SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z11_D_8MOD501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		5 PHE A  25
VAL A  21
ILE A 152
GLY A 153
LEU A 268
 None
 0.86A 1z11D-1a7jA:
0.0		 1z11D-1a7jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 ILE A 395
GLY A 351
ILE A 373
LEU A 413
PHE A 415
 None
5GP  A 467 (-3.2A)
None
None
None
 0.96A 1z11D-1ao0A:
0.0		 1z11D-1ao0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 PHE A 223
ILE A 254
GLY A 255
ILE A 202
LEU A 204
 None
 1.01A 1z11D-1gg3A:
0.0		 1z11D-1gg3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 5 VAL T  80
ILE T 247
GLY T 244
ILE T  31
LEU T  10
 None
 0.95A 1z11D-1lthT:
0.0		 1z11D-1lthT:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5z AMPA RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 VAL A  25
ILE A  54
GLY A  60
ILE A  91
LEU A 100
 None
 1.11A 1z11D-1m5zA:
undetectable		 1z11D-1m5zA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A 164
ILE A 148
THR A 343
ILE A 221
LEU A 210
 None
 1.10A 1z11D-1pv9A:
0.0		 1z11D-1pv9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlm PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 PHE A 149
PHE A 104
ILE A  93
GLY A  94
ILE A 172
 None
 1.03A 1z11D-1rlmA:
0.0		 1z11D-1rlmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rro RAT ONCOMODULIN

(Rattus rattus) 		PF13499
(EF-hand_7) 		5 PHE A  29
VAL A 106
GLY A  34
ILE A   2
PHE A  70
 None
 1.05A 1z11D-1rroA:
undetectable		 1z11D-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		5 PHE A 242
PHE A 210
ILE A 105
GLY A  22
ILE A 185
 None
 1.07A 1z11D-1t47A:
undetectable		 1z11D-1t47A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 VAL A  52
GLY A  38
THR A  23
LEU A  63
PHE A  99
 None
 1.07A 1z11D-1wczA:
0.0		 1z11D-1wczA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmj THIOREDOXIN H-TYPE

(Oryza sativa) 		PF00085
(Thioredoxin) 		5 PHE A  87
VAL A  97
ILE A 109
ILE A  46
PHE A  50
 None
 1.12A 1z11D-1wmjA:
undetectable		 1z11D-1wmjA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A 167
ILE A 151
THR A 346
ILE A 224
LEU A 213
 None
 1.05A 1z11D-1wy2A:
undetectable		 1z11D-1wy2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		5 VAL A 309
ASN A 123
ILE A 122
ILE A 298
LEU A 304
 None
 1.00A 1z11D-1xg2A:
undetectable		 1z11D-1xg2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Bacillus
subtilis) 		PF02547
(Queuosine_synth) 		5 VAL A 197
ILE A  47
ILE A 295
LEU A  56
PHE A 184
 None
 0.91A 1z11D-1yy3A:
undetectable		 1z11D-1yy3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 5 ASN A 284
GLY A 236
ILE A 215
LEU A 219
PHE A 202
 None
 1.10A 1z11D-2ajaA:
undetectable		 1z11D-2ajaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fco RECOMBINATION
PROTEIN U
(PENICILLIN-BINDING
PROTEIN RELATED
FACTOR A)

(Geobacillus
kaustophilus) 		PF03838
(RecU) 		5 PHE A  98
VAL A 193
ILE A  52
THR A  40
ILE A 187
 None
 1.10A 1z11D-2fcoA:
undetectable		 1z11D-2fcoA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 256
ILE A 291
GLY A 292
ILE A 301
LEU A 300
 None
 1.08A 1z11D-2g17A:
undetectable		 1z11D-2g17A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		5 ILE A  66
GLY A  65
ILE A  97
LEU A  38
PHE A  42
 None
 1.06A 1z11D-2icgA:
undetectable		 1z11D-2icgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k78 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN C

