SIMILAR PATTERNS OF AMINO ACIDS FOR 1Z11_B_8MOB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 PHE A 127
PHE A 108
ILE A 313
ILE A 266
LEU A 262
 None
 1.04A 1z11B-1a4eA:
0.0		 1z11B-1a4eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		5 PHE A  25
VAL A  21
ILE A 152
GLY A 153
LEU A 268
 None
 0.78A 1z11B-1a7jA:
0.0		 1z11B-1a7jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 PHE A 223
ILE A 254
GLY A 255
ILE A 202
LEU A 204
 None
 0.93A 1z11B-1gg3A:
0.0		 1z11B-1gg3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PHE A  43
ILE A  97
ILE A  61
LEU A  57
PHE A  28
 HEM  A1398 (-3.9A)
None
HEM  A1398 (-4.3A)
HEM  A1398 (-3.9A)
None
 1.05A 1z11B-1gvhA:
undetectable		 1z11B-1gvhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		6 PHE B 329
ASN B 374
GLY B 355
THR B 358
ILE B 370
LEU B 379
 None
 1.43A 1z11B-1i8kB:
0.0		 1z11B-1i8kB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens) 		PF00079
(Serpin) 		5 VAL A 221
PHE A 217
GLY A 144
ILE A 270
LEU A 205
 None
 0.93A 1z11B-1jmoA:
0.0		 1z11B-1jmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 PHE A 757
ILE A 707
GLY A 708
THR A 712
LEU A 748
 None
 0.96A 1z11B-1l5jA:
0.0		 1z11B-1l5jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m93 SERINE PROTEINASE
INHIBITOR 2
SERINE PROTEINASE
INHIBITOR 2

(Cowpox virus;
Cowpox virus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 VAL B 198
PHE C 318
THR B 291
ILE B 284
PHE B 238
 None
 0.93A 1z11B-1m93B:
0.0		 1z11B-1m93B:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 PHE A 178
PHE A 177
GLY A 251
ILE A 127
PHE A  41
 None
 1.04A 1z11B-1nj8A:
undetectable		 1z11B-1nj8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjl OUTER SURFACE
PROTEIN B

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 VAL C 224
PHE C 260
ILE C 205
ILE C 248
LEU C 246
 None
 1.07A 1z11B-1rjlC:
undetectable		 1z11B-1rjlC:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlm PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 PHE A 149
PHE A 104
ILE A  93
GLY A  94
ILE A 172
 None
 1.03A 1z11B-1rlmA:
undetectable		 1z11B-1rlmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  30
VAL A 107
PHE A  31
ILE A  51
PHE A  67
 None
 1.05A 1z11B-1ttxA:
undetectable		 1z11B-1ttxA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		5 VAL A 309
ASN A 123
ILE A 122
ILE A 298
LEU A 304
 None
 1.01A 1z11B-1xg2A:
undetectable		 1z11B-1xg2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Bacillus
subtilis) 		PF02547
(Queuosine_synth) 		5 VAL A 197
ILE A  47
ILE A 295
LEU A  56
PHE A 184
 None
 0.83A 1z11B-1yy3A:
undetectable		 1z11B-1yy3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk5 F17G ADHESIN SUBUNIT

(Escherichia
coli) 		PF09222
(Fim-adh_lectin) 		5 VAL A 139
PHE A 171
GLY A  75
ILE A 144
LEU A 168
 None
 1.06A 1z11B-1zk5A:
undetectable		 1z11B-1zk5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 5 ASN A 284
GLY A 236
ILE A 215
LEU A 219
PHE A 202
 None
 1.07A 1z11B-2ajaA:
undetectable		 1z11B-2ajaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 PHE A  88
PHE A  21
GLY A 302
LEU A 100
PHE A  91
 None
 0.92A 1z11B-2f8tA:
undetectable		 1z11B-2f8tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		5 ILE A  66
GLY A  65
ILE A  97
LEU A  38
PHE A  42
 None
 1.00A 1z11B-2icgA:
undetectable		 1z11B-2icgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 PHE A 293
GLY A 279
THR A 261
ILE A 308
LEU A 304
 None
 0.87A 1z11B-2ipcA:
undetectable		 1z11B-2ipcA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k78 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN C

