SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z37_A_ADNA300_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jdz | 5'-METHYLTHIOADENOSINE PHOSPHORYLASE (Sulfolobussolfataricus) |
PF01048(PNP_UDP_1) | 8 | ARG A 86THR A 89GLY A 91VAL A 179GLU A 180MET A 181GLU A 182SER A 204 | SO4 A 250 ( 3.1A)SO4 A 250 ( 3.0A)FMB A 270 (-3.3A)FMB A 270 (-4.6A)FMB A 270 (-4.6A)FMB A 270 (-3.8A)FMB A 270 (-2.8A)FMB A 270 (-3.2A) | 0.66A | 1z37A-1jdzA:33.6 | 1z37A-1jdzA:34.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jdz | 5'-METHYLTHIOADENOSINE PHOSPHORYLASE (Sulfolobussolfataricus) |
PF01048(PNP_UDP_1) | 5 | MET A 181ARG A 86THR A 89GLU A 182SER A 204 | FMB A 270 (-3.8A)SO4 A 250 ( 3.1A)SO4 A 250 ( 3.0A)FMB A 270 (-2.8A)FMB A 270 (-3.2A) | 1.32A | 1z37A-1jdzA:33.6 | 1z37A-1jdzA:34.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1odi | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermusthermophilus) |
PF01048(PNP_UDP_1) | 8 | MET A 65ARG A 87THR A 90GLY A 92GLU A 179MET A 180GLU A 181SER A 203 | ADN A1237 (-4.1A)SO4 A1236 ( 2.8A)SO4 A1236 ( 3.0A)ADN A1237 (-3.4A)ADN A1237 (-4.9A)ADN A1237 (-3.7A)ADN A1237 (-3.0A)ADN A1237 ( 3.7A) | 0.43A | 1z37A-1odiA:36.1 | 1z37A-1odiA:37.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pk9 | PURINE NUCLEOSIDEPHOSPHORYLASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 6 | ARG A 87GLY A 177VAL A 178GLU A 179MET A 180GLU A 181 | PO4 A 309 ( 2.8A)None2FA A 306 (-4.8A)2FA A 306 (-4.7A)2FA A 306 (-3.8A)2FA A 306 (-2.9A) | 1.43A | 1z37A-1pk9A:38.2 | 1z37A-1pk9A:58.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pk9 | PURINE NUCLEOSIDEPHOSPHORYLASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 8 | MET A 64ARG A 87GLY A 92VAL A 178GLU A 179MET A 180GLU A 181SER A 203 | 2FA A 306 (-3.6A)PO4 A 309 ( 2.8A)2FA A 306 (-3.5A)2FA A 306 (-4.8A)2FA A 306 (-4.7A)2FA A 306 (-3.8A)2FA A 306 (-2.9A)2FA A 306 ( 3.9A) | 0.36A | 1z37A-1pk9A:38.2 | 1z37A-1pk9A:58.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybf | AMP NUCLEOSIDASE (Bacteroidesthetaiotaomicron) |
PF01048(PNP_UDP_1) | 5 | MET A 71GLY A 98VAL A 184MET A 186SER A 209 | None | 0.95A | 1z37A-1ybfA:24.5 | 1z37A-1ybfA:24.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z34 | PURINE NUCLEOSIDEPHOSPHORYLASE (Trichomonasvaginalis) |
PF01048(PNP_UDP_1) | 5 | ARG A 87THR A 90MET A 64GLU A 181SER A 203 | 2FD A 300 ( 4.5A)2FD A 300 (-4.2A)2FD A 300 (-3.8A)2FD A 300 (-2.8A)2FD A 300 (-3.6A) | 1.46A | 1z37A-1z34A:44.5 | 1z37A-1z34A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z34 | PURINE NUCLEOSIDEPHOSPHORYLASE (Trichomonasvaginalis) |
