SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z95_A_198A501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7)
PF01068
(DNA_ligase_A_M)
4 LEU A 154
MET A 177
LEU A  90
ILE A   4
None
0.98A 1z95A-1a0iA:
undetectable
1z95A-1a0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm0 P300/CBP ASSOCIATING
FACTOR


(Homo sapiens)
no annotation 4 LEU B 603
ASN B 604
LEU B 593
ILE B 571
None
0.86A 1z95A-1cm0B:
0.0
1z95A-1cm0B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria))
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
4 LEU C 559
LEU C 529
LEU C 578
ILE C 528
None
0.96A 1z95A-1ea9C:
undetectable
1z95A-1ea9C:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa)
PF00561
(Abhydrolase_1)
4 LEU A 162
ASN A 163
LEU A 131
ILE A 121
OCP  A 382 ( 4.4A)
None
None
None
1.02A 1z95A-1ex9A:
0.0
1z95A-1ex9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1


(Homo sapiens)
PF02263
(GBP)
PF02841
(GBP_C)
4 ASN A 302
LEU A 118
LEU A 296
ILE A  14
None
1.01A 1z95A-1f5nA:
0.0
1z95A-1f5nA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis)
PF01261
(AP_endonuc_2)
4 ASN A  66
LEU A  16
LEU A  11
ILE A  31
None
0.93A 1z95A-1i60A:
0.0
1z95A-1i60A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE


(Arabidopsis
thaliana)
PF01053
(Cys_Met_Meta_PP)
4 ASN A 254
LEU A 291
LEU A 142
ILE A 271
None
0.95A 1z95A-1ibjA:
undetectable
1z95A-1ibjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE


(Sulfolobus
acidocaldarius)
PF00128
(Alpha-amylase)
PF09196
(DUF1953)
4 LEU A 163
LEU A 127
LEU A 174
ILE A 125
None
0.89A 1z95A-1iv8A:
3.6
1z95A-1iv8A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1


(Mus musculus)
PF01979
(Amidohydro_1)
4 LEU A 196
LEU A 181
LEU A 188
ILE A 242
None
0.96A 1z95A-1kcxA:
undetectable
1z95A-1kcxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)


(Bifidobacterium
longum)
no annotation 4 LEU T 152
ASN T 151
LEU T  22
ILE T 248
None
0.83A 1z95A-1lthT:
undetectable
1z95A-1lthT:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE


(Bos taurus)
PF07748
(Glyco_hydro_38C)
4 LEU E 956
LEU E 992
LEU E 903
ILE E 990
None
0.97A 1z95A-1o7dE:
undetectable
1z95A-1o7dE:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus)
PF00285
(Citrate_synt)
4 LEU A  18
LEU A  38
LEU A 340
ILE A  35
None
1.02A 1z95A-1o7xA:
undetectable
1z95A-1o7xA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens)
PF13855
(LRR_8)
4 LEU A 149
LEU A 185
LEU A 142
ILE A 190
None
0.96A 1z95A-1oznA:
undetectable
1z95A-1oznA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p16 MRNA CAPPING ENZYME
ALPHA SUBUNIT


(Candida
albicans)
PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C)
4 LEU A 239
LEU A 147
MET A 199
LEU A 159
G  A1167 (-4.5A)
None
None
None
1.00A 1z95A-1p16A:
undetectable
1z95A-1p16A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
4 LEU A 102
MET A  19
LEU A 277
ILE A  35
None
0.90A 1z95A-1q14A:
undetectable
1z95A-1q14A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178


(Aquifex
aeolicus)
PF00582
(Usp)
4 LEU A   4
LEU A 120
LEU A 127
ILE A 133
None
0.94A 1z95A-1q77A:
undetectable
1z95A-1q77A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE


(Escherichia
coli)
PF02901
(PFL-like)
4 LEU A1536
LEU A1604
MET A1483
LEU A1438
None
1.00A 1z95A-1qhmA:
undetectable
1z95A-1qhmA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN


(Rhinovirus B)
PF00073
(Rhv)
4 ASN 2 190
LEU 3  52
LEU 3 207
ILE 2 225
None
1.01A 1z95A-1rhi2:
undetectable
1z95A-1rhi2:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL


(Nicotiana
tabacum)
PF01593
(Amino_oxidase)
4 LEU A 473
ASN A 468
LEU A 450
ILE A 453
None
FAD  A 600 (-4.4A)
None
None
0.84A 1z95A-1sezA:
undetectable
1z95A-1sezA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5c CENTROMERIC PROTEIN
E


