SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z95_A_198A501_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0i | DNA LIGASE (Escherichiavirus T7) |
PF01068(DNA_ligase_A_M) | 4 | LEU A 154MET A 177LEU A 90ILE A 4 | None | 0.98A | 1z95A-1a0iA:undetectable | 1z95A-1a0iA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cm0 | P300/CBP ASSOCIATINGFACTOR (Homo sapiens) |
no annotation | 4 | LEU B 603ASN B 604LEU B 593ILE B 571 | None | 0.86A | 1z95A-1cm0B:0.0 | 1z95A-1cm0B:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ea9 | CYCLOMALTODEXTRINASE (Bacillus sp.(in: Bacteria)) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 4 | LEU C 559LEU C 529LEU C 578ILE C 528 | None | 0.96A | 1z95A-1ea9C:undetectable | 1z95A-1ea9C:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ex9 | LACTONIZING LIPASE (Pseudomonasaeruginosa) |
PF00561(Abhydrolase_1) | 4 | LEU A 162ASN A 163LEU A 131ILE A 121 | OCP A 382 ( 4.4A)NoneNoneNone | 1.02A | 1z95A-1ex9A:0.0 | 1z95A-1ex9A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f5n | INTERFERON-INDUCEDGUANYLATE-BINDINGPROTEIN 1 (Homo sapiens) |
PF02263(GBP)PF02841(GBP_C) | 4 | ASN A 302LEU A 118LEU A 296ILE A 14 | None | 1.01A | 1z95A-1f5nA:0.0 | 1z95A-1f5nA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i60 | IOLI PROTEIN (Bacillussubtilis) |
PF01261(AP_endonuc_2) | 4 | ASN A 66LEU A 16LEU A 11ILE A 31 | None | 0.93A | 1z95A-1i60A:0.0 | 1z95A-1i60A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ibj | CYSTATHIONINEBETA-LYASE (Arabidopsisthaliana) |
PF01053(Cys_Met_Meta_PP) | 4 | ASN A 254LEU A 291LEU A 142ILE A 271 | None | 0.95A | 1z95A-1ibjA:undetectable | 1z95A-1ibjA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 4 | LEU A 163LEU A 127LEU A 174ILE A 125 | None | 0.89A | 1z95A-1iv8A:3.6 | 1z95A-1iv8A:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcx | DIHYDROPYRIMIDINASERELATED PROTEIN-1 (Mus musculus) |
PF01979(Amidohydro_1) | 4 | LEU A 196LEU A 181LEU A 188ILE A 242 | None | 0.96A | 1z95A-1kcxA:undetectable | 1z95A-1kcxA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lth | L-LACTATEDEHYDROGENASE (T-AND R- STATETETRAMER COMPLEX) (Bifidobacteriumlongum) |
no annotation | 4 | LEU T 152ASN T 151LEU T 22ILE T 248 | None | 0.83A | 1z95A-1lthT:undetectable | 1z95A-1lthT:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7d | LYSOSOMALALPHA-MANNOSIDASE (Bos taurus) |
PF07748(Glyco_hydro_38C) | 4 | LEU E 956LEU E 992LEU E 903ILE E 990 | None | 0.97A | 1z95A-1o7dE:undetectable | 1z95A-1o7dE:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7x | CITRATE SYNTHASE (Sulfolobussolfataricus) |
PF00285(Citrate_synt) | 4 | LEU A 18LEU A 38LEU A 340ILE A 35 | None | 1.02A | 1z95A-1o7xA:undetectable | 1z95A-1o7xA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ozn | RETICULON 4 RECEPTOR (Homo sapiens) |
PF13855(LRR_8) | 4 | LEU A 149LEU A 185LEU A 142ILE A 190 | None | 0.96A | 1z95A-1oznA:undetectable | 1z95A-1oznA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p16 | MRNA CAPPING ENZYMEALPHA SUBUNIT (Candidaalbicans) |
PF01331(mRNA_cap_enzyme)PF03919(mRNA_cap_C) | 4 | LEU A 239LEU A 147MET A 199LEU A 159 | G A1167 (-4.5A)NoneNoneNone | 1.00A | 1z95A-1p16A:undetectable | 1z95A-1p16A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q14 | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 4 | LEU A 102MET A 19LEU A 277ILE A 35 | None | 0.90A | 1z95A-1q14A:undetectable | 1z95A-1q14A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q77 | HYPOTHETICAL PROTEINAQ_178 (Aquifexaeolicus) |