PF01048(PNP_UDP_1) | 9 | MET A 64ARG A 87THR A 90GLY A 92VAL A 178GLU A 179MET A 180GLU A 181SER A 203 | 2FD A 300 (-3.8A)2FD A 300 ( 4.5A)2FD A 300 (-4.2A)2FD A 300 (-3.1A)2FD A 300 (-4.7A)None2FD A 300 (-3.7A)2FD A 300 (-2.8A)2FD A 300 (-3.6A) | 0.36A | 1z37A-1z34A:44.5 | 1z37A-1z34A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zos | 5'-METHYLTHIOADENOSINE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Streptococcuspneumoniae) |
PF01048(PNP_UDP_1) | 6 | GLY A 78VAL A 171GLU A 172MET A 173GLU A 174SER A 196 | MTM A 301 (-3.6A)NoneNoneMTM A 301 (-3.5A)MTM A 301 (-2.6A)MTM A 301 (-3.4A) | 0.66A | 1z37A-1zosA:22.3 | 1z37A-1zosA:24.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2bsx | PURINE NUCLEOSIDEPHOSPHORYLASE (Plasmodiumfalciparum) |
PF01048(PNP_UDP_1) | 6 | ARG A 88GLY A 93VAL A 181GLU A 182MET A 183GLU A 184 | NOS A1248 ( 4.5A)NOS A1248 (-4.0A)NOS A1248 ( 4.4A)NoneNOS A1248 (-3.4A)NOS A1248 (-3.1A) | 0.59A | 1z37A-2bsxA:33.3 | 1z37A-2bsxA:30.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yvp | MUTT/NUDIX FAMILYPROTEIN (Thermusthermophilus) |
PF00293(NUDIX) | 5 | THR A 134GLY A 96VAL A 95GLU A 94GLU A 139 | NoneNoneNone MG A 184 (-2.5A) MG A 183 (-2.5A) | 1.39A | 1z37A-2yvpA:undetectable | 1z37A-2yvpA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0f | PUTATIVEPHOSPHOGLUCOMUTASE (Thermusthermophilus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | ARG A 155GLY A 23VAL A 24GLU A 158GLU A 159 | None | 1.48A | 1z37A-2z0fA:undetectable | 1z37A-2z0fA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bje | NUCLEOSIDEPHOSPHORYLASE,PUTATIVE (Trypanosomabrucei) |
PF01048(PNP_UDP_1) | 7 | MET A 87ARG A 137GLY A 142GLU A 284MET A 285GLU A 286SER A 309 | R1P A 401 ( 3.9A)R1P A 401 (-3.0A)URA A 501 (-3.4A)R1P A 401 ( 4.6A)R1P A 401 ( 3.9A)R1P A 401 (-2.6A)URA A 501 (-3.2A) | 1.03A | 1z37A-3bjeA:29.0 | 1z37A-3bjeA:26.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bje | NUCLEOSIDEPHOSPHORYLASE,PUTATIVE (Trypanosomabrucei) |
PF01048(PNP_UDP_1) | 7 | MET A 87ARG A 137THR A 140GLY A 142GLU A 284MET A 285GLU A 286 | R1P A 401 ( 3.9A)R1P A 401 (-3.0A)R1P A 401 (-3.0A)URA A 501 (-3.4A)R1P A 401 ( 4.6A)R1P A 401 ( 3.9A)R1P A 401 (-2.6A) | 0.45A | 1z37A-3bjeA:29.0 | 1z37A-3bjeA:26.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bl6 | 5'-METHYLTHIOADENOSINENUCLEOSIDASE/S-ADENOSYLHOMOCYSTEINENUCLEOSIDASE (Staphylococcusaureus) |
PF01048(PNP_UDP_1) | 6 | GLY A 77VAL A 170GLU A 171MET A 172GLU A 173SER A 195 | FMC A 229 (-3.6A)FMC A 229 ( 4.7A)FMC A 229 (-4.7A)FMC A 229 (-3.5A)FMC A 229 (-2.5A)FMC A 229 (-3.5A) | 0.48A | 1z37A-3bl6A:24.6 | 1z37A-3bl6A:25.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dp9 | MTA/SAH NUCLEOSIDASE (Vibrio cholerae) |
PF01048(PNP_UDP_1) | 6 | GLY A 78VAL A 172GLU A 173MET A 174GLU A 175SER A 197 | BIG A 301 (-3.7A)BIG A 301 (-4.9A)NoneBIG A 301 (-3.6A)BIG A 301 (-2.8A)BIG A 301 (-3.3A) | 0.51A | 1z37A-3dp9A:24.1 | 1z37A-3dp9A:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eei | 5-METHYLTHIOADENOSINENUCLEOSIDASE/S-ADENOSYLHOMOCYSTEINENUCLEOSIDASE (Neisseriameningitidis) |
