SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z9H_A_IMNA379_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 5 PRO A  79
PRO A  35
SER A  56
ILE A  57
LEU A  87
 None
HEM  A 120 (-4.8A)
None
HEM  A 120 (-4.2A)
None
 1.21A 1z9hA-1c2rA:
undetectable		 1z9hA-1c2rA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		5 PRO A 580
SER A 695
TYR A 694
ILE A 698
LEU A 639
 None
 1.01A 1z9hA-1d5fA:
0.0		 1z9hA-1d5fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		5 THR A  38
TYR A 121
SER A   6
ILE A   7
VAL A  50
 None
None
None
HBI  A 198 (-4.1A)
None
 1.31A 1z9hA-1dr6A:
undetectable		 1z9hA-1dr6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 PRO A 168
PRO A 254
VAL A  77
SER A 161
VAL A  70
 None
 1.41A 1z9hA-1i7oA:
0.0		 1z9hA-1i7oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 PRO A 437
TYR A 400
ILE A 401
VAL A 308
LEU A 288
 None
 1.29A 1z9hA-1kfwA:
0.0		 1z9hA-1kfwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 TYR A 304
PRO A 298
PRO A 387
ILE A 334
LEU A 345
 None
 1.07A 1z9hA-1lrwA:
0.0		 1z9hA-1lrwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 TYR A  62
THR A  63
PRO A  65
VAL A  94
LEU A  71
 None
 1.44A 1z9hA-1o4sA:
0.5		 1z9hA-1o4sA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of3 BETA-MANNOSIDASE

(Thermotoga
maritima) 		PF09212
(CBM27) 		5 TYR A  83
VAL A  52
ILE A  84
VAL A 151
LEU A  54
 None
 1.31A 1z9hA-1of3A:
undetectable		 1z9hA-1of3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 TYR A 252
THR A 248
PRO A 210
VAL A 247
LEU A 180
 None
 1.39A 1z9hA-1td2A:
1.8		 1z9hA-1td2A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 THR X  71
PRO X 301
VAL X  31
TYR X  83
ILE X 150
 None
 1.08A 1z9hA-1ul1X:
undetectable		 1z9hA-1ul1X:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		5 THR C 307
PRO C 143
PRO C 315
VAL C 145
LEU C 282
 None
None
HEM  C 404 (-4.4A)
None
HEM  C 402 ( 4.5A)
 1.44A 1z9hA-1vrnC:
undetectable		 1z9hA-1vrnC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w66 LIPOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03099
(BPL_LplA_LipB) 		5 THR A 155
VAL A 207
TYR A 105
ILE A  94
LEU A 109
 None
 1.37A 1z9hA-1w66A:
undetectable		 1z9hA-1w66A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbm HYPOTHETICAL PROTEIN
AF1704

(Archaeoglobus
fulgidus) 		PF02621
(VitK2_biosynth) 		5 TYR A  80
PRO A  82
TYR A 149
ILE A 147
VAL A  83
 None
 1.32A 1z9hA-1zbmA:
undetectable		 1z9hA-1zbmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		5 SER A 126
TYR A 129
ILE A 154
VAL A 112
LEU A 125
 None
 1.25A 1z9hA-1zmrA:
undetectable		 1z9hA-1zmrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 TYR A 196
PRO A 198
VAL A 312
ILE A 333
LEU A 214
 None
 1.25A 1z9hA-2b3xA:
undetectable		 1z9hA-2b3xA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhv COMB10

(Helicobacter
pylori) 		PF03743
(TrbI) 		5 THR A 284
PRO A 356
VAL A 194
ILE A 354
LEU A 182
 None
 1.30A 1z9hA-2bhvA:
undetectable		 1z9hA-2bhvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 PRO A  21
VAL A 414
SER A 376
ILE A 373
LEU A 411
 None
 1.42A 1z9hA-2eo5A:
undetectable		 1z9hA-2eo5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		6 THR A 288
CYH A 287
SER A  61
TYR A 180
ILE A 181
LEU A 291
 NDP  A 501 (-4.2A)
None
None
None
None
None
 1.31A 1z9hA-2gv8A:
undetectable		 1z9hA-2gv8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		5 TYR A 118
PRO A 114
PRO A 165
VAL A 102
ILE A  33
 None
 1.16A 1z9hA-2he3A:
2.9		 1z9hA-2he3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocz 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
pyogenes) 		PF01487
(DHquinase_I) 		5 VAL A   4
TYR A 198
TYR A  92
ILE A 114
LEU A  28
 None
 1.12A 1z9hA-2oczA:
undetectable		 1z9hA-2oczA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 221
PRO A 217
TYR A  38
ILE A  96
LEU A  83
 None
 1.43A 1z9hA-2okcA:
undetectable		 1z9hA-2okcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 TYR A 151
THR A 154
PRO A 153
VAL A  54
LEU A  59
 None
 1.37A 1z9hA-2p3xA:
1.0		 1z9hA-2p3xA:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbj PROSTAGLANDIN E
SYNTHASE 2