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 PHE A  53
VAL A  72
ILE A 117
GLY A  80
PHE A 104
 ZNH  A 151 (-3.6A)
None
ZNH  A 151 (-4.0A)
None
None
 1.03A 1z11D-2k78A:
undetectable		 1z11D-2k78A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 PHE A  84
ILE A 212
THR A 214
ILE A  59
LEU A  75
 None
 1.06A 1z11D-2n0sA:
undetectable		 1z11D-2n0sA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		9 PHE A 107
PHE A 111
VAL A 117
ILE A 300
GLY A 301
THR A 305
ILE A 366
LEU A 370
PHE A 480
 None
None
HEM  A 500 (-3.7A)
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.1A)
HEM  A 500 ( 3.8A)
None
 0.32A 1z11D-2pg6A:
64.7		 1z11D-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A  90
GLY A 241
THR A 211
LEU A 189
PHE A 187
 None
 1.10A 1z11D-2v7bA:
undetectable		 1z11D-2v7bA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 PHE A 372
VAL A 375
GLY A 120
ILE A  48
LEU A  57
 None
 1.10A 1z11D-2vn8A:
undetectable		 1z11D-2vn8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9y FATTY ACID/RETINOL
BINDING PROTEIN
PROTEIN 7, ISOFORM
A, CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF05823
(Gp-FAR-1) 		5 VAL A  53
THR A 101
ILE A  25
LEU A  60
PHE A  21
 None
 0.97A 1z11D-2w9yA:
undetectable		 1z11D-2w9yA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 PHE A  53
VAL A  66
ILE A  30
LEU A  64
PHE A   8
 None
 1.11A 1z11D-2xf8A:
undetectable		 1z11D-2xf8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxv SULFUR
OXYGENASE/REDUCTASE

(Acidianus
tengchongensis) 		PF07682
(SOR) 		5 VAL A 252
ILE A 290
GLY A 164
ILE A 180
LEU A 184
 None
 1.12A 1z11D-3bxvA:
undetectable		 1z11D-3bxvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
 None
 0.94A 1z11D-3c2gA:
undetectable		 1z11D-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 VAL A 232
ASN A 226
ILE A 369
ILE A 343
LEU A 247
 None
 1.09A 1z11D-3da1A:
undetectable		 1z11D-3da1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52

(Homo sapiens) 		PF00270
(DEAD) 		5 VAL A 312
ILE A 307
THR A 291
ILE A 240
LEU A 315
 None
 1.11A 1z11D-3dkpA:
undetectable		 1z11D-3dkpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 1.03A 1z11D-3e3xA:
undetectable		 1z11D-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
 None
 1.07A 1z11D-3ed4A:
undetectable		 1z11D-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		5 VAL A 221
ILE A 258
ILE A 233
LEU A 225
PHE A 263
 None
A  E  37 ( 3.9A)
None
None
None
 1.07A 1z11D-3epjA:
undetectable		 1z11D-3epjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 PHE A 109
VAL A 294
ILE A 249
GLY A 246
LEU A 205
 None
 1.08A 1z11D-3ghyA:
undetectable		 1z11D-3ghyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h15 PROTEIN MCM10
HOMOLOG

