SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z2B_C_VLBC800

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 VAL A  43
TYR A 191
THR A  37
LEU A 188
 None
 0.97A 1z2bB-1ea6A:
undetectable		 1z2bB-1ea6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ASP A 126
THR A 227
PRO A 228
TYR A 233
 None
 0.96A 1z2bB-1ff9A:
undetectable		 1z2bB-1ff9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		5 VAL A 331
THR A 328
PRO A 329
TYR A 319
LEU A 323
 None
 1.50A 1z2bB-1gcyA:
undetectable		 1z2bB-1gcyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1heh ENDO-1,4-BETA-XYLANA
SE D

(Cellulomonas
fimi) 		no annotation 4 VAL C 626
THR C 636
PRO C 637
LEU C 590
 None
 0.86A 1z2bB-1hehC:
undetectable		 1z2bB-1hehC:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6x AUTOINDUCER-2
PRODUCTION PROTEIN
LUXS

(Helicobacter
pylori) 		PF02664
(LuxS) 		4 VAL A  20
TYR A  37
THR A  95
LEU A 101
 None
 0.85A 1z2bB-1j6xA:
undetectable		 1z2bB-1j6xA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98

(Homo sapiens) 		PF04096
(Nucleoporin2) 		4 VAL A 775
THR A 749
TYR A 724
LEU A 719
 None
 1.04A 1z2bB-1ko6A:
undetectable		 1z2bB-1ko6A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 LYS A2239
VAL A2240
THR A2164
LEU A2161
 None
 0.89A 1z2bB-1mi1A:
undetectable		 1z2bB-1mi1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpp PAPD CHAPERONE

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 ASP A 130
THR A 188
PRO A 189
LEU A 156
 None
 0.83A 1z2bB-1qppA:
undetectable		 1z2bB-1qppA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r24 PROTEIN (IGG3-KAPPA
ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B  48
THR B  97
TYR B  94
LEU B  81
 None
 1.00A 1z2bB-1r24B:
undetectable		 1z2bB-1r24B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		4 VAL A 291
ASP A 294
TYR A 144
LEU A 151
 None
 1.01A 1z2bB-1ry6A:
undetectable		 1z2bB-1ry6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		4 LYS A  44
VAL A  43
TYR A   7
LEU A  55
 None
 0.70A 1z2bB-1si1A:
undetectable		 1z2bB-1si1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 LYS A 414
VAL A 415
THR A 474
LEU A 460
 None
 1.00A 1z2bB-1tf0A:
undetectable		 1z2bB-1tf0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 202
THR A 242
TYR A 184
LEU A 155
 None
 1.00A 1z2bB-1tkcA:
undetectable		 1z2bB-1tkcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 LYS A 250
VAL A 249
TYR A  29
LEU A 209
 None
 0.88A 1z2bB-1ua4A:
4.5		 1z2bB-1ua4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 VAL A 361
PRO A 359
TYR A 348
LEU A 352
 None
 1.01A 1z2bB-1ud3A:
undetectable		 1z2bB-1ud3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 VAL A  86
ASP A  91
THR A  66
LEU A  69
 None
 0.98A 1z2bB-1uqwA:
undetectable		 1z2bB-1uqwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger) 		PF01764
(Lipase_3) 		4 VAL A 115
THR A 128
TYR A 150
LEU A 146
 None
 0.97A 1z2bB-1uswA:
3.6		 1z2bB-1uswA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 VAL A 240
TYR A 242
THR A 283
LEU A 203
 None
 1.00A 1z2bB-1w18A:
undetectable		 1z2bB-1w18A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4s POLYBROMO 1 PROTEIN

(Gallus gallus) 		PF01426
(BAH) 		4 LYS A1032
VAL A 962
TYR A 956
LEU A 991
 None
 0.99A 1z2bB-1w4sA:
undetectable		 1z2bB-1w4sA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7r HYPOTHETICAL PROTEIN
SA2161

(Staphylococcus
aureus) 		PF13673
(Acetyltransf_10) 		4 LYS A 112
VAL A 115
THR A 122
PRO A 121
 None
 0.98A 1z2bB-1y7rA:
undetectable		 1z2bB-1y7rA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 VAL A 461
THR A 442
TYR A 486
LEU A 489
 None
 1.01A 1z2bB-1yfoA:
undetectable		 1z2bB-1yfoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		4 VAL A 153
THR A 121
PRO A 122
LEU A 124
 None
 0.93A 1z2bB-1yyaA:
undetectable		 1z2bB-1yyaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 THR A 160
PRO A 159
TYR A 139
LEU A 157
 None
 0.92A 1z2bB-1z45A:
7.2		 1z2bB-1z45A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 LYS A  49
VAL A  50
THR A  68
LEU A  94
 None
 1.03A 1z2bB-1zypA:
undetectable		 1z2bB-1zypA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 VAL A 222
THR A 238
TYR A 271
LEU A 285
 None
 0.93A 1z2bB-2b5mA:
undetectable		 1z2bB-2b5mA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5u COLICIN E3