(Macaca
fascicularis) 		PF13417
(GST_N_3) 		12 TYR A 107
THR A 109
CYH A 110
PRO A 111
PRO A 134
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.0A)
HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.31A 1z9hA-2pbjA:
44.7		 1z9hA-2pbjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		5 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.18A 1z9hA-2rkcA:
undetectable		 1z9hA-2rkcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 PRO A 353
VAL A 296
SER A 435
VAL A 454
LEU A 434
 None
 1.32A 1z9hA-2ww9A:
undetectable		 1z9hA-2ww9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 5 THR A  16
PRO A 122
SER A 189
TYR A 187
ILE A  63
 None
 1.24A 1z9hA-2x5qA:
undetectable		 1z9hA-2x5qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		5 THR A 179
VAL A 195
TYR A 177
ILE A 214
LEU A 198
 None
 1.20A 1z9hA-2x7vA:
undetectable		 1z9hA-2x7vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR B  95
VAL B 107
TYR B  71
ILE B  97
LEU B  59
 None
 1.44A 1z9hA-2y7cB:
undetectable		 1z9hA-2y7cB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		5 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.19A 1z9hA-3alxA:
undetectable		 1z9hA-3alxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Escherichia
coli) 		PF00106
(adh_short) 		5 THR A 114
VAL A 154
SER A 158
ILE A 129
VAL A 111
 None
 1.40A 1z9hA-3asuA:
undetectable		 1z9hA-3asuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 PRO A 960
PRO A 941
SER A 910
ILE A 913
LEU A 680
 None
 1.34A 1z9hA-3bg9A:
undetectable		 1z9hA-3bg9A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk6 PH STOMATIN

(Pyrococcus
horikoshii) 		PF01145
(Band_7) 		5 VAL A  72
SER A 113
ILE A 115
VAL A 161
LEU A  70
 None
 1.32A 1z9hA-3bk6A:
undetectable		 1z9hA-3bk6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 TYR A 174
THR A 175
PRO A 177
PRO A 171
LEU A 192
 None
 1.13A 1z9hA-3d0kA:
undetectable		 1z9hA-3d0kA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 TYR A 174
THR A 175
PRO A 177
SER A 157
LEU A 192
 None
 1.42A 1z9hA-3d0kA:
undetectable		 1z9hA-3d0kA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d89 RIESKE
DOMAIN-CONTAINING
PROTEIN

(Mus musculus) 		PF13806
(Rieske_2) 		5 TYR A  85
CYH A  80
PRO A  81
VAL A  42
ILE A  87
 FES  A 201 (-4.0A)
FES  A 201 (-2.3A)
None
None
None
 1.08A 1z9hA-3d89A:
undetectable		 1z9hA-3d89A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		5 VAL A 251
SER A  86
TYR A  87
ILE A  84
LEU A 256
 None
None
GAL  A 701 (-4.8A)
None
None
 1.25A 1z9hA-3dh4A:
3.0		 1z9hA-3dh4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 THR A  35
VAL A  91
TYR A 120
ILE A 381
VAL A  32
 None
 1.37A 1z9hA-3e1kA:
undetectable		 1z9hA-3e1kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 TYR A 151
THR A 104
PRO A 166
VAL A 293
ILE A 134
 None
 1.19A 1z9hA-3e77A:
undetectable		 1z9hA-3e77A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 TYR A 358
PRO A 158
VAL A  82
ILE A 148
LEU A  56
 None
 1.29A 1z9hA-3e7wA:
undetectable		 1z9hA-3e7wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 CYH A 106
PRO A 107
VAL A  88
TYR A 133
LEU A 137
 None
 1.38A 1z9hA-3eh2A:
undetectable		 1z9hA-3eh2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		5 THR A 130
PRO A 132
VAL A 287
ILE A 266
LEU A 257
 None
 1.32A 1z9hA-3fkqA:
2.0		 1z9hA-3fkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy7 CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 3