PF00582(Usp) | 4 | LEU A 4LEU A 120LEU A 127ILE A 133 | None | 0.94A | 1z95A-1q77A:undetectable | 1z95A-1q77A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhm | PYRUVATEFORMATE-LYASE (Escherichiacoli) |
PF02901(PFL-like) | 4 | LEU A1536LEU A1604MET A1483LEU A1438 | None | 1.00A | 1z95A-1qhmA:undetectable | 1z95A-1qhmA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rhi | HUMAN RHINOVIRUS 3COAT PROTEIN (Rhinovirus B) |
PF00073(Rhv) | 4 | ASN 2 190LEU 3 52LEU 3 207ILE 2 225 | None | 1.01A | 1z95A-1rhi2:undetectable | 1z95A-1rhi2:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sez | PROTOPORPHYRINOGENOXIDASE,MITOCHONDRIAL (Nicotianatabacum) |
PF01593(Amino_oxidase) | 4 | LEU A 473ASN A 468LEU A 450ILE A 453 | NoneFAD A 600 (-4.4A)NoneNone | 0.84A | 1z95A-1sezA:undetectable | 1z95A-1sezA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5c | CENTROMERIC PROTEINE (Homo sapiens) |
PF00225(Kinesin) | 4 | LEU A 292LEU A 272LEU A 265ILE A 281 | None | 0.87A | 1z95A-1t5cA:undetectable | 1z95A-1t5cA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uik | ALPHA PRIME SUBUNITOF BETA-CONGLYCININ (Glycine max) |
PF00190(Cupin_1) | 4 | LEU A 181LEU A 263LEU A 171ILE A 265 | None | 0.99A | 1z95A-1uikA:undetectable | 1z95A-1uikA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukv | GTP-BINDING PROTEINYPT1 (Saccharomycescerevisiae) |
PF00071(Ras) | 4 | ASN Y 16MET Y 145LEU Y 103ILE Y 73 | None | 0.87A | 1z95A-1ukvY:undetectable | 1z95A-1ukvY:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgm | 378AA LONGHYPOTHETICAL CITRATESYNTHASE (Sulfurisphaeratokodaii) |
PF00285(Citrate_synt) | 4 | LEU A 19LEU A 39LEU A 341ILE A 36 | None | 1.00A | 1z95A-1vgmA:undetectable | 1z95A-1vgmA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w2w | 5-METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE (Saccharomycescerevisiae) |
PF01008(IF-2B) | 4 | ASN A 96LEU A 136LEU A 129ILE A 122 | None | 0.99A | 1z95A-1w2wA:undetectable | 1z95A-1w2wA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xec | DECORIN (Bos taurus) |
PF01462(LRRNT)PF13855(LRR_8) | 4 | LEU A 112MET A 119LEU A 126ILE A 178 | None | 0.95A | 1z95A-1xecA:undetectable | 1z95A-1xecA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkt | FATTY ACID SYNTHASE (Homo sapiens) |
PF00975(Thioesterase) | 4 | LEU A2234ASN A2235LEU A2490ILE A2494 | None | 0.97A | 1z95A-1xktA:undetectable | 1z95A-1xktA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yx2 | AMINOMETHYLTRANSFERASE (Bacillussubtilis) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | LEU A 109MET A 70LEU A 98ILE A 141 | None | 0.99A | 1z95A-1yx2A:undetectable | 1z95A-1yx2A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z85 | HYPOTHETICAL PROTEINTM1380 (Thermotogamaritima) |
PF04452(Methyltrans_RNA) | 4 | LEU A 210LEU A 166LEU A 162ILE A 151 | None | 0.99A | 1z95A-1z85A:undetectable | 1z95A-1z85A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy9 | ALPHA-GALACTOSIDASE (Thermotogamaritima) |
PF02065(Melibiase) | 4 | LEU A 312LEU A 329LEU A 298ILE A 352 | None | 1.00A | 1z95A-1zy9A:undetectable | 1z95A-1zy9A:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a4v | PEROXIREDOXIN DOT5 (Saccharomycescerevisiae) |