PF01048(PNP_UDP_1) | 6 | GLY A 81VAL A 175GLU A 176MET A 177GLU A 178SER A 200 | MTM A 234 (-3.9A)MTM A 234 ( 4.9A)MTM A 234 (-4.6A)MTM A 234 (-3.8A)MTM A 234 (-2.6A)MTM A 234 (-3.4A) | 0.51A | 1z37A-3eeiA:24.0 | 1z37A-3eeiA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emv | URIDINEPHOSPHORYLASE,PUTATIVE (Plasmodiumvivax) |
PF01048(PNP_UDP_1) | 6 | ARG A 89GLY A 94VAL A 182GLU A 183MET A 184GLU A 185 | SO4 A 254 (-3.2A)NoneNoneNoneNoneNone | 0.34A | 1z37A-3emvA:33.3 | 1z37A-3emvA:29.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euf | URIDINEPHOSPHORYLASE 1 (Homo sapiens) |
PF01048(PNP_UDP_1) | 7 | MET A 110ARG A 138THR A 141GLY A 143GLU A 248MET A 249GLU A 250 | BAU A 400 (-3.5A)PO4 A 401 (-3.0A)PO4 A 401 ( 3.0A)BAU A 400 (-3.3A)NoneBAU A 400 (-3.8A)PO4 A 401 ( 4.2A) | 0.45A | 1z37A-3eufA:23.7 | 1z37A-3eufA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kvy | URIDINEPHOSPHORYLASE (Bos taurus) |
PF01048(PNP_UDP_1) | 7 | MET A 109ARG A 137THR A 140GLY A 142GLU A 247MET A 248GLU A 249 | R2B A 313 (-3.9A)SO4 A 311 ( 3.0A)SO4 A 311 ( 3.1A)URA A 312 (-3.3A)R2B A 313 ( 4.4A)URA A 312 ( 3.7A)R2B A 313 (-2.6A) | 0.49A | 1z37A-3kvyA:23.8 | 1z37A-3kvyA:26.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mb8 | PURINE NUCLEOSIDEPHOSPHORYLASE (Toxoplasmagondii) |
PF01048(PNP_UDP_1) | 5 | ARG A 93THR A 96GLY A 98MET A 187GLU A 188 | PO4 A 281 ( 3.0A)PO4 A 281 ( 3.2A)IMH A 280 (-3.2A)IMH A 280 (-3.8A)IMH A 280 (-2.5A) | 0.40A | 1z37A-3mb8A:32.4 | 1z37A-3mb8A:30.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4v | MTA/SAH NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 6 | GLY A 78VAL A 171GLU A 172MET A 173GLU A 174SER A 196 | 4CT A 233 (-3.8A)4CT A 233 ( 4.9A)None4CT A 233 (-3.6A)4CT A 233 (-3.0A)4CT A 233 (-3.3A) | 0.42A | 1z37A-3o4vA:23.9 | 1z37A-3o4vA:26.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3of3 | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE 1 (Vibrio cholerae) |
PF01048(PNP_UDP_1) | 6 | ARG A 101GLY A 191VAL A 192GLU A 193MET A 194GLU A 195 | PO4 A 501 (-2.8A)NoneDIH A 500 (-4.8A)NoneDIH A 500 (-3.8A)DIH A 500 (-2.9A) | 1.42A | 1z37A-3of3A:38.1 | 1z37A-3of3A:55.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3of3 | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE 1 (Vibrio cholerae) |
PF01048(PNP_UDP_1) | 8 | MET A 78ARG A 101GLY A 106VAL A 192GLU A 193MET A 194GLU A 195SER A 217 | DIH A 500 (-3.6A)PO4 A 501 (-2.8A)DIH A 500 (-4.0A)DIH A 500 (-4.8A)NoneDIH A 500 (-3.8A)DIH A 500 (-2.9A)DIH A 500 (-3.3A) | 0.43A | 1z37A-3of3A:38.1 | 1z37A-3of3A:55.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p0f | URIDINEPHOSPHORYLASE 2 (Homo sapiens) |