(Escherichia
coli) 		PF03515
(Cloacin)
PF09000
(Cytotoxic)
PF11570
(E2R135) 		4 VAL A 287
ASP A 187
PRO A 228
LEU A 230
 None
 1.01A 1z2bB-2b5uA:
undetectable		 1z2bB-2b5uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 VAL A 158
THR A 435
PRO A 436
LEU A 438
 None
 1.03A 1z2bB-2bxyA:
undetectable		 1z2bB-2bxyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 VAL A 366
PRO A 364
TYR A 353
LEU A 357
 None
 1.02A 1z2bB-2dieA:
2.9		 1z2bB-2dieA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjc ANTIGEN TPF1

(Treponema
pallidum) 		PF00210
(Ferritin) 		4 VAL A 127
TYR A  56
TYR A  75
LEU A  72
 None
 0.98A 1z2bB-2fjcA:
undetectable		 1z2bB-2fjcA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 VAL A 192
ASP A 197
TYR A 186
LEU A 211
 None
 1.01A 1z2bB-2g3nA:
undetectable		 1z2bB-2g3nA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu1 ZINC PEPTIDASE

(Vibrio cholerae) 		PF01551
(Peptidase_M23)
PF04225
(OapA) 		4 VAL A 245
ASP A 207
TYR A 278
LEU A 281
 None
 0.96A 1z2bB-2gu1A:
undetectable		 1z2bB-2gu1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3e G-RICH

(Carassius
auratus) 		PF05881
(CNPase) 		4 THR A 108
PRO A 109
TYR A  59
LEU A  56
 None
 0.92A 1z2bB-2i3eA:
undetectable		 1z2bB-2i3eA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 ASP A 121
THR A 169
PRO A 168
LEU A 164
 None
 0.80A 1z2bB-2id5A:
undetectable		 1z2bB-2id5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ASP A 678
THR A 904
TYR A 907
LEU A 622
 None
 0.82A 1z2bB-2inyA:
undetectable		 1z2bB-2inyA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 363
THR A 344
TYR A 388
LEU A 391
 None
 0.97A 1z2bB-2jjdA:
undetectable		 1z2bB-2jjdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjf PROTEIN HIT1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS B  75
VAL B  76
TYR B 104
LEU B 105
 None
 1.01A 1z2bB-2mjfB:
undetectable		 1z2bB-2mjfB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 VAL A  60
TYR A  70
THR A  67
LEU A 152
 None
 0.93A 1z2bB-2n7gA:
undetectable		 1z2bB-2n7gA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 VAL A 246
ASP A 241
THR A  22
LEU A 315
 None
 0.98A 1z2bB-2nqnA:
2.1		 1z2bB-2nqnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		4 LYS A 569
VAL A 570
TYR A 579
LEU A 558
 None
 1.02A 1z2bB-2pfiA:
undetectable		 1z2bB-2pfiA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 VAL A 134
THR A 760
PRO A 759
LEU A 757
 None
 0.85A 1z2bB-2pi5A:
undetectable		 1z2bB-2pi5A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 VAL A 417
ASP A 419
PRO A 380
LEU A 385
 None
 1.02A 1z2bB-2qtzA:
4.5		 1z2bB-2qtzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		4 ASP A 198
THR A  38
PRO A  39
LEU A  31
 None
 0.73A 1z2bB-2qy6A:
2.7		 1z2bB-2qy6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 VAL A 104
ASP A 108
PRO A 169
LEU A 167
 None
 1.01A 1z2bB-2rfqA:
undetectable		 1z2bB-2rfqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 VAL A 184
THR A 165
TYR A 224
LEU A 170
 None
 1.03A 1z2bB-2v28A:
undetectable		 1z2bB-2v28A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LYS A 431
VAL A 430
THR A 424
LEU A 545
 None
 0.99A 1z2bB-2vdcA:
2.3		 1z2bB-2vdcA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 VAL A 262
TYR A 308
THR A 292
LEU A 240
 None
 1.03A 1z2bB-2vmfA:
undetectable		 1z2bB-2vmfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 VAL A  83
THR A  76
TYR A  71
LEU A  99
 None
 0.82A 1z2bB-2xheA:
3.7		 1z2bB-2xheA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		4 VAL A 139
TYR A 192
TYR A 164
LEU A 189
 None
 0.84A 1z2bB-2yf0A:
undetectable		 1z2bB-2yf0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 259
TYR A 123
THR A 114
TYR A 146
 None
 0.96A 1z2bB-2z1qA:
undetectable		 1z2bB-2z1qA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhh REDOX-SENSITIVE
TRANSCRIPTIONAL
ACTIVATOR SOXR

