None
 1.50A 1zeaH-2ifxA:
undetectable
1zeaL-2ifxA:
undetectable		 1zeaH-2ifxA:
20.85
1zeaL-2ifxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOUB PROTEIN

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF06234
(TmoB) 		3 TRP A 373
ARG C  42
PHE C  14
 None
 0.99A 1zeaH-2incA:
undetectable
1zeaL-2incA:
undetectable		 1zeaH-2incA:
19.79
1zeaL-2incA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixc DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
RMLC

(Mycobacterium
tuberculosis) 		PF00908
(dTDP_sugar_isom) 		3 TRP A  29
ARG A 108
PHE A  27
 None
 1.48A 1zeaH-2ixcA:
undetectable
1zeaL-2ixcA:
undetectable		 1zeaH-2ixcA:
21.30
1zeaL-2ixcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwj TYPE III EXPORT
PROTEIN PSCE
TYPE III EXPORT
PROTEIN PSCG

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF08988
(T3SS_needle_E)
PF09477
(Type_III_YscG) 		3 TRP G  31
ARG G  34
PHE E  49
 NI  E1072 (-4.8A)
None
NI  E1072 (-2.9A)
 1.42A 1zeaH-2uwjG:
undetectable
1zeaL-2uwjG:
undetectable		 1zeaH-2uwjG:
17.51
1zeaL-2uwjG:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		3 TRP A 158
ARG A 131
PHE A 161
 None
None
ACT  A1384 (-3.7A)
 1.50A 1zeaH-2vatA:
undetectable
1zeaL-2vatA:
undetectable		 1zeaH-2vatA:
16.14
1zeaL-2vatA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 TRP A  95
ARG A  97
PHE A 103
 None
 1.32A 1zeaH-2veaA:
undetectable
1zeaL-2veaA:
undetectable		 1zeaH-2veaA:
18.00
1zeaL-2veaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		3 TRP A 312
ARG A 304
PHE A 255
 None
 1.33A 1zeaH-2w9mA:
undetectable
1zeaL-2w9mA:
undetectable		 1zeaH-2w9mA:
17.56
1zeaL-2w9mA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 TRP A 335
ARG A 344
PHE A 337
 PEG  A1622 ( 4.0A)
None
None
 1.44A 1zeaH-2xydA:
undetectable
1zeaL-2xydA:
undetectable		 1zeaH-2xydA:
15.41
1zeaL-2xydA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 TRP A 467
ARG A 199
PHE A 462
 MAW  A1003 (-3.8A)
MAW  A1003 (-3.7A)
MAW  A1003 (-4.4A)
 1.25A 1zeaH-3aflA:
4.5
1zeaL-3aflA:
4.3		 1zeaH-3aflA:
13.69
1zeaL-3aflA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d37 TAIL PROTEIN, 43 KDA

(Neisseria
meningitidis) 		no annotation 3 TRP A 295
ARG A 319
PHE A 321
 None
 1.02A 1zeaH-3d37A:
undetectable
1zeaL-3d37A:
undetectable		 1zeaH-3d37A:
18.02
1zeaL-3d37A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		3 TRP A 219
ARG A 380
PHE A 376
 None
 1.39A 1zeaH-3e1tA:
undetectable
1zeaL-3e1tA:
undetectable		 1zeaH-3e1tA:
17.23
1zeaL-3e1tA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4d ESTERASE D

(Agrobacterium
fabrum) 		PF00756
(Esterase) 		3 TRP A  47
ARG A 163
PHE A 164
 None
 1.49A 1zeaH-3e4dA:
undetectable
1zeaL-3e4dA:
undetectable		 1zeaH-3e4dA:
21.60
1zeaL-3e4dA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfk 4-METHYLMUCONOLACTON
E METHYLISOMERASE