PF01048(PNP_UDP_1) | 7 | MET A 116ARG A 144THR A 147GLY A 149GLU A 254MET A 255GLU A 256 | BAU A 400 (-3.4A)NoneBAU A 400 (-4.5A)BAU A 400 (-3.5A)NoneBAU A 400 (-3.9A)None | 0.40A | 1z37A-3p0fA:23.6 | 1z37A-3p0fA:27.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qpb | URIDINEPHOSPHORYLASE (Streptococcuspyogenes) |
PF01048(PNP_UDP_1) | 6 | ARG A 94THR A 97GLY A 99GLU A 196MET A 197GLU A 198 | R1P A1254 (-3.1A)R1P A1254 (-3.0A)URA A1255 (-3.2A)R1P A1254 ( 4.4A)R1P A1254 (-3.9A)R1P A1254 (-2.6A) | 0.43A | 1z37A-3qpbA:32.8 | 1z37A-3qpbA:34.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tl6 | PURINE NUCLEOSIDEPHOSPHORYLASE (Entamoebahistolytica) |
PF01048(PNP_UDP_1) | 8 | MET A 69ARG A 92GLY A 97VAL A 182GLU A 183MET A 184GLU A 185SER A 207 | NoneSO4 A 239 (-3.2A)NoneNoneNoneNoneSO4 A 239 ( 4.4A)None | 0.45A | 1z37A-3tl6A:35.2 | 1z37A-3tl6A:45.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uav | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Bacillus cereus) |
PF01048(PNP_UDP_1) | 5 | ARG A 87THR A 90MET A 64GLU A 181SER A 203 | SO4 A 236 (-2.7A)SO4 A 236 (-3.0A)NoneSO4 A 236 ( 4.4A)None | 1.49A | 1z37A-3uavA:37.4 | 1z37A-3uavA:47.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uav | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Bacillus cereus) |
PF01048(PNP_UDP_1) | 9 | MET A 64ARG A 87THR A 90GLY A 92VAL A 178GLU A 179MET A 180GLU A 181SER A 203 | NoneSO4 A 236 (-2.7A)SO4 A 236 (-3.0A)NoneNoneNoneNoneSO4 A 236 ( 4.4A)None | 0.53A | 1z37A-3uavA:37.4 | 1z37A-3uavA:47.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dao | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Bacillussubtilis) |
PF01048(PNP_UDP_1) | 6 | ARG A 87GLY A 176VAL A 177GLU A 178MET A 179GLU A 180 | NoneNoneADE A 301 (-4.4A)NoneADE A 301 ( 4.3A)None | 1.44A | 1z37A-4daoA:36.2 | 1z37A-4daoA:46.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dao | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Bacillussubtilis) |
PF01048(PNP_UDP_1) | 8 | MET A 64ARG A 87GLY A 92VAL A 177GLU A 178MET A 179GLU A 180SER A 202 | NoneNoneADE A 301 (-3.5A)ADE A 301 (-4.4A)NoneADE A 301 ( 4.3A)NoneADE A 301 (-3.5A) | 0.31A | 1z37A-4daoA:36.2 | 1z37A-4daoA:46.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g41 | MTA/SAH NUCLEOSIDASE (Streptococcuspyogenes) |
PF01048(PNP_UDP_1) | 5 | GLY A 78GLU A 172MET A 173GLU A 174SER A 196 | GLY A 78 ( 0.0A)GLU A 172 ( 0.5A)MET A 173 ( 0.0A)GLU A 174 ( 0.6A)SER A 196 ( 0.0A) | 0.80A | 1z37A-4g41A:23.1 | 1z37A-4g41A:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g41 | MTA/SAH NUCLEOSIDASE (Streptococcuspyogenes) |