(Escherichia
coli) 		PF00376
(MerR)
PF09278
(MerR-DNA-bind) 		4 VAL A  57
THR A  38
TYR A  31
LEU A  28
 None
 0.87A 1z2bB-2zhhA:
undetectable		 1z2bB-2zhhA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 VAL B 144
THR B 137
TYR B 163
LEU B 107
 None
 1.01A 1z2bB-3adaB:
undetectable		 1z2bB-3adaB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 VAL A 107
ASP A 111
PRO A 172
LEU A 170
 None
 1.03A 1z2bB-3afeA:
undetectable		 1z2bB-3afeA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 LYS A 259
VAL A 258
ASP A 264
LEU A 288
 None
 0.85A 1z2bB-3ai5A:
undetectable		 1z2bB-3ai5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqq CALCIUM-REGULATED
HEAT STABLE PROTEIN
1

(Homo sapiens) 		PF00313
(CSD) 		4 VAL A 107
TYR A 109
THR A  80
LEU A  90
 None
 1.04A 1z2bB-3aqqA:
undetectable		 1z2bB-3aqqA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 LYS A 726
TYR A 778
PRO A 776
LEU A 777
 None
 0.98A 1z2bB-3av6A:
undetectable		 1z2bB-3av6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		4 ASP A 173
PRO A 242
TYR A 177
LEU A 246
 None
 0.89A 1z2bB-3c1oA:
6.6		 1z2bB-3c1oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		4 LYS A  81
VAL A  82
TYR A 108
LEU A 291
 None
 0.92A 1z2bB-3cg1A:
undetectable		 1z2bB-3cg1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		4 ASP A  60
THR A  28
PRO A  29
LEU A  22
 None
 0.87A 1z2bB-3d5nA:
undetectable		 1z2bB-3d5nA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		4 VAL A 185
ASP A 188
TYR A  25
LEU A  20
 None
 0.92A 1z2bB-3dqpA:
6.3		 1z2bB-3dqpA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0r C3-DEGRADING
PROTEINASE (CPPA
PROTEIN)

(Streptococcus
pneumoniae) 		PF14506
(CppA_N)
PF14507
(CppA_C) 		4 LYS A  99
TYR A 104
PRO A 134
LEU A  88
 None
 0.98A 1z2bB-3e0rA:
undetectable		 1z2bB-3e0rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 TYR A 185
THR A 180
TYR A 226
LEU A 186
 None
 1.02A 1z2bB-3fdhA:
undetectable		 1z2bB-3fdhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 VAL A 244
ASP A 200
TYR A 251
TYR A 187
 None
 1.00A 1z2bB-3g0tA:
undetectable		 1z2bB-3g0tA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ASP A 580
TYR A 608
THR A 575
PRO A 576
 None
 0.97A 1z2bB-3h09A:
undetectable		 1z2bB-3h09A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02271
(UCR_14kD) 		4 ASP F  40
THR C 372
TYR C 380
LEU C 378
 None
 1.00A 1z2bB-3h1lF:
undetectable		 1z2bB-3h1lF:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 4 THR A 121
PRO A 120
TYR A 104
LEU A 118
 None
 0.96A 1z2bB-3iusA:
6.4		 1z2bB-3iusA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 VAL A 217
PRO A 231
TYR A 234
LEU A 298
 None
 1.01A 1z2bB-3j31A:
undetectable		 1z2bB-3j31A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9o UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LYS B  27
VAL B  26
ASP B  32
LEU B  56
 None
 0.80A 1z2bB-3k9oB:
undetectable		 1z2bB-3k9oB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		5 VAL A 105
ASP A  31
THR A 122
TYR A 172
LEU A 127
 None
 1.29A 1z2bB-3kx6A:
undetectable		 1z2bB-3kx6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 VAL A 146
TYR A 117
PRO A 124
LEU A 127
 None
 1.03A 1z2bB-3l9cA:
undetectable		 1z2bB-3l9cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		4 VAL A 431
ASP A  50
TYR A  61
LEU A  58
 None
 1.01A 1z2bB-3m1uA:
undetectable		 1z2bB-3m1uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 VAL A  98
TYR A 164
TYR A 127
LEU A 124
 None
 0.99A 1z2bB-3mmtA:
undetectable		 1z2bB-3mmtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 VAL A 330
THR A 275
TYR A 340
LEU A 345
 None
 0.98A 1z2bB-3n0qA:
undetectable		 1z2bB-3n0qA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 VAL A 259
TYR A 374
THR A 300
TYR A 272
 None
 1.02A 1z2bB-3n0wA:
5.1		 1z2bB-3n0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LYS B  27
VAL B  26
ASP B  32
LEU B  56
 None
 0.74A 1z2bB-3n3kB:
undetectable		 1z2bB-3n3kB:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 VAL A 328
ASP A 401
TYR A 309
LEU A 228
 None
 1.02A 1z2bB-3ob8A:
undetectable		 1z2bB-3ob8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL A  27
ASP A  23
THR A  48
LEU A   9
 None
 0.86A 1z2bB-3odtA:
undetectable		 1z2bB-3odtA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ASP A 178
THR A  18
PRO A  19
LEU A  11
 SAM  A 670 (-3.4A)
None
None
None
 0.79A 1z2bB-3ps9A:
2.4		 1z2bB-3ps9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A  36
ASP A 142
TYR A 108
LEU A  46
 None
 0.89A 1z2bB-3pxlA:
undetectable		 1z2bB-3pxlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LYS A 621
THR A 529
PRO A 530
LEU A 564
 None
 0.86A 1z2bB-3qfsA:
3.0		 1z2bB-3qfsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 VAL A 382
ASP A 402
PRO A 422
LEU A 442
 None
 0.94A 1z2bB-3qp9A:
4.3		 1z2bB-3qp9A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		4 LYS A 263
THR A 406
TYR A 389
LEU A 331
 None
 1.03A 1z2bB-3r7tA:
2.4		 1z2bB-3r7tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 VAL A  92
ASP A 225
TYR A  91
THR A 113
 None
None
EDO  A 265 (-3.6A)
None
 1.03A 1z2bB-3r9sA:
undetectable		 1z2bB-3r9sA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LYS A 133
VAL A 134
TYR A 149
LEU A 150
 None
 0.95A 1z2bB-3rr5A:
undetectable		 1z2bB-3rr5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LYS A 141
ASP A 338
THR A 128
PRO A 129
 None
None
None
EDO  A 701 (-4.9A)
 0.99A 1z2bB-3sthA:
3.1		 1z2bB-3sthA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 374
TYR A 376
THR A 365
LEU A 411
 None
 0.92A 1z2bB-3urhA:
undetectable		 1z2bB-3urhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		4 LYS A 127
VAL A 126
ASP A 132
LEU A 156
 SO4  A 204 (-2.9A)
None
None
None
 0.79A 1z2bB-3vdzA:
undetectable		 1z2bB-3vdzA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 VAL A 449
ASP A 482
TYR A 443
LEU A 466
 None
 1.03A 1z2bB-3vm7A:
undetectable		 1z2bB-3vm7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 VAL A 136
ASP A 138
THR A 485
TYR A 174
 None
 1.04A 1z2bB-3vssA:
undetectable		 1z2bB-3vssA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 VAL A 257
ASP A 100
TYR A 262
TYR A 265
 None
 1.03A 1z2bB-3vv3A:
2.6		 1z2bB-3vv3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 VAL A  54
ASP A 395
THR A 190
LEU A  68
 None
 1.03A 1z2bB-3wiqA:
undetectable		 1z2bB-3wiqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		4 ASP A 511
TYR A 447
PRO A 273
LEU A 435
 None
 0.93A 1z2bB-4ag6A:
undetectable		 1z2bB-4ag6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 VAL A 648
THR A 630
TYR A 665
LEU A 724
 None
 0.93A 1z2bB-4bziA:
undetectable		 1z2bB-4bziA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c45 PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
2