(Homo sapiens)
PF00225
(Kinesin)
4 LEU A 292
LEU A 272
LEU A 265
ILE A 281
None
0.87A 1z95A-1t5cA:
undetectable
1z95A-1t5cA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ


(Glycine max)
PF00190
(Cupin_1)
4 LEU A 181
LEU A 263
LEU A 171
ILE A 265
None
0.99A 1z95A-1uikA:
undetectable
1z95A-1uikA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1


(Saccharomyces
cerevisiae)
PF00071
(Ras)
4 ASN Y  16
MET Y 145
LEU Y 103
ILE Y  73
None
0.87A 1z95A-1ukvY:
undetectable
1z95A-1ukvY:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE


(Sulfurisphaera
tokodaii)
PF00285
(Citrate_synt)
4 LEU A  19
LEU A  39
LEU A 341
ILE A  36
None
1.00A 1z95A-1vgmA:
undetectable
1z95A-1vgmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE


(Saccharomyces
cerevisiae)
PF01008
(IF-2B)
4 ASN A  96
LEU A 136
LEU A 129
ILE A 122
None
0.99A 1z95A-1w2wA:
undetectable
1z95A-1w2wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus)
PF01462
(LRRNT)
PF13855
(LRR_8)
4 LEU A 112
MET A 119
LEU A 126
ILE A 178
None
0.95A 1z95A-1xecA:
undetectable
1z95A-1xecA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens)
PF00975
(Thioesterase)
4 LEU A2234
ASN A2235
LEU A2490
ILE A2494
None
0.97A 1z95A-1xktA:
undetectable
1z95A-1xktA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE


(Bacillus
subtilis)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 LEU A 109
MET A  70
LEU A  98
ILE A 141
None
0.99A 1z95A-1yx2A:
undetectable
1z95A-1yx2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z85 HYPOTHETICAL PROTEIN
TM1380


(Thermotoga
maritima)
PF04452
(Methyltrans_RNA)
4 LEU A 210
LEU A 166
LEU A 162
ILE A 151
None
0.99A 1z95A-1z85A:
undetectable
1z95A-1z85A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima)
PF02065
(Melibiase)
4 LEU A 312
LEU A 329
LEU A 298
ILE A 352
None
1.00A 1z95A-1zy9A:
undetectable
1z95A-1zy9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae)
PF00578
(AhpC-TSA)
4 LEU A  75
ASN A  76
LEU A  84
ILE A  87
None
0.84A 1z95A-2a4vA:
undetectable
1z95A-2a4vA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 704
ASN A 705
MET A 787
LEU A 873
ILE A 898
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
None
0.42A 1z95A-2ax9A:
41.9
1z95A-2ax9A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14


(Homo sapiens)
PF00443
(UCH)
4 LEU A 319
ASN A 413
LEU A 478
LEU A 352
None
0.91A 1z95A-2aynA:
undetectable
1z95A-2aynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1w CASPASE RECRUITMENT
DOMAIN PROTEIN 4


(Homo sapiens)
PF00619
(CARD)
4 LEU A  40
ASN A  43
LEU A  23
ILE A  20
None
0.96A 1z95A-2b1wA:
undetectable
1z95A-2b1wA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
4 LEU A 243
LEU A 238
MET A 312
LEU A 348
None
0.83A 1z95A-2b42A:
undetectable
1z95A-2b42A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1


(Homo sapiens)
PF02263
(GBP)
PF02841
(GBP_C)
4 ASN A 302
LEU A 118
LEU A 296
ILE A  14
ASN  A 302 ( 0.6A)
LEU  A 118 ( 0.5A)
LEU  A 296 ( 0.5A)
ILE  A  14 ( 0.6A)
0.96A 1z95A-2b92A:
undetectable
1z95A-2b92A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE


(Legionella
pneumophila)
PF05761
(5_nucleotid)
4 LEU A 299
LEU A 195
MET A 431
ILE A 199
None
0.81A 1z95A-2bdeA:
undetectable
1z95A-2bdeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832


(Danio rerio)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7)
4 LEU A 182
LEU A 268
MET A 107
LEU A 167
None
1.01A 1z95A-2be4A:
undetectable
1z95A-2be4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon)
PF07859
(Abhydrolase_3)
4 LEU A  77
LEU A 166
LEU A 174
ILE A 165
None
0.97A 1z95A-2c7bA:
undetectable
1z95A-2c7bA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE


(Salmonella
enterica)
PF00006
(ATP-synt_ab)
4 LEU A 424
LEU A 169
LEU A 390
ILE A 368
None
0.94A 1z95A-2dpyA:
undetectable
1z95A-2dpyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efv HYPOTHETICAL PROTEIN
MJ0366


