SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z2B_C_VLBC800_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 VAL A  43
TYR A 191
THR A  37
LEU A 188
 None
 0.97A 1z2bB-1ea6A:
undetectable		 1z2bB-1ea6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ASP A 126
THR A 227
PRO A 228
TYR A 233
 None
 0.96A 1z2bB-1ff9A:
undetectable		 1z2bB-1ff9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		5 VAL A 331
THR A 328
PRO A 329
TYR A 319
LEU A 323
 None
 1.50A 1z2bB-1gcyA:
undetectable		 1z2bB-1gcyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1heh ENDO-1,4-BETA-XYLANA
SE D

(Cellulomonas
fimi) 		no annotation 4 VAL C 626
THR C 636
PRO C 637
LEU C 590
 None
 0.86A 1z2bB-1hehC:
undetectable		 1z2bB-1hehC:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6x AUTOINDUCER-2
PRODUCTION PROTEIN
LUXS

(Helicobacter
pylori) 		PF02664
(LuxS) 		4 VAL A  20
TYR A  37
THR A  95
LEU A 101
 None
 0.85A 1z2bB-1j6xA:
undetectable		 1z2bB-1j6xA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98

(Homo sapiens) 		PF04096
(Nucleoporin2) 		4 VAL A 775
THR A 749
TYR A 724
LEU A 719
 None
 1.04A 1z2bB-1ko6A:
undetectable		 1z2bB-1ko6A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 LYS A2239
VAL A2240
THR A2164
LEU A2161
 None
 0.89A 1z2bB-1mi1A:
undetectable		 1z2bB-1mi1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpp PAPD CHAPERONE

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 ASP A 130
THR A 188
PRO A 189
LEU A 156
 None
 0.83A 1z2bB-1qppA:
undetectable		 1z2bB-1qppA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r24 PROTEIN (IGG3-KAPPA
ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B  48
THR B  97
TYR B  94
LEU B  81
 None
 1.00A 1z2bB-1r24B:
undetectable		 1z2bB-1r24B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		4 VAL A 291
ASP A 294
TYR A 144
LEU A 151
 None
 1.01A 1z2bB-1ry6A:
undetectable		 1z2bB-1ry6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		4 LYS A  44
VAL A  43
TYR A   7
LEU A  55
 None
 0.70A 1z2bB-1si1A:
undetectable		 1z2bB-1si1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 LYS A 414
VAL A 415
THR A 474
LEU A 460
 None
 1.00A 1z2bB-1tf0A:
undetectable		 1z2bB-1tf0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 202
THR A 242
TYR A 184
LEU A 155
 None
 1.00A 1z2bB-1tkcA:
undetectable		 1z2bB-1tkcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 LYS A 250
VAL A 249
TYR A  29
LEU A 209
 None
 0.88A 1z2bB-1ua4A:
4.5		 1z2bB-1ua4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 VAL A 361
PRO A 359
TYR A 348
LEU A 352
 None
 1.01A 1z2bB-1ud3A:
undetectable		 1z2bB-1ud3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 VAL A  86
ASP A  91
THR A  66
LEU A  69
 None
 0.98A 1z2bB-1uqwA:
undetectable		 1z2bB-1uqwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger) 		PF01764
(Lipase_3) 		4 VAL A 115
THR A 128
TYR A 150
LEU A 146
 None
 0.97A 1z2bB-1uswA:
3.6		 1z2bB-1uswA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 VAL A 240
TYR A 242
THR A 283
LEU A 203
 None
 1.00A 1z2bB-1w18A:
undetectable		 1z2bB-1w18A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4s POLYBROMO 1 PROTEIN

(Gallus gallus) 		PF01426
(BAH) 		4 LYS A1032
VAL A 962
TYR A 956
LEU A 991
 None
 0.99A 1z2bB-1w4sA:
undetectable		 1z2bB-1w4sA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7r HYPOTHETICAL PROTEIN
SA2161