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 PHE A  53
VAL A  72
ILE A 117
GLY A  80
PHE A 104
 ZNH  A 151 (-3.6A)
None
ZNH  A 151 (-4.0A)
None
None
 1.05A 1z11B-2k78A:
undetectable		 1z11B-2k78A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 365
PHE A 361
ILE A 382
LEU A 433
PHE A 378
 None
 1.06A 1z11B-2p54A:
undetectable		 1z11B-2p54A:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		10 PHE A 107
PHE A 111
VAL A 117
PHE A 118
ILE A 300
GLY A 301
THR A 305
ILE A 366
LEU A 370
PHE A 480
 None
None
HEM  A 500 (-3.7A)
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.1A)
HEM  A 500 ( 3.8A)
None
 0.34A 1z11B-2pg6A:
64.4		 1z11B-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9y FATTY ACID/RETINOL
BINDING PROTEIN
PROTEIN 7, ISOFORM
A, CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF05823
(Gp-FAR-1) 		5 VAL A  53
THR A 101
ILE A  25
LEU A  60
PHE A  21
 None
 0.89A 1z11B-2w9yA:
undetectable		 1z11B-2w9yA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbv FIBER PROTEIN

(Canine
mastadenovirus
A) 		no annotation 5 PHE A 516
VAL A 411
PHE A 519
GLY A 404
ILE A 377
 None
None
None
None
SIA  A1545 ( 4.3A)
 1.04A 1z11B-2wbvA:
undetectable		 1z11B-2wbvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bin BAND 4.1-LIKE
PROTEIN 3

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 PHE A 332
ILE A 363
GLY A 364
ILE A 311
LEU A 313
 None
 1.07A 1z11B-3binA:
undetectable		 1z11B-3binA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
 None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
 1.05A 1z11B-3bptA:
undetectable		 1z11B-3bptA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
 None
 1.01A 1z11B-3c2gA:
undetectable		 1z11B-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxm URACIL-DNA
GLYCOSYLASE

(Leishmania
naiffi) 		PF03167
(UDG) 		6 PHE A 287
PHE A 162
THR A 269
ILE A 186
LEU A 136
PHE A 187
 None
 1.40A 1z11B-3cxmA:
undetectable		 1z11B-3cxmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 VAL A 232
ASN A 226
ILE A 369
ILE A 343
LEU A 247
 None
 1.04A 1z11B-3da1A:
undetectable		 1z11B-3da1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 288
VAL A 217
PHE A 310
ILE A 200
LEU A 227
 None
NAG  A 760 (-3.9A)
None
None
None
 0.90A 1z11B-3dkhA:
undetectable		 1z11B-3dkhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.94A 1z11B-3e3xA:
undetectable		 1z11B-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
 None
 1.06A 1z11B-3ed4A:
undetectable		 1z11B-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi5 HEAVY CHAIN OF FAB
FRAGMENT OF AL-57
AGAINST ALPHA L I
DOMAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 PHE H  29
ASN H  74
GLY H  55
THR H  58
ILE H  70
LEU H  79
 None
 1.43A 1z11B-3hi5H:
undetectable		 1z11B-3hi5H:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 VAL A 842
PHE A 820
ILE A 765
GLY A 740
ILE A 735
 None
 1.04A 1z11B-3ihyA:
undetectable		 1z11B-3ihyA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkc TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		PF00440
(TetR_N)
PF14278
(TetR_C_8) 		5 PHE A  65
PHE A  69
ILE A  95
ILE A 146
LEU A 114
 None
 1.02A 1z11B-3kkcA:
undetectable		 1z11B-3kkcA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens) 		PF00431
(CUB) 		5 PHE B1270
PHE B1210
PHE B1207
LEU B1205
PHE B1176
 None
 0.93A 1z11B-3kq4B:
undetectable		 1z11B-3kq4B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		5 PHE A 154
ILE A 207
GLY A 206
ILE A 223
LEU A  87
 None
 1.05A 1z11B-3ks7A:
undetectable		 1z11B-3ks7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liz 4C3 MONOCLONAL
ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 PHE H  29
ASN H  74
GLY H  55
THR H  58
ILE H  70
LEU H  79
 None
 1.44A 1z11B-3lizH:
undetectable		 1z11B-3lizH:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		5 VAL A  88
ASN A 231
ILE A 234
GLY A 235
THR A 239
 HEM  A 397 ( 3.8A)
GOL  A 399 (-4.2A)
GOL  A 400 ( 4.0A)
GOL  A 399 ( 3.6A)
HEM  A 397 (-3.5A)
 0.90A 1z11B-3mgxA:
29.8		 1z11B-3mgxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00287
(Na_K-ATPase) 		5 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
 None
 0.91A 1z11B-3n23B:
undetectable		 1z11B-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		5 PHE A 263
ILE A 296
GLY A 297
ILE A 316
LEU A 289
 None
 0.99A 1z11B-3n9xA:
undetectable		 1z11B-3n9xA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 PHE A 268
ILE A 301
GLY A 302
ILE A 321
LEU A 294
 None
 1.02A 1z11B-3nieA:
undetectable		 1z11B-3nieA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 PHE A 193
VAL A 146
GLY A 191
LEU A 164
PHE A 174
 None
 1.01A 1z11B-3odtA:
undetectable		 1z11B-3odtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		6 PHE A 331
VAL A 333
ILE A 317
GLY A 316
LEU A 269
PHE A 351
 None
 1.30A 1z11B-3pj0A:
undetectable		 1z11B-3pj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u15 PROTEIN MDM4

