SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z9H_D_IMND476

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 5 PRO A  79
PRO A  35
SER A  56
ILE A  57
LEU A  87
 None
HEM  A 120 (-4.8A)
None
HEM  A 120 (-4.2A)
None
 1.22A 1z9hD-1c2rA:
undetectable		 1z9hD-1c2rA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqk CH3 DOMAIN OF MAK33
ANTIBODY

(Mus musculus) 		PF07654
(C1-set) 		5 THR A  55
PRO A  57
ILE A  38
VAL A  40
VAL A  67
 None
 1.17A 1z9hD-1cqkA:
undetectable		 1z9hD-1cqkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		5 PRO A 580
SER A 695
TYR A 694
ILE A 698
LEU A 639
 None
 1.00A 1z9hD-1d5fA:
0.0		 1z9hD-1d5fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Escherichia
coli) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		6 THR A  49
ILE A  19
VAL A  21
TYR A  26
ILE A   2
VAL A  47
 None
 1.41A 1z9hD-1d8lA:
1.1		 1z9hD-1d8lA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		5 THR A 130
ILE A 290
TYR A 103
VAL A 129
LEU A 101
 None
 1.23A 1z9hD-1dhsA:
0.0		 1z9hD-1dhsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo9
PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		5 ILE B 461
VAL B 399
TYR B 437
ILE B 525
VAL B 380
 None
 1.18A 1z9hD-1eo9B:
undetectable		 1z9hD-1eo9B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 THR A 359
CYH A 358
PRO A 357
ILE A 342
VAL A 345
 None
 1.20A 1z9hD-1epvA:
0.0		 1z9hD-1epvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igy IGG1 INTACT ANTIBODY
MAB61.1.3

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR B 422
PRO B 424
ILE B 400
VAL B 402
VAL B 437
 None
 1.22A 1z9hD-1igyB:
undetectable		 1z9hD-1igyB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 PRO A  67
ILE A 401
VAL A  35
ILE A 411
LEU A  37
 None
 1.20A 1z9hD-1kcxA:
0.0		 1z9hD-1kcxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 ILE A 237
VAL A 239
TYR A 257
ILE A 258
LEU A 204
 None
 1.02A 1z9hD-1kczA:
undetectable		 1z9hD-1kczA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 ILE A 237
VAL A 239
TYR A 257
ILE A 258
LEU A 204
 None
 1.02A 1z9hD-1kkrA:
undetectable		 1z9hD-1kkrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 CYH A 483
PRO A 484
ILE A 521
SER A 355
VAL A 525
 MYR  A   1 ( 4.5A)
None
None
None
None
 1.14A 1z9hD-1opkA:
undetectable		 1z9hD-1opkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 THR A 212
ILE A 155
VAL A 153
VAL A 214
LEU A 237
 None
 1.22A 1z9hD-1q1rA:
undetectable		 1z9hD-1q1rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		5 THR A  98
ILE A 127
VAL A  30
VAL A  99
LEU A  28
 GOL  A 902 ( 4.8A)
None
None
None
None
 1.13A 1z9hD-1q3kA:
undetectable		 1z9hD-1q3kA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)