(Pseudomonas
reinekei) 		PF09448
(MmlI) 		3 TRP A  87
ARG A  84
PHE A  88
 4ML  A 201 (-4.4A)
4ML  A 202 (-3.5A)
4ML  A 201 ( 3.6A)
 1.14A 1zeaH-3hfkA:
undetectable
1zeaL-3hfkA:
undetectable		 1zeaH-3hfkA:
19.19
1zeaL-3hfkA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		3 TRP A  29
ARG A  32
PHE A 247
 None
 1.40A 1zeaH-3hoaA:
undetectable
1zeaL-3hoaA:
undetectable		 1zeaH-3hoaA:
15.55
1zeaL-3hoaA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		3 TRP A 215
ARG A 374
PHE A 370
 None
 1.33A 1zeaH-3i3lA:
undetectable
1zeaL-3i3lA:
undetectable		 1zeaH-3i3lA:
15.70
1zeaL-3i3lA:
17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ifl 12A11 FAB ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP H  49
ARG H 100
PHE H 107
 None
 1.43A 1zeaH-3iflH:
18.9
1zeaL-3iflH:
17.3		 1zeaH-3iflH:
66.97
1zeaL-3iflH:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itq PROLYL
4-HYDROXYLASE, ALPHA
SUBUNIT DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13640
(2OG-FeII_Oxy_3) 		3 TRP A 209
ARG A 211
PHE A 131
 GOL  A 968 (-4.4A)
None
None
 1.48A 1zeaH-3itqA:
undetectable
1zeaL-3itqA:
undetectable		 1zeaH-3itqA:
21.12
1zeaL-3itqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		3 TRP A 284
ARG A 410
PHE A 406
 None
 1.31A 1zeaH-3k11A:
undetectable
1zeaL-3k11A:
undetectable		 1zeaH-3k11A:
17.78
1zeaL-3k11A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 TRP A 727
ARG A 648
PHE A 646
 None
 1.40A 1zeaH-3k1dA:
4.0
1zeaL-3k1dA:
2.3		 1zeaH-3k1dA:
14.52
1zeaL-3k1dA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld1 REPLICASE
POLYPROTEIN 1A

(Avian
coronavirus) 		no annotation 3 TRP A 137
ARG A  41
PHE A  25
 None
 1.36A 1zeaH-3ld1A:
undetectable
1zeaL-3ld1A:
undetectable		 1zeaH-3ld1A:
20.56
1zeaL-3ld1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TRP A 408
ARG A 405
PHE A 470
 None
 1.23A 1zeaH-3nqpA:
undetectable
1zeaL-3nqpA:
undetectable		 1zeaH-3nqpA:
16.33
1zeaL-3nqpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oby PROTEIN PELOTA
HOMOLOG

(Archaeoglobus
fulgidus) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 TRP A  26
ARG A  29
PHE A  72
 None
 1.21A 1zeaH-3obyA:
undetectable
1zeaL-3obyA:
undetectable		 1zeaH-3obyA:
20.22
1zeaL-3obyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		3 TRP A 298
ARG A 175
PHE A 292
 None
 1.49A 1zeaH-3p9uA:
undetectable
1zeaL-3p9uA:
undetectable		 1zeaH-3p9uA:
19.30
1zeaL-3p9uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 TRP A1498
ARG A1490
PHE A1492
 None
 1.15A 1zeaH-3ptaA:
undetectable
1zeaL-3ptaA:
undetectable		 1zeaH-3ptaA:
13.01
1zeaL-3ptaA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		3 TRP A 302
ARG A 271
PHE A 291
 None
 1.22A 1zeaH-3q6tA:
undetectable
1zeaL-3q6tA:
undetectable		 1zeaH-3q6tA:
19.94
1zeaL-3q6tA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		3 TRP A 141
ARG A 262
PHE A 246
 None
 1.43A 1zeaH-3rd5A:
undetectable
1zeaL-3rd5A:
undetectable		 1zeaH-3rd5A:
20.54
1zeaL-3rd5A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		3 TRP A 233
ARG A 229
PHE A 270
 None
 1.43A 1zeaH-3szbA:
undetectable
1zeaL-3szbA:
undetectable		 1zeaH-3szbA:
18.31
1zeaL-3szbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA
F420-REDUCING
HYDROGENASE, SUBUNIT
BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6)
PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		3 TRP B 264
ARG B 261
PHE C 281
 None
SF4  C1282 ( 4.4A)
None
 1.22A 1zeaH-4ci0B:
undetectable
1zeaL-4ci0B:
undetectable		 1zeaH-4ci0B:
20.79
1zeaL-4ci0B:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		3 TRP A  99
ARG A 217
PHE A  91
 None
 1.40A 1zeaH-4g1cA:
undetectable
1zeaL-4g1cA:
undetectable		 1zeaH-4g1cA:
20.22
1zeaL-4g1cA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gri GLUTAMATE--TRNA
LIGASE

(Borreliella
burgdorferi) 		PF00749
(tRNA-synt_1c) 		3 TRP A 392
ARG A 479
PHE A 384
 None
 1.31A 1zeaH-4griA:
undetectable
1zeaL-4griA:
undetectable		 1zeaH-4griA:
16.93
1zeaL-4griA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht4 NICKING ENZYME