(Homo sapiens) 		PF02201
(SWIB) 		5 VAL A  74
PHE A  90
GLY A  57
ILE A  36
LEU A  81
 None
None
03M  A   1 ( 4.0A)
None
None
 1.03A 1z11B-3u15A:
undetectable		 1z11B-3u15A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN

(Sinorhizobium
meliloti) 		PF08534
(Redoxin) 		5 VAL A 132
PHE A  31
ILE A 110
LEU A   9
PHE A 106
 None
 0.73A 1z11B-3umaA:
undetectable		 1z11B-3umaA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 PHE B 748
ASN B 586
ILE B 579
LEU B 617
PHE B 605
 None
 1.07A 1z11B-3v0aB:
undetectable		 1z11B-3v0aB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zks XA4813

(Lama glama) 		PF07686
(V-set) 		6 PHE D 188
ASN D 233
GLY D 214
THR D 217
ILE D 229
LEU D 238
 None
 1.50A 1z11B-3zksD:
undetectable		 1z11B-3zksD:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		5 ASN A 129
ILE A 196
GLY A 195
THR A 245
LEU A 164
 None
 1.06A 1z11B-4a05A:
undetectable		 1z11B-4a05A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayh METAL-BINDING
PROTEIN YODA

(Salmonella
enterica) 		PF09223
(ZinT) 		5 PHE A 154
PHE A 141
ILE A  85
GLY A  86
LEU A  32
 None
 1.06A 1z11B-4ayhA:
undetectable		 1z11B-4ayhA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 VAL V1202
ILE V1180
GLY V1182
ILE V1263
LEU V1250
 None
 0.96A 1z11B-4bxsV:
undetectable		 1z11B-4bxsV:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 706
GLY A 367
ILE A 285
LEU A 387
PHE A 346
 None
 0.92A 1z11B-4bziA:
undetectable		 1z11B-4bziA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 PHE H 556
ILE H 595
ILE H 533
LEU H 527
PHE H 587
 None
 0.97A 1z11B-4c8qH:
undetectable		 1z11B-4c8qH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 PHE A 143
PHE A 113
ILE A 154
LEU A 117
PHE A 139
 None
PLM  A 301 (-4.8A)
PLM  A 301 (-4.4A)
PLM  A 301 ( 4.7A)
None
 1.08A 1z11B-4dolA:
undetectable		 1z11B-4dolA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 PHE A  94
VAL A  89
GLY A  22
ILE A  74
LEU A  76
 None
 0.99A 1z11B-4ei8A:
undetectable		 1z11B-4ei8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		5 VAL A  58
PHE A  75
GLY A  36
ILE A 123
LEU A  60
 None
 0.73A 1z11B-4eiuA:
undetectable		 1z11B-4eiuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
 None
 0.96A 1z11B-4eutA:
undetectable		 1z11B-4eutA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 VAL A 151
ASN A 170
ILE A 138
LEU A 135
PHE A 159
 None
 0.86A 1z11B-4fdwA:
undetectable		 1z11B-4fdwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
 HEM  A 502 (-3.9A)
None
None
None
None
 0.84A 1z11B-4grcA:
undetectable		 1z11B-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igv KIROLA