(Homo sapiens) 		PF01329
(Pterin_4a) 		4 LYS A  92
VAL A  91
THR A  79
LEU A   9
 None
 1.04A 1z2bB-4c45A:
undetectable		 1z2bB-4c45A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 VAL A 448
ASP A 446
THR A   6
PRO A   7
 None
 0.87A 1z2bB-4dshA:
2.6		 1z2bB-4dshA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Clostridioides
difficile) 		PF00590
(TP_methylase) 		4 VAL A 226
THR A 205
TYR A 182
LEU A 177
 None
 0.96A 1z2bB-4e16A:
undetectable		 1z2bB-4e16A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqb SPERMIDINE/PUTRESCIN
E ABC SUPERFAMILY
ATP BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 VAL A 252
ASP A 317
THR A 234
TYR A 145
 None
 0.77A 1z2bB-4eqbA:
undetectable		 1z2bB-4eqbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 VAL A 381
THR A  58
TYR A  44
LEU A  33
 None
 1.00A 1z2bB-4gq1A:
undetectable		 1z2bB-4gq1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfx TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 3

(Homo sapiens) 		PF06881
(Elongin_A) 		4 TYR A  64
THR A  19
PRO A  20
TYR A  24
 None
 0.95A 1z2bB-4hfxA:
undetectable		 1z2bB-4hfxA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		4 VAL A 173
THR A 293
PRO A 292
LEU A 156
 None
 0.96A 1z2bB-4hw8A:
undetectable		 1z2bB-4hw8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hx3 NEUTRAL PROTEINASE
INHIBITOR SCNPI

