SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z95_A_198A501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		5 LEU A 171
GLY A 170
VAL A 183
HIS A  98
ILE A 102
 None
 1.47A 1z95A-1a0dA:
0.0		 1z95A-1a0dA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 229
GLN A 199
VAL A 226
ARG A 284
ILE A 238
 None
BR  A2008 (-4.0A)
None
None
None
 1.44A 1z95A-1jhdA:
0.0		 1z95A-1jhdA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 GLY A 170
GLN A 172
HIS A  63
THR A 116
ILE A 151
 SAM  A 501 (-3.3A)
SAM  A 501 (-3.0A)
None
None
None
 1.42A 1z95A-1oltA:
0.0		 1z95A-1oltA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 GLY A 158
GLN A 157
MET A  84
VAL A  82
MET A  81
 None
 1.48A 1z95A-1ryyA:
undetectable		 1z95A-1ryyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  92
HIS A 235
THR A 226
ILE A 225
 None
 1.45A 1z95A-1tqhA:
0.0		 1z95A-1tqhA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.19A 1z95A-1tqhA:
0.0		 1z95A-1tqhA:
23.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
VAL A 746
MET A 749
ARG A 752
HIS A 874
THR A 877
MET A 895
ILE A 899
 BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.0A)
None
None
 0.40A 1z95A-2ax9A:
41.9		 1z95A-2ax9A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.05A 1z95A-2de2A:
0.0		 1z95A-2de2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		5 LEU A 156
GLY A 153
THR A 231
MET A 166
ILE A 186
 None
 1.41A 1z95A-2e1dA:
0.0		 1z95A-2e1dA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei0 1,2-DIHYDROXYNAPHTHA
LENE DIOXYGENASE

(Pseudomonas sp.
C18) 		PF00903
(Glyoxalase) 		5 LEU A  10
GLY A  11
VAL A  56
HIS A  52
ILE A 127
 None
 1.41A 1z95A-2ei0A:
0.0		 1z95A-2ei0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 LEU A 597
GLY A 598
MET A 603
VAL A 604
HIS A 628
 None
None
None
None
D5M  A  21 (-4.0A)
 1.47A 1z95A-2g8gA:
undetectable		 1z95A-2g8gA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8x URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
4) 		PF03167
(UDG) 		5 LEU A 146
MET A 188
VAL A 186
HIS A 235
ILE A 118
 None
 1.34A 1z95A-2j8xA:
undetectable		 1z95A-2j8xA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		5 GLN A 384
MET A 382
VAL A 381
HIS A 453
THR A 451
 None
None
None
EDO  A 700 (-3.8A)
None
 1.45A 1z95A-2o0aA:
undetectable		 1z95A-2o0aA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A 155
GLY A 140
GLN A  30
VAL A 199
ILE A  17
 None
 1.29A 1z95A-2psyA:
undetectable		 1z95A-2psyA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
None
 0.45A 1z95A-2q3yA:
37.0		 1z95A-2q3yA:
60.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 GLY A 482
GLN A 483
HIS A 439
THR A  42
ILE A 444
 None
 1.49A 1z95A-2vf8A:
undetectable		 1z95A-2vf8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 LEU A1876
GLY A1875
HIS A1530
THR A1624
ILE A1871
 None
 1.26A 1z95A-2vz9A:
undetectable		 1z95A-2vz9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 301
GLY A 300
GLN A 298
THR A 327
ILE A 359
 None
 1.39A 1z95A-2y6eA:
undetectable		 1z95A-2y6eA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME

(Histophilus
somni) 		PF01063
(Aminotran_4) 		5 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.18A 1z95A-3cebA:
undetectable		 1z95A-3cebA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A  58
GLN A  59
ARG A  43
THR A 244
ILE A 276
 None
 1.39A 1z95A-3fhhA:
undetectable		 1z95A-3fhhA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 LEU L 274
GLY L 270
VAL S 415
HIS S 354
ILE S 433
 None
 1.42A 1z95A-3g9kL:
undetectable		 1z95A-3g9kL:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilw DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF00521
(DNA_topoisoIV) 		5 GLN A 277
ARG A  98
THR A 496
MET A 253
ILE A 234
 None
GOL  A 501 (-4.5A)
None
None
None
 1.49A 1z95A-3ilwA:
undetectable		 1z95A-3ilwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		5 LEU A  11
GLY A  36
HIS A 133
THR A   6
ILE A  42
 None
 1.10A 1z95A-3iq0A:
undetectable		 1z95A-3iq0A:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 718
MET A 756
MET A 759
VAL A 760
HIS A 888
ILE A 913
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
None
None
 1.39A 1z95A-3kbaA:
34.4		 1z95A-3kbaA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
ILE A 913
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 0.70A 1z95A-3kbaA:
34.4		 1z95A-3kbaA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLY A 722
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
MET A 909
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 1.04A 1z95A-3kbaA:
34.4		 1z95A-3kbaA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  58
GLY A  59
GLN A  62
MET A 330
ILE A 329
 None
 1.19A 1z95A-3l06A:
undetectable		 1z95A-3l06A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY A 429
MET A 487
VAL A 765
THR A 426
ILE A 404
 None
 1.31A 1z95A-3la4A:
undetectable		 1z95A-3la4A:
14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
 0.59A 1z95A-3ry9A:
36.4		 1z95A-3ry9A:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLN A 916
MET A 834
VAL A 895
MET A 934
ILE A 937
 GOL  A1904 (-4.5A)
None
None
GOL  A1905 (-4.1A)
None
 1.13A 1z95A-3va7A:
undetectable		 1z95A-3va7A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 GLY D 426
GLN D 427
ARG D 210
THR D 137
ILE D 423
 None
 1.40A 1z95A-3w3aD:
undetectable		 1z95A-3w3aD:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 LEU A  28
GLY A 200
GLN A  29
HIS A 204
ILE A 195
 None
 1.47A 1z95A-4ad9A:
undetectable		 1z95A-4ad9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1