(Xenopus laevis) 		PF09329
(zf-primase) 		5 VAL A 251
ILE A 246
GLY A 373
THR A 340
LEU A 370
 None
 1.11A 1z11D-3h15A:
undetectable		 1z11D-3h15A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 PHE A 136
ASN A 138
GLY A 142
ILE A 121
LEU A 125
 None
 1.10A 1z11D-3jq1A:
undetectable		 1z11D-3jq1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		5 PHE A 154
ILE A 207
GLY A 206
ILE A 223
LEU A  87
 None
 1.11A 1z11D-3ks7A:
undetectable		 1z11D-3ks7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		5 PHE A 273
PHE A 276
ASN A 379
ILE A 353
LEU A 302
 None
 1.03A 1z11D-3lcaA:
undetectable		 1z11D-3lcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Mus musculus) 		PF00079
(Serpin) 		5 PHE A 278
ILE A 326
ILE A 237
LEU A 275
PHE A 358
 None
 1.11A 1z11D-3lw2A:
undetectable		 1z11D-3lw2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		5 VAL A  88
ASN A 231
ILE A 234
GLY A 235
THR A 239
 HEM  A 397 ( 3.8A)
GOL  A 399 (-4.2A)
GOL  A 400 ( 4.0A)
GOL  A 399 ( 3.6A)
HEM  A 397 (-3.5A)
 0.92A 1z11D-3mgxA:
30.2		 1z11D-3mgxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00287
(Na_K-ATPase) 		5 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
 None
 0.91A 1z11D-3n23B:
undetectable		 1z11D-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		5 PHE A 263
ILE A 296
GLY A 297
ILE A 316
LEU A 289
 None
 1.03A 1z11D-3n9xA:
undetectable		 1z11D-3n9xA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 PHE A 268
ILE A 301
GLY A 302
ILE A 321
LEU A 294
 None
 1.03A 1z11D-3nieA:
undetectable		 1z11D-3nieA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 PHE A 193
VAL A 146
GLY A 191
LEU A 164
PHE A 174
 None
 1.02A 1z11D-3odtA:
undetectable		 1z11D-3odtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		6 PHE A 331
VAL A 333
ILE A 317
GLY A 316
LEU A 269
PHE A 351
 None
 1.34A 1z11D-3pj0A:
undetectable		 1z11D-3pj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		5 ASN A 260
ILE A 185
GLY A 186
ILE A 241
LEU A 178
 None
 1.10A 1z11D-3tovA:
undetectable		 1z11D-3tovA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unn MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF00498
(FHA) 		5 VAL A  64
ILE A  71
THR A  98
ILE A 121
LEU A  34
 None
 1.06A 1z11D-3unnA:
undetectable		 1z11D-3unnA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va1 MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Mus musculus) 		PF00498
(FHA) 		5 VAL A  64
ILE A  71
THR A  98
ILE A 121
LEU A  34
 None
 1.12A 1z11D-3va1A:
undetectable		 1z11D-3va1A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PENTON PROTEIN

(Bovine
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		5 PHE M 260
PHE M 239
ILE M 250
GLY M 249
THR M 337
 None
 1.10A 1z11D-3zifM:
undetectable		 1z11D-3zifM:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		5 ASN A 129
ILE A 196
GLY A 195
THR A 245
LEU A 164
 None
 1.07A 1z11D-4a05A:
undetectable		 1z11D-4a05A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 147
ILE A 119
ILE A  95
LEU A  89
PHE A  97
 None
 1.10A 1z11D-4aipA:
undetectable		 1z11D-4aipA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 PHE A 171
VAL A 169
ILE A 109
LEU A 221
PHE A 252
 None
 1.11A 1z11D-4aslA:
undetectable		 1z11D-4aslA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 VAL V1202
ILE V1180
GLY V1182
ILE V1263
LEU V1250
 None
 1.00A 1z11D-4bxsV:
undetectable		 1z11D-4bxsV:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		5 VAL A2065
ILE A2074
ILE A2052
LEU A2059
PHE A2048
 None
 1.05A 1z11D-4by6A:
undetectable		 1z11D-4by6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 PHE H 556
ILE H 595
ILE H 533
LEU H 527
PHE H 587
 None
 1.07A 1z11D-4c8qH:
undetectable		 1z11D-4c8qH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		5 VAL A 429
ILE A  91
GLY A  92
THR A 296
LEU A 427
 None
 1.06A 1z11D-4dyoA:
undetectable		 1z11D-4dyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 PHE A  94
VAL A  89
GLY A  22
ILE A  74
LEU A  76
 None
 0.94A 1z11D-4ei8A:
undetectable		 1z11D-4ei8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eu2 PROTEASOME COMPONENT
C7-ALPHA