(Staphylococcus
aureus) 		PF13673
(Acetyltransf_10) 		4 LYS A 112
VAL A 115
THR A 122
PRO A 121
 None
 0.98A 1z2bB-1y7rA:
undetectable		 1z2bB-1y7rA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 VAL A 461
THR A 442
TYR A 486
LEU A 489
 None
 1.01A 1z2bB-1yfoA:
undetectable		 1z2bB-1yfoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		4 VAL A 153
THR A 121
PRO A 122
LEU A 124
 None
 0.93A 1z2bB-1yyaA:
undetectable		 1z2bB-1yyaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 THR A 160
PRO A 159
TYR A 139
LEU A 157
 None
 0.92A 1z2bB-1z45A:
7.2		 1z2bB-1z45A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 LYS A  49
VAL A  50
THR A  68
LEU A  94
 None
 1.03A 1z2bB-1zypA:
undetectable		 1z2bB-1zypA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 VAL A 222
THR A 238
TYR A 271
LEU A 285
 None
 0.93A 1z2bB-2b5mA:
undetectable		 1z2bB-2b5mA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5u COLICIN E3

(Escherichia
coli) 		PF03515
(Cloacin)
PF09000
(Cytotoxic)
PF11570
(E2R135) 		4 VAL A 287
ASP A 187
PRO A 228
LEU A 230
 None
 1.01A 1z2bB-2b5uA:
undetectable		 1z2bB-2b5uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 VAL A 158
THR A 435
PRO A 436
LEU A 438
 None
 1.03A 1z2bB-2bxyA:
undetectable		 1z2bB-2bxyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 VAL A 366
PRO A 364
TYR A 353
LEU A 357
 None
 1.02A 1z2bB-2dieA:
2.9		 1z2bB-2dieA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjc ANTIGEN TPF1

(Treponema
pallidum) 		PF00210
(Ferritin) 		4 VAL A 127
TYR A  56
TYR A  75
LEU A  72
 None
 0.98A 1z2bB-2fjcA:
undetectable		 1z2bB-2fjcA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 VAL A 192
ASP A 197
TYR A 186
LEU A 211
 None
 1.01A 1z2bB-2g3nA:
undetectable		 1z2bB-2g3nA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu1 ZINC PEPTIDASE

(Vibrio cholerae) 		PF01551
(Peptidase_M23)
PF04225
(OapA) 		4 VAL A 245
ASP A 207
TYR A 278
LEU A 281
 None
 0.96A 1z2bB-2gu1A:
undetectable		 1z2bB-2gu1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3e G-RICH