(Staphylococcus
aureus) 		PF03389
(MobA_MobL) 		3 TRP A 169
ARG A 170
PHE A   6
 None
 1.48A 1zeaH-4ht4A:
2.1
1zeaL-4ht4A:
undetectable		 1zeaH-4ht4A:
21.89
1zeaL-4ht4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		3 TRP A  91
ARG A  94
PHE A 133
 None
 1.41A 1zeaH-4m2gA:
undetectable
1zeaL-4m2gA:
undetectable		 1zeaH-4m2gA:
18.28
1zeaL-4m2gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 TRP A 410
ARG A  56
PHE A  59
 None
 1.40A 1zeaH-4pdxA:
undetectable
1zeaL-4pdxA:
undetectable		 1zeaH-4pdxA:
17.76
1zeaL-4pdxA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		3 TRP A 490
ARG A 544
PHE A 540
 None
 1.49A 1zeaH-4r89A:
undetectable
1zeaL-4r89A:
undetectable		 1zeaH-4r89A:
15.81
1zeaL-4r89A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		3 TRP A  61
ARG A 153
PHE A  53
 None
 1.40A 1zeaH-4twiA:
undetectable
1zeaL-4twiA:
undetectable		 1zeaH-4twiA:
20.54
1zeaL-4twiA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uao IMMUNOGLOBULIN R31C2
VH AND CH1 REGIONS

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP C  47
ARG C  95
PHE C 100
 None
 1.25A 1zeaH-4uaoC:
24.8
1zeaL-4uaoC:
15.1		 1zeaH-4uaoC:
67.87
1zeaL-4uaoC:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt0 PROTEIN LIGF

(Sphingobium sp.
SYK-6) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 TRP A 115
ARG A 150
PHE A 155
 None
 1.39A 1zeaH-4xt0A:
undetectable
1zeaL-4xt0A:
undetectable		 1zeaH-4xt0A:
21.15
1zeaL-4xt0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 TRP B 241
ARG B 122
PHE B 254
 None
 1.45A 1zeaH-4ztuB:
undetectable
1zeaL-4ztuB:
undetectable		 1zeaH-4ztuB:
18.70
1zeaL-4ztuB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		3 TRP A 580
ARG A 578
PHE A 542
 None
 1.36A 1zeaH-4zu9A:
undetectable
1zeaL-4zu9A:
undetectable		 1zeaH-4zu9A:
14.51
1zeaL-4zu9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 TRP A 125
ARG A 126
PHE A 117
 XP4  A1404 ( 4.4A)
None
None
 1.06A 1zeaH-4zxiA:
undetectable
1zeaL-4zxiA:
undetectable		 1zeaH-4zxiA:
10.25
1zeaL-4zxiA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 TRP B 241
ARG B 122
PHE B 254
 None
 1.45A 1zeaH-5c53B:
undetectable
1zeaL-5c53B:
undetectable		 1zeaH-5c53B:
12.56
1zeaL-5c53B:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 3 TRP A 557
ARG A 497
PHE A 495
 None
 1.34A 1zeaH-5h2tA:
undetectable
1zeaL-5h2tA:
undetectable		 1zeaH-5h2tA:
15.75
1zeaL-5h2tA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		3 TRP A 420
ARG A 378
PHE A 404
 None
 1.44A 1zeaH-5huuA:
undetectable
1zeaL-5huuA:
undetectable		 1zeaH-5huuA:
16.91
1zeaL-5huuA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		3 TRP A 427
ARG A 385
PHE A 411
 None
 1.47A 1zeaH-5hvmA:
undetectable
1zeaL-5hvmA:
undetectable		 1zeaH-5hvmA:
17.81
1zeaL-5hvmA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		3 TRP A 427
ARG A 385
PHE A 411
 None
 1.47A 1zeaH-5hvoA:
undetectable
1zeaL-5hvoA:
undetectable		 1zeaH-5hvoA:
18.83
1zeaL-5hvoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 TRP A1131
ARG A1187
PHE A1133
 None
 1.41A 1zeaH-5i6iA:
undetectable
1zeaL-5i6iA:
undetectable		 1zeaH-5i6iA:
7.49
1zeaL-5i6iA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlw HOMEOTIC PROTEIN
ANTENNAPEDIA

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		3 TRP A  56
ARG A  53
PHE A  20
 None
 1.45A 1zeaH-5jlwA:
undetectable
1zeaL-5jlwA:
undetectable		 1zeaH-5jlwA:
12.50
1zeaL-5jlwA:
14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP A  47
ARG A  99
PHE A 105
 None
 1.20A 1zeaH-5kn5A:
21.5
1zeaL-5kn5A:
17.4		 1zeaH-5kn5A:
59.63
1zeaL-5kn5A:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7n PLEXIN-A1

(Mus musculus) 		PF01833
(TIG) 		3 TRP A1003
ARG A1004
PHE A1001
 None
 1.45A 1zeaH-5l7nA:
4.1
1zeaL-5l7nA:
4.7		 1zeaH-5l7nA:
21.97
1zeaL-5l7nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcl DNA REPAIR PROTEIN
RAD14