(Rattus
norvegicus) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 THR A1269
ILE A1130
VAL A1124
ILE A1016
LEU A1078
 None
 1.22A 1z9hD-1qqfA:
undetectable		 1z9hD-1qqfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 THR A 176
ILE A 169
VAL A 152
SER A 189
LEU A 184
 None
 1.23A 1z9hD-1sezA:
undetectable		 1z9hD-1sezA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		6 THR X  71
PRO X 301
ILE X  79
VAL X  31
TYR X  83
ILE X 150
 None
 1.20A 1z9hD-1ul1X:
undetectable		 1z9hD-1ul1X:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		5 PRO A  36
ILE A 421
VAL A 381
SER A 365
ILE A 368
 None
 1.17A 1z9hD-1xkdA:
undetectable		 1z9hD-1xkdA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 THR A 248
CYH A 264
ILE A 268
ILE A 245
VAL A 250
 None
ZN  A 501 (-2.2A)
None
None
None
 1.09A 1z9hD-1z6rA:
undetectable		 1z9hD-1z6rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 THR B 445
ILE B 296
VAL B 300
TYR B 441
ILE B 442
 None
 1.16A 1z9hD-2bg9B:
2.4		 1z9hD-2bg9B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes) 		5 THR A 574
ILE A 582
VAL A 594
ILE A 208
LEU A 597
 None
 1.14A 1z9hD-2bw3A:
undetectable		 1z9hD-2bw3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		5 ILE A 172
VAL A 193
TYR A 153
ILE A 178
LEU A 194
 None
 1.23A 1z9hD-2grmA:
3.0		 1z9hD-2grmA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		6 THR A 288
CYH A 287
SER A  61
TYR A 180
ILE A 181
LEU A 291
 NDP  A 501 (-4.2A)
None
None
None
None
None
 1.31A 1z9hD-2gv8A:
undetectable		 1z9hD-2gv8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3r ZGC 92866

(Danio rerio) 		PF04051
(TRAPP) 		5 THR B 143
ILE B  89
VAL B  93
VAL B 147
LEU B  65
 None
 1.23A 1z9hD-2j3rB:
undetectable		 1z9hD-2j3rB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE

(Acanthamoeba
polyphaga
mimivirus) 		PF00579
(tRNA-synt_1b) 		5 PRO A 258
ILE A 259
VAL A 303
ILE A 232
LEU A 267
 PRO  A 258 ( 1.1A)
ILE  A 259 ( 0.7A)
VAL  A 303 ( 0.6A)
ILE  A 232 ( 0.7A)
LEU  A 267 ( 0.6A)
 1.15A 1z9hD-2j5bA:
2.7		 1z9hD-2j5bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		5 ILE A 128
VAL A  90
TYR A  92
VAL A 116
LEU A  52
 None
 1.08A 1z9hD-2jepA:
undetectable		 1z9hD-2jepA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocz 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
pyogenes) 		PF01487
(DHquinase_I) 		5 VAL A   4
TYR A 198
TYR A  92
ILE A 114
LEU A  28
 None
 1.11A 1z9hD-2oczA:
undetectable		 1z9hD-2oczA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbj PROSTAGLANDIN E
SYNTHASE 2

(Macaca
fascicularis) 		PF13417
(GST_N_3) 		12 THR A 109
CYH A 110
PRO A 111
PRO A 134
ILE A 246
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
HEM  A 476 ( 3.8A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.35A 1z9hD-2pbjA:
44.7		 1z9hD-2pbjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppw CONSERVED DOMAIN
PROTEIN

(Streptococcus
pneumoniae) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 THR A  70
ILE A   3
VAL A  65
ILE A   6
LEU A  60
 None
 1.21A 1z9hD-2ppwA:
undetectable		 1z9hD-2ppwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 ILE A 124
VAL A 178
TYR A  42
VAL A  57
LEU A  72
 None
 1.12A 1z9hD-2rd5A:
undetectable		 1z9hD-2rd5A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		5 THR A 223
ILE A 292
SER A 280
ILE A 282
LEU A 294
 None
 1.22A 1z9hD-2vrkA:
undetectable		 1z9hD-2vrkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 5 THR A  16
PRO A 122
SER A 189
TYR A 187
ILE A  63
 None
 1.22A 1z9hD-2x5qA:
undetectable		 1z9hD-2x5qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		5 THR A 179
VAL A 195
TYR A 177
ILE A 214
LEU A 198
 None
 1.19A 1z9hD-2x7vA:
undetectable		 1z9hD-2x7vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqw COMPLEMENT C3

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 THR A 276
ILE A 137
VAL A 131
ILE A  23
LEU A  85
 None
 1.21A 1z9hD-2xqwA:
2.0		 1z9hD-2xqwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 THR B1247
ILE B1108
VAL B1102
ILE B 994
LEU B1056
 None
 1.15A 1z9hD-2xwbB:
2.2		 1z9hD-2xwbB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzh PROBABLE THIOL
PEROXIDASE