(Pseudomonas
virus phi6) 		no annotation 5 LEU A 439
GLY A 440
VAL A 457
HIS A 630
ILE A 632
 None
 1.32A 1z95A-4btgA:
undetectable		 1z95A-4btgA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A  83
GLY A  82
VAL A  79
ARG A 101
THR A 169
 None
 1.45A 1z95A-4c23A:
undetectable		 1z95A-4c23A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 LEU A 214
GLY A 213
MET A 174
HIS A  76
ILE A  46
 None
None
None
GOL  A 402 (-4.4A)
GOL  A 402 (-4.3A)
 1.38A 1z95A-4f62A:
undetectable		 1z95A-4f62A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 LEU A 146
GLN A  55
VAL A 208
THR A 130
ILE A 129
 None
 1.20A 1z95A-4f7aA:
undetectable		 1z95A-4f7aA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 GLY A 422
VAL A 454
ARG A 376
HIS A 442
ILE A 440
 None
 1.47A 1z95A-4fddA:
undetectable		 1z95A-4fddA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY B 429
MET B 487
VAL B 765
THR B 426
ILE B 404
 None
 1.31A 1z95A-4g7eB:
undetectable		 1z95A-4g7eB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 LEU A 326
GLY A 328
ARG A 255
THR A 318
ILE A 340
 PLP  A 500 (-4.1A)
PLP  A 500 (-3.4A)
PLP  A 500 (-3.0A)
None
None
 1.24A 1z95A-4k6nA:
undetectable		 1z95A-4k6nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 219
GLY A 216
MET A 277
VAL A 281
HIS A 145
 None
 1.04A 1z95A-4l52A:
undetectable		 1z95A-4l52A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		5 LEU A 159
GLY A 244
VAL A 102
THR A 202
ILE A 196
 None
 1.42A 1z95A-4llfA:
undetectable		 1z95A-4llfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.29A 1z95A-4n78A:
undetectable		 1z95A-4n78A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 321
GLN A 328
VAL A 493
THR A 471
ILE A 473
 None
 1.47A 1z95A-4ny4A:
undetectable		 1z95A-4ny4A:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 568
GLN A 570
MET A 604
ARG A 611
ILE A 757
 None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
None
 1.22A 1z95A-4p6wA:
32.4		 1z95A-4p6wA:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 566
GLY A 567
GLN A 570
MET A 601
MET A 604
ARG A 611
ILE A 757
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
None
 0.85A 1z95A-4p6wA:
32.4		 1z95A-4p6wA:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 772
GLN A 776
MET A 807
ARG A 817
ILE A 964
 CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
None
 0.67A 1z95A-4udbA:
33.4		 1z95A-4udbA:
48.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 GLY A  61
GLN A  60
MET A  74
VAL A  75
ARG A  81
 None
 1.38A 1z95A-4wutA:
undetectable		 1z95A-4wutA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 5 LEU A 290
GLY A 291
HIS A 120
THR A 116
ILE A 115
 None
None
ZN  A 401 ( 3.3A)
ST9  A 403 (-4.2A)
ST9  A 403 (-4.1A)
 1.39A 1z95A-4zyoA:
undetectable		 1z95A-4zyoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B
LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		5 GLY B 289
GLN B 285
VAL B 275
THR A 101
ILE A  52
 None
 1.36A 1z95A-5ey5B:
undetectable		 1z95A-5ey5B:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 LEU A 536
GLY A 501
VAL A 497
THR A 562
ILE A 591
 None
 1.40A 1z95A-5fg3A:
undetectable		 1z95A-5fg3A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLN A 916
MET A 834
VAL A 895
MET A 934
ILE A 937
 None
 1.14A 1z95A-5i8iA:
undetectable		 1z95A-5i8iA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 LEU A 274
GLY A 192
MET A 265
THR A 195
ILE A 204
 None
 1.43A 1z95A-5jfmA:
undetectable		 1z95A-5jfmA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 123
GLY A 124
HIS A 163
THR A 131
ILE A 160
 None
 1.46A 1z95A-5mufA:
undetectable		 1z95A-5mufA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 772
GLN A 776
MET A 807
ARG A 817
ILE A 964
 ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
None
 0.64A 1z95A-5mwpA:
36.9		 1z95A-5mwpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN

(Mojiang
henipavirus) 		PF00423
(HN) 		5 LEU A 368
GLY A 367
VAL A 400
THR A 431
MET A 365
 None
 1.34A 1z95A-5nopA:
undetectable		 1z95A-5nopA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.71A 1z95A-5uc1A:
22.6		 1z95A-5uc1A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 562
GLY A 563
GLN A 566
MET A 600
ARG A 607
 486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
486  A 801 (-3.5A)
 0.76A 1z95A-5uc1A:
22.6		 1z95A-5uc1A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		5 GLY 3 468
MET 3 462
VAL 3 489
MET 3 490
THR 3 432
 None
 1.47A 1z95A-5udb3:
undetectable		 1z95A-5udb3:
13.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 GLY A  37
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 226
 None
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
None
 1.08A 1z95A-5ufsA:
34.5		 1z95A-5ufsA:
55.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 226
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
None
 0.83A 1z95A-5ufsA:
34.5		 1z95A-5ufsA:
55.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 523
MET A 521
THR A 527
MET A 537
ILE A 553
 None
 1.27A 1z95A-5vncA:
undetectable		 1z95A-5vncA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb0 FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		no annotation 5 LEU F 221
GLY F 257
VAL F 251
THR F  45
ILE F 124
 None
 1.40A 1z95A-5wb0F:
undetectable		 1z95A-5wb0F:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 LEU A 698
GLY A 728
VAL A 644
MET A 645
ILE A 411
 None
 1.05A 1z95A-6a91A:
undetectable		 1z95A-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 654
GLY B 655
MET A 151
VAL A 149
THR B 689
 None
 1.30A 1z95A-6bzgB:
undetectable		 1z95A-6bzgB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 LEU A  22
GLY A 408
VAL A  52
MET A  53
HIS A 450
 None
 1.40A 1z95A-6c7sA:
undetectable		 1z95A-6c7sA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL
ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 LEU D 294
GLY D 295
VAL A 289
THR A  37
ILE A  87
 None
 1.50A 1z95A-6f5dD:
undetectable		 1z95A-6f5dD:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 LEU M 238
GLY M 239
MET M 294
MET M 243
ILE M 301
 None
 1.48A 1z95A-6g2jM:
undetectable		 1z95A-6g2jM:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7) 		PF01068
(DNA_ligase_A_M) 		4 LEU A 154
MET A 177
LEU A  90
ILE A   4
 None
 0.98A 1z95A-1a0iA:
undetectable		 1z95A-1a0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm0 P300/CBP ASSOCIATING
FACTOR