(Methanocaldococcus
jannaschii)
PF10802
(DUF2540)
4 LEU A  79
ASN A  76
LEU A  44
ILE A  48
None
PO4  A 101 (-4.0A)
None
None
1.01A 1z95A-2efvA:
undetectable
1z95A-2efvA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE


(Streptococcus
mutans)
PF04371
(PAD_porph)
4 LEU A 312
MET A 274
LEU A 320
ILE A  56
None
0.96A 1z95A-2ewoA:
undetectable
1z95A-2ewoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK


(Salmonella
enterica)
PF03519
(Invas_SpaK)
PF09052
(SipA)
4 LEU A 119
ASN A 120
LEU A  40
LEU C  31
None
0.97A 1z95A-2fm8A:
undetectable
1z95A-2fm8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go2 KUNITZ-TYPE SERINE
PROTEASE INHIBITOR
BBKI


(Bauhinia
bauhinioides)
PF00197
(Kunitz_legume)
4 LEU A  63
ASN A  14
LEU A 109
ILE A  76
None
EDO  A 700 (-3.3A)
None
None
0.91A 1z95A-2go2A:
undetectable
1z95A-2go2A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig6 NIMC/NIMA FAMILY
PROTEIN


(Clostridium
acetobutylicum)
PF01243
(Putative_PNPOx)
4 LEU A  73
MET A  53
LEU A  16
ILE A  71
None
0.91A 1z95A-2ig6A:
undetectable
1z95A-2ig6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens)
PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc)
4 LEU A 566
LEU A 803
LEU A 797
ILE A 782
None
0.95A 1z95A-2jfdA:
undetectable
1z95A-2jfdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A


(Mus musculus)
PF14580
(LRR_9)
4 ASN A  74
LEU A  80
LEU A  69
ILE A 100
None
1.01A 1z95A-2jqdA:
undetectable
1z95A-2jqdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE


(Pyrococcus
horikoshii)
PF13419
(HAD_2)
4 LEU A 179
LEU A 108
LEU A 116
ILE A 145
None
0.99A 1z95A-2om6A:
undetectable
1z95A-2om6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3


(Homo sapiens)
PF01853
(MOZ_SAS)
4 LEU A 614
LEU A 662
LEU A 669
ILE A 647
None
None
None
ACO  A 850 (-4.6A)
1.02A 1z95A-2ozuA:
undetectable
1z95A-2ozuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE


(Aneurinibacillus
thermoaerophilus)
PF16363
(GDP_Man_Dehyd)
4 LEU A   4
LEU A  97
LEU A 105
ILE A 162
None
1.02A 1z95A-2pk3A:
undetectable
1z95A-2pk3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE


(Escherichia
virus N4)
no annotation 4 ASN A 617
MET A 569
LEU A 611
ILE A 654
None
1.01A 1z95A-2po4A:
undetectable
1z95A-2po4A:
12.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
4 LEU A  32
ASN A  33
MET A 115
LEU A 201
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
0.88A 1z95A-2q3yA:
37.0
1z95A-2q3yA:
60.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql7 CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
4 LEU A 180
LEU A  97
LEU A 104
ILE A  72
None
1.01A 1z95A-2ql7A:
undetectable
1z95A-2ql7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmo DETHIOBIOTIN
SYNTHETASE


(Helicobacter
pylori)
PF13500
(AAA_26)
4 LEU A 121
ASN A 130
LEU A 138
LEU A 168
None
0.85A 1z95A-2qmoA:
undetectable
1z95A-2qmoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT


(Escherichia
coli)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
4 ASN B  68
LEU B  39
LEU B   3
ILE B   7
None
1.00A 1z95A-2wp9B:
undetectable
1z95A-2wp9B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes)
PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
4 LEU A 780
LEU A 562
LEU A 648
ILE A 652
None
0.90A 1z95A-2wyhA:
undetectable
1z95A-2wyhA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
4 LEU A 238
ASN A 239
LEU A 292
LEU A 295
None
0.89A 1z95A-2x05A:
undetectable
1z95A-2x05A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A


(Brevibacillus
brevis)
PF00668
(Condensation)
4 ASN A 412
LEU A 441
LEU A 424
ILE A 438
None
0.94A 1z95A-2xhgA:
undetectable
1z95A-2xhgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1


(Mus musculus)
PF07679
(I-set)
PF13855
(LRR_8)
4 LEU A 129
LEU A 165
LEU A 122
ILE A 170
None
0.86A 1z95A-2xotA:
undetectable
1z95A-2xotA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE


(Aquifex
aeolicus)
PF00551
(Formyl_trans_N)
4 LEU A  83
LEU A  15
LEU A 178
ILE A  19
None
1.01A 1z95A-2ywrA:
undetectable
1z95A-2ywrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znv AMSH-LIKE PROTEASE

(Homo sapiens)
PF01398
(JAB)
4 LEU A 340
LEU A 275
LEU A 433
ILE A 346
None
0.96A 1z95A-2znvA:
undetectable
1z95A-2znvA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE


(Geobacillus
stearothermophilus)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 ASN A 477
LEU A 310
LEU A 307
ILE A 407
None
1.02A 1z95A-3a74A:
undetectable
1z95A-3a74A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
4 ASN A 439
LEU A 467
LEU A 455
ILE A 463
None
1.02A 1z95A-3ayxA:
undetectable
1z95A-3ayxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 LEU A  51
LEU A  84
LEU A  44
ILE A  68
None
0.99A 1z95A-3b2dA:
undetectable
1z95A-3b2dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ


(Bacteroides
thetaiotaomicron)
PF00884
(Sulfatase)
PF16347
(DUF4976)
4 LEU A  71
LEU A 355
LEU A 338
ILE A 353
None
EDO  A 503 (-4.4A)
None
EDO  A 503 (-3.7A)
1.00A 1z95A-3b5qA:
undetectable
1z95A-3b5qA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdn PHEROMONE-BINDING
PROTEIN ASP1


(Apis mellifera)
PF01395
(PBP_GOBP)
4 LEU A 104
MET A  70
LEU A  53
ILE A  45
None
None
GOL  A 126 ( 4.9A)
None
0.95A 1z95A-3cdnA:
undetectable
1z95A-3cdnA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR


(Vibrio
parahaemolyticus)
PF13377
(Peripla_BP_3)
4 LEU A  75
LEU A 315
LEU A 153
ILE A 318
None
0.92A 1z95A-3d8uA:
undetectable
1z95A-3d8uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450


(Streptomyces
coelicolor)
PF00067
(p450)
4 LEU A 226
LEU A 245
LEU A 272
ILE A 264
None
0.93A 1z95A-3dbgA:
undetectable
1z95A-3dbgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570


(Thermotoga
maritima)
PF09936
(Methyltrn_RNA_4)
4 ASN X  28
LEU X   9
LEU X  87
ILE X  34
None
0.86A 1z95A-3dcmX:
undetectable
1z95A-3dcmX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE


(Bacillus cereus)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 LEU A 189
LEU A 281
LEU A 260
ILE A 290
None
1.02A 1z95A-3dhvA:
undetectable
1z95A-3dhvA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB


(Sinorhizobium
meliloti)
no annotation 4 LEU A 104
ASN A 108
LEU A  86
ILE A 123
None
1.01A 1z95A-3e4pA:
undetectable
1z95A-3e4pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN


(Aeropyrum
pernix)
PF13458
(Peripla_BP_6)
4 ASN A 272
LEU A 187
LEU A 220
ILE A 200
None
0.89A 1z95A-3eafA:
undetectable
1z95A-3eafA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN


(Aeropyrum
pernix)
PF13458
(Peripla_BP_6)
4 ASN A 272
LEU A 187
MET A 260
ILE A 200
None
0.96A 1z95A-3eafA:
undetectable
1z95A-3eafA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE


(Brucella
melitensis)
PF13561
(adh_short_C2)
4 ASN A 178
LEU A 159
LEU A 166
ILE A 160
None
0.98A 1z95A-3emkA:
undetectable
1z95A-3emkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY


(Methanopyrus
kandleri)
PF00493
(MCM)
4 ASN A 347
LEU A 243
LEU A 377
ILE A 361
None
0.91A 1z95A-3f8tA:
undetectable
1z95A-3f8tA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger)
PF06441
(EHN)
4 LEU A 213
ASN A 214
LEU A 114
ILE A 127
None
0.92A 1z95A-3g0iA:
undetectable
1z95A-3g0iA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE


(Bartonella
henselae)
PF13561
(adh_short_C2)
4 ASN A 178
LEU A 159
LEU A 166
ILE A 160
None
0.98A 1z95A-3grpA:
undetectable
1z95A-3grpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY


(Strongyloides
stercoralis)
PF00104
(Hormone_recep)
4 LEU A 657
ASN A 655
LEU A 694
ILE A 714
None
0.84A 1z95A-3gyuA:
17.8
1z95A-3gyuA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
4 LEU A 245
LEU A 240
MET A 314
LEU A 350
None
0.79A 1z95A-3hd8A:
undetectable
1z95A-3hd8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 LEU A 566
LEU A 803
LEU A 797
ILE A 782
None
0.95A 1z95A-3hhdA:
undetectable
1z95A-3hhdA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe)
PF08389
(Xpo1)
4 ASN T 258
MET T 233
LEU T 273
ILE T 309
None
0.99A 1z95A-3icqT:
undetectable
1z95A-3icqT:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae)
no annotation 4 LEU A1037
ASN A1038
LEU A1015
ILE A1061
None
GOL  A   1 ( 4.3A)
None
None
0.96A 1z95A-3kfoA:
undetectable
1z95A-3kfoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF02940
(mRNA_triPase)
4 LEU A 432
ASN A 431
LEU A 502
ILE A 497
None
1.02A 1z95A-3kyhA:
undetectable
1z95A-3kyhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE


(Xanthomonas
campestris)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 LEU A   7
ASN A   8
LEU A 153
ILE A 195
None
1.02A 1z95A-3l06A:
undetectable
1z95A-3l06A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis)
PF00118
(Cpn60_TCP1)
4 LEU A 269
ASN A 263
LEU A 257
LEU A 231
None
0.99A 1z95A-3m6cA:
undetectable
1z95A-3m6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN
SENSORY/REGULATORY
PROTEIN RPFC


(Xanthomonas
campestris)
PF00072
(Response_reg)
PF00378
(ECH_1)
4 LEU D 521
ASN D 519
LEU D 498
LEU A 163
None
1.02A 1z95A-3m6mD:
undetectable
1z95A-3m6mD:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE


(Yersinia pestis)
PF00579
(tRNA-synt_1b)
5 LEU A  37
ASN A  32
LEU A 297
LEU A  78
ILE A 219
None
1.43A 1z95A-3n9iA:
undetectable
1z95A-3n9iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica)
PF13520
(AA_permease_2)
4 LEU A 197
ASN A 198
LEU A 362
ILE A 359
None
0.99A 1z95A-3ncyA:
undetectable
1z95A-3ncyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Enterococcus
faecalis)
PF01467
(CTP_transf_like)
4 LEU A 147
ASN A  16
LEU A  54
ILE A  22
None
1.00A 1z95A-3nd6A:
undetectable
1z95A-3nd6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar)
PF00069
(Pkinase)
4 LEU A 217
LEU A 136
LEU A 157
ILE A 207
None
0.97A 1z95A-3ohtA:
undetectable
1z95A-3ohtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1


(Bifidobacterium
longum)
PF01547
(SBP_bac_1)
4 LEU A 372
MET A  54
LEU A 417
ILE A 425
None
1.02A 1z95A-3ombA:
undetectable
1z95A-3ombA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsi PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
4 LEU A   7
LEU A  82
MET A 116
LEU A  29
None
0.62A 1z95A-3rsiA:
undetectable
1z95A-3rsiA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1


(synthetic
construct)
PF00104
(Hormone_recep)
4 LEU A  32
ASN A  33
LEU A 201
ILE A 226
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.2A)
None
0.57A 1z95A-3ry9A:
36.4
1z95A-3ry9A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1


(synthetic
construct)
PF00104
(Hormone_recep)
4 LEU A  32
MET A 115
LEU A 201
ILE A 226
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
None
0.93A 1z95A-3ry9A:
36.4
1z95A-3ry9A:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei)
PF01370
(Epimerase)
5 LEU A 170
ASN A 171
LEU A  75
LEU A 174
ILE A 238
None
1.31A 1z95A-3slgA:
undetectable
1z95A-3slgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE


(Borreliella
burgdorferi)
PF01406
(tRNA-synt_1e)
4 LEU A   5
ASN A   7
LEU A 237
ILE A 243
None
0.83A 1z95A-3sp1A:
undetectable
1z95A-3sp1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT


([Eubacterium]
rectale)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 LEU A 328
MET A 284
LEU A 338
ILE A 357
None
1.02A 1z95A-3t0pA:
undetectable
1z95A-3t0pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
4 LEU A  44
ASN A  45
LEU A  84
ILE A  89
None
0.90A 1z95A-3t6qA:
undetectable
1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
4 LEU A  51
LEU A  84
LEU A  44
ILE A  68
None
0.93A 1z95A-3t6qA:
undetectable
1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
4 LEU A 457
ASN A 479
LEU A 501
LEU A 450
None
1.02A 1z95A-3t6qA:
undetectable
1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdu DCN1-LIKE PROTEIN 1

(Homo sapiens)
PF03556
(Cullin_binding)
4 ASN A 197
LEU A 239
MET A 227
ILE A 208
None
0.83A 1z95A-3tduA:
undetectable
1z95A-3tduA:
22.01