PF00578(AhpC-TSA) | 4 | LEU A 75ASN A 76LEU A 84ILE A 87 | None | 0.84A | 1z95A-2a4vA:undetectable | 1z95A-2a4vA:22.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ax9 | ANDROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 704ASN A 705MET A 787LEU A 873ILE A 898 | BHM A 1 (-4.0A)BHM A 1 (-3.6A)BHM A 1 (-3.6A)BHM A 1 (-4.4A)None | 0.42A | 1z95A-2ax9A:41.9 | 1z95A-2ax9A:99.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayn | UBIQUITINCARBOXYL-TERMINALHYDROLASE 14 (Homo sapiens) |
PF00443(UCH) | 4 | LEU A 319ASN A 413LEU A 478LEU A 352 | None | 0.91A | 1z95A-2aynA:undetectable | 1z95A-2aynA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b1w | CASPASE RECRUITMENTDOMAIN PROTEIN 4 (Homo sapiens) |
PF00619(CARD) | 4 | LEU A 40ASN A 43LEU A 23ILE A 20 | None | 0.96A | 1z95A-2b1wA:undetectable | 1z95A-2b1wA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b42 | XYLANASE INHIBITOR-I (Triticumaestivum) |
PF14541(TAXi_C)PF14543(TAXi_N) | 4 | LEU A 243LEU A 238MET A 312LEU A 348 | None | 0.83A | 1z95A-2b42A:undetectable | 1z95A-2b42A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b92 | INTERFERON-INDUCEDGUANYLATE-BINDINGPROTEIN 1 (Homo sapiens) |
PF02263(GBP)PF02841(GBP_C) | 4 | ASN A 302LEU A 118LEU A 296ILE A 14 | ASN A 302 ( 0.6A)LEU A 118 ( 0.5A)LEU A 296 ( 0.5A)ILE A 14 ( 0.6A) | 0.96A | 1z95A-2b92A:undetectable | 1z95A-2b92A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bde | CYTOSOLIC IMP-GMPSPECIFIC5'-NUCLEOTIDASE (Legionellapneumophila) |
PF05761(5_nucleotid) | 4 | LEU A 299LEU A 195MET A 431ILE A 199 | None | 0.81A | 1z95A-2bdeA:undetectable | 1z95A-2bdeA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2be4 | HYPOTHETICAL PROTEINLOC449832 (Danio rerio) |
PF13202(EF-hand_5)PF13499(EF-hand_7) | 4 | LEU A 182LEU A 268MET A 107LEU A 167 | None | 1.01A | 1z95A-2be4A:undetectable | 1z95A-2be4A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7b | CARBOXYLESTERASE (unculturedarchaeon) |
PF07859(Abhydrolase_3) | 4 | LEU A 77LEU A 166LEU A 174ILE A 165 | None | 0.97A | 1z95A-2c7bA:undetectable | 1z95A-2c7bA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpy | FLAGELLUM-SPECIFICATP SYNTHASE (Salmonellaenterica) |
PF00006(ATP-synt_ab) | 4 | LEU A 424LEU A 169LEU A 390ILE A 368 | None | 0.94A | 1z95A-2dpyA:undetectable | 1z95A-2dpyA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2efv | HYPOTHETICAL PROTEINMJ0366 (Methanocaldococcusjannaschii) |
PF10802(DUF2540) | 4 | LEU A 79ASN A 76LEU A 44ILE A 48 | NonePO4 A 101 (-4.0A)NoneNone | 1.01A | 1z95A-2efvA:undetectable | 1z95A-2efvA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewo | PUTATIVE AGMATINEDEIMINASE (Streptococcusmutans) |
PF04371(PAD_porph) | 4 | LEU A 312MET A 274LEU A 320ILE A 56 | None | 0.96A | 1z95A-2ewoA:undetectable | 1z95A-2ewoA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fm8 | CELL INVASIONPROTEIN SIPASURFACE PRESENTATIONOF ANTIGENS PROTEINSPAK (Salmonellaenterica) |
PF03519(Invas_SpaK)PF09052(SipA) | 4 | LEU A 119ASN A 120LEU A 40LEU C 31 | None | 0.97A | 1z95A-2fm8A:undetectable | 1z95A-2fm8A:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2go2 | KUNITZ-TYPE SERINEPROTEASE INHIBITORBBKI (Bauhiniabauhinioides) |