(Carassius
auratus) 		PF05881
(CNPase) 		4 THR A 108
PRO A 109
TYR A  59
LEU A  56
 None
 0.92A 1z2bB-2i3eA:
undetectable		 1z2bB-2i3eA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 ASP A 121
THR A 169
PRO A 168
LEU A 164
 None
 0.80A 1z2bB-2id5A:
undetectable		 1z2bB-2id5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ASP A 678
THR A 904
TYR A 907
LEU A 622
 None
 0.82A 1z2bB-2inyA:
undetectable		 1z2bB-2inyA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 363
THR A 344
TYR A 388
LEU A 391
 None
 0.97A 1z2bB-2jjdA:
undetectable		 1z2bB-2jjdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjf PROTEIN HIT1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS B  75
VAL B  76
TYR B 104
LEU B 105
 None
 1.01A 1z2bB-2mjfB:
undetectable		 1z2bB-2mjfB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 VAL A  60
TYR A  70
THR A  67
LEU A 152
 None
 0.93A 1z2bB-2n7gA:
undetectable		 1z2bB-2n7gA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 VAL A 246
ASP A 241
THR A  22
LEU A 315
 None
 0.98A 1z2bB-2nqnA:
2.1		 1z2bB-2nqnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		4 LYS A 569
VAL A 570
TYR A 579
LEU A 558
 None
 1.02A 1z2bB-2pfiA:
undetectable		 1z2bB-2pfiA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 VAL A 134
THR A 760
PRO A 759
LEU A 757
 None
 0.85A 1z2bB-2pi5A:
undetectable		 1z2bB-2pi5A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 VAL A 417
ASP A 419
PRO A 380
LEU A 385
 None
 1.02A 1z2bB-2qtzA:
4.5		 1z2bB-2qtzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		4 ASP A 198
THR A  38
PRO A  39
LEU A  31
 None
 0.73A 1z2bB-2qy6A:
2.7		 1z2bB-2qy6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 VAL A 104
ASP A 108
PRO A 169
LEU A 167
 None
 1.01A 1z2bB-2rfqA:
undetectable		 1z2bB-2rfqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 VAL A 184
THR A 165
TYR A 224
LEU A 170
 None
 1.03A 1z2bB-2v28A:
undetectable		 1z2bB-2v28A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LYS A 431
VAL A 430
THR A 424
LEU A 545
 None
 0.99A 1z2bB-2vdcA:
2.3		 1z2bB-2vdcA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 VAL A 262
TYR A 308
THR A 292
LEU A 240
 None
 1.03A 1z2bB-2vmfA:
undetectable		 1z2bB-2vmfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 VAL A  83
THR A  76
TYR A  71
LEU A  99
 None
 0.82A 1z2bB-2xheA:
3.7		 1z2bB-2xheA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		4 VAL A 139
TYR A 192
TYR A 164
LEU A 189
 None
 0.84A 1z2bB-2yf0A:
undetectable		 1z2bB-2yf0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 259
TYR A 123
THR A 114
TYR A 146
 None
 0.96A 1z2bB-2z1qA:
undetectable		 1z2bB-2z1qA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhh REDOX-SENSITIVE
TRANSCRIPTIONAL
ACTIVATOR SOXR

(Escherichia
coli) 		PF00376
(MerR)
PF09278
(MerR-DNA-bind) 		4 VAL A  57
THR A  38
TYR A  31
LEU A  28
 None
 0.87A 1z2bB-2zhhA:
undetectable		 1z2bB-2zhhA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 VAL B 144
THR B 137
TYR B 163
LEU B 107
 None
 1.01A 1z2bB-3adaB:
undetectable		 1z2bB-3adaB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 VAL A 107
ASP A 111
PRO A 172
LEU A 170
 None
 1.03A 1z2bB-3afeA:
undetectable		 1z2bB-3afeA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 LYS A 259
VAL A 258
ASP A 264
LEU A 288
 None
 0.85A 1z2bB-3ai5A:
undetectable		 1z2bB-3ai5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqq CALCIUM-REGULATED
HEAT STABLE PROTEIN
1

(Homo sapiens) 		PF00313
(CSD) 		4 VAL A 107
TYR A 109
THR A  80
LEU A  90
 None
 1.04A 1z2bB-3aqqA:
undetectable		 1z2bB-3aqqA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 LYS A 726
TYR A 778
PRO A 776
LEU A 777
 None
 0.98A 1z2bB-3av6A:
undetectable		 1z2bB-3av6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		4 ASP A 173
PRO A 242
TYR A 177
LEU A 246
 None
 0.89A 1z2bB-3c1oA:
6.6		 1z2bB-3c1oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		4 LYS A  81
VAL A  82
TYR A 108
LEU A 291
 None
 0.92A 1z2bB-3cg1A:
undetectable		 1z2bB-3cg1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		4 ASP A  60
THR A  28
PRO A  29
LEU A  22
 None
 0.87A 1z2bB-3d5nA:
undetectable		 1z2bB-3d5nA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		4 VAL A 185
ASP A 188
TYR A  25
LEU A  20
 None
 0.92A 1z2bB-3dqpA:
6.3		 1z2bB-3dqpA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0r C3-DEGRADING
PROTEINASE (CPPA
PROTEIN)