(Streptomyces
caespitosus) 		PF00720
(SSI) 		4 VAL B  78
THR B  98
TYR B 111
LEU B 105
 None
 0.97A 1z2bB-4hx3B:
undetectable		 1z2bB-4hx3B:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		4 VAL B 152
ASN B  59
VAL B 244
ILE B 248
 None
FE  B 501 (-3.2A)
None
None
 0.98A 1z2bC-1bouB:
undetectable		 1z2bC-1bouB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 PRO L 479
VAL L 473
ASN L 481
VAL L  37
ILE L  14
 None
 1.49A 1z2bC-1cc1L:
undetectable		 1z2bC-1cc1L:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		4 VAL A 480
ASN A 481
VAL A  36
ILE A 291
 None
 0.96A 1z2bC-1f8rA:
undetectable		 1z2bC-1f8rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 VAL A  18
ASN A  19
VAL A  46
ILE A  48
 None
 0.65A 1z2bC-1m0wA:
undetectable		 1z2bC-1m0wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 183
VAL A 170
VAL A 157
ILE A 206
 None
 1.09A 1z2bC-1mldA:
5.7		 1z2bC-1mldA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		4 PRO X 132
VAL X 133
VAL X 483
ILE X 441
 None
 1.01A 1z2bC-1ogoX:
undetectable		 1z2bC-1ogoX:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 VAL A  32
ASN A  64
VAL A  22
ILE A  87
 None
 1.05A 1z2bC-1qjcA:
undetectable		 1z2bC-1qjcA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgy BETA-LACTAMASE

(Citrobacter
freundii) 		PF00144
(Beta-lactamase) 		4 VAL A  12
ASN A  13
VAL A  30
ILE A  32
 None
 1.05A 1z2bC-1rgyA:
undetectable		 1z2bC-1rgyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 227
VAL A 214
VAL A 201
ILE A 250
 None
 0.97A 1z2bC-1smkA:
2.5		 1z2bC-1smkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		4 PRO A 102
VAL A  77
VAL A  88
ILE A 100
 None
 0.93A 1z2bC-1v6zA:
undetectable		 1z2bC-1v6zA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcl PROTEIN TYROSINE
PHOSPHATASE 4A1

(Rattus
norvegicus) 		PF00782
(DSPc) 		4 PRO A 112
VAL A 115
VAL A  12
ILE A  21
 None
 0.79A 1z2bC-1zclA:
undetectable		 1z2bC-1zclA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 139
ASN A 138
VAL A 102
ILE A  75
 None
 0.93A 1z2bC-2cvoA:
4.1		 1z2bC-2cvoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		4 VAL A 110
ASN A 109
VAL A 143
ILE A 140
 None
 1.05A 1z2bC-2dc4A:
undetectable		 1z2bC-2dc4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 VAL A  46
ASN A  47
VAL A 102
ILE A 104
 None
 1.07A 1z2bC-2e3dA:
undetectable		 1z2bC-2e3dA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 VAL A 446
ASN A 445
VAL A 548
ILE A 545
 None
 0.95A 1z2bC-2f3oA:
undetectable		 1z2bC-2f3oA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 VAL A 165
ASN A 167
VAL A 209
ILE A 139
 None
GSP  A 300 (-3.2A)
None
None
 1.07A 1z2bC-2hf8A:
undetectable		 1z2bC-2hf8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		4 PRO A 153
VAL A  67
VAL A 121
ILE A 125
 None
 1.05A 1z2bC-2mkiA:
undetectable		 1z2bC-2mkiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxf PUTATIVE DIMETAL
PHOSPHATASE

(Danio rerio) 		PF00149
(Metallophos) 		4 PRO A 184
VAL A 195
ASN A 175
ILE A 239
 None
 1.10A 1z2bC-2nxfA:
undetectable		 1z2bC-2nxfA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0i C PROTEIN
ALPHA-ANTIGEN

(Streptococcus
agalactiae) 		PF08829
(AlphaC_N)
PF17480
(AlphaC_C) 		4 VAL 1 216
ASN 1 217
VAL 1 171
ILE 1 168
 None
 1.05A 1z2bC-2o0i1:
undetectable		 1z2bC-2o0i1:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 184
VAL A 171
VAL A 158
ILE A 206
 None
 1.05A 1z2bC-2pwzA:
5.7		 1z2bC-2pwzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG

(Arabidopsis
thaliana) 		PF03070
(TENA_THI-4) 		4 PRO A 158
VAL A 159
VAL A  28
ILE A  30
 None
 0.83A 1z2bC-2q4xA:
undetectable		 1z2bC-2q4xA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rem DISULFIDE
OXIDOREDUCTASE

(Xylella
fastidiosa) 		PF13462
(Thioredoxin_4) 		4 PRO A 154
VAL A 152
VAL A 161
ILE A  33
 None
 1.08A 1z2bC-2remA:
undetectable		 1z2bC-2remA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 VAL A 154
ASN A 153
VAL A 141
ILE A 111
 None
 0.86A 1z2bC-2vfwA:
undetectable		 1z2bC-2vfwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 PRO A 130
VAL A 135
VAL A  70
ILE A  85
 None
 1.11A 1z2bC-2vunA:
2.3		 1z2bC-2vunA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 PRO A 116
VAL A 119
ASN A 120
VAL A 186
 None
 1.05A 1z2bC-2y5wA:
undetectable		 1z2bC-2y5wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		4 PRO A  13
VAL A  38
ASN A  40
ILE A  19
 None
 1.06A 1z2bC-3adrA:
undetectable		 1z2bC-3adrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax1 SERRATE RNA EFFECTOR
MOLECULE