PF00197(Kunitz_legume) | 4 | LEU A 63ASN A 14LEU A 109ILE A 76 | NoneEDO A 700 (-3.3A)NoneNone | 0.91A | 1z95A-2go2A:undetectable | 1z95A-2go2A:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ig6 | NIMC/NIMA FAMILYPROTEIN (Clostridiumacetobutylicum) |
PF01243(Putative_PNPOx) | 4 | LEU A 73MET A 53LEU A 16ILE A 71 | None | 0.91A | 1z95A-2ig6A:undetectable | 1z95A-2ig6A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfd | FATTY ACID SYNTHASE (Homo sapiens) |
PF00698(Acyl_transf_1)PF16197(KAsynt_C_assoc) | 4 | LEU A 566LEU A 803LEU A 797ILE A 782 | None | 0.95A | 1z95A-2jfdA:undetectable | 1z95A-2jfdA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jqd | ACIDIC LEUCINE-RICHNUCLEARPHOSPHOPROTEIN 32FAMILY MEMBER A (Mus musculus) |
PF14580(LRR_9) | 4 | ASN A 74LEU A 80LEU A 69ILE A 100 | None | 1.01A | 1z95A-2jqdA:undetectable | 1z95A-2jqdA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2om6 | PROBABLEPHOSPHOSERINEPHOSPHATASE (Pyrococcushorikoshii) |
PF13419(HAD_2) | 4 | LEU A 179LEU A 108LEU A 116ILE A 145 | None | 0.99A | 1z95A-2om6A:undetectable | 1z95A-2om6A:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozu | HISTONEACETYLTRANSFERASEMYST3 (Homo sapiens) |
PF01853(MOZ_SAS) | 4 | LEU A 614LEU A 662LEU A 669ILE A 647 | NoneNoneNoneACO A 850 (-4.6A) | 1.02A | 1z95A-2ozuA:undetectable | 1z95A-2ozuA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pk3 | GDP-6-DEOXY-D-LYXO-4-HEXULOSE REDUCTASE (Aneurinibacillusthermoaerophilus) |
PF16363(GDP_Man_Dehyd) | 4 | LEU A 4LEU A 97LEU A 105ILE A 162 | None | 1.02A | 1z95A-2pk3A:undetectable | 1z95A-2pk3A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po4 | VIRION RNAPOLYMERASE (Escherichiavirus N4) |
no annotation | 4 | ASN A 617MET A 569LEU A 611ILE A 654 | None | 1.01A | 1z95A-2po4A:undetectable | 1z95A-2po4A:12.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 4 | LEU A 32ASN A 33MET A 115LEU A 201 | 1CA A 247 (-4.0A)1CA A 247 (-2.9A)1CA A 247 ( 3.7A)1CA A 247 ( 4.2A) | 0.88A | 1z95A-2q3yA:37.0 | 1z95A-2q3yA:60.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ql7 | CASPASE-7 (Homo sapiens) |
PF00656(Peptidase_C14) | 4 | LEU A 180LEU A 97LEU A 104ILE A 72 | None | 1.01A | 1z95A-2ql7A:undetectable | 1z95A-2ql7A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmo | DETHIOBIOTINSYNTHETASE (Helicobacterpylori) |
PF13500(AAA_26) | 4 | LEU A 121ASN A 130LEU A 138LEU A 168 | None | 0.85A | 1z95A-2qmoA:undetectable | 1z95A-2qmoA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wp9 | SUCCINATEDEHYDROGENASEIRON-SULFUR SUBUNIT (Escherichiacoli) |
PF13085(Fer2_3)PF13534(Fer4_17) | 4 | ASN B 68LEU B 39LEU B 3ILE B 7 | None | 1.00A | 1z95A-2wp9B:undetectable | 1z95A-2wp9B:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wyh | ALPHA-MANNOSIDASE (Streptococcuspyogenes) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 4 | LEU A 780LEU A 562LEU A 648ILE A 652 | None | 0.90A | 1z95A-2wyhA:undetectable | 1z95A-2wyhA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x05 | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 4 | LEU A 238ASN A 239LEU A 292LEU A 295 | None | 0.89A | 1z95A-2x05A:undetectable | 1z95A-2x05A:13.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhg | TYROCIDINESYNTHETASE A (Brevibacillusbrevis) |