PF01048(PNP_UDP_1) | 5 | VAL A 171GLU A 172MET A 173GLU A 174SER A 196 | VAL A 171 ( 0.6A)GLU A 172 ( 0.5A)MET A 173 ( 0.0A)GLU A 174 ( 0.6A)SER A 196 ( 0.0A) | 0.81A | 1z37A-4g41A:23.1 | 1z37A-4g41A:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jos | ADENOSYLHOMOCYSTEINENUCLEOSIDASE (Francisellaphilomiragia) |
PF01048(PNP_UDP_1) | 5 | GLY A 79GLU A 171MET A 172GLU A 173SER A 195 | ADE A 301 (-3.7A)NoneADE A 301 (-4.1A)NoneADE A 301 (-3.3A) | 0.47A | 1z37A-4josA:23.2 | 1z37A-4josA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwt | METHYLTHIOADENOSINENUCLEOSIDASE (Sulfurimonasdenitrificans) |
PF01048(PNP_UDP_1) | 5 | GLY A 78GLU A 171MET A 172GLU A 173SER A 195 | ADE A 305 (-3.6A)NoneADE A 305 (-4.1A)NoneADE A 305 (-3.2A) | 0.49A | 1z37A-4jwtA:22.7 | 1z37A-4jwtA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kn5 | METHYLTHIOADENOSINENUCLEOSIDASE (Weissellaparamesenteroides) |
PF01048(PNP_UDP_1) | 5 | GLY A 78GLU A 173MET A 174GLU A 175SER A 197 | EDO A 301 (-3.3A)NoneNoneNoneNone | 0.74A | 1z37A-4kn5A:22.2 | 1z37A-4kn5A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l0m | PUTATIVE5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Borreliellaburgdorferi) |
PF01048(PNP_UDP_1) | 5 | GLY A 81VAL A 178MET A 180GLU A 181SER A 203 | ADE A 301 (-3.6A)NoneADE A 301 ( 4.2A)NoneADE A 301 (-3.1A) | 0.41A | 1z37A-4l0mA:22.7 | 1z37A-4l0mA:21.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ldn | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Aliivibriofischeri) |
PF01048(PNP_UDP_1) | 5 | ARG A 88GLY A 178VAL A 179GLU A 180GLU A 182 | PO4 A 301 (-2.9A)NoneNoneNonePO4 A 301 ( 4.7A) | 1.47A | 1z37A-4ldnA:36.8 | 1z37A-4ldnA:45.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ldn | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Aliivibriofischeri) |
PF01048(PNP_UDP_1) | 7 | MET A 65ARG A 88GLY A 93VAL A 179GLU A 180MET A 181GLU A 182 | NonePO4 A 301 (-2.9A)NoneNoneNoneNonePO4 A 301 ( 4.7A) | 0.48A | 1z37A-4ldnA:36.8 | 1z37A-4ldnA:45.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lkr | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Shewanellaoneidensis) |
PF01048(PNP_UDP_1) | 6 | MET A 64ARG A 87GLY A 92MET A 180GLU A 181SER A 203 | None | 0.50A | 1z37A-4lkrA:37.0 | 1z37A-4lkrA:42.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m3n | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Meiothermusruber) |
PF01048(PNP_UDP_1) | 5 | MET A 64ARG A 87THR A 90MET A 180GLU A 181 | None | 0.92A | 1z37A-4m3nA:36.3 | 1z37A-4m3nA:50.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m3n | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Meiothermusruber) |
PF01048(PNP_UDP_1) | 8 | MET A 64THR A 90GLY A 92VAL A 178GLU A 179MET A 180GLU A 181SER A 203 | None | 0.43A | 1z37A-4m3nA:36.3 | 1z37A-4m3nA:50.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m7w | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Leptotrichiabuccalis) |