(Homo sapiens) 		no annotation 4 LEU B 603
ASN B 604
LEU B 593
ILE B 571
 None
 0.86A 1z95A-1cm0B:
0.0		 1z95A-1cm0B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 LEU C 559
LEU C 529
LEU C 578
ILE C 528
 None
 0.96A 1z95A-1ea9C:
undetectable		 1z95A-1ea9C:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 LEU A 162
ASN A 163
LEU A 131
ILE A 121
 OCP  A 382 ( 4.4A)
None
None
None
 1.02A 1z95A-1ex9A:
0.0		 1z95A-1ex9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 ASN A 302
LEU A 118
LEU A 296
ILE A  14
 None
 1.01A 1z95A-1f5nA:
0.0		 1z95A-1f5nA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		4 ASN A  66
LEU A  16
LEU A  11
ILE A  31
 None
 0.93A 1z95A-1i60A:
0.0		 1z95A-1i60A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		4 ASN A 254
LEU A 291
LEU A 142
ILE A 271
 None
 0.95A 1z95A-1ibjA:
undetectable		 1z95A-1ibjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 LEU A 163
LEU A 127
LEU A 174
ILE A 125
 None
 0.89A 1z95A-1iv8A:
3.6		 1z95A-1iv8A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 LEU A 196
LEU A 181
LEU A 188
ILE A 242
 None
 0.96A 1z95A-1kcxA:
undetectable		 1z95A-1kcxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 LEU T 152
ASN T 151
LEU T  22
ILE T 248
 None
 0.83A 1z95A-1lthT:
undetectable		 1z95A-1lthT:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		4 LEU E 956
LEU E 992
LEU E 903
ILE E 990
 None
 0.97A 1z95A-1o7dE:
undetectable		 1z95A-1o7dE:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00285
(Citrate_synt) 		4 LEU A  18
LEU A  38
LEU A 340
ILE A  35
 None
 1.02A 1z95A-1o7xA:
undetectable		 1z95A-1o7xA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU A 149
LEU A 185
LEU A 142
ILE A 190
 None
 0.96A 1z95A-1oznA:
undetectable		 1z95A-1oznA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p16 MRNA CAPPING ENZYME
ALPHA SUBUNIT

(Candida
albicans) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 LEU A 239
LEU A 147
MET A 199
LEU A 159
 G  A1167 (-4.5A)
None
None
None
 1.00A 1z95A-1p16A:
undetectable		 1z95A-1p16A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 LEU A 102
MET A  19
LEU A 277
ILE A  35
 None
 0.90A 1z95A-1q14A:
undetectable		 1z95A-1q14A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178

(Aquifex
aeolicus) 		PF00582
(Usp) 		4 LEU A   4
LEU A 120
LEU A 127
ILE A 133
 None
 0.94A 1z95A-1q77A:
undetectable		 1z95A-1q77A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 LEU A1536
LEU A1604
MET A1483
LEU A1438
 None
 1.00A 1z95A-1qhmA:
undetectable		 1z95A-1qhmA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		4 ASN 2 190
LEU 3  52
LEU 3 207
ILE 2 225
 None
 1.01A 1z95A-1rhi2:
undetectable		 1z95A-1rhi2:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		4 LEU A 473
ASN A 468
LEU A 450
ILE A 453
 None
FAD  A 600 (-4.4A)
None
None
 0.84A 1z95A-1sezA:
undetectable		 1z95A-1sezA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5c CENTROMERIC PROTEIN
E