PF00668(Condensation) | 4 | ASN A 412LEU A 441LEU A 424ILE A 438 | None | 0.94A | 1z95A-2xhgA:undetectable | 1z95A-2xhgA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xot | AMPHOTERIN-INDUCEDPROTEIN 1 (Mus musculus) |
PF07679(I-set)PF13855(LRR_8) | 4 | LEU A 129LEU A 165LEU A 122ILE A 170 | None | 0.86A | 1z95A-2xotA:undetectable | 1z95A-2xotA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywr | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE (Aquifexaeolicus) |
PF00551(Formyl_trans_N) | 4 | LEU A 83LEU A 15LEU A 178ILE A 19 | None | 1.01A | 1z95A-2ywrA:undetectable | 1z95A-2ywrA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2znv | AMSH-LIKE PROTEASE (Homo sapiens) |
PF01398(JAB) | 4 | LEU A 340LEU A 275LEU A 433ILE A 346 | None | 0.96A | 1z95A-2znvA:undetectable | 1z95A-2znvA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a74 | LYSYL-TRNASYNTHETASE (Geobacillusstearothermophilus) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 4 | ASN A 477LEU A 310LEU A 307ILE A 407 | None | 1.02A | 1z95A-3a74A:undetectable | 1z95A-3a74A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 4 | ASN A 439LEU A 467LEU A 455ILE A 463 | None | 1.02A | 1z95A-3ayxA:undetectable | 1z95A-3ayxA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | LEU A 51LEU A 84LEU A 44ILE A 68 | None | 0.99A | 1z95A-3b2dA:undetectable | 1z95A-3b2dA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b5q | PUTATIVE SULFATASEYIDJ (Bacteroidesthetaiotaomicron) |
PF00884(Sulfatase)PF16347(DUF4976) | 4 | LEU A 71LEU A 355LEU A 338ILE A 353 | NoneEDO A 503 (-4.4A)NoneEDO A 503 (-3.7A) | 1.00A | 1z95A-3b5qA:undetectable | 1z95A-3b5qA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdn | PHEROMONE-BINDINGPROTEIN ASP1 (Apis mellifera) |
PF01395(PBP_GOBP) | 4 | LEU A 104MET A 70LEU A 53ILE A 45 | NoneNoneGOL A 126 ( 4.9A)None | 0.95A | 1z95A-3cdnA:undetectable | 1z95A-3cdnA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8u | PURR TRANSCRIPTIONALREGULATOR (Vibrioparahaemolyticus) |
PF13377(Peripla_BP_3) | 4 | LEU A 75LEU A 315LEU A 153ILE A 318 | None | 0.92A | 1z95A-3d8uA:undetectable | 1z95A-3d8uA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbg | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 4 | LEU A 226LEU A 245LEU A 272ILE A 264 | None | 0.93A | 1z95A-3dbgA:undetectable | 1z95A-3dbgA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcm | UNCHARACTERIZEDPROTEIN TM_1570 (Thermotogamaritima) |
PF09936(Methyltrn_RNA_4) | 4 | ASN X 28LEU X 9LEU X 87ILE X 34 | None | 0.86A | 1z95A-3dcmX:undetectable | 1z95A-3dcmX:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dhv | D-ALANINE-POLY(PHOSPHORIBITOL) LIGASE (Bacillus cereus) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | LEU A 189LEU A 281LEU A 260ILE A 290 | None | 1.02A | 1z95A-3dhvA:undetectable | 1z95A-3dhvA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4p | C4-DICARBOXYLATETRANSPORT SENSORPROTEIN DCTB (Sinorhizobiummeliloti) |
no annotation | 4 | LEU A 104ASN A 108LEU A 86ILE A 123 | None | 1.01A | 1z95A-3e4pA:undetectable | 1z95A-3e4pA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eaf | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Aeropyrumpernix) |
PF13458(Peripla_BP_6) | 4 | ASN A 272LEU A 187LEU A 220ILE A 200 | None | 0.89A | 1z95A-3eafA:undetectable | 1z95A-3eafA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eaf | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Aeropyrumpernix) |