PF01048(PNP_UDP_1) | 9 | MET A 65ARG A 88THR A 91GLY A 93VAL A 179GLU A 180MET A 181GLU A 182SER A 204 | NonePO4 A 400 (-3.0A)PO4 A 400 (-3.5A)NoneNoneNoneNonePO4 A 400 ( 4.4A)None | 0.35A | 1z37A-4m7wA:37.7 | 1z37A-4m7wA:45.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m7w | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Leptotrichiabuccalis) |
PF01048(PNP_UDP_1) | 5 | MET A 181ARG A 88THR A 91GLU A 182SER A 204 | NonePO4 A 400 (-3.0A)PO4 A 400 (-3.5A)PO4 A 400 ( 4.4A)None | 1.43A | 1z37A-4m7wA:37.7 | 1z37A-4m7wA:45.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pbx | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE S (Homo sapiens) |
PF00041(fn3)PF07679(I-set) | 5 | ARG A 228THR A 149VAL A 146GLU A 147SER A 196 | None | 1.39A | 1z37A-4pbxA:undetectable | 1z37A-4pbxA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pr3 | 5'-METHYLTHIOADENOSINE NUCLEOSIDASE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Brucellamelitensis) |
PF01048(PNP_UDP_1) | 5 | GLY A 67VAL A 142MET A 144GLU A 145SER A 167 | ADE A 501 (-3.7A)ADE A 501 (-4.7A)ADE A 501 (-4.0A)NoneADE A 501 (-3.5A) | 0.54A | 1z37A-4pr3A:9.7 | 1z37A-4pr3A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qez | 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Bacillusanthracis) |
no annotation | 6 | GLY B 78VAL B 172GLU B 173MET B 174GLU B 175SER B 197 | ADE B 301 (-3.2A)NoneTRS B 302 ( 4.8A)TRS B 302 (-4.2A)TRS B 302 (-2.7A)ADE B 301 (-3.0A) | 0.62A | 1z37A-4qezB:22.9 | 1z37A-4qezB:25.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfb | CT263 (Chlamydiatrachomatis) |
no annotation | 5 | GLY A 74VAL A 135MET A 137GLU A 138SER A 160 | None | 0.50A | 1z37A-4qfbA:17.2 | 1z37A-4qfbA:24.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r2w | URIDINEPHOSPHORYLASE (Shewanellaoneidensis) |
PF01048(PNP_UDP_1) | 6 | ARG A 88THR A 91GLY A 93GLU A 193MET A 194GLU A 195 | SO4 A 302 ( 2.8A)SO4 A 302 ( 3.0A)NoneGOL A 303 (-4.9A)GOL A 303 (-3.5A)GOL A 303 (-2.9A) | 0.34A | 1z37A-4r2wA:31.2 | 1z37A-4r2wA:31.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r31 | URIDINEPHOSPHORYLASE (Actinobacillussuccinogenes) |
PF01048(PNP_UDP_1) | 5 | THR A 92GLY A 94GLU A 194MET A 195GLU A 196 | NoneNoneNoneGOL A 301 (-4.0A)GOL A 301 (-2.6A) | 0.74A | 1z37A-4r31A:31.2 | 1z37A-4r31A:28.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4tym | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Streptococcusagalactiae) |
PF01048(PNP_UDP_1) | 8 | MET A 86ARG A 109THR A 112GLY A 114GLU A 201MET A 202GLU A 203SER A 225 | NoneSO4 A 301 (-2.8A)SO4 A 301 (-3.7A)NoneNoneNoneSO4 A 301 ( 4.4A)None | 0.44A | 1z37A-4tymA:37.1 | 1z37A-4tymA:42.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4tym | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Streptococcusagalactiae) |