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 292
LEU A 272
LEU A 265
ILE A 281
 None
 0.87A 1z95A-1t5cA:
undetectable		 1z95A-1t5cA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		4 LEU A 181
LEU A 263
LEU A 171
ILE A 265
 None
 0.99A 1z95A-1uikA:
undetectable		 1z95A-1uikA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 ASN Y  16
MET Y 145
LEU Y 103
ILE Y  73
 None
 0.87A 1z95A-1ukvY:
undetectable		 1z95A-1ukvY:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 LEU A  19
LEU A  39
LEU A 341
ILE A  36
 None
 1.00A 1z95A-1vgmA:
undetectable		 1z95A-1vgmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 ASN A  96
LEU A 136
LEU A 129
ILE A 122
 None
 0.99A 1z95A-1w2wA:
undetectable		 1z95A-1w2wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 112
MET A 119
LEU A 126
ILE A 178
 None
 0.95A 1z95A-1xecA:
undetectable		 1z95A-1xecA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 LEU A2234
ASN A2235
LEU A2490
ILE A2494
 None
 0.97A 1z95A-1xktA:
undetectable		 1z95A-1xktA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A 109
MET A  70
LEU A  98
ILE A 141
 None
 0.99A 1z95A-1yx2A:
undetectable		 1z95A-1yx2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z85 HYPOTHETICAL PROTEIN
TM1380

(Thermotoga
maritima) 		PF04452
(Methyltrans_RNA) 		4 LEU A 210
LEU A 166
LEU A 162
ILE A 151
 None
 0.99A 1z95A-1z85A:
undetectable		 1z95A-1z85A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 LEU A 312
LEU A 329
LEU A 298
ILE A 352
 None
 1.00A 1z95A-1zy9A:
undetectable		 1z95A-1zy9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA) 		4 LEU A  75
ASN A  76
LEU A  84
ILE A  87
 None
 0.84A 1z95A-2a4vA:
undetectable		 1z95A-2a4vA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 704
ASN A 705
MET A 787
LEU A 873
ILE A 898
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
None
 0.42A 1z95A-2ax9A:
41.9		 1z95A-2ax9A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 319
ASN A 413
LEU A 478
LEU A 352
 None
 0.91A 1z95A-2aynA:
undetectable		 1z95A-2aynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1w CASPASE RECRUITMENT
DOMAIN PROTEIN 4

(Homo sapiens) 		PF00619
(CARD) 		4 LEU A  40
ASN A  43
LEU A  23
ILE A  20
 None
 0.96A 1z95A-2b1wA:
undetectable		 1z95A-2b1wA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 243
LEU A 238
MET A 312
LEU A 348
 None
 0.83A 1z95A-2b42A:
undetectable		 1z95A-2b42A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 ASN A 302
LEU A 118
LEU A 296
ILE A  14
 ASN  A 302 ( 0.6A)
LEU  A 118 ( 0.5A)
LEU  A 296 ( 0.5A)
ILE  A  14 ( 0.6A)
 0.96A 1z95A-2b92A:
undetectable		 1z95A-2b92A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		4 LEU A 299
LEU A 195
MET A 431
ILE A 199
 None
 0.81A 1z95A-2bdeA:
undetectable		 1z95A-2bdeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 LEU A 182
LEU A 268
MET A 107
LEU A 167
 None
 1.01A 1z95A-2be4A:
undetectable		 1z95A-2be4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		4 LEU A  77
LEU A 166
LEU A 174
ILE A 165
 None
 0.97A 1z95A-2c7bA:
undetectable		 1z95A-2c7bA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 424
LEU A 169
LEU A 390
ILE A 368
 None
 0.94A 1z95A-2dpyA:
undetectable		 1z95A-2dpyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efv HYPOTHETICAL PROTEIN
MJ0366