PF13458(Peripla_BP_6) | 4 | ASN A 272LEU A 187MET A 260ILE A 200 | None | 0.96A | 1z95A-3eafA:undetectable | 1z95A-3eafA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emk | GLUCOSE/RIBITOLDEHYDROGENASE (Brucellamelitensis) |
PF13561(adh_short_C2) | 4 | ASN A 178LEU A 159LEU A 166ILE A 160 | None | 0.98A | 1z95A-3emkA:undetectable | 1z95A-3emkA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8t | PREDICTED ATPASEINVOLVED INREPLICATION CONTROL,CDC46/MCM FAMILY (Methanopyruskandleri) |
PF00493(MCM) | 4 | ASN A 347LEU A 243LEU A 377ILE A 361 | None | 0.91A | 1z95A-3f8tA:undetectable | 1z95A-3f8tA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g0i | EPOXIDE HYDROLASE (Aspergillusniger) |
PF06441(EHN) | 4 | LEU A 213ASN A 214LEU A 114ILE A 127 | None | 0.92A | 1z95A-3g0iA:undetectable | 1z95A-3g0iA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grp | 3-OXOACYL-(ACYLCARRIERPROTEIN)REDUCTASE (Bartonellahenselae) |
PF13561(adh_short_C2) | 4 | ASN A 178LEU A 159LEU A 166ILE A 160 | None | 0.98A | 1z95A-3grpA:undetectable | 1z95A-3grpA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyu | NUCLEAR HORMONERECEPTOR OF THESTEROID/THYROIDHORMONE RECEPTORSSUPERFAMILY (Strongyloidesstercoralis) |
PF00104(Hormone_recep) | 4 | LEU A 657ASN A 655LEU A 694ILE A 714 | None | 0.84A | 1z95A-3gyuA:17.8 | 1z95A-3gyuA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hd8 | XYLANASE INHIBITOR (Triticumaestivum) |
PF14541(TAXi_C)PF14543(TAXi_N) | 4 | LEU A 245LEU A 240MET A 314LEU A 350 | None | 0.79A | 1z95A-3hd8A:undetectable | 1z95A-3hd8A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhd | FATTY ACID SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | LEU A 566LEU A 803LEU A 797ILE A 782 | None | 0.95A | 1z95A-3hhdA:undetectable | 1z95A-3hhdA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icq | EXPORTIN-T (Schizosaccharomycespombe) |
PF08389(Xpo1) | 4 | ASN T 258MET T 233LEU T 273ILE T 309 | None | 0.99A | 1z95A-3icqT:undetectable | 1z95A-3icqT:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfo | NUCLEOPORIN NUP133 (Saccharomycescerevisiae) |
no annotation | 4 | LEU A1037ASN A1038LEU A1015ILE A1061 | NoneGOL A 1 ( 4.3A)NoneNone | 0.96A | 1z95A-3kfoA:undetectable | 1z95A-3kfoA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyh | MRNA-CAPPING ENZYMESUBUNIT BETA (Saccharomycescerevisiae) |
PF02940(mRNA_triPase) | 4 | LEU A 432ASN A 431LEU A 502ILE A 497 | None | 1.02A | 1z95A-3kyhA:undetectable | 1z95A-3kyhA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l06 | N-ACETYLORNITHINECARBAMOYLTRANSFERASE (Xanthomonascampestris) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | LEU A 7ASN A 8LEU A 153ILE A 195 | None | 1.02A | 1z95A-3l06A:undetectable | 1z95A-3l06A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6c | 60 KDA CHAPERONIN 1 (Mycobacteriumtuberculosis) |
PF00118(Cpn60_TCP1) | 4 | LEU A 269ASN A 263LEU A 257LEU A 231 | None | 0.99A | 1z95A-3m6cA:undetectable | 1z95A-3m6cA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6m | RPFF PROTEINSENSORY/REGULATORYPROTEIN RPFC (Xanthomonascampestris) |
PF00072(Response_reg)PF00378(ECH_1) | 4 | LEU D 521ASN D 519LEU D 498LEU A 163 | None | 1.02A | 1z95A-3m6mD:undetectable | 1z95A-3m6mD:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n9i | TRYPTOPHANYL-TRNASYNTHETASE (Yersinia pestis) |