(Actinidia
deliciosa) 		PF00407
(Bet_v_1) 		5 PHE A 136
ASN A  38
ILE A  39
ILE A  23
PHE A  24
 None
 1.02A 1z11B-4igvA:
undetectable		 1z11B-4igvA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 PHE A 287
ILE A 253
GLY A 232
ILE A 304
LEU A 310
 None
None
SAH  A 501 (-3.6A)
SAH  A 501 ( 4.5A)
None
 1.07A 1z11B-4ineA:
undetectable		 1z11B-4ineA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		5 PHE A 163
PHE A 352
GLY A 346
LEU A 337
PHE A  21
 None
 1.00A 1z11B-4j34A:
undetectable		 1z11B-4j34A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kys THIAMINE
PYRIDINYLASE I

(Clostridium
botulinum) 		PF01547
(SBP_bac_1) 		5 PHE A  91
PHE A  93
GLY A 105
ILE A 131
LEU A  98
 None
 1.06A 1z11B-4kysA:
undetectable		 1z11B-4kysA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgi UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF13678
(Peptidase_M85) 		5 VAL A  94
PHE A  90
ILE A 108
GLY A 106
LEU A  84
 None
 0.98A 1z11B-4lgiA:
undetectable		 1z11B-4lgiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 VAL X 109
ILE X  75
GLY X  74
THR X  69
LEU X 111
 None
 1.04A 1z11B-4li3X:
undetectable		 1z11B-4li3X:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		PF00793
(DAHP_synth_1) 		5 PHE A 241
PHE A 201
ASN A 142
ILE A  99
ILE A  17
 None
 1.06A 1z11B-4lu0A:
undetectable		 1z11B-4lu0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.03A 1z11B-4mn8A:
undetectable		 1z11B-4mn8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.05A 1z11B-4mnaA:
undetectable		 1z11B-4mnaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		5 VAL A  94
PHE A  90
ILE A 108
GLY A 106
LEU A  84
 None
 0.95A 1z11B-4o2iA:
undetectable		 1z11B-4o2iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 PHE A 124
ILE A 252
THR A 254
ILE A  99
LEU A 115
 None
 1.07A 1z11B-4r0vA:
undetectable		 1z11B-4r0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 6 PHE A  89
VAL A  94
ILE A   6
THR A  50
ILE A 115
LEU A  78
 None
 1.49A 1z11B-4rkzA:
undetectable		 1z11B-4rkzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 6 PHE A  89
VAL A  94
PHE A  85
ILE A   6
THR A  50
LEU A  78
 None
 1.43A 1z11B-4rkzA:
undetectable		 1z11B-4rkzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 ILE A 182
GLY A 181
THR A 184
ILE A 222
LEU A 218
 None
 0.87A 1z11B-4tx8A:
undetectable		 1z11B-4tx8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 VAL A   7
ILE A  14
GLY A  15
ILE A  21
LEU A 125
 None
 0.92A 1z11B-4udnA:
undetectable		 1z11B-4udnA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		5 VAL A 166
ILE A 129
THR A 138
ILE A 140
LEU A 163
 None
 1.06A 1z11B-4w7gA:
undetectable		 1z11B-4w7gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		5 VAL A 256
PHE A 280
THR A 309
ILE A 311
LEU A 322
 None
 0.93A 1z11B-4yj1A:
undetectable		 1z11B-4yj1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A  99
ILE A   6
ILE A  35
LEU A  94
PHE A  14
 None
 0.98A 1z11B-4ywoA:
undetectable		 1z11B-4ywoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 VAL A 101
ILE A  17
GLY A  18
ILE A  24
LEU A 287
 None
NAD  A 501 (-3.9A)
None
None
None
 0.97A 1z11B-4zqgA:
undetectable		 1z11B-4zqgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		5 PHE B 187
ASN B 284
ILE B 285
GLY B 282
LEU B 242
 None
 0.97A 1z11B-5aw4B:
undetectable		 1z11B-5aw4B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 PHE A 216
PHE A 252
ILE A 107
ILE A 151
PHE A 132
 None
 1.07A 1z11B-5c6uA:
undetectable		 1z11B-5c6uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		5 VAL A 186
PHE A 209
THR A 237
ILE A 239
LEU A 250
 None
 0.97A 1z11B-5d6aA:
undetectable		 1z11B-5d6aA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dr5 ABD09097 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 PHE H  29
ASN H  74
GLY H  55
THR H  58
ILE H  70
LEU H  79
 None
 1.47A 1z11B-5dr5H:
undetectable		 1z11B-5dr5H:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 PHE A 336
VAL A 239
GLY A 346
LEU A 128
PHE A 131
 HEM  A 401 ( 4.0A)
None
None
None
None
 0.84A 1z11B-5fw4A:
undetectable		 1z11B-5fw4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 5 VAL A 473
ILE A 491
GLY A 493
ILE A 448
PHE A 525
 None
 1.00A 1z11B-5h4eA:
undetectable		 1z11B-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 5 PHE A 724
ILE A 704
ILE A 581
LEU A 738
PHE A 728
 None
 1.06A 1z11B-5id6A:
undetectable		 1z11B-5id6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikg DYE-DECOLORIZING
PEROXIDASE