(Streptococcus
pneumoniae) 		PF14506
(CppA_N)
PF14507
(CppA_C) 		4 LYS A  99
TYR A 104
PRO A 134
LEU A  88
 None
 0.98A 1z2bB-3e0rA:
undetectable		 1z2bB-3e0rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 TYR A 185
THR A 180
TYR A 226
LEU A 186
 None
 1.02A 1z2bB-3fdhA:
undetectable		 1z2bB-3fdhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 VAL A 244
ASP A 200
TYR A 251
TYR A 187
 None
 1.00A 1z2bB-3g0tA:
undetectable		 1z2bB-3g0tA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ASP A 580
TYR A 608
THR A 575
PRO A 576
 None
 0.97A 1z2bB-3h09A:
undetectable		 1z2bB-3h09A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02271
(UCR_14kD) 		4 ASP F  40
THR C 372
TYR C 380
LEU C 378
 None
 1.00A 1z2bB-3h1lF:
undetectable		 1z2bB-3h1lF:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 4 THR A 121
PRO A 120
TYR A 104
LEU A 118
 None
 0.96A 1z2bB-3iusA:
6.4		 1z2bB-3iusA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 VAL A 217
PRO A 231
TYR A 234
LEU A 298
 None
 1.01A 1z2bB-3j31A:
undetectable		 1z2bB-3j31A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9o UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LYS B  27
VAL B  26
ASP B  32
LEU B  56
 None
 0.80A 1z2bB-3k9oB:
undetectable		 1z2bB-3k9oB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		5 VAL A 105
ASP A  31
THR A 122
TYR A 172
LEU A 127
 None
 1.29A 1z2bB-3kx6A:
undetectable		 1z2bB-3kx6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 VAL A 146
TYR A 117
PRO A 124
LEU A 127
 None
 1.03A 1z2bB-3l9cA:
undetectable		 1z2bB-3l9cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		4 VAL A 431
ASP A  50
TYR A  61
LEU A  58
 None
 1.01A 1z2bB-3m1uA:
undetectable		 1z2bB-3m1uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 VAL A  98
TYR A 164
TYR A 127
LEU A 124
 None
 0.99A 1z2bB-3mmtA:
undetectable		 1z2bB-3mmtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 VAL A 330
THR A 275
TYR A 340
LEU A 345
 None
 0.98A 1z2bB-3n0qA:
undetectable		 1z2bB-3n0qA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 VAL A 259
TYR A 374
THR A 300
TYR A 272
 None
 1.02A 1z2bB-3n0wA:
5.1		 1z2bB-3n0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LYS B  27
VAL B  26
ASP B  32
LEU B  56
 None
 0.74A 1z2bB-3n3kB:
undetectable		 1z2bB-3n3kB:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 VAL A 328
ASP A 401
TYR A 309
LEU A 228
 None
 1.02A 1z2bB-3ob8A:
undetectable		 1z2bB-3ob8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL A  27
ASP A  23
THR A  48
LEU A   9
 None
 0.86A 1z2bB-3odtA:
undetectable		 1z2bB-3odtA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ASP A 178
THR A  18
PRO A  19
LEU A  11
 SAM  A 670 (-3.4A)
None
None
None
 0.79A 1z2bB-3ps9A:
2.4		 1z2bB-3ps9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A  36
ASP A 142
TYR A 108
LEU A  46
 None
 0.89A 1z2bB-3pxlA:
undetectable		 1z2bB-3pxlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LYS A 621
THR A 529
PRO A 530
LEU A 564
 None
 0.86A 1z2bB-3qfsA:
3.0		 1z2bB-3qfsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 VAL A 382
ASP A 402
PRO A 422
LEU A 442
 None
 0.94A 1z2bB-3qp9A:
4.3		 1z2bB-3qp9A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		4 LYS A 263
THR A 406
TYR A 389
LEU A 331
 None
 1.03A 1z2bB-3r7tA:
2.4		 1z2bB-3r7tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 VAL A  92
ASP A 225
TYR A  91
THR A 113
 None
None
EDO  A 265 (-3.6A)
None
 1.03A 1z2bB-3r9sA:
undetectable		 1z2bB-3r9sA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LYS A 133
VAL A 134
TYR A 149
LEU A 150
 None
 0.95A 1z2bB-3rr5A:
undetectable		 1z2bB-3rr5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LYS A 141
ASP A 338
THR A 128
PRO A 129
 None
None
None
EDO  A 701 (-4.9A)
 0.99A 1z2bB-3sthA:
3.1		 1z2bB-3sthA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 374
TYR A 376
THR A 365
LEU A 411
 None
 0.92A 1z2bB-3urhA:
undetectable		 1z2bB-3urhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		4 LYS A 127
VAL A 126
ASP A 132
LEU A 156
 SO4  A 204 (-2.9A)
None
None
None
 0.79A 1z2bB-3vdzA:
undetectable		 1z2bB-3vdzA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 VAL A 449
ASP A 482
TYR A 443
LEU A 466
 None
 1.03A 1z2bB-3vm7A:
undetectable		 1z2bB-3vm7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 VAL A 136
ASP A 138
THR A 485
TYR A 174
 None
 1.04A 1z2bB-3vssA:
undetectable		 1z2bB-3vssA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 VAL A 257
ASP A 100
TYR A 262
TYR A 265
 None
 1.03A 1z2bB-3vv3A:
2.6		 1z2bB-3vv3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 VAL A  54
ASP A 395
THR A 190
LEU A  68
 None
 1.03A 1z2bB-3wiqA:
undetectable		 1z2bB-3wiqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		4 ASP A 511
TYR A 447
PRO A 273
LEU A 435
 None
 0.93A 1z2bB-4ag6A:
undetectable		 1z2bB-4ag6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 VAL A 648
THR A 630
TYR A 665
LEU A 724
 None
 0.93A 1z2bB-4bziA:
undetectable		 1z2bB-4bziA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c45 PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
2