(Methanocaldococcus
jannaschii) 		PF10802
(DUF2540) 		4 LEU A  79
ASN A  76
LEU A  44
ILE A  48
 None
PO4  A 101 (-4.0A)
None
None
 1.01A 1z95A-2efvA:
undetectable		 1z95A-2efvA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		4 LEU A 312
MET A 274
LEU A 320
ILE A  56
 None
 0.96A 1z95A-2ewoA:
undetectable		 1z95A-2ewoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK

(Salmonella
enterica) 		PF03519
(Invas_SpaK)
PF09052
(SipA) 		4 LEU A 119
ASN A 120
LEU A  40
LEU C  31
 None
 0.97A 1z95A-2fm8A:
undetectable		 1z95A-2fm8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go2 KUNITZ-TYPE SERINE
PROTEASE INHIBITOR
BBKI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 LEU A  63
ASN A  14
LEU A 109
ILE A  76
 None
EDO  A 700 (-3.3A)
None
None
 0.91A 1z95A-2go2A:
undetectable		 1z95A-2go2A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig6 NIMC/NIMA FAMILY
PROTEIN

(Clostridium
acetobutylicum) 		PF01243
(Putative_PNPOx) 		4 LEU A  73
MET A  53
LEU A  16
ILE A  71
 None
 0.91A 1z95A-2ig6A:
undetectable		 1z95A-2ig6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		4 LEU A 566
LEU A 803
LEU A 797
ILE A 782
 None
 0.95A 1z95A-2jfdA:
undetectable		 1z95A-2jfdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Mus musculus) 		PF14580
(LRR_9) 		4 ASN A  74
LEU A  80
LEU A  69
ILE A 100
 None
 1.01A 1z95A-2jqdA:
undetectable		 1z95A-2jqdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		4 LEU A 179
LEU A 108
LEU A 116
ILE A 145
 None
 0.99A 1z95A-2om6A:
undetectable		 1z95A-2om6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 LEU A 614
LEU A 662
LEU A 669
ILE A 647
 None
None
None
ACO  A 850 (-4.6A)
 1.02A 1z95A-2ozuA:
undetectable		 1z95A-2ozuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A   4
LEU A  97
LEU A 105
ILE A 162
 None
 1.02A 1z95A-2pk3A:
undetectable		 1z95A-2pk3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 ASN A 617
MET A 569
LEU A 611
ILE A 654
 None
 1.01A 1z95A-2po4A:
undetectable		 1z95A-2po4A:
12.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 LEU A  32
ASN A  33
MET A 115
LEU A 201
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
 0.88A 1z95A-2q3yA:
37.0		 1z95A-2q3yA:
60.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql7 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 180
LEU A  97
LEU A 104
ILE A  72
 None
 1.01A 1z95A-2ql7A:
undetectable		 1z95A-2ql7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmo DETHIOBIOTIN
SYNTHETASE

(Helicobacter
pylori) 		PF13500
(AAA_26) 		4 LEU A 121
ASN A 130
LEU A 138
LEU A 168
 None
 0.85A 1z95A-2qmoA:
undetectable		 1z95A-2qmoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 ASN B  68
LEU B  39
LEU B   3
ILE B   7
 None
 1.00A 1z95A-2wp9B:
undetectable		 1z95A-2wp9B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU A 780
LEU A 562
LEU A 648
ILE A 652
 None
 0.90A 1z95A-2wyhA:
undetectable		 1z95A-2wyhA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 238
ASN A 239
LEU A 292
LEU A 295
 None
 0.89A 1z95A-2x05A:
undetectable		 1z95A-2x05A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		4 ASN A 412
LEU A 441
LEU A 424
ILE A 438
 None
 0.94A 1z95A-2xhgA:
undetectable		 1z95A-2xhgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		4 LEU A 129
LEU A 165
LEU A 122
ILE A 170
 None
 0.86A 1z95A-2xotA:
undetectable		 1z95A-2xotA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		4 LEU A  83
LEU A  15
LEU A 178
ILE A  19
 None
 1.01A 1z95A-2ywrA:
undetectable		 1z95A-2ywrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znv AMSH-LIKE PROTEASE