(Aquifex
aeolicus) 		PF08534
(Redoxin) 		5 THR A  52
PRO A  54
ILE A 152
VAL A   5
LEU A  14
 None
 1.20A 1z9hD-2yzhA:
1.7		 1z9hD-2yzhA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 PRO A 431
ILE A 481
VAL A 475
ILE A 444
LEU A 472
 None
 1.10A 1z9hD-2zy2A:
2.2		 1z9hD-2zy2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		5 PRO A 233
ILE A 105
VAL A 107
TYR A  76
VAL A 131
 None
 1.17A 1z9hD-3ailA:
undetectable		 1z9hD-3ailA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 657
VAL A 689
SER A 644
ILE A 643
VAL A 669
 None
 1.20A 1z9hD-3bwtA:
3.1		 1z9hD-3bwtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmn PUTATIVE DNA
HELICASE

(Lactobacillus
plantarum) 		PF13538
(UvrD_C_2) 		5 THR A 608
ILE A 733
VAL A 713
ILE A 604
LEU A 743
 None
ACT  A   6 (-4.3A)
None
None
None
 1.11A 1z9hD-3dmnA:
undetectable		 1z9hD-3dmnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy7 CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 3

(Homo sapiens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 THR A 218
CYH A 219
PRO A 220
VAL A  10
LEU A  41
 None
 1.20A 1z9hD-3fy7A:
9.8		 1z9hD-3fy7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj7 TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF11734
(TilS_C) 		5 PRO A 377
PRO A 364
VAL A 343
SER A 357
LEU A 341
 None
 1.01A 1z9hD-3hj7A:
undetectable		 1z9hD-3hj7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 PRO A 942
PRO A 902
ILE A 884
ILE A 928
VAL A 945
 None
 1.11A 1z9hD-3iayA:
2.6		 1z9hD-3iayA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 PRO A 942
PRO A 902
ILE A 884
TYR A 957
VAL A 945
 None
 1.07A 1z9hD-3iayA:
2.6		 1z9hD-3iayA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 PRO A 597
ILE A 442
SER A 454
VAL A 390
LEU A 490
 None
 1.20A 1z9hD-3ixwA:
0.5		 1z9hD-3ixwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		5 THR C 124
PRO C 126
TYR C 174
ILE C 170
VAL C 123
 None
 1.23A 1z9hD-3j7aC:
undetectable		 1z9hD-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		5 PRO B 588
ILE B 573
VAL B 569
VAL B 492
LEU B 566
 None
 1.15A 1z9hD-3jb9B:
undetectable		 1z9hD-3jb9B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbb ALLOPHYCOCYANIN BETA
CHAIN

(Halomicronema
hongdechloris) 		PF00502
(Phycobilisome) 		5 THR B 126
ILE B 156
TYR B 116
ILE B 123
LEU B 112
 CYC  B 201 (-4.2A)
None
CYC  B 201 (-4.9A)
SO4  B 203 (-4.2A)
CYC  B 201 ( 4.4A)
 1.04A 1z9hD-3jbbB:
undetectable		 1z9hD-3jbbB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens) 		PF00168
(C2) 		5 CYH A1605
ILE A1568
VAL A1545
ILE A1625
LEU A1543
 None
 1.08A 1z9hD-3jzyA:
undetectable		 1z9hD-3jzyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PRO A 229
ILE A 336
TYR A 307
VAL A 325
LEU A 400
 None
 1.14A 1z9hD-3kzuA:
undetectable		 1z9hD-3kzuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyw YBBR FAMILY PROTEIN