(Saccharomyces
cerevisiae) 		PF05181
(XPA_C) 		3 TRP A 291
ARG A 294
PHE A 237
 None
 1.37A 1zeaH-5lclA:
undetectable
1zeaL-5lclA:
undetectable		 1zeaH-5lclA:
17.51
1zeaL-5lclA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcl DNA REPAIR PROTEIN
RAD14

(Saccharomyces
cerevisiae) 		PF05181
(XPA_C) 		3 TRP B 291
ARG B 294
PHE B 237
 None
 1.40A 1zeaH-5lclB:
undetectable
1zeaL-5lclB:
undetectable		 1zeaH-5lclB:
18.28
1zeaL-5lclB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 TRP A1649
ARG A1646
PHE A1170
 None
 1.48A 1zeaH-5lkzA:
undetectable
1zeaL-5lkzA:
undetectable		 1zeaH-5lkzA:
16.55
1zeaL-5lkzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		3 TRP A  86
ARG A  78
PHE A  57
 None
 1.26A 1zeaH-5m09A:
undetectable
1zeaL-5m09A:
undetectable		 1zeaH-5m09A:
22.06
1zeaL-5m09A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 TRP A4185
ARG A4271
PHE A4268
 None
 1.42A 1zeaH-5nugA:
undetectable
1zeaL-5nugA:
undetectable		 1zeaH-5nugA:
4.35
1zeaL-5nugA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 TRP A1687
ARG A1684
PHE A1207
 None
 1.46A 1zeaH-5u7gA:
undetectable
1zeaL-5u7gA:
undetectable		 1zeaH-5u7gA:
16.29
1zeaL-5u7gA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 TRP A 180
ARG A 211
PHE A 213
 None
 1.48A 1zeaH-5ujzA:
undetectable
1zeaL-5ujzA:
undetectable		 1zeaH-5ujzA:
19.70
1zeaL-5ujzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwo ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF05291
(Bystin) 		3 TRP A 417
ARG A 411
PHE A 364
 None
 1.08A 1zeaH-5wwoA:
undetectable
1zeaL-5wwoA:
undetectable		 1zeaH-5wwoA:
20.29
1zeaL-5wwoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		3 TRP J  41
ARG J  38
PHE J  10
 None
C  2 404 ( 4.2A)
None
 1.35A 1zeaH-5xyiJ:
undetectable
1zeaL-5xyiJ:
undetectable		 1zeaH-5xyiJ:
21.21
1zeaL-5xyiJ:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN

(Mus musculus) 		no annotation 3 TRP A 293
ARG A 204
PHE A 237
 None
 1.31A 1zeaH-5z1wA:
undetectable
1zeaL-5z1wA:
undetectable		 1zeaH-5z1wA:
undetectable
1zeaL-5z1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 3 TRP A  48
ARG A  49
PHE A 323
 None
 1.29A 1zeaH-5zqjA:
undetectable
1zeaL-5zqjA:
undetectable		 1zeaH-5zqjA:
undetectable
1zeaL-5zqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY

(Thermobifida
fusca) 		no annotation 3 TRP G 888
ARG G 622
PHE G 944
 None
 1.39A 1zeaH-6c66G:
undetectable
1zeaL-6c66G:
undetectable		 1zeaH-6c66G:
undetectable
1zeaL-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 3 TRP B 312
ARG B  18
PHE B 300
 None
 1.30A 1zeaH-6c6lB:
undetectable
1zeaL-6c6lB:
undetectable		 1zeaH-6c6lB:
undetectable
1zeaL-6c6lB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Danio rerio) 		no annotation 3 TRP A  95
ARG A 213
PHE A  87
 None
 1.43A 1zeaH-6enxA:
undetectable
1zeaL-6enxA:
undetectable		 1zeaH-6enxA:
21.53
1zeaL-6enxA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 3 TRP A 210
ARG A 188
PHE A 203
 None
 1.09A 1zeaH-6eoqA:
undetectable
1zeaL-6eoqA:
undetectable		 1zeaH-6eoqA:
undetectable
1zeaL-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 TRP A 237
ARG A 215
PHE A 230
 None
 0.86A 1zeaH-6eotA:
undetectable
1zeaL-6eotA:
undetectable		 1zeaH-6eotA:
undetectable
1zeaL-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 TRP i 417
ARG i 411
PHE i 364
 None
 1.08A 1zeaH-6faii:
undetectable
1zeaL-6faii:
undetectable		 1zeaH-6faii:
undetectable
1zeaL-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL

(endosymbiont of
Tevnia
jerichonana) 		no annotation 3 TRP A  75
ARG A  74
PHE A 137
 None
 0.90A 1zeaH-6fvsA:
2.5
1zeaL-6fvsA:
3.1		 1zeaH-6fvsA:
undetectable
1zeaL-6fvsA:
undetectable