(Arabidopsis
thaliana) 		PF04959
(ARS2)
PF12066
(DUF3546) 		4 VAL A 363
ASN A 362
VAL A 386
ILE A 388
 None
 1.01A 1z2bC-3ax1A:
undetectable		 1z2bC-3ax1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 PRO A 391
VAL A 281
VAL A 312
ILE A 327
 None
 1.06A 1z2bC-3b4wA:
undetectable		 1z2bC-3b4wA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		4 PRO A 170
VAL A 188
ASN A 189
ILE A 220
 None
 0.97A 1z2bC-3bexA:
undetectable		 1z2bC-3bexA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		4 PRO A 212
VAL A 215
VAL A 185
ILE A 181
 None
PEG  A 428 (-4.4A)
None
None
 1.04A 1z2bC-3fd0A:
undetectable		 1z2bC-3fd0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 VAL A 467
ASN A 486
VAL A  35
ILE A  37
 None
 0.90A 1z2bC-3fw6A:
undetectable		 1z2bC-3fw6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 VAL A 140
ASN A 141
VAL A  71
ILE A  69
 None
 1.05A 1z2bC-3gbrA:
2.6		 1z2bC-3gbrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		4 PRO A 177
VAL A 229
VAL A 208
ILE A 175
 None
 1.07A 1z2bC-3gemA:
6.8		 1z2bC-3gemA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2u RAVER-1

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL B  75
ASN B  72
VAL B  98
ILE B  63
 None
 1.06A 1z2bC-3h2uB:
undetectable		 1z2bC-3h2uB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN

(Sinorhizobium
meliloti) 		PF13185
(GAF_2) 		4 VAL A  69
ASN A  68
VAL A  83
ILE A  87
 None
 0.92A 1z2bC-3hcyA:
undetectable		 1z2bC-3hcyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 PRO A 220
VAL A 223
VAL A 270
ILE A 267
 None
 1.11A 1z2bC-3hkoA:
undetectable		 1z2bC-3hkoA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Mycobacterium
tuberculosis) 		PF01597
(GCV_H) 		4 PRO A  89
VAL A  92
ASN A  93
VAL A  61
 None
 0.85A 1z2bC-3iftA:
undetectable		 1z2bC-3iftA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		4 PRO A 209
VAL A 187
ASN A 188
VAL A 206
 None
 1.03A 1z2bC-3iv3A:
undetectable		 1z2bC-3iv3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 PRO A 205
VAL A 183
ASN A 184
VAL A 202
 None
 1.05A 1z2bC-3jrkA:
undetectable		 1z2bC-3jrkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p DSL1

(Kluyveromyces
lactis) 		PF11989
(Dsl1_C) 		4 VAL C 522
ASN C 523
VAL C 578
ILE C 573
 None
 1.04A 1z2bC-3k8pC:
undetectable		 1z2bC-3k8pC:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		4 PRO A 209
VAL A 187
ASN A 188
VAL A 206
 None
 1.03A 1z2bC-3kaoA:
undetectable		 1z2bC-3kaoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 VAL A 480
ASN A 481
VAL A  36
ILE A 291
 None
 0.88A 1z2bC-3kveA:
undetectable		 1z2bC-3kveA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxu GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Bartonella
henselae) 		PF01597
(GCV_H) 		4 PRO A  84
VAL A  87
ASN A  88
VAL A  56
 None
 0.94A 1z2bC-3mxuA:
undetectable		 1z2bC-3mxuA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 VAL A 434
ASN A 433
VAL A 212
ILE A 210
 None
 1.09A 1z2bC-3my7A:
undetectable		 1z2bC-3my7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 PRO A 208
VAL A 186
ASN A 187
VAL A 205
 None
 1.03A 1z2bC-3myoA:
undetectable		 1z2bC-3myoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		4 VAL A 314
ASN A 316
VAL A  69
ILE A 115
 None
 1.06A 1z2bC-3nwnA:
undetectable		 1z2bC-3nwnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Vibrio cholerae) 		PF02348
(CTP_transf_3) 		4 VAL A   6
ASN A  96
VAL A  82
ILE A  88
 None
 1.08A 1z2bC-3oamA:
undetectable		 1z2bC-3oamA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A  85
ASN A  82
VAL A  23
ILE A  66
 None
 1.02A 1z2bC-3pv2A:
undetectable		 1z2bC-3pv2A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A  85
ASN A  82
VAL A  23
ILE A  66
 None
 0.98A 1z2bC-3pv4A:
undetectable		 1z2bC-3pv4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 PRO A 204
VAL A 275
VAL A 248
ILE A 253
 NAD  A 284 (-4.0A)
None
None
None
 1.10A 1z2bC-3pxxA:
6.5		 1z2bC-3pxxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 PRO A  85
VAL A  80
ASN A  81
VAL A  88
 None
 1.07A 1z2bC-3q9oA:
undetectable		 1z2bC-3q9oA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL A  92
ASN A 272
VAL A 191
ILE A  90
 None
 1.06A 1z2bC-3qdkA:
undetectable		 1z2bC-3qdkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 VAL A 277
ASN A 275
VAL A 223
ILE A 221
 None
 1.07A 1z2bC-3rjyA:
undetectable		 1z2bC-3rjyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqb UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF13622
(4HBT_3) 		4 PRO A 191
VAL A 193
VAL A 201
ILE A 203
 None
 1.01A 1z2bC-3rqbA:
undetectable		 1z2bC-3rqbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 VAL A 734
ASN A 735
VAL A 891
ILE A 837
 None
 0.99A 1z2bC-3uatA:
undetectable		 1z2bC-3uatA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 VAL A 125
ASN A 129
VAL A 171
ILE A  84
 ANP  A 601 (-3.8A)
None
None
ANP  A 601 (-4.3A)
 0.96A 1z2bC-3zkbA:
undetectable		 1z2bC-3zkbA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1