(Desulfitobacterium
hafniense) 		no annotation 5 THR A  31
ILE A  74
VAL A  63
ILE A  69
LEU A   7
 None
 1.24A 1z9hD-3lywA:
undetectable		 1z9hD-3lywA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg3 ORANGE
CAROTENOID-BINDING
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 PRO A 226
PRO A 103
ILE A 286
VAL A 273
LEU A 250
 GOL  A 326 (-3.8A)
GOL  A 325 ( 3.8A)
ECH  A 351 ( 4.2A)
ECH  A 351 (-4.1A)
ECH  A 351 ( 3.6A)
 1.21A 1z9hD-3mg3A:
undetectable		 1z9hD-3mg3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		5 THR A 430
ILE A 456
VAL A 488
ILE A 465
LEU A 477
 None
 1.18A 1z9hD-3nvqA:
undetectable		 1z9hD-3nvqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owv DNA-ENTRY NUCLEASE

(Streptococcus
pneumoniae) 		PF01223
(Endonuclease_NS) 		5 THR A 187
PRO A  49
VAL A 233
TYR A 265
VAL A 156
 None
 1.23A 1z9hD-3owvA:
undetectable		 1z9hD-3owvA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdd GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		no annotation 5 THR A  82
ILE A  19
SER A   6
ILE A   4
VAL A  84
 None
 1.02A 1z9hD-3pddA:
undetectable		 1z9hD-3pddA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdg FIBRONECTIN(III)-LIK
E MODULE

(Ruminiclostridium
thermocellum) 		no annotation 5 THR A  82
ILE A  19
SER A   6
ILE A   4
VAL A  84
 None
 0.97A 1z9hD-3pdgA:
undetectable		 1z9hD-3pdgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qoy 50S RIBOSOMAL
PROTEIN L1

(Aquifex
aeolicus) 		PF00687
(Ribosomal_L1) 		5 THR A 148
PRO A 144
PRO A 178
VAL A 128
VAL A 149
 None
 1.12A 1z9hD-3qoyA:
undetectable		 1z9hD-3qoyA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Yersinia pestis) 		PF01557
(FAA_hydrolase) 		5 THR A 161
PRO A 192
ILE A  71
VAL A  98
LEU A 208
 None
 1.20A 1z9hD-3s52A:
undetectable		 1z9hD-3s52A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		5 PRO A 186
ILE A 291
VAL A 259
ILE A 165
VAL A 151
 None
 1.20A 1z9hD-3t8jA:
undetectable		 1z9hD-3t8jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		5 ILE A  19
VAL A  84
TYR A  82
VAL A  93
LEU A 108
 None
 1.19A 1z9hD-3v48A:
undetectable		 1z9hD-3v48A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		5 ILE A  65
VAL A   9
ILE A  61
VAL A  80
LEU A  99
 None
 1.17A 1z9hD-3w3sA:
undetectable		 1z9hD-3w3sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		5 PRO A 140
ILE A 366
TYR A 129
ILE A 361
VAL A 324
 None
 1.02A 1z9hD-3zmrA:
undetectable		 1z9hD-3zmrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 THR A 535
ILE A 688
SER A 531
VAL A 536
LEU A 704
 ACP  A 900 (-3.9A)
None
ACP  A 900 (-3.9A)
None
None
 1.13A 1z9hD-4ayxA:
4.7		 1z9hD-4ayxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 THR B 445
ILE B 296
VAL B 300
TYR B 441
ILE B 442
 None
 1.15A 1z9hD-4booB:
2.4		 1z9hD-4booB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		5 THR B 129
ILE B 169
TYR B 119
ILE B 126
LEU B 115
 CYC  B 201 (-4.2A)
None
None
None
CYC  B 201 ( 4.9A)
 1.01A 1z9hD-4f0uB:
undetectable		 1z9hD-4f0uB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 ILE M 426
VAL M 509
SER M 435
ILE M 433
VAL M 470
 None
 1.17A 1z9hD-4gq2M:
undetectable		 1z9hD-4gq2M:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt7 IG EPSILON CHAIN C
REGION