(Homo sapiens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 THR A 218
CYH A 219
PRO A 220
VAL A  10
LEU A  41
 None
 1.19A 1z9hA-3fy7A:
9.8		 1z9hA-3fy7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 TYR A 246
VAL A 127
ILE A 117
VAL A 256
LEU A 123
 None
None
None
None
NAD  A 400 ( 4.2A)
 1.43A 1z9hA-3gvhA:
2.2		 1z9hA-3gvhA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		5 THR A 100
PRO A 210
VAL A  82
TYR A  83
LEU A  65
 None
 1.44A 1z9hA-3h04A:
undetectable		 1z9hA-3h04A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj7 TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF11734
(TilS_C) 		5 PRO A 377
PRO A 364
VAL A 343
SER A 357
LEU A 341
 None
 1.01A 1z9hA-3hj7A:
undetectable		 1z9hA-3hj7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		PF00912
(Transgly) 		5 THR A 135
VAL A  70
ILE A 172
VAL A 139
LEU A  73
 None
 1.43A 1z9hA-3hzsA:
undetectable		 1z9hA-3hzsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irz URO-ADHERENCE FACTOR
A

(Staphylococcus
saprophyticus) 		PF17210
(SdrD_B) 		5 PRO A 612
VAL A 635
TYR A 645
VAL A 620
LEU A 637
 None
 1.36A 1z9hA-3irzA:
undetectable		 1z9hA-3irzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		5 THR C 124
PRO C 126
TYR C 174
ILE C 170
VAL C 123
 None
 1.25A 1z9hA-3j7aC:
undetectable		 1z9hA-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		5 CYH A 285
PRO A 394
PRO A 321
VAL A 313
LEU A 278
 None
 1.41A 1z9hA-3k2wA:
undetectable		 1z9hA-3k2wA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		5 PRO A  46
VAL A 141
ILE A  61
VAL A 116
LEU A 145
 None
 1.32A 1z9hA-3lcrA:
undetectable		 1z9hA-3lcrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF08762
(CRPV_capsid) 		5 THR A 175
PRO A 202
SER A 220
ILE A 117
VAL A 173
 None
 1.37A 1z9hA-3napA:
undetectable		 1z9hA-3napA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 VAL A 470
TYR A 417
ILE A 418
VAL A 425
LEU A 434
 None
 1.44A 1z9hA-3o8oA:
undetectable		 1z9hA-3o8oA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owv DNA-ENTRY NUCLEASE

(Streptococcus
pneumoniae) 		PF01223
(Endonuclease_NS) 		5 THR A 187
PRO A  49
VAL A 233
TYR A 265
VAL A 156
 None
 1.25A 1z9hA-3owvA:
undetectable		 1z9hA-3owvA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piw TYPE I INTERFERON 2

(Danio rerio) 		PF00143
(Interferon) 		5 TYR A 124
VAL A  13
ILE A  67
VAL A  60
LEU A  95
 None
 1.40A 1z9hA-3piwA:
undetectable		 1z9hA-3piwA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		5 THR A 343
TYR A 289
TYR A 352
ILE A 355
LEU A 282
 None
 1.33A 1z9hA-3pmmA:
0.9		 1z9hA-3pmmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 PRO A 231
PRO A 203
ILE A 205
VAL A 234
LEU A 209
 None
 1.44A 1z9hA-3qfwA:
undetectable		 1z9hA-3qfwA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 TYR A  77
THR A  78
VAL A 150
ILE A  58
VAL A  81
 None
 1.22A 1z9hA-3qlbA:
undetectable		 1z9hA-3qlbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qoy 50S RIBOSOMAL
PROTEIN L1