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 PHE A 186
ILE A 194
GLY A  47
THR A  51
ILE A 154
 None
 1.08A 1z11D-4eu2A:
undetectable		 1z11D-4eu2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
 None
 0.94A 1z11D-4eutA:
undetectable		 1z11D-4eutA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
 None
 0.93A 1z11D-4euuA:
undetectable		 1z11D-4euuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 VAL A 151
ASN A 170
ILE A 138
LEU A 135
PHE A 159
 None
 0.87A 1z11D-4fdwA:
undetectable		 1z11D-4fdwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		5 VAL A 404
ILE A 480
ILE A 381
LEU A 354
PHE A 268
 None
 1.07A 1z11D-4gf8A:
undetectable		 1z11D-4gf8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
 HEM  A 502 (-3.9A)
None
None
None
None
 0.83A 1z11D-4grcA:
undetectable		 1z11D-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 PHE A 373
VAL A 276
GLY A 383
LEU A 165
PHE A 168
 HEM  A 501 (-4.0A)
None
None
GOL  A 503 (-3.8A)
None
 0.85A 1z11D-4gs1A:
undetectable		 1z11D-4gs1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 5 PHE B 390
VAL B 290
GLY B 400
LEU B 177
PHE B 180
 HEM  B 501 (-3.9A)
None
None
None
None
 0.85A 1z11D-4gt2B:
undetectable		 1z11D-4gt2B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igv KIROLA

(Actinidia
deliciosa) 		PF00407
(Bet_v_1) 		5 PHE A 136
ASN A  38
ILE A  39
ILE A  23
PHE A  24
 None
 1.05A 1z11D-4igvA:
undetectable		 1z11D-4igvA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ASN A 159
ILE A 158
ILE A 227
LEU A 229
PHE A 237
 None
 1.12A 1z11D-4l60A:
undetectable		 1z11D-4l60A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 VAL X 109
ILE X  75
GLY X  74
THR X  69
LEU X 111
 None
 1.00A 1z11D-4li3X:
undetectable		 1z11D-4li3X:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.03A 1z11D-4mn8A:
undetectable		 1z11D-4mn8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.03A 1z11D-4mnaA:
undetectable		 1z11D-4mnaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		6 PHE A 240
ASN A 258
ILE A 260
ILE A 277
LEU A 253
PHE A 268
 None
 1.49A 1z11D-4qxeA:
undetectable		 1z11D-4qxeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 PHE A 124
ILE A 252
THR A 254
ILE A  99
LEU A 115
 None
 1.04A 1z11D-4r0vA:
undetectable		 1z11D-4r0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 ILE A 182
GLY A 181
THR A 184
ILE A 222
LEU A 218
 None
 0.89A 1z11D-4tx8A:
undetectable		 1z11D-4tx8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 VAL A   7
ILE A  14
GLY A  15
ILE A  21
LEU A 125
 None
 0.90A 1z11D-4udnA:
undetectable		 1z11D-4udnA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		6 PHE A 520
PHE A 519
ILE A 508
THR A 102
ILE A 106
PHE A 222
 None
 1.37A 1z11D-4wbdA:
undetectable		 1z11D-4wbdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens) 		no annotation 5 ILE A 149
GLY A 148
THR A 171
LEU A 183
PHE A 238
 None
 1.07A 1z11D-4wmyA:
undetectable		 1z11D-4wmyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A  99
ILE A   6
ILE A  35
LEU A  94
PHE A  14
 None
 1.05A 1z11D-4ywoA:
undetectable		 1z11D-4ywoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 VAL A 101
ILE A  17
GLY A  18
ILE A  24
LEU A 287
 None
NAD  A 501 (-3.9A)
None
None
None
 1.06A 1z11D-4zqgA:
undetectable		 1z11D-4zqgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		5 PHE B 187
ASN B 284
ILE B 285
GLY B 282
LEU B 242
 None
 0.99A 1z11D-5aw4B:
undetectable		 1z11D-5aw4B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 PHE A 216
PHE A 252
ILE A 107
ILE A 151
PHE A 132
 None
 1.08A 1z11D-5c6uA:
undetectable		 1z11D-5c6uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 VAL A 314
ILE A 361
GLY A 170
ILE A 258
LEU A 283
 NAD  A 401 (-4.0A)
None
None
None
NAD  A 401 (-4.2A)
 1.07A 1z11D-5ceeA:
undetectable		 1z11D-5ceeA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 ILE A 459
GLY A 507
ILE A 498
LEU A 475
PHE A 536
 None
 0.82A 1z11D-5cslA:
undetectable		 1z11D-5cslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		5 PHE A2142
VAL A2089
ILE A2082
THR A2080
ILE A2076
 None
 1.11A 1z11D-5ejsA:
undetectable		 1z11D-5ejsA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 PHE C 204
VAL C  17
ILE C 234
THR C 239
LEU C 139
 None
 1.06A 1z11D-5flzC:
undetectable		 1z11D-5flzC:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		5 PHE A1032
PHE A1034
VAL A1110
ILE A1060
LEU A1121
 None
 0.98A 1z11D-5fv0A:
undetectable		 1z11D-5fv0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 PHE A 336
VAL A 239
GLY A 346
LEU A 128
PHE A 131
 HEM  A 401 ( 4.0A)
None
None
None
None
 0.85A 1z11D-5fw4A:
undetectable		 1z11D-5fw4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 6 PHE A 480
VAL A 473
ILE A 491
GLY A 493
ILE A 448
PHE A 525
 None
 1.34A 1z11D-5h4eA:
undetectable		 1z11D-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		5 ILE A1381
THR A1383
ILE A1479
LEU A1428
PHE A1477
 None
 1.11A 1z11D-5hccA:
undetectable		 1z11D-5hccA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 5 PHE A 724
ILE A 704
ILE A 581
LEU A 738
PHE A 728
 None
 1.09A 1z11D-5id6A:
undetectable		 1z11D-5id6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 VAL A 370
ILE A 355
ILE A 396
LEU A 432
PHE A 360
 None
 1.10A 1z11D-5jbgA:
undetectable		 1z11D-5jbgA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		5 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
 HEM  A 901 (-3.8A)
None
None
None
None
 0.85A 1z11D-5mapA:
undetectable		 1z11D-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5p PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		no annotation
no annotation 		5 PHE A 812
VAL B 666
ILE A 820
GLY A 819
ILE A 861
 None
 1.07A 1z11D-5n5pA:
undetectable		 1z11D-5n5pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 PHE A1135
VAL A1275
ILE A1190
GLY A1259
LEU A1130
 None
 1.11A 1z11D-5x7sA:
undetectable		 1z11D-5x7sA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 ILE A   8
THR A  42
ILE A  22
LEU A  32
PHE A  83
 None
 1.11A 1z11D-5xsqA:
undetectable		 1z11D-5xsqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
 None
 0.96A 1z11D-5xsyA:
undetectable		 1z11D-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhu MYELIN REGULATORY
FACTOR

(Homo sapiens) 		no annotation 5 VAL A 395
GLY A 375
ILE A 518
LEU A 495
PHE A 472
 None
 1.08A 1z11D-5yhuA:
undetectable		 1z11D-5yhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 5 VAL A 405
ILE A 481
ILE A 382
LEU A 355
PHE A 269
 None
 1.03A 1z11D-5yqwA:
undetectable		 1z11D-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhu MYELIN REGULATORY
FACTOR

(Homo sapiens) 		no annotation 5 VAL A 395
GLY A 375
ILE A 518
LEU A 495
PHE A 472
 None
 1.10A 1z11D-5zhuA:
undetectable		 1z11D-5zhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 233
VAL A 215
ILE A 224
ILE A 139
LEU A 208
 None
 1.01A 1z11D-6amsA:
undetectable		 1z11D-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		no annotation 5 PHE A 309
GLY A 252
ILE A 282
LEU A 273
PHE A 280
 None
 1.05A 1z11D-6d2kA:
undetectable		 1z11D-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 PHE L 297
VAL L 285
GLY L 473
ILE L 324
LEU L 323
 None
 1.10A 1z11D-6ehsL:
undetectable		 1z11D-6ehsL:
undetectable