(Homo sapiens) 		PF07654
(C1-set) 		5 THR A 493
PRO A 495
ILE A 474
VAL A 476
VAL A 505
 None
 1.18A 1z9hD-4gt7A:
undetectable		 1z9hD-4gt7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		5 PRO A 100
ILE A  62
VAL A 135
VAL A 104
LEU A  43
 None
 1.13A 1z9hD-4hl7A:
undetectable		 1z9hD-4hl7A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		5 CYH A 164
PRO A  60
ILE A 166
ILE A  35
LEU A 190
 None
 1.20A 1z9hD-4i14A:
undetectable		 1z9hD-4i14A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 THR A1144
ILE A1163
VAL A1166
ILE A1140
VAL A1147
 None
 1.06A 1z9hD-4ll6A:
2.1		 1z9hD-4ll6A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 THR A1144
ILE A1163
VAL A1166
ILE A1140
VAL A1147
 None
 1.15A 1z9hD-4ll8A:
undetectable		 1z9hD-4ll8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbz MAJOR CAPSID PROTEIN
VP1

(African green
monkey
polyomavirus) 		PF00718
(Polyoma_coat) 		5 CYH A  87
PRO A 205
PRO A  51
TYR A 150
ILE A 267
 None
 1.18A 1z9hD-4mbzA:
undetectable		 1z9hD-4mbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 THR A 460
ILE A 428
VAL A 430
SER A 449
VAL A 458
 None
 1.08A 1z9hD-4nbqA:
2.9		 1z9hD-4nbqA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9x COPPER HOMEOSTASIS
PROTEIN CUTC

(Bacillus
anthracis) 		PF03932
(CutC) 		5 PRO A 128
ILE A 122
VAL A 144
ILE A 166
LEU A 173
 None
 1.22A 1z9hD-4r9xA:
undetectable		 1z9hD-4r9xA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		5 THR A 531
ILE A 557
ILE A 550
VAL A 529
LEU A 660
 None
 1.17A 1z9hD-4wiwA:
undetectable		 1z9hD-4wiwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsh ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		5 THR B 167
ILE B  93
VAL B  95
ILE B 218
VAL B  89
 None
 1.15A 1z9hD-4xshB:
undetectable		 1z9hD-4xshB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 THR A 171
ILE A 166
VAL A 185
ILE A 172
LEU A 247
 None
 1.14A 1z9hD-4yaiA:
undetectable		 1z9hD-4yaiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a24 DIONAIN-1

(Dionaea
muscipula) 		PF00112
(Peptidase_C1) 		5 PRO A  99
ILE A  84
VAL A  78
TYR A  77
VAL A  32
 None
 1.18A 1z9hD-5a24A:
undetectable		 1z9hD-5a24A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		5 ILE A 254
VAL A 248
TYR A 243
ILE A 273
VAL A 235
 None
 1.23A 1z9hD-5a2rA:
1.4		 1z9hD-5a2rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5h ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		5 ILE A  16
VAL A 220
ILE A 189
VAL A 213
LEU A 197
 None
 1.12A 1z9hD-5b5hA:
undetectable		 1z9hD-5b5hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 PRO A 533
ILE A 178
VAL A 170
ILE A 188
LEU A 203
 None
 1.09A 1z9hD-5bptA:
undetectable		 1z9hD-5bptA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 5 PRO A 166
VAL A 185
ILE A 143
VAL A 169
LEU A 178
 None
 1.07A 1z9hD-5bw4A:
undetectable		 1z9hD-5bw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2c CHLORIDE PUMPING
RHODOPSIN

(Nonlabens
marinus) 		PF01036
(Bac_rhodopsin) 		5 CYH A 105
PRO A 104
ILE A 103
SER A 234
TYR A 238
 None
None
None
RET  A1273 (-3.2A)
None
 1.07A 1z9hD-5g2cA:
undetectable		 1z9hD-5g2cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan SPLICEOSOMAL PROTEIN
DIB1