PF00579(tRNA-synt_1b) | 5 | LEU A 37ASN A 32LEU A 297LEU A 78ILE A 219 | None | 1.43A | 1z95A-3n9iA:undetectable | 1z95A-3n9iA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ncy | ADIC (Salmonellaenterica) |
PF13520(AA_permease_2) | 4 | LEU A 197ASN A 198LEU A 362ILE A 359 | None | 0.99A | 1z95A-3ncyA:undetectable | 1z95A-3ncyA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nd6 | PHOSPHOPANTETHEINEADENYLYLTRANSFERASE (Enterococcusfaecalis) |
PF01467(CTP_transf_like) | 4 | LEU A 147ASN A 16LEU A 54ILE A 22 | None | 1.00A | 1z95A-3nd6A:undetectable | 1z95A-3nd6A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oht | P38A (Salmo salar) |
PF00069(Pkinase) | 4 | LEU A 217LEU A 136LEU A 157ILE A 207 | None | 0.97A | 1z95A-3ohtA:undetectable | 1z95A-3ohtA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3omb | EXTRACELLULARSOLUTE-BINDINGPROTEIN, FAMILY 1 (Bifidobacteriumlongum) |
PF01547(SBP_bac_1) | 4 | LEU A 372MET A 54LEU A 417ILE A 425 | None | 1.02A | 1z95A-3ombA:undetectable | 1z95A-3ombA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rsi | PUTATIVE ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteroidesabscessus) |
PF00378(ECH_1) | 4 | LEU A 7LEU A 82MET A 116LEU A 29 | None | 0.62A | 1z95A-3rsiA:undetectable | 1z95A-3rsiA:20.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 4 | LEU A 32ASN A 33LEU A 201ILE A 226 | 1CA A 249 (-3.9A)1CA A 249 (-3.0A)1CA A 249 ( 4.2A)None | 0.57A | 1z95A-3ry9A:36.4 | 1z95A-3ry9A:54.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 4 | LEU A 32MET A 115LEU A 201ILE A 226 | 1CA A 249 (-3.9A)1CA A 249 (-3.6A)1CA A 249 ( 4.2A)None | 0.93A | 1z95A-3ry9A:36.4 | 1z95A-3ry9A:54.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slg | PBGP3 PROTEIN (Burkholderiapseudomallei) |
PF01370(Epimerase) | 5 | LEU A 170ASN A 171LEU A 75LEU A 174ILE A 238 | None | 1.31A | 1z95A-3slgA:undetectable | 1z95A-3slgA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sp1 | CYSTEINYL-TRNASYNTHETASE (Borreliellaburgdorferi) |
PF01406(tRNA-synt_1e) | 4 | LEU A 5ASN A 7LEU A 237ILE A 243 | None | 0.83A | 1z95A-3sp1A:undetectable | 1z95A-3sp1A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0p | DNA POLYMERASE III,BETA SUBUNIT ([Eubacterium]rectale) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | LEU A 328MET A 284LEU A 338ILE A 357 | None | 1.02A | 1z95A-3t0pA:undetectable | 1z95A-3t0pA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6q | CD180 ANTIGEN (Mus musculus) |
PF13855(LRR_8) | 4 | LEU A 44ASN A 45LEU A 84ILE A 89 | None | 0.90A | 1z95A-3t6qA:undetectable | 1z95A-3t6qA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6q | CD180 ANTIGEN (Mus musculus) |
PF13855(LRR_8) | 4 | LEU A 51LEU A 84LEU A 44ILE A 68 | None | 0.93A | 1z95A-3t6qA:undetectable | 1z95A-3t6qA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6q | CD180 ANTIGEN (Mus musculus) |
PF13855(LRR_8) | 4 | LEU A 457ASN A 479LEU A 501LEU A 450 | None | 1.02A | 1z95A-3t6qA:undetectable | 1z95A-3t6qA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdu | DCN1-LIKE PROTEIN 1 (Homo sapiens) |
PF03556(Cullin_binding) | 4 | ASN A 197LEU A 239MET A 227ILE A 208 | None | 0.83A | 1z95A-3tduA:undetectable | 1z95A-3tduA:22.01 |