PF01048(PNP_UDP_1) | 5 | MET A 202ARG A 109THR A 112GLU A 203SER A 225 | NoneSO4 A 301 (-2.8A)SO4 A 301 (-3.7A)SO4 A 301 ( 4.4A)None | 1.45A | 1z37A-4tymA:37.1 | 1z37A-4tymA:42.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7n | MTA/SAH NUCLEOSIDASE (Aeromonashydrophila) |
PF01048(PNP_UDP_1) | 6 | THR A 104GLY A 106GLU A 219MET A 220GLU A 221SER A 243 | SAH A 301 (-4.3A)SAH A 301 (-3.2A)SAH A 301 (-4.9A)SAH A 301 (-3.6A)SAH A 301 (-2.6A)SAH A 301 ( 4.0A) | 0.36A | 1z37A-5b7nA:23.6 | 1z37A-5b7nA:25.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyf | PUTATIVE URIDINEPHOSPHORYLASE (Schistosomamansoni) |
PF01048(PNP_UDP_1) | 5 | ARG A 121THR A 124GLU A 232MET A 233GLU A 234 | FLC A 301 (-3.0A)FLC A 301 (-3.7A)NoneNoneFLC A 301 (-2.8A) | 0.37A | 1z37A-5cyfA:23.5 | 1z37A-5cyfA:26.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dk6 | 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Colwelliapsychrerythraea) |
PF01048(PNP_UDP_1) | 6 | GLY A 78VAL A 177GLU A 178MET A 179GLU A 180SER A 202 | ADE A 302 (-3.6A)ADE A 302 (-4.6A)NoneADE A 302 (-4.1A)NoneADE A 302 (-3.2A) | 0.47A | 1z37A-5dk6A:23.4 | 1z37A-5dk6A:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iz1 | FRUCTOSE-1,6-BISPHOSPHATASE (Physcomitrellapatens) |
PF00316(FBPase) | 5 | THR A 278GLY A 276VAL A 267MET A 259SER A 289 | None | 0.73A | 1z37A-5iz1A:undetectable | 1z37A-5iz1A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1z | AMINODEOXYFUTALOSINENUCLEOSIDASE (Helicobacterpylori) |
PF01048(PNP_UDP_1) | 6 | GLY A 80VAL A 172GLU A 173MET A 174GLU A 175SER A 197 | 4CT A 301 (-3.4A)4CT A 301 ( 4.5A)None4CT A 301 (-3.0A)4CT A 301 (-2.2A)4CT A 301 ( 2.8A) | 0.35A | 1z37A-5k1zA:23.7 | 1z37A-5k1zA:24.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lhv | URIDINEPHOSPHORYLASE (Vibrio cholerae) |
PF01048(PNP_UDP_1) | 6 | ARG A 90THR A 93GLY A 95GLU A 195MET A 196GLU A 197 | SO4 A 301 ( 3.0A)SO4 A 301 ( 2.9A)URI A 303 ( 3.4A)URI A 303 ( 4.6A)URI A 303 ( 3.7A)URI A 303 (-2.7A) | 0.37A | 1z37A-5lhvA:31.4 | 1z37A-5lhvA:30.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ue1 | 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Aliivibriofischeri) |
PF01048(PNP_UDP_1) | 6 | GLY A 78VAL A 172GLU A 173MET A 174GLU A 175SER A 197 | 9DA A 301 (-3.5A)NoneTRS A 302 ( 4.6A)TRS A 302 (-3.9A)TRS A 302 (-2.7A)9DA A 301 (-3.2A) | 0.59A | 1z37A-5ue1A:24.2 | 1z37A-5ue1A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g7x | - (-) |
no annotation | 8 | MET A 64ARG A 87THR A 90GLY A 92GLU A 179MET A 180GLU A 181SER A 203 | NonePO4 A 304 ( 4.4A)PO4 A 304 (-2.8A)IMD A 302 ( 4.2A)NoneIMD A 302 (-4.6A)PO4 A 304 ( 4.7A)None | 0.46A | 1z37A-6g7xA:37.6 | 1z37A-6g7xA:undetectable |