(Homo sapiens) 		PF01329
(Pterin_4a) 		4 LYS A  92
VAL A  91
THR A  79
LEU A   9
 None
 1.04A 1z2bB-4c45A:
undetectable		 1z2bB-4c45A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 VAL A 448
ASP A 446
THR A   6
PRO A   7
 None
 0.87A 1z2bB-4dshA:
2.6		 1z2bB-4dshA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Clostridioides
difficile) 		PF00590
(TP_methylase) 		4 VAL A 226
THR A 205
TYR A 182
LEU A 177
 None
 0.96A 1z2bB-4e16A:
undetectable		 1z2bB-4e16A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqb SPERMIDINE/PUTRESCIN
E ABC SUPERFAMILY
ATP BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 VAL A 252
ASP A 317
THR A 234
TYR A 145
 None
 0.77A 1z2bB-4eqbA:
undetectable		 1z2bB-4eqbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 VAL A 381
THR A  58
TYR A  44
LEU A  33
 None
 1.00A 1z2bB-4gq1A:
undetectable		 1z2bB-4gq1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfx TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 3

(Homo sapiens) 		PF06881
(Elongin_A) 		4 TYR A  64
THR A  19
PRO A  20
TYR A  24
 None
 0.95A 1z2bB-4hfxA:
undetectable		 1z2bB-4hfxA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		4 VAL A 173
THR A 293
PRO A 292
LEU A 156
 None
 0.96A 1z2bB-4hw8A:
undetectable		 1z2bB-4hw8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hx3 NEUTRAL PROTEINASE
INHIBITOR SCNPI

(Streptomyces
caespitosus) 		PF00720
(SSI) 		4 VAL B  78
THR B  98
TYR B 111
LEU B 105
 None
 0.97A 1z2bB-4hx3B:
undetectable		 1z2bB-4hx3B:
16.34