(Caenorhabditis
elegans) 		PF10250
(O-FucT) 		4 VAL A 354
ASN A 352
VAL A 248
ILE A 252
 None
 0.76A 1z2bC-3zy3A:
undetectable		 1z2bC-3zy3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		4 VAL A 450
ASN A 449
VAL A 432
ILE A 289
 None
 1.05A 1z2bC-4ag6A:
undetectable		 1z2bC-4ag6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		4 VAL A  46
ASN A  47
VAL A 102
ILE A 104
 None
 1.05A 1z2bC-4d48A:
undetectable		 1z2bC-4d48A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d73 1-CYS PEROXIREDOXIN

(Plasmodium
falciparum) 		PF08534
(Redoxin) 		4 VAL B 231
ASN B 230
VAL B 197
ILE B 199
 None
 0.99A 1z2bC-4d73B:
undetectable		 1z2bC-4d73B:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 PRO A 230
VAL A 102
VAL A  67
ILE A 121
 None
 0.94A 1z2bC-4eq9A:
undetectable		 1z2bC-4eq9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		4 PRO A  69
VAL A   7
ASN A  71
VAL A  50
 None
None
ATP  A 908 (-4.1A)
ATP  A 908 (-3.7A)
 1.05A 1z2bC-4fflA:
undetectable		 1z2bC-4fflA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		4 PRO A 269
VAL A 282
VAL A 234
ILE A 232
 None
 1.09A 1z2bC-4fj6A:
undetectable		 1z2bC-4fj6A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		4 VAL A 135
ASN A 134
VAL A 154
ILE A 158
 None
 1.07A 1z2bC-4iviA:
undetectable		 1z2bC-4iviA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 PRO A  13
VAL A  16
ASN A  17
VAL A   5
 None
 0.71A 1z2bC-4iwhA:
undetectable		 1z2bC-4iwhA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		4 PRO A  22
ASN A  26
VAL A   9
ILE A  11
 None
 0.93A 1z2bC-4k28A:
undetectable		 1z2bC-4k28A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD

(Mycobacterium
tuberculosis) 		PF02559
(CarD_CdnL_TRCF) 		4 VAL B 101
ASN B 102
VAL B  62
ILE B   2
 None
 0.95A 1z2bC-4kbmB:
undetectable		 1z2bC-4kbmB:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		4 PRO A  51
VAL A  54
VAL A  71
ILE A  75
 None
 0.97A 1z2bC-4kkmA:
undetectable		 1z2bC-4kkmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		4 VAL D  47
ASN D  46
VAL D  78
ILE D  81
 None
 1.07A 1z2bC-4m75D:
undetectable		 1z2bC-4m75D:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyi HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 VAL A  87
ASN A  88
VAL A  36
ILE A  38
 None
 0.93A 1z2bC-4qyiA:
3.5		 1z2bC-4qyiA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		4 PRO A  87
VAL A 124
VAL A 283
ILE A 287
 None
 0.97A 1z2bC-4twbA:
4.9		 1z2bC-4twbA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u13 PUTATIVE POLYKETIDE
CYCLASE SMA1630

(Sinorhizobium
meliloti) 		PF12680
(SnoaL_2) 		4 PRO A   4
VAL A   7
ASN A   8
VAL A  74
 None
 1.09A 1z2bC-4u13A:
undetectable		 1z2bC-4u13A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen K88 FIMBRIAL PROTEIN
AC

(Escherichia
coli) 		PF02432
(Fimbrial_K88) 		4 VAL A 257
ASN A 256
VAL A  29
ILE A  60
 None
 0.85A 1z2bC-4wenA:
undetectable		 1z2bC-4wenA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 VAL A 173
ASN A 292
VAL A 315
ILE A 317
 None
 1.02A 1z2bC-4xdoA:
undetectable		 1z2bC-4xdoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzk PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS

(Vibrio
splendidus) 		PF03496
(ADPrib_exo_Tox) 		4 PRO A 138
VAL A 136
ASN A 197
VAL A 238
 None
 1.11A 1z2bC-4xzkA:
undetectable		 1z2bC-4xzkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 PRO A 583
VAL A 586
VAL A 595
ILE A  48
 None
 0.97A 1z2bC-5ah5A:
undetectable		 1z2bC-5ah5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bx1 PROTEIN TYROSINE
PHOSPHATASE TYPE IVA
1

(Homo sapiens) 		PF00782
(DSPc) 		4 PRO A 112
VAL A 115
VAL A  12
ILE A  21
 SO4  A 202 (-4.5A)
None
None
None
 0.97A 1z2bC-5bx1A:
undetectable		 1z2bC-5bx1A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		4 PRO A  99
VAL A 101
ASN A 102
VAL A   2
 None
None
None
SAH  A 201 (-4.2A)
 1.03A 1z2bC-5bxyA:
2.5		 1z2bC-5bxyA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 PRO A 749
VAL A 752
VAL A 706
ILE A 703
 None
 1.05A 1z2bC-5dztA:
undetectable		 1z2bC-5dztA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		4 PRO A2230
VAL A2233
ASN A2234
VAL A2219
 None
 1.04A 1z2bC-5dzzA:
undetectable		 1z2bC-5dzzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		4 VAL A 440
ASN A 443
VAL A 415
ILE A 460
 None
 1.08A 1z2bC-5f0kA:
undetectable		 1z2bC-5f0kA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS)
no annotation 		4 PRO A 552
VAL A 556
VAL B  40
ILE B  53
 None
 1.03A 1z2bC-5gk9A:
undetectable		 1z2bC-5gk9A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		4 PRO A 208
VAL A 186
ASN A 187
VAL A 205
 None
 1.06A 1z2bC-5hjlA:
undetectable		 1z2bC-5hjlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S15

(Pyrococcus
abyssi) 		PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N) 		4 VAL Q 103
ASN Q 104
VAL Q 157
ILE Q  99
 None
 1.02A 1z2bC-5jb3Q:
undetectable		 1z2bC-5jb3Q:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 PRO A  22
VAL A 269
VAL A 279
ILE A  20
 None
 1.07A 1z2bC-5kswA:
undetectable		 1z2bC-5kswA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		4 VAL A  99
ASN A 100
VAL A  45
ILE A 138
 None
 1.01A 1z2bC-5m2oA:
undetectable		 1z2bC-5m2oA:
16.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 PRO A 325
VAL A 328
VAL A 353
ILE A 355
 None
 0.69A 1z2bC-5nd4A:
55.9		 1z2bC-5nd4A:
92.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		4 PRO A 138
ASN A 140
VAL A  73
ILE A  71
 None
 1.05A 1z2bC-5ny5A:
undetectable		 1z2bC-5ny5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 VAL A 358
ASN A 359
VAL A 368
ILE A 223
 None
 0.80A 1z2bC-5ucdA:
undetectable		 1z2bC-5ucdA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 PRO A 325
VAL A 328
ASN A 329
ILE A 355
 None
 0.92A 1z2bC-5ucyA:
51.9		 1z2bC-5ucyA:
86.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 PRO A 325
VAL A 328
ASN A 329
VAL A 353
 None
 1.01A 1z2bC-5ucyA:
51.9		 1z2bC-5ucyA:
86.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 255
VAL A 258
VAL A 285
ILE A 264
 None
 1.06A 1z2bC-5vm2A:
4.1		 1z2bC-5vm2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL A 651
ASN A 650
VAL A 607
ILE A 605
 None
 0.87A 1z2bC-5vrbA:
undetectable		 1z2bC-5vrbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 VAL A  52
ASN A  56
VAL A  46
ILE A  48
 None
 0.94A 1z2bC-5wi5A:
undetectable		 1z2bC-5wi5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao8 ARGININE--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 PRO A 512
VAL A 506
VAL A 145
ILE A 142
 None
 1.03A 1z2bC-6ao8A:
undetectable		 1z2bC-6ao8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 184
VAL A 171
VAL A 158
ILE A 206
 None
 1.10A 1z2bC-6aooA:
5.7		 1z2bC-6aooA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A  62
ASN A  61
VAL A  28
ILE A  11
 None
 0.94A 1z2bC-6bzgA:
undetectable		 1z2bC-6bzgA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 116
ASN A 113
VAL A  36
ILE A  42
 None
EGY  A 801 (-3.3A)
None
None
 1.08A 1z2bC-6c26A:
undetectable		 1z2bC-6c26A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 4 PRO L 533
VAL L 527
VAL L  28
ILE L   5
 None
 1.09A 1z2bC-6ehsL:
undetectable		 1z2bC-6ehsL:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila) 		no annotation 4 VAL A 380
ASN A 381
VAL A 362
ILE A 370
 None
 0.89A 1z2bC-6g0cA:
undetectable		 1z2bC-6g0cA:
10.80