(Saccharomyces
cerevisiae) 		PF02966
(DIM1) 		5 ILE D  59
VAL D  28
ILE D 116
VAL D  53
LEU D  26
 None
 1.14A 1z9hD-5ganD:
undetectable		 1z9hD-5ganD:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		5 THR A 359
PRO A 361
SER A 330
TYR A 329
LEU A 353
 None
 1.21A 1z9hD-5h9xA:
undetectable		 1z9hD-5h9xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		5 PRO A 151
ILE A 158
SER A 216
ILE A 129
VAL A 161
 None
 1.06A 1z9hD-5jqxA:
undetectable		 1z9hD-5jqxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 PRO C  28
SER C  33
TYR C  32
ILE C 555
LEU C  87
 None
 1.21A 1z9hD-5k1cC:
undetectable		 1z9hD-5k1cC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k97 FLAP ENDONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 THR A  71
ILE A  79
VAL A  31
TYR A  83
ILE A 150
 None
 1.00A 1z9hD-5k97A:
undetectable		 1z9hD-5k97A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00499
(Oxidored_q3)
PF06444
(NADH_dehy_S2_C) 		5 THR N  12
PRO N  42
ILE N  19
SER J 160
ILE J 163
 None
 1.15A 1z9hD-5lc5N:
undetectable		 1z9hD-5lc5N:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00499
(Oxidored_q3)
PF06444
(NADH_dehy_S2_C) 		5 THR N  12
PRO N  42
ILE N  19
VAL J 156
ILE J 163
 None
 1.00A 1z9hD-5lc5N:
undetectable		 1z9hD-5lc5N:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgk IG EPSILON CHAIN C
REGION

(Homo sapiens) 		PF07654
(C1-set) 		5 THR A 493
PRO A 495
ILE A 474
VAL A 476
VAL A 505
 None
 1.20A 1z9hD-5lgkA:
undetectable		 1z9hD-5lgkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 ILE A 739
VAL A 720
SER A 709
TYR A 708
VAL A 674
 None
 1.18A 1z9hD-5mswA:
1.8		 1z9hD-5mswA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 THR A  99
PRO A  70
TYR A  95
ILE A  96
LEU A 186
 None
 1.16A 1z9hD-5mtzA:
undetectable		 1z9hD-5mtzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		5 THR B 126
ILE B 156
TYR B 116
ILE B 123
LEU B 112
 CYC  B 201 (-2.8A)
None
CYC  B 201 ( 4.1A)
PEG  B 203 (-3.1A)
CYC  B 201 (-4.4A)
 1.01A 1z9hD-5tjfB:
undetectable		 1z9hD-5tjfB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 PRO A 228
PRO A 103
ILE A 288
VAL A 275
LEU A 252
 None
None
None
EQ3  A 403 (-4.7A)
EQ3  A 403 (-4.4A)
 1.18A 1z9hD-5ui2A:
undetectable		 1z9hD-5ui2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg CTEA
RADICAL SAM DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13165
(SCIFF)
PF13186
(SPASM)
PF13353
(Fer4_12) 		5 CYH A 441
ILE A  14
VAL A  23
ILE A 329
LEU B   7
 None
 1.09A 1z9hD-5wggA:
undetectable		 1z9hD-5wggA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wos BCL-2-LIKE PROTEIN
11
CNPV058 BCL-2 LIKE
PROTEIN

(Canarypox
virus;
Homo sapiens) 		no annotation 5 ILE A  81
SER A  92
ILE A  94
VAL A  77
LEU B  62
 None
 0.94A 1z9hD-5wosA:
undetectable		 1z9hD-5wosA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 5 THR A 102
ILE A 294
VAL A 292
ILE A 354
LEU A 324
 None
 1.14A 1z9hD-5yemA:
undetectable		 1z9hD-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 THR A 295
PRO A 409
VAL A 257
ILE A 246
VAL A 296
 None
 1.20A 1z9hD-5zb3A:
undetectable		 1z9hD-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A

(Danio rerio) 		no annotation 5 THR A 375
PRO A 341
ILE A 406
VAL A 402
LEU A 382
 None
 1.20A 1z9hD-6g1kA:
undetectable		 1z9hD-6g1kA:
14.24