(Auricularia
auricula-judae) 		PF04261
(Dyp_perox) 		5 PHE A 139
PHE A  35
ILE A  43
LEU A  76
PHE A  68
 None
 1.05A 1z11B-5ikgA:
undetectable		 1z11B-5ikgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 PHE B 758
ILE B1055
GLY B1054
ILE A 670
LEU A 805
 None
 0.92A 1z11B-5ip9B:
undetectable		 1z11B-5ip9B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 VAL A 370
ILE A 355
ILE A 396
LEU A 432
PHE A 360
 None
 1.04A 1z11B-5jbgA:
undetectable		 1z11B-5jbgA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Sinorhizobium
meliloti) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 VAL A 142
ILE A 151
GLY A 149
ILE A 190
LEU A 165
 None
 1.07A 1z11B-5l0zA:
undetectable		 1z11B-5l0zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 PHE A 556
ILE A 595
ILE A 533
LEU A 527
PHE A 587
 None
 1.05A 1z11B-5lmgA:
undetectable		 1z11B-5lmgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		5 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
 HEM  A 901 (-3.8A)
None
None
None
None
 0.85A 1z11B-5mapA:
undetectable		 1z11B-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 PHE A 104
PHE A 108
ILE A 150
GLY A 148
LEU A 143
 None
 1.08A 1z11B-5nr1A:
undetectable		 1z11B-5nr1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk1 PROTEIN MDM4

(Homo sapiens) 		no annotation 5 VAL A  74
PHE A  90
GLY A  57
ILE A  36
LEU A  81
 None
 1.06A 1z11B-5vk1A:
undetectable		 1z11B-5vk1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 PHE A 353
ILE A 362
ILE A 271
LEU A 287
PHE A 267
 None
 1.06A 1z11B-5w7zA:
undetectable		 1z11B-5w7zA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
 None
 0.95A 1z11B-5xsyA:
undetectable		 1z11B-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 5 VAL A 405
ILE A 481
ILE A 382
LEU A 355
PHE A 269
 None
 1.03A 1z11B-5yqwA:
undetectable		 1z11B-5yqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 233
VAL A 215
ILE A 224
ILE A 139
LEU A 208
 None
 1.06A 1z11B-6amsA:
undetectable		 1z11B-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 6 VAL A1218
PHE A1287
ILE A1002
GLY A1014
ILE A1020
LEU A1021
 None
 1.40A 1z11B-6b3rA:
undetectable		 1z11B-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		no annotation 5 PHE A 309
GLY A 252
ILE A 282
LEU A 273
PHE A 280
 None
 1.04A 1z11B-6d2kA:
undetectable		 1z11B-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL

(endosymbiont of
Tevnia
jerichonana) 		no annotation 5 PHE A 117
ILE A  23
GLY A  22
ILE A  17
PHE A 189
 None
 0.94A 1z11B-6fvsA:
undetectable		 1z11B-6fvsA:
undetectable