(Homo sapiens) 		PF01398
(JAB) 		4 LEU A 340
LEU A 275
LEU A 433
ILE A 346
 None
 0.96A 1z95A-2znvA:
undetectable		 1z95A-2znvA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ASN A 477
LEU A 310
LEU A 307
ILE A 407
 None
 1.02A 1z95A-3a74A:
undetectable		 1z95A-3a74A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 ASN A 439
LEU A 467
LEU A 455
ILE A 463
 None
 1.02A 1z95A-3ayxA:
undetectable		 1z95A-3ayxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A  51
LEU A  84
LEU A  44
ILE A  68
 None
 0.99A 1z95A-3b2dA:
undetectable		 1z95A-3b2dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A  71
LEU A 355
LEU A 338
ILE A 353
 None
EDO  A 503 (-4.4A)
None
EDO  A 503 (-3.7A)
 1.00A 1z95A-3b5qA:
undetectable		 1z95A-3b5qA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdn PHEROMONE-BINDING
PROTEIN ASP1

(Apis mellifera) 		PF01395
(PBP_GOBP) 		4 LEU A 104
MET A  70
LEU A  53
ILE A  45
 None
None
GOL  A 126 ( 4.9A)
None
 0.95A 1z95A-3cdnA:
undetectable		 1z95A-3cdnA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		4 LEU A  75
LEU A 315
LEU A 153
ILE A 318
 None
 0.92A 1z95A-3d8uA:
undetectable		 1z95A-3d8uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 LEU A 226
LEU A 245
LEU A 272
ILE A 264
 None
 0.93A 1z95A-3dbgA:
undetectable		 1z95A-3dbgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570

(Thermotoga
maritima) 		PF09936
(Methyltrn_RNA_4) 		4 ASN X  28
LEU X   9
LEU X  87
ILE X  34
 None
 0.86A 1z95A-3dcmX:
undetectable		 1z95A-3dcmX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 189
LEU A 281
LEU A 260
ILE A 290
 None
 1.02A 1z95A-3dhvA:
undetectable		 1z95A-3dhvA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB

(Sinorhizobium
meliloti) 		no annotation 4 LEU A 104
ASN A 108
LEU A  86
ILE A 123
 None
 1.01A 1z95A-3e4pA:
undetectable		 1z95A-3e4pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 ASN A 272
LEU A 187
LEU A 220
ILE A 200
 None
 0.89A 1z95A-3eafA:
undetectable		 1z95A-3eafA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 ASN A 272
LEU A 187
MET A 260
ILE A 200
 None
 0.96A 1z95A-3eafA:
undetectable		 1z95A-3eafA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 ASN A 178
LEU A 159
LEU A 166
ILE A 160
 None
 0.98A 1z95A-3emkA:
undetectable		 1z95A-3emkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		4 ASN A 347
LEU A 243
LEU A 377
ILE A 361
 None
 0.91A 1z95A-3f8tA:
undetectable		 1z95A-3f8tA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		4 LEU A 213
ASN A 214
LEU A 114
ILE A 127
 None
 0.92A 1z95A-3g0iA:
undetectable		 1z95A-3g0iA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		4 ASN A 178
LEU A 159
LEU A 166
ILE A 160
 None
 0.98A 1z95A-3grpA:
undetectable		 1z95A-3grpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY

(Strongyloides
stercoralis) 		PF00104
(Hormone_recep) 		4 LEU A 657
ASN A 655
LEU A 694
ILE A 714
 None
 0.84A 1z95A-3gyuA:
17.8		 1z95A-3gyuA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 245
LEU A 240
MET A 314
LEU A 350
 None
 0.79A 1z95A-3hd8A:
undetectable		 1z95A-3hd8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 566
LEU A 803
LEU A 797
ILE A 782
 None
 0.95A 1z95A-3hhdA:
undetectable		 1z95A-3hhdA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 ASN T 258
MET T 233
LEU T 273
ILE T 309
 None
 0.99A 1z95A-3icqT:
undetectable		 1z95A-3icqT:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A1037
ASN A1038
LEU A1015
ILE A1061
 None
GOL  A   1 ( 4.3A)
None
None
 0.96A 1z95A-3kfoA:
undetectable		 1z95A-3kfoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF02940
(mRNA_triPase) 		4 LEU A 432
ASN A 431
LEU A 502
ILE A 497
 None
 1.02A 1z95A-3kyhA:
undetectable		 1z95A-3kyhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A   7
ASN A   8
LEU A 153
ILE A 195
 None
 1.02A 1z95A-3l06A:
undetectable		 1z95A-3l06A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 269
ASN A 263
LEU A 257
LEU A 231
 None
 0.99A 1z95A-3m6cA:
undetectable		 1z95A-3m6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN
SENSORY/REGULATORY
PROTEIN RPFC

(Xanthomonas
campestris) 		PF00072
(Response_reg)
PF00378
(ECH_1) 		4 LEU D 521
ASN D 519
LEU D 498
LEU A 163
 None
 1.02A 1z95A-3m6mD:
undetectable		 1z95A-3m6mD:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		5 LEU A  37
ASN A  32
LEU A 297
LEU A  78
ILE A 219
 None
 1.43A 1z95A-3n9iA:
undetectable		 1z95A-3n9iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		4 LEU A 197
ASN A 198
LEU A 362
ILE A 359
 None
 0.99A 1z95A-3ncyA:
undetectable		 1z95A-3ncyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		4 LEU A 147
ASN A  16
LEU A  54
ILE A  22
 None
 1.00A 1z95A-3nd6A:
undetectable		 1z95A-3nd6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		4 LEU A 217
LEU A 136
LEU A 157
ILE A 207
 None
 0.97A 1z95A-3ohtA:
undetectable		 1z95A-3ohtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 LEU A 372
MET A  54
LEU A 417
ILE A 425
 None
 1.02A 1z95A-3ombA:
undetectable		 1z95A-3ombA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsi PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 LEU A   7
LEU A  82
MET A 116
LEU A  29
 None
 0.62A 1z95A-3rsiA:
undetectable		 1z95A-3rsiA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  32
ASN A  33
LEU A 201
ILE A 226
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.2A)
None
 0.57A 1z95A-3ry9A:
36.4		 1z95A-3ry9A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  32
MET A 115
LEU A 201
ILE A 226
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
None
 0.93A 1z95A-3ry9A:
36.4		 1z95A-3ry9A:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		5 LEU A 170
ASN A 171
LEU A  75
LEU A 174
ILE A 238
 None
 1.31A 1z95A-3slgA:
undetectable		 1z95A-3slgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		4 LEU A   5
ASN A   7
LEU A 237
ILE A 243
 None
 0.83A 1z95A-3sp1A:
undetectable		 1z95A-3sp1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT

([Eubacterium]
rectale) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 328
MET A 284
LEU A 338
ILE A 357
 None
 1.02A 1z95A-3t0pA:
undetectable		 1z95A-3t0pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU A  44
ASN A  45
LEU A  84
ILE A  89
 None
 0.90A 1z95A-3t6qA:
undetectable		 1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU A  51
LEU A  84
LEU A  44
ILE A  68
 None
 0.93A 1z95A-3t6qA:
undetectable		 1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU A 457
ASN A 479
LEU A 501
LEU A 450
 None
 1.02A 1z95A-3t6qA:
undetectable		 1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdu DCN1-LIKE PROTEIN 1

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 ASN A 197
LEU A 239
MET A 227
ILE A 208
 None
 0.83A 1z95A-3tduA:
undetectable		 1z95A-3tduA:
22.01