(Aquifex
aeolicus) 		PF00687
(Ribosomal_L1) 		5 THR A 148
PRO A 144
PRO A 178
VAL A 128
VAL A 149
 None
 1.12A 1z9hA-3qoyA:
undetectable		 1z9hA-3qoyA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		5 THR A 342
TYR A 288
TYR A 351
ILE A 354
LEU A 281
 None
 1.32A 1z9hA-3qwtA:
0.8		 1z9hA-3qwtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		5 THR A 244
PRO A 352
SER A 311
TYR A 306
VAL A 247
 ACY  A 401 ( 4.5A)
None
None
None
None
 1.38A 1z9hA-3u37A:
undetectable		 1z9hA-3u37A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 THR A  72
PRO A  70
TYR A 524
TYR A  50
LEU A  54
 None
 1.36A 1z9hA-3wajA:
2.2		 1z9hA-3wajA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 PRO A 266
PRO A 278
VAL A 643
SER A 646
VAL A 269
 None
 1.41A 1z9hA-3x1lA:
undetectable		 1z9hA-3x1lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zri CLPB PROTEIN

(Vibrio cholerae) 		PF02861
(Clp_N) 		5 TYR A 127
VAL A  53
SER A 113
ILE A 116
LEU A  45
 None
 1.20A 1z9hA-3zriA:
undetectable		 1z9hA-3zriA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		5 TYR A 129
VAL A 226
TYR A  77
ILE A 212
LEU A 228
 None
 1.45A 1z9hA-3zseA:
undetectable		 1z9hA-3zseA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 TYR A 544
SER A 531
ILE A 509
VAL A 536
LEU A 704
 None
ACP  A 900 (-3.9A)
ACP  A 900 (-4.8A)
None
None
 1.44A 1z9hA-4ayxA:
4.7		 1z9hA-4ayxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk5 DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		5 TYR E1193
THR E1195
CYH E1194
PRO E1157
VAL E1236
 None
 1.45A 1z9hA-4gk5E:
2.2		 1z9hA-4gk5E:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		5 TYR A  96
CYH A  98
VAL A  76
ILE A  94
LEU A  79
 None
 1.34A 1z9hA-4h0pA:
undetectable		 1z9hA-4h0pA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		5 TYR B 196
PRO B 138
VAL B 511
ILE B 503
VAL B 240
 None
 1.43A 1z9hA-4hxeB:
undetectable		 1z9hA-4hxeB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		5 THR A 214
CYH A 213
SER A 236
TYR A 239
ILE A 240
 None
 1.37A 1z9hA-4jjpA:
2.2		 1z9hA-4jjpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		5 TYR A 179
VAL A   8
TYR A  17
ILE A 180
LEU A   6
 None
 1.38A 1z9hA-4jkxA:
undetectable		 1z9hA-4jkxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 THR A 991
VAL A1114
TYR A1032
ILE A1029
LEU A1078
 None
 1.37A 1z9hA-4lnvA:
2.8		 1z9hA-4lnvA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4r EPHRIN TYPE-A
RECEPTOR 4

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		5 PRO A 379
VAL A 384
TYR A 386
TYR A 409
LEU A 403
 None
 1.30A 1z9hA-4m4rA:
undetectable		 1z9hA-4m4rA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbz MAJOR CAPSID PROTEIN
VP1

(African green
monkey
polyomavirus) 		PF00718
(Polyoma_coat) 		5 CYH A  87
PRO A 205
PRO A  51
TYR A 150
ILE A 267
 None
 1.19A 1z9hA-4mbzA:
undetectable		 1z9hA-4mbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 PRO A 893
PRO A 864
TYR A 859
TYR A 831
LEU A 782
 None
 1.42A 1z9hA-4nmeA:
undetectable		 1z9hA-4nmeA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		5 PRO A 378
PRO A 309
TYR A 294
ILE A 295
LEU A 362
 None
 1.44A 1z9hA-4q65A:
undetectable		 1z9hA-4q65A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 380
CYH A 382
VAL A  18
ILE A 377
LEU A 322
 None
 1.26A 1z9hA-4uphA:
undetectable		 1z9hA-4uphA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 5 PRO A 166
VAL A 185
ILE A 143
VAL A 169
LEU A 178
 None
 1.07A 1z9hA-5bw4A:
undetectable		 1z9hA-5bw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 VAL A 138
TYR A 135
ILE A 428
VAL A 422
LEU A 144
 None
 1.41A 1z9hA-5cwaA:
undetectable		 1z9hA-5cwaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		5 TYR B 361
THR B 360
PRO B 363
VAL B 185
LEU B 269
 None
NA  B 402 (-3.8A)
None
None
None
 1.28A 1z9hA-5dynB:
undetectable		 1z9hA-5dynB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		5 THR A1064
CYH A1063
SER A1079
TYR A1078
VAL A1065
 None
 1.44A 1z9hA-5gutA:
undetectable		 1z9hA-5gutA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		5 THR A 359
PRO A 361
SER A 330
TYR A 329
LEU A 353
 None
 1.22A 1z9hA-5h9xA:
undetectable		 1z9hA-5h9xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 PRO C  28
SER C  33
TYR C  32
ILE C 555
LEU C  87
 None
 1.20A 1z9hA-5k1cC:
undetectable		 1z9hA-5k1cC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR

(Yersinia
enterocolitica) 		PF03472
(Autoind_bind) 		5 TYR A 110
THR A 111
TYR A  50
SER A  32
VAL A  69
 None
None
482  A 201 (-4.5A)
482  A 201 (-2.8A)
482  A 201 (-4.6A)
 1.26A 1z9hA-5l09A:
undetectable		 1z9hA-5l09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 THR A  99
PRO A  70
TYR A  95
ILE A  96
LEU A 186
 None
 1.16A 1z9hA-5mtzA:
undetectable		 1z9hA-5mtzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 THR A 666
PRO A 664
PRO A 837
SER A 636
VAL A 690
 None
 1.44A 1z9hA-5n4lA:
undetectable		 1z9hA-5n4lA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 5 PRO A 864
VAL A 943
SER A 851
VAL A1024
LEU A1022
 None
 1.44A 1z9hA-5ngyA:
undetectable		 1z9hA-5ngyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 PRO A1296
VAL A1309
ILE A1253
VAL A1297
LEU A1305
 None
 1.43A 1z9hA-5t8vA:
3.4		 1z9hA-5t8vA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PRO A 247
VAL A  79
ILE A 108
VAL A 143
LEU A  83
 None
 1.34A 1z9hA-5u2aA:
2.1		 1z9hA-5u2aA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		5 PRO A 190
VAL A 197
SER A 201
VAL A 207
LEU A 203
 None
 1.45A 1z9hA-5veoA:
undetectable		 1z9hA-5veoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		PF01253
(SUI1) 		5 PRO A 517
TYR A 564
ILE A 523
VAL A 546
LEU A 556
 None
 1.28A 1z9hA-5w2fA:
2.2		 1z9hA-5w2fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 THR A 120
CYH A 119
PRO A 204
VAL A 170
TYR A 192
 AQD  A1201 (-4.4A)
AQD  A1201 ( 3.9A)
OLA  A1209 ( 4.0A)
None
None
 1.31A 1z9hA-5wivA:
2.2		 1z9hA-5wivA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE

(Marinomonas
mediterranea) 		no annotation 5 TYR A 141
THR A 140
TYR A 122
ILE A 119
LEU A  85
 None
 1.45A 1z9hA-5x32A:
undetectable		 1z9hA-5x32A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		5 THR B 237
PRO B 239
VAL B 153
VAL B 314
LEU B 155
 None
 1.37A 1z9hA-5xeqB:
undetectable		 1z9hA-5xeqB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 TYR A 335
PRO A 329
PRO A 418
ILE A 365
LEU A 376
 None
 0.98A 1z9hA-5xm3A:
undetectable		 1z9hA-5xm3A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9s VV2_1132

(Vibrio
vulnificus) 		no annotation 5 PRO A 180
TYR A 198
SER A 200
TYR A 201
LEU A 234
 None
 1.45A 1z9hA-5y9sA:
undetectable		 1z9hA-5y9sA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 THR A 295
PRO A 409
VAL A 257
ILE A 246
VAL A 296
 None
 1.19A 1z9hA-5zb3A:
undetectable		 1z9hA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 5 TYR A 285
PRO A 323
VAL A 238
TYR A 316
LEU A 218
 None
 1.31A 1z9hA-6c4rA:
undetectable		 1z9hA-6c4rA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 TYR A 798
THR A 800
PRO A 881
ILE A 863
VAL A 785
 None
 1.43A 1z9hA-6eojA:
undetectable		 1z9hA-6eojA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 TYR O 272
THR O 159
PRO O 161
TYR O 101
ILE O 155
 None
 1.34A 1z9hA-6g2jO:
undetectable		 1z9hA-6g2jO:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 5 PRO A  79
PRO A 393
VAL A  73
ILE A 295
LEU A  69
 None
 1.35A 1z9hA-6gk6A:
undetectable		 1z9hA-6